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Jurnal Sains dan Kesehatan
Published by Universitas Mulawarman
ISSN : 23030267     EISSN : 24076082     DOI : https://doi.org/10.25026/jsk
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology
Jurnal Sains dan Kesehatan (J. Sains. Kes) (e-ISSN 2407-6082, p-ISSN 2303-0267), is a national journal with ISSN and published four times a year in 2015. In 2016 the publishing frequency changed to twice a year. In 2021 the frequency increased to six times a year. Jurnal Sains dan Kesehatan is published online by the Faculty of Pharmacy, Mulawarman University, Samarinda City, East Kalimantan. Since 2019, the Jurnal Sains dan Kesehatan has been accredited to SINTA. Jurnal Sains dan Kesehatan publishes manuscripts (Original research Article, review articles, and Short communication) on original work, either experimental or theoretical in the following areas: Pharmaceutics, Pharmaceutical Chemistry, Pharmacology & Toxicology, Pharmaceutical Biotechnology & Microbiology, Pharmacy practice & Hospital Pharmacy, Case Study & Full clinical trials, Clinical Pharmacy, Medicine, and other related fields. The purpose of publishing the Jurnal Sains dan Kesehatan is to provide scientific information about the development of science and technology in the field of Science and Health. Lingkup naskah Jurnal Sains dan Kesehatan mencakup bidang ilmu: Kimia Farmasi Biologi Farmasi Farmakologi Teknologi Farmasi dan Farmasetika Farmasi Klinik dan Komunitas Kedokteran dan Bidang ilmu lain yang terkait Tujuan penerbitan Jurnal Sains dan Kesehatan adalah memberikan informasi ilmiah tentang perkembangan ilmu pengetahuan dan teknologi bidang Farmasi dan yang terkait
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 12 Documents
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Search results for , issue "Vol. 5 No. 1 (2023): J. Sains Kes." : 12 Documents clear
Diseksi Spontan Arteri Koroner: Diagnosis dan Manajemen: Coronary Artery Spontaneous Dissection: Diagnosis and Management Sidhi Laksono; Yogi Subandra
Jurnal Sains dan Kesehatan Vol. 5 No. 1 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i1.1137

Abstract

Spontaneous coronary artery dissection (SCAD) is one of the rare causes of ACS cases but is increasing in incidence in young women with low cardiovascular risk assessment. In addition, SCAD has risk factors for pregnancy and fibromuscular dysplasia. Establishing the diagnosis of SCAD by coronary angiography is a challenge because the characteristics of SCAD are similar to other causes of ACS and often missed. It is hoped that SCAD can be a research concern to support diagnosis and management to produce better outcomes. Keywords: coronary artery spontaneous dissection, diagnosis, management, acute coronary syndrome Abstrak Diseksi spontan arteri koroner (Spontaneous Coronary Artery Dissection: SCAD) salah satu penyebab kasus SKA yang jarang tetapi meningkat insidensi pada wanita muda dengan penilaian risiko kardivaskular rendah. Selain itu SCAD memiliki faktor risiko terhadap kehamilan, dan penyakit fibromuscular dysplasia. Penegakan diagnosis SCAD dengan angiografi koroner menjadi tantangan dikarenakan karakteristik SCAD yang mirip dengan penyebab ACS lainnya dan sering kali terlewat. Diharapkan SCAD dapat menjadi perhatian penelitiaan untuk mendukung penegakan diagnosis dan manajemen guna menghasilkan keluaran lebih baik. Kata Kunci: diseksi spontan arteri koroner, diagnosis, manajemen, sindroma korone akut
Detection of Flavonoid Compounds of Daruju Root Extract (Acanthus ilicifolius Linn) using Thin Layer Chromatography and UV-Vis Spectrophotometry Aden Dhana Rizkita; Ilham Maulana; Sintia Ayu Dewi
Jurnal Sains dan Kesehatan Vol. 5 No. 1 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i1.1185

