cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
Rolan Rusli
Contact Email
rolan@farmasi.unmul.ac.id
Phone
+6285222221907
Journal Mail Official
admin@farmasi.unmul.ac.id
Editorial Address
Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus Unmul Gunung Kelua, Kota Samarinda, Kalimantan Timur, Indonesia, 75119
Location
Kota samarinda,
Kalimantan timur
INDONESIA
Jurnal Sains dan Kesehatan
Published by Universitas Mulawarman
ISSN : 23030267     EISSN : 24076082     DOI : https://doi.org/10.25026/jsk
Core Subject : Health, Science, Agriculture,
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology
Jurnal Sains dan Kesehatan (J. Sains. Kes) (e-ISSN 2407-6082, p-ISSN 2303-0267), is a national journal with ISSN and published four times a year in 2015. In 2016 the publishing frequency changed to twice a year. In 2021 the frequency increased to six times a year. Jurnal Sains dan Kesehatan is published online by the Faculty of Pharmacy, Mulawarman University, Samarinda City, East Kalimantan. Since 2019, the Jurnal Sains dan Kesehatan has been accredited to SINTA. Jurnal Sains dan Kesehatan publishes manuscripts (Original research Article, review articles, and Short communication) on original work, either experimental or theoretical in the following areas: Pharmaceutics, Pharmaceutical Chemistry, Pharmacology & Toxicology, Pharmaceutical Biotechnology & Microbiology, Pharmacy practice & Hospital Pharmacy, Case Study & Full clinical trials, Clinical Pharmacy, Medicine, and other related fields. The purpose of publishing the Jurnal Sains dan Kesehatan is to provide scientific information about the development of science and technology in the field of Science and Health. Lingkup naskah Jurnal Sains dan Kesehatan mencakup bidang ilmu: Kimia Farmasi Biologi Farmasi Farmakologi Teknologi Farmasi dan Farmasetika Farmasi Klinik dan Komunitas Kedokteran dan Bidang ilmu lain yang terkait Tujuan penerbitan Jurnal Sains dan Kesehatan adalah memberikan informasi ilmiah tentang perkembangan ilmu pengetahuan dan teknologi bidang Farmasi dan yang terkait
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 41 Documents
 1   2   3   4   5 
Search results for , issue "Vol. 5 No. 5 (2023): J. Sains Kes." : 41 Documents clear
Quantitative and Qualitative Analysis of Antibiotics in the Intensive Care Unit (ICU) Mareta Rindang Andarsari; Lisa Ariyanti Zainu; Sri Rahayu Saleh; Aminatush Sholichah; Dewi Wara Shinta; Cahyo Wibisono Nugroho
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1128

Abstract

The high incidence of infection in the ICU requires frequent use of antibiotics, thereby increasing the risk of developing antibiotic resistance when used irrationally. To assess the quantity and quality of antibiotic use, the World Health Organization (WHO) recommends using the Anatomical Therapeutic Chemical (ATC) classification system or the Defined Daily Dose (DDD) method. In that study, 25 articles were analyzed, including 21 quantitative research articles and four qualitative research articles. These articles were obtained from three databases: PubMed Central (PMC), Research Gate, and Google Scholar. The most commonly used antibiotics in the ICU are ceftriaxone (1×2g, IV) with a DDD value of 358,139/100 bed-days, meropenem (3×2g, IV) with a DDD value of 289,747/100 bed-days, and piperacillin-tazobactam (4×4.5g, IV) with a DDD value of 164,816/100 bed-days. These values indicate the number of antibiotics used in relation to 100 days of sleep. In addition, evaluation of the quality of antibiotic use in the ICU revealed that it is generally characterized by irrational use. By conducting such research, healthcare professionals can optimize the use of antibiotics in the ICU, leading to more effective treatment outcomes while minimizing the development of antibiotic resistance. Keywords: Antibiotics, ATC/DDD, Gyssens, intensive care unit
Analisis Efek Samping Kanamisin dan Kapreomisin terhadap Fungsi Ginjal pada Pasien TB RO di RSUD Dr. Soetomo: Adverse Effect Analysis of Kanamicin and Capreomycin on Kidney Function in DR TB Patients at Dr. Soetomo Hospital Syefi Nuraeni Fitriana; Bambang Subakti Zulkarnain; Heri Yulimanida
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1174

