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Rachmat Hidayat
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dr.rachmat.hidayat@gmail.com
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+6288225053819
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eureka.herba.indonesia@gmail.com
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Dr. Moh Ali street Palembang South Sumatera Indonesia
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INDONESIA
Eureka Herba Indonesia
Published by HM Publisher
ISSN : -     EISSN : 27465152     DOI : https://doi.org/10.37275/ehi.v1i1.1
Core Subject : Health,
Medicine & Pharmacology
Eureka Herba Indonesia (EHI) is peer review scientific journal that focused on reserach in exploration potential Herba of Indonesia for enhancing healthy. EHI focused on : 1. Medicinal Plants. 2. Efficacy of Herba Study. 3. Safety of Herba Study. 4. Animals that potential for developing as healthy products. 5. Minerals that potential for developing as healthy products.
Arjuna Subject : Kedokteran - Kedokteran Komplemen dan Alternatif
Articles 45 Documents
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The Effects of Sambiloto Leaf Extract (Andrographis paniculata) on Blood Sugar Regulation: An In Vivo Study Rachmat Hidayat; Lusia Hayati
Eureka Herba Indonesia Vol. 1 No. 1 (2020): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v1i1.1

Abstract

Sambiloto (Andrographis paniculata) is one of the most common plants in Indonesia. Sambiloto contains quite varied secondary metabolites, where this plant is rich in flavonoids, alkaloids, terpenes and glycosides. This study aims to assess the effect of Sambiloto (Andrographis paniculata) leaf extract on blood sugar levels and the expression of GLUT4 protein in muscle tissue which indicates the potential of the test extract's ability to improve blood glucose intake to cells so that it can maintain blood sugar regulation. The process of extracting sambiloto is carried out by maceration in which 500 grams of simplicia are macerated with 96% ethanol for 72 hours. After 1 week of adaptation, the mice were randomly divided into the following six groups, each containing 5 animals: Normal control group, diabetes group (negative control), diabetes + metformin group (Met; 45 mg/kg), Diabetes + ES group (50 mg/kg), diabetes + ES group (100 mg/kg) and diabetes + ES group (200 mg/kg). The treatment with sambiloto extract was able to reduce blood sugar levels significantly, were at the ES 100 and 200 mg/kg BW doses it was able to reduce blood sugar levels to reach the target below 200 mg/kg BW. The dominant flavonoids in Sambiloto leaf extract are believed to be responsible for the effect of blood glucose regulation. In conclusion, Sambiloto extract affects lowering blood sugar levels in diabetes mellitus white rats by increasing glucose intake in cells and tissues.
Curcuma zedoaria (Christm.) Roscoe: Benefits and Bioactivity Marina Silalahi
Eureka Herba Indonesia Vol. 1 No. 2 (2020): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v1i2.10

Abstract

Curcuma zedoaria (Christm.) Roscoe or Temu Putih is a native plant in India and has been long cultivated in Indonesia. By the local communities in Java, it has been used as a component of the Jammu and the traditional medicine. This article is based on literature from offline and online media. Offline literature used the books, whereas online media used Web, Scopus, Pubmed, and scientific journals. Based on a study of ethnobotany Curcuma zedoaria was used as medicine and spices. The main secondary metabolites of Curcuma zedoaria rhizomes are terpenoids, especially sesquiterpenoids and monoterpenoids. Curcuma zedoaria have bioactivities as anticholesterol, anti-tumor/cancer, anti-inflammation, fever, antipyretic, analgesic dan anti-microbial
The Potency of Cinnamomum Zeylanicum to Prevent Diseases: A Review Casey Christiany; Susana Elya Sudrajat; Ika Rahayu
Eureka Herba Indonesia Vol. 2 No. 1 (2021): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v2i1.11