Abstract

The isolation and detection of flavonoids in the extract of Daruju root has been carried out. extract obtained from maceration modification using 96% ethanol, ethanol extract The extraction result is concentrated with a rotary evaporator and then evaporated above water bath until a thick extract is obtained. The resulting extract was further separated using a separating funnel and diethyl ether and n-butanol as solvents. Then the thick extract was tested for plavonoid preliminaries by reacting the thick extract with H2SO4 and Mg the results obtained were a change in color to yellow, it proved that the extract was positive for plavonoid. After that, TLC was carried out to purify the extract which would later detect plavonoid using a UV-Vis spectrophotometer. TLC results show an Rf value of 0.6-0.8. UV-Vis spectrophotometer results at a wavelength of 200-800 nm give results in fraction A with a maximum wavelength at 291 nm which is suspected to have detected flavonoids.
Gambaran Tingkat Pengetahuan tentang Period After Opening (PAO) dan Perilaku Penyimpanan Kosmetika Perawatan pada Remaja di Kota Tangerang: The Level of Knowledge about Period After Opening (PAO) and Storage Behavior of Cosmetics in Adolescents in Tangerang Yopi Septianingrum; Ulya Safrina; Nanda Puspita; Surahman Surahman
Jurnal Sains dan Kesehatan Vol. 5 No. 1 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i1.1478

Abstract

Period After Opening (PAO) is the time limit for using cosmetics after the packaging is opened. Information about PAO is different from the expiration date of cosmetic products. This information is generally contained in cosmetic packaging to ensure quality and safety. This study aimed to describe the knowledge level about the Period After Opening (PAO) and cosmetic storage behavior in adolescents in RW 02 Gondrong Village, Cipondoh District, Tangerang City, in 2022. This research uses a quantitative descriptive survey method. The sampling technique in this study was random cluster sampling followed by 91 respondents. Data collection was carried out using a questionnaire. The data analysis used was univariate. Based on the study results, most respondents were aged 16-18 years, with 45 respondents (49.5%) and high school/MA/equivalent education (37.4%). Most of them use cleaning cosmetics, with 44 respondents (48.4%). As many as 77 respondents (84.6%) used ready-made products (non-concoctions), and 51 respondents (56.0%) bought them at a price range of IDR 50,000 - IDR 200,000. Most respondents store skincare at room temperature, with 66 respondents (72.5%). In this study, the majority of respondents, namely 75 people (82.4%), stated that there was no PAO information on brochures or cosmetic packaging. Nonetheless, more than half of the respondents had good knowledge of PAO, with 51 respondents (56.0%). Knowledge of PAO in cosmetics is essential to guide the safe use of cosmetics for consumers, especially teenagers. Keywords: Cosmetics, knowledge, Period after Opening (PAO) Abstrak Period After Opening (PAO) adalah batas waktu penggunaan kosmetik setelah kemasan kosmetik dibuka, dimana produk masih aman digunakan. Tujuan dari penelitian ini adalah mengetahui gambaran tingkat pengetahuan tentang Period After Opening (PAO) dan perilaku penyimpanan kosmetika pada remaja di RW 02 Kelurahan Gondrong Kecamatan Cipondoh Kota Tangerang tahun 2022. Penelitian ini menggunakan metode survei deskriptif kuantitatif. Teknik pengambilan sampel dalam penelitian ini yaitu cluster random sampling dan diikuti oleh 91 responden. Pengumpulan data dilakukan dengan menggunakan kuesioner. Analisis data yang digunakan berupa analisis univariat. Berdasarkan hasil penelitian diketahui bahwa, mayoritas responden berusia 16 – 18 tahun sejumlah 45 responden (49,5%) dan lebih dari separo responden memiliki pengetahuan yang baik dengan jumlah 51 responden (56,0%). Mayoritas responden menggunakan kosmetika pembersih dengan jumlah 44 responden (48,4%), jenis sediaan skincare produk yang sudah jadi atau non racikan dengan jumlah 77 responden (84,6%), dan mayoritas responden membeli skincare dengan kisaran harga Rp 50.000 - Rp 200.000. Pada penelitian ini dijelaskan, bahwa mayoritas responden tidak memiliki skincare yang terdapat informasi PAO pada brosur atau kemasannya dan mayoritas responden menyimpan skincare pada ruang kamar dengan jumlah 66 responden (72,5%). Kata Kunci: Kosmetika, Pengetahuan, Period after Opening (PAO)
Analisa Fitokimia dan Aktivitas Antioksidan Sirup Poliherbal yang Mengandung Daun Kelor, Rimpang Kunyit, dan Rimpang Jahe: Phytochemical Analysis and Antioxidant Activity of Polyherbal Syrup Containing Moringa Leaf, Turmeric, and Ginger Rhizoma Nurmalia Zakaria; Fauziah Fauziah; Rinaldi Rinaldi; Yuni Dewi Safrida; Erliana Winingsih
Jurnal Sains dan Kesehatan Vol. 5 No. 1 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i1.1494