Abstract

The high of adverse effect of resistant TB treatment and the long duration of the treatment is the main obstacle in the success of resistant TB therapy. One of the serious and life-threatening adverse effect of the treatment is nephrotoxic. Kanamycin and capreomycin are MDR TB drugs that can induce nephrotoxic and kidney disorder. This study aims to determine the incidence of hypokalemia and nephrotoxic induced by kanamycin and capreomycin, the onset of the kidney disorder, and its management. Data were collected retrospectively from the medical records of patients in the MDR TB outpatient clinic at Dr. Soetomo Hospital Surabaya during the period January 2018-June 2020. There were 183 patient medical records and only 112 medical records that met the inclusion criteria. The adverse effects studied were hypokalemia and nephrotoxicity which were analyzed based on potassium and creatinine serum levels. The result showed that adverse effect on kidney disorders were more common in the group of patients taking capreomycin than in the group of patients taking kanamycin. Hypokalemia were found 70.45% and nephrotoxicity were found 30.23% in the capreomycin group, while in the kanamycin group, hypokalemia were found 38.24% and nephrotoxicity were found 20.29%. Keywords: kanamycin, capreomycin, MDR TB, nephrotoxicity Abstrak Tingginya efek samping dan lamanya terapi pengobatan TB resisten menjadi kendala utama dalam keberhasilan terapi TB resisten. Salah satu efek samping obat yang serius dan dapat mengancam jiwa adalah gangguan ginjal. Kanamisin dan kapreomisin merupakan obat TB MDR yang dapat menyebabkan efek samping gangguan ginjal. Penelitian ini bertujuan untuk mengetahui insidensi efek samping hipokalemia dan nefrotoksik pada pasien TB MDR, berapa lama onsetnya, dan bagaimana cara pengatasannya. Pengambilan data dilakukan secara retrospektif dari rekam medis pasien di poli rawat jalan TB MDR RSUD dr. Soetomo Surabaya selama periode Januari 2018-Juni 2020. Didapatkan 183 rekam medis pasien dan yang memenuhi kriteria inklusi sebanyak 112 rekam medis. Efek samping yang diteliti adalah hipokalemia dan nefrotoksik yang dianalisis berdasarkan kadar kalium dan serum kreatinin. Hasil penelitian menunjukkan efek samping terhadap gangguan ginjal lebih banyak ditemukan pada kelompok pasien yang menggunakan kapreomisin dibandingkan pada kelompok pasien yang menggunakan kanamisin, yaitu hipokalemia 70,45% dan nefrotoksik 30,23% pada kelompok kapreomisin, sedangkan pada kelompok kanamisin hipokalemia 38,24% dan nefrotoksik 20,29%. Kata Kunci: kanamisin, kapreomisin, TB MDR, gangguan ginjal 
Analisis Kandungan Natrium Siklamat pada Jamu Sinom di Pasar Besar Malang: Analysis of Sodium Cyclamate Content in Jamu Sinom at Malang Market Fendi Yoga Wardana; Vita Mariah
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1620