Abstract

Plants are an important source of traditional medicines that can be used to improve health. Cinnamon (Cinnamomum zeylanicum) has long been recognized to have many benefits. Cinnamon was used traditionally as a remedy for arthritis, diarrhea, allergies, and ulcers. This literature review aimed to identify the bioactive compounds and bioactivity of cinnamon. Literature searches used PubMed and Google Scholar. A total of 55 full-text articles met the inclusion criteria of the review. The extract or essential oil of cinnamon contains many bioactive compounds, such as eugenol, cinnamic acid, linalool, β-caryophyllene, coumarin, and trans cinnamyl acetate, and 1.8 cineole. These compounds have several bioactivities including anti-cancer, anti-arrhythmia, anti-inflammatory, anti-diabetic, anti-atherosclerosis, anti-cholinesterase, and anti-lipid oxidation. Cinnamon extract has excellent potential as an antioxidant and antidiabetic agent. Its potential and unique taste have contributed to its wide use in herbal remedies.
Safety Assessment of Combination of Tinospora crispa Extract, Andrographis paniculata, Cinnamomum burmanii, Syzygium polyanthum and Momordica charantia in Hepar and Renal Function Rachmat Hidayat; Patricia Wulandari
Eureka Herba Indonesia Vol. 2 No. 1 (2021): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v2i1.13

Abstract

Tinospora crispa, Andrographis paniculata, Cinamomum burmanii, Syzygium polyanthum and Momordica charantia contain phenolics and flavonoids which are rich in benefits. Phenolic compounds are compounds that have an aromatic ring with one or more hydroxy groups, compounds derived from plants that have the same characteristics, namely aromatic rings containing one or more hydroxyl groups. Herbal plants, which are rich in phenolic compounds, have the efficacy, among others, as antioxidants, anti- inflammatory, antimicrobial, anti-fungal and prevents tumor growth. The acute toxicity test is a procedure designed to determine the median lethal dose of a substance and its possible mechanism of action and target organs. In simple terms, toxicity can be defined as the ability of a compound that can cause harmful effects or deviate from the biological mechanism in an organism.
Potential Combination of Tinospora crispa, Andrographis paniculata, Cinnamomum burmanii, Syzygium polyanthum, and Momordica charantia Extracts Against Intake of Glucose in Muscle Rats-Induced Diabetes Mellitus Rachmat Hidayat; Patricia Wulandari
Eureka Herba Indonesia Vol. 2 No. 1 (2021): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v2i1.14

Abstract

Diabetes mellitus is a chronic condition that disturbs the body's blood sugar regulation. This disorder is characterized by a decrease in the ability of body cells to intake glucose into cells. Due to the failure of cells in glucose intake, glucose buildup occurs in the extracellular, namely in the plasma. These medicinal plants contain quite varied secondary metabolites, and these plants are rich in flavonoids, alkaloids, terpenes, and glycosides. The content of these secondary metabolite compounds is believed to be rich in antioxidant effects so that it has the effect of being able to suppress various oxidative stress conditions that cause damage to various organs due to blood sugar dysregulation. The effect of Tinospora crispa, Andrographis paniculata, Cinnamomum burmanii, Syzygium polyanthum and Momordica charantia extract on blood sugar levels and GLUT4 protein expression in muscle tissue shows the potential of the test extract's ability to improve blood glucose intake to cells so as to maintain blood sugar regulation.
Methods of Extraction: Maceration, Percolation and Decoction Rachmat Hidayat; Patricia Wulandari
Eureka Herba Indonesia Vol. 2 No. 1 (2021): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v2i1.15

Abstract

Today, natural medicines not only provide the primary healthcare needs for the majority of the population in developing countries but have attracted more and more attention in developed countries due to soaring healthcare costs and universal financial austerity. In the USA, approximately 49% of the population has tried natural medicines for the prevention and treatment of diseases. Chemicals known to have medicinal benefits are considered to be “active ingredients” or “active principles” of natural medicines. Natural products have provided the primary sources for new drug development.
The Efficacy of the Consumption of Manalagi Apples and Fuji Apples on Decreasing Plaque Index in Students of Madrasah Aliyah Al-Hidayah Labuhan Batu Selatan, North Sumatra Molek; Dwi Setya Rini; Mangatas Halomoan Parluhutan Hutagulung
Eureka Herba Indonesia Vol. 2 No. 1 (2021): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v2i1.16