Abstract

Polyherbal syrup containing Moringa leaves, turmeric rhizome and ginger rhizome (SPKKJ) is believed empirically by the people of Banda Aceh, Aceh, Indonesia, to be able to maintain health and increase body immunity. These indications are caused by antioxidant phytochemical compounds. The combination of the three in the form of syrup is one of the dosage forms with the oral route, that has the fastest absorption time and is easy to use. This study aims to analyze the phytochemical compounds and antioxidant activity of SPKKJ by DPPH scavenging. This research is an experimental quantitative study where the IC50 value of syrup preparation will be calculated based on the percent inhibition of DPPH scavening. The variables that played a role in this study were moringa leaf syrup (S1), turmeric rhizome syrup (S2), ginger rhizome syrup (S3), and SPKKJ (S4). A comparison was used as a positive control in the form of Vitamin C. The results showed that SPKKJ contained saponins, tannins, and alkaloids. IC50 of SPKKJ is 0.21 g/mL which is a very strong antioxidant. The IC50 value of SPKKJ was higher than S1, S2, S3 and Vitamin C, with a significant difference to Vitamin C (p
Analisis Penggunaan E-purchasing pada Pengadaan Obat Esensial di Dinas Kesehatan Kota Pekalongan: Analysis of E-purchasing Application in the Procurement of Essential Medicines at Pekalongan Public Health Office Jamaludin Al Jamaludin Efendi; Ekanita Desiani; Amanda Kusumaning Astari
Jurnal Sains dan Kesehatan Vol. 5 No. 1 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i1.1495

Abstract

E-purchasing is an electronic system provider in the procedure of purchasing goods/services based on the e-catalogue available. However, along with the application of e-purchasing, some problems still could as with the delivery duration, empty stock, and failure to produce the drugs according to plan. Therefore, this study is being conducted to analyze the use of e-purchasing in the procurement of essential drugs at the Pekalongan City Health Office in 2018-2020. This research was conducted qualitatively with a quantitative approach. The data was taken retrospectively from the pharmacy department of Pekalongan City Health Office in 2018-2020. Next, the obtained data were sorted according to the type of drug based on DOEN 2019. The results of this study indicate that the use of e-purchasing in the procurement of essential drugs at Pekalongan City Health Office is effective. In the drugs procurement through e-purchasing, there consist 89 types of drugs in accordance with the indicator. The realization of drugs according to the order are 86 types of drugs with a percentage of 96.63%. While the drug lead time is in accordance with the agreement on 88 types of drugs or equivalent to 98.89%. Drug prices are increased in 20 types of drugs from 28 types of indicator drugs with a percentage of 71.43%. Keywords: E-purchasing, Drugs procurement, Essential drug Abstrak E-purchasing adalah penyedia sistem elektronik dalam tata cara pembeliaan barang/jasa berdasarkan e-catalogue yang disediakan. Akan tetapi, seiring dengan pemakaiaan e-purchasing ada saja masalah yang bisa timbul diantaranya lamanya pengiriman, kekosongan persediaan, dan tidak terealisasikannya obat sesuai rencana. Oleh karena itu, dilakukan penelitian untuk menganalisa penggunaan e-purchasing pada pengadaan obat esensial di Dinas Kesehatan Kota Pekalongan pada tahun 2018-2020. Penelitian ini dilakukan secara kualitatif dengan pendekatan kuantitatif. Data diambil secara retrospektif di Dinas Kesehatan Kota Pekalongan bagian farmasi pada tahun 2018 – 2020. Lalu data disunting sesuai dengan jenis obat berdasarkan Daftar Obat Esensial Nasional (DOEN) 2019. Hasil penelitian ini menunjukkan bahwa penggunaan e-purchasing pada pengadaan obat esensial di Dinas Kesehatan Kota Pekalongan berjalan efektif. Pada pengadaan obat melalui e-purchasing  terdapat 89 jenis obat sesuai indikator. Realisasi obat yang sesuai dengan pemesanan yaitu sejumlah 86 jenis obat dengan persentase 96,63%. Sedangkan lead time obat sesuai dengan kesepakatan pada 88 jenis obat atau setara dengan 98,89%. Harga obat mengalami peningkatan pada 20 jenis obat dari 28 jenis obat indikator dengan prosentase 71,43%.  Hambatan yang sering terjadi adalah waktu pengiriman barang, akan tetapi tidak mempengaruhi ketersediaan obat dan selalu mengkonfirmasi kepada penyedia terkait pengiriman barang. Sehingga dapat dikatakan penggunaan e-purchasing ini efektif dan efisien untuk pengadaan obat. Kata Kunci: E-purchasing, Pengadaan obat, Obat esensial
Potensi Aktivitas Antibakterial Ekstrak Bunga Telang (Clitoria Ternatea): Potential Antibacterial Activity of Telang Flower Extract (Clitoria Ternatea) Muflihah Rizkawati; Leonny Dwi Rizkita
Jurnal Sains dan Kesehatan Vol. 5 No. 1 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i1.1512

Abstract

High burden rate of antimicrobial resistance (AMR) worldwide encourages for more new studies of therapeutic strategies to minimize the further morbidities and mortalities, especially in country with heavy prevalence of infection disease. One of the alternative approach is through the nature. Butterfly pea (Clitoria ternatea) or Asian Pigeonwing is indigenous decorative plant commonly found in tropical region of the world, such as Pacific Asia, South America and Madagascar. The bright purple colour is notably utilized as natural food colouring in many Asian cuisine. The particular plant has been used for years as medicinal plant in various preparations, mostly as decoction for herbal drink/tea. However, scientific analysis to identify the possible health benefits are required to support the vaguely empirical testimony. The antibacterial component owned by butterfly pea plant is not limited by its flower petals only, but also the rest of the body, from the roots to the stem. The extraction process of butterfly pea plant shows myriad of phytochemical compounds with high pharmacological activity, especially as antibacterial against various bacteria such as E. coli and Bacillus cereus. Thus, this review compiles the recent ten years original article reported the antibacterial activities of Clitoria ternatea. Keywords: telang flower, Clitoria ternatea, butterfly pea, antibacterial Abstrak Angka beban global yang diakibatkan oleh kejadian resistensi antimikroba mendorong untuk dilakukan lebih banyak studi yang menelusuri strategi terapi terbaru guna mengurangi penambahan angka morbiditas dan mortalitas terutama pada negara dengan kasus penyakit infeksi yang sering. Salah satu pendekatan yang dapat dilakukan ialah melalui pengamatan terhadap potensi alam. Bunga telang (Clitoria ternatea) merupakan tanaman hias yang banyak ditemukan di negara tropis seperti Asia Pasifik, Amerika Selatan dan Madagaskar. Warna ungu terang yang menjadi khas tanaman tersebut sudah banyak dimanfaatkan sebagai pewarna makanan alami di beragam masakan Asia. Selain itu, tanaman ini juga telah digunakan sejak lama sebagai obat tradisional dalam berbagai sediaan, terutama seduhan rebusan. Namun, pendekatan saintifik diperlukan untuk mendukung pernyataan berbasis empiris. Komponen antimikroba milik bunga telang tidak hanya terbatas pada bagian kelopak bunganya saja namun semua bagian tubuhnya, mulai dari akar hingga batang. Proses ekstraksi tanaman bunga telang menunjukkan komponen fitokimia yang berkhasiat terutama sebagai antimikroba melawan E. coli dan Bacilus cereus. Oleh karena itu, ulasan ini dibuat guna mengkompilasi berbagai penelitian yang melaporkan aktivitas antibakteri Clitoria ternatea. Kata Kunci: Bunga telang, Clitoria ternatea, Antibakteri
Penerapan Teknik Nanopresipitasi pada Nanoenkapsulasi Teofilin dengan Variasi Konsentrasi Polimer dan Surfaktan: Application of Nanoprecipitation Technique on Theophylline Nanoencapsulation with Variation of Polymer Concentration Mar’atus Sholikhah; Rahayu Apriyanti; Sarmadi Sarmadi
Jurnal Sains dan Kesehatan Vol. 5 No. 1 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i1.1521