Abstract

Caries is a common oral and dental disease. The main etiology of caries is plaque. Chewing fibrous fruits can prevent plaque accumulation, including Manalagi apples and Fuji apples. The purpose of this study was to determine the differences in the effectiveness of consuming manalagi apples with fuji apples on the reduction of the plaque index in Madrasah Aliyah Al-Hidayah students. This type of research is a quasi-experimental design with pre-test and post-test control groups. The total sample was 32 students aged 16-18. Data were analyzed by statistical test T-Test. Based on the results of the paired t-test statistical test, it was found that the average plaque index before chewing an apple was 0.63 ± 0.42 after 0.26 ± 0.26 with a mean of 0.37 ± 0.16. Meanwhile, the plaque index before chewing on Fuji apples was 1.01 ± 0.59 after 0.87 ± 0.54 with a mean of 0.14 ± 0.05. The results of the independent statistical t-test showed that the value of p = 0.001, which means that there is a difference in chewing Manalagi apples with Fuji apples to decrease the plaque index. The conclusion of this study is that consuming manalagi apples is more effective than fuji apples in reducing the plaque index
The Effect of Cucumber Fruit (Cucumis Sativus L) on pH Saliva at The Rapha-EL Orphanage Foundation Molek; Sinta Marito; Mangatas Halomoan Parluhutan Hutagulung
Eureka Herba Indonesia Vol. 2 No. 2 (2021): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v2i2.17

Abstract

Increasing the pH of saliva will affect oral health. One way to increase the pH of saliva is to chew fruit that is fibrous, crunchy, and contains lots of water. The research objective was to determine the effect of cucumber on salivary pH at the Bina Mandiri Social Orphanage. This type of research is a one-group pretest and posttest group design. The study population was the children at the Rapha-El Orphanage Foundation. The sample size is determined based on the Roscoe formula of 20 people. Methods of data collection by measuring the pH of saliva before and after chewing cucumbers using a digital pH meter. The data that has been collected, is then analyzed by paired t-test. The results showed that there was a difference in the average pH of saliva before and after chewing cucumber (p = 0.001). The conclusion is that there is an effect of chewing cucumber on increasing the pH of saliva in children at the Rapha- El Orphanage Foundation.
Antibacterial and Antifungal Activity of Clove Extract (Syzygium Aromaticum): Review Nathaniel Hiwandika; Susana Elya Sudrajat; Ika Rahayu
Eureka Herba Indonesia Vol. 2 No. 2 (2021): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v2i2.18

Abstract

Cloves is one of the native Indonesian plants and is used in many aspects of life. Cloves are used in multiple industries and as detergents, soaps, perfumes, food seasonings, aromatherapy, etc. Cloves are mainly used for ingredients in kretek cigarettes in Indonesia. Various studies of cloves reported they have good pharmacological and therapeutic effects. The main compounds of clove extract are eugenol and β-caryophyllene, which are powerful antibacterial and antifungal agents. The clove ethanolic extract showed the activity to inhibit Gram-positive and negative bacteria such as B. cereus, S. aureus, E. coli, P. aeruginosa, S. pneumonia, S. aureus,S. epidermidis, A. hydrophila, K. pneumoniae, P. gingivalis, and P. mirabilis . Clove essential oil has shown the ability to inhibit the growth of V. inaequalis, C. Albicans, C. glabrata, and C. tropicalis. Cloves extract can be used as an essential ingredient in various medicines. However, it requires further research and trials.
The Potential of Cinnamon as Anti-Depressant Chris Alberto Amin; Afiahana Andatia; Fathia Daffa Putri; Siti Nurhayati Utami; M. Yusuf Wijahaska
Eureka Herba Indonesia Vol. 2 No. 2 (2021): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v2i2.19

Abstract

Depression is a feeling of loss of interest or pleasure, sadness, feelings of guilt or inferiority, disturbances in sleep or appetite, feelings of tiredness, and poor concentration and the desire to end life. In Indonesia, according to the Indonesian Ministry of Health in 2018, the prevalence of depressive disorders in Indonesia is 6.1%. Based on the 2013 Riskesdas report, the prevalence of suicide in Indonesia is mostly carried out by women, which is around 0.8% compared to men, which has a prevalence of 0.6%. Until now, the first line of depression therapy is the Serotonin Re-Uptake Inhibitor (SSRI) group. Although this drug is effective in improving symptoms of depression, this drug can cause several side effects such as insomnia or drowsiness, weight gain, and sexual dysfunction. Therefore, we need an alternative medicine that can replace conventional medicine which has less side effects. Cinnamon is one of the many plants found in Indonesia which is believed to have the potential to overcome various diseases. Based on previous research, there are many active components contained in cinnamon that have anti-depressant effects. Active components such as Phenol, Cinnamaldehyde, Turmerone, Proanthocyanidin and Linalool as well as Eugenol can provide anti-depressant effects through anti-inflammatory prevention.

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