Abstract

Theophylline is a xanthine derivative used in the treatment of asthma that causes smooth muscle relaxation, especially bronchial smooth muscle dilation. So far, the pharmaceutical dosage forms of theophylline are very diverse, and most of them are intended for oral use. Oral administration of drugs is known to be prone to causing gastrointestinal disorders such as indigestion. In addition, its stability is also easy to change due to the influence of enzymes, pH, and microbial degradation. One of the most promising drug delivery systems is nanoencapsulation. The purpose of this study was to obtain the optimum formula for theophylline nanoencapsulation (NET) using an optimization system. Theophylline nanoencapsulation was prepared by applying various concentrations of PEG 6000 and SLS, starting from the smallest ratio of 1:1 to the largest ratio of 3:1. The characterization carried out on the five NET formulas included transmittance percentage, particle size, and polydispersity index (PDI). The selected optimal NET formula was then used to determine the zeta potential using Particle Size Analyzer. The ratio of 1.667:1 between PEG 6000 and SLS is the most optimal composition capable of producing NET with a particle size of 11.9 nm, a PDI of 0.12 µm, and a zeta potential of +18,87 mV. Keywords: Nanoencapsulation, nanoparticles, nanoprecipitation, theophylline Abstrak Teofilin merupakan derivat xantin yang digunakan dalam terapi asma yang menyebabkan relaksasi otot polos, khususnya dilatasi otot polos bronkus. Sejauh ini bentuk sediaan farmasi teofilin sangat beragam dan sebagian besar ditujukan untuk penggunaan secara oral. Pemberian obat peroral diketahui rentan menyebabkan gangguan saluran cerna seperti indigesti. Selain itu, stabilitasnya juga mudah berubah karena adanya pengaruh enzim, pH, dan degradasi mikroba. Salah satu sistem penghantaran obat yang menjanjikan adalah nanoenkapsulasi. Tujuan dari penelitian ini adalah untuk memperoleh formula optimum dari nanoenkapsulasi teofilin (NET) menggunakan sistem optimasi. Nanoenkapsulasi teofilin dipreparasi dengan menerapkan variasi konsentrasi PEG 6000 dan SLS mulai dari perbandingan terkecil 1:1 hingga terbesar 3:1. Adapun karakterisasi yang dilakukan terhadap lima formula NET meliputi persentase transmitan, ukuran partikel, dan indeks polidispersitas (PDI). Formula optimum NET terpilih kemudian ditetapkan zeta potensialnya menggunakan Particle Size Analyzer. Perbandingan antara PEG 6000 dan SLS sebesar 1,667:1 merupakan komposisi paling optimum yang mampu menghasilkan NET dengan ukuran partikel 11,9 nm, PDI 0,12 µm, dan zeta potensial sebesar +18,87 mV. Kata Kunci: Nanoenkapsulasi, nanopartikel, nanopresipitasi, teofilin
Kajian Praklinis Ekstrak Etanol Herba Tridax procumbens (Linn.) sebagai Antidiabetik pada Tikus Putih Diabetes (Rattus norvegicus) yang Diinduksi Streptozotosin: Preclinical Study of Ethanol Extract of Herba Tridax procumbens (Linn.) as Antidiabetic in Streptozotocin-Induced Diabetic White Rats (Rattus norvegicus) Syaiful Katadi; Irman Idrus; Arman Rusman; Sitti Sarfila
Jurnal Sains dan Kesehatan Vol. 5 No. 1 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i1.1597

Abstract

This study aims to conduct a preclinical study of the antidiabetic effect of the ethanol extract of the herb Tridax procumbens (Asteraceae) in streptozotocin-induced diabetic rats. The research procedure began by collecting test samples of the Tridax procumbens Linn (TP) herb. All parts of the TP plant which were air-dried were extracted with ethanol (95%) by maceration for 72 hours, then phytochemical screening was carried out to determine the content of secondary metabolites in general. The antidiabetic test was initiated by inducing male Wistar rats with streptozotocin (50 mg/jk, i.p.) and nicotinamide (120 mg/kg, i.p.) by injection. Diabetic rats were treated with glibenclamide (0.25 mg/kg, po) and TP extract (250 and 500 mg/kg, p.o.) for 21 consecutive days. Blood samples were collected periodically to measure the hypoglycemic effect of the TP extract. Then, variations in body weight at the fair were monitored for all experimental animals. The results showed that TP extract had a significant antidiabetic effect on diabetic white rats (Rattus norvegicus), with the best results given TP extract at a dose of 500 mg/kg. Keywords: Tridax procumbens, diabetes mellitus, antidiabetic Abstrak Penelitian ini bertujuan untuk melakukan kajian praklinis efek antidiabetes dari ekstrak etanol herba Tridax procumbens (Asteraceae) pada tikus diabetes yang diinduksi streptozotocin. Prosedur penelitian dimulai dengan mengumpulkan sampel uji herba Tridax procumbens Linn (TP). Seluruh bagian tanaman TP yang telah dikeringkan diekstraksi dengan etanol (95%) dengan cara dimaserasi selama 72 jam, selanjutnya dilakukan skrining fitokimia untuk mengetahui kandungan metabolit sekundernya secara umum. Untuk Uji antidiabetes dimulai dengan menginduksi tikus Wistar jantan dengan streptozotocin (50 mg/kg, ip) dan nicotinamide (120 mg/kg, ip). Tikus diabetes diobati dengan glibenklamid (0,25 mg/kg, po) dan ekstrak TP (250 dan 500 mg/kg, p.o.) selama 21 hari berturut-turut. Sampel darah dikumpulkan secara berkala untuk mengukur efek hipoglikemik ektrak TP. Kemudian, variasi berat badan mingguan dipantau untuk semua hewan percobaan. Hasil penelitian menunjukkan ekstrak TP memiliki efek antidiabetik yang signifikan terhadap tikus putih diabetes (Rattus norvegicus), dengan hasil terbaik pada pemberian ekstrak TP dosis 500 mg/KgBB. Kata Kunci: Tridax procumbens, diabetes mellitus, antidiabetik
Pemanfaatan Limbah Pati Kulit Pisang (Musa paradisiaca) sebagai Bahan Pengikat Granul Parasetamol dengan Metode Granulasi Basah: Utilization of Waste Banana Peel Starch (Musa paradisiaca) as a Binder Material for Paracetamol Granules Using Wet Granulation Method Ingwe Violenneofita Cheiya; Rolan Rusli; Nurul Fitriani
Jurnal Sains dan Kesehatan Vol. 5 No. 1 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i1.1606

Abstract

Starch is a carbohydrate that can be used as a binder in pharmaceutical preparations. Paracetamol has poor flowability and compactibility with its crystalline form, it is necessary to make granules by wet granulation method with starch as a binder. This study used banana peel waste (Musa paradisiaca) as a source of starch. Three granule formulations (F1, F2, and F3) were prepared using the wet granulation method with banana peel waste starch as a binder with concentrations of 5% (F1), 8% (F2), and 10% (F3) w/v. The results showed that the granule quality test included testing of moisture content, flow rate, angle of repose, and compressibility index, with the results of the granule moisture content test being 3.52%, granule flow rate 4.8 seconds, angle of repose 37.7°, and index compressibility of 10% meets the parameters of a good granule preparation. Keywords: Granule, Kepok banana peel, Starch, Paracetamol Abstrak Pati atau amilum merupakan karbohidrat yang dapat digunakan sebagai bahan pengikat pada sediaan farmasi. Parasetamol memiliki sifat alir dan kompaktibilitas yang buruk dengan bentuknya yang kristal, maka perlu dibuat granul dengan metode granulasi basah dengan pati sebagai pengikatnya. Penelitian ini menggunakan limbah kulit pisang (Musa paradisiaca) sebagai sumber pati. Tiga formula sediaan granul (F1, F2, dan F3) dibuat menggunakan metode granulasi basah dengan pati limbah kulit buah pisang sebagai pengikat dengan konsentrasi 5% (F1), 8% (F2), dan 10% (F3) b/v. Hasil penelitian menunjukan bahwa uji kualitas granul meliputi pengujian kadar lembab, laju alir, sudut diam, dan indeks kompresibilitas, dengan hasil uji kadar lembab granul 3,52%, laju alir granul 4,8 detik, sudut diam 37,7°, dan indeks kompresibilitas 10% memenuhi parameter sediaan granul yang baik. Kata Kunci: Granul, Kulit buah pisang kepok, Pati, Parasetamol
Protein Intake, Nutritional Status, and Family Socioeconomic Relationships with Learning Achievement of Children Aged 13-15 Years at Nabil Husein Junior High School Samarinda Year 2022 Jamil Anshory; Aulia Dwi Nur Anggraini; Satriani Satriani
Jurnal Sains dan Kesehatan Vol. 5 No. 1 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i1.1669

Abstract

Nutritional problems in adolescents will affect the quality of human resources which can result in reduced generations and have an impact on the nation's economic situation in the future. Vulnerable aged 13-15 years experiencing nutritional needs much faster. Protein intake, nutritional status and socioeconomic status in several studies showed different results. The purpose of this study was to determine the relationship between protein intake, nutritional status, and socioeconomic status with the learning achievement of children aged 13-15 years at SMP Nabil Husein Samarinda. Quantitative research design, correlational descriptive type, cross sectional approach. The sample used was 49 students of class VIII using a purposive sampling technique. Protein intake was obtained through a 24-hour food recall interview, nutritional status measurements based on BMI/Age, and socioeconomic status were obtained by filling out a questionnaire form. The results obtained from this study were the relationship between protein intake and learning achievement with a p-value of 0.670, nutritional status with learning achievement with a p-value of 0.358, parents' education with learning achievement with a p-value of 0.429, parental income with learning achievement with a p-value -value 0.441, parents' work with learning achievement with a p-value of 0.437. The conclusion of this study is that there is no relationship between protein intake, nutritional status and socioeconomic status of parents with learning achievement of class VIII students of Junior High School Nabil Husein Samarinda.

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