Abstract

Jamu is a traditional medicine used by people in Indonesia. The use of additional sweeteners such as sodium cyclamate needs to be wary of its use, because it can cause harmful effects to the body in the future. The herbs that have been circulating in the community are allegedly added with additional sweeteners during the manufacturing process. The aim of this study was to determine the content of sodium cyclamate in jamu sinom at Pasar Besar Malang. The design of this study was an experimental laboratory with purposive sampling on 6 samples of jamu sinom. Qualitative analysis was tested by precipitation method, while quantitative analysis was performed by spectrophotometry UV-Vis. The results of the qualitative test showed that there were 2 positive samples containing sodium cyclamate, namely sample B and sample D which were marked by the formation of a white precipitate. Based on the results of the quantitative test with spectrophotometry UV-Vis, it was found that 2 samples did not comply with BPOM standards with sodium cyclamate levels of 5.053% in sample B and 1.959% in sample D. Keywords: Jamu, Sodium Cyclamate, Precipitation, Spectrophotometry UV-Vis Abstrak Jamu merupakan obat tradisional yang banyak dimanfaatkan oleh masyarakat di Indonesia. Penggunaan bahan pemanis buatan seperti natrium siklamat perlu diwaspadai penggunaannya, karena dapat menimbulkan efek yang berbahaya bagi tubuh dikemudian hari. Jamu yang telah beredar di masyarakat disinyalir ditambahkan pemanis buatan saat proses pembuatannya. Tujuan penelitian adalah mengetahui kandungan natrium siklamat dalam jamu sinom yang dipasarkan di Pasar Besar Malang. Desain penelitian ini adalah laboratorium eksperimental dengan teknik purposive sampling pada 6 jenis sampel jamu sinom. Pengujian analisa kualitatif dilakukan dengan metode pengendapan, sedangkan analisa kuantitatif dilakukan dengan spektrofotometri UV-Vis. Hasil uji kualitatif menunjukkan terdapat 2 sampel positif mengandung natrium siklamat yaitu sampel B dan sampel D yang ditandai dengan terbentuknya endapan berwarna putih. Berdasarkan hasil uji kuantitatif dengan spektrofotometri UV-Vis, didapatkan 2 sampel tidak memenuhi standar BPOM dengan kadar natrium siklamat sebesar 5,053% pada sampel B dan 1,959% pada sampel D. Kata Kunci: Jamu, Natrium Siklamat, Pengendapan, Spektrofotometri UV-Vis.
Efek Pemberian Gel Ekstrak Etanol Daun Ekor Naga (Rhaphidophora pinnata (L.f) Schott) Sebagai Antiinflamasi Metode Carrageenan-Induced Air Pouch: The Effect of Administering Ethanolic Extract Gel from Ekor Naga (Rhaphidophora pinnata (L.f) Schott) Leaves as an Anti-Inflammation Carrageenan-Induced Air Pouch Method Fathnur Sani K; Kristin Simamora; Havizur Rahman; Ave Olivia Rahman; Yuliawati Yuliawati
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1707

Abstract

The ethanol extract ekor naga leaves (Rhaphidophora pinnata (L.f) Schott) has been studied as an anti-inflammatory agent. This study aims to formulate a topical preparation of ekor naga leavesextract gel so that it can be a futher step from previous research as a product development effort. The research method used is experimental design. The treatment group was divided into five groups: positive control (Hydrocortisone), Formula 0 (Gel Base), Formula 1 (10% Extract Concentration), Formula 2 (15% Extract Concentration), and Formula 3 (20% Extract Concentration). The test animals used in each treatment group were 5 animals. The data obtained were analyzed using one way ANOVA with a 95% confidence level. The results showed that the more extracts, the better the anti-inflammatory effect. However, based on preparation evaluation data in previous studies regarding gel formulations, it was concluded that formula 2 was the best formula with an effect that was statistically almost the same as formula 3 and had good gel stability in the formulation. Keywords: Ekor Naga Leaves, Gel, Inflammation, Air Pouch Abstrak Ekstrak etanol daun ekor naga  (Rhaphidophora pinnata (L.f) Schott) telah diteliti memiliki efek sebagai agen antiinflamasi. Penenlitian ini bertujuan untuk memformulasi sediaan topikal gel ekstrak daun ekor naga sehingga dapat menjadi menjadi langkah lanjut dari penelitian sebelumnya sebagai upaya pengembangan produk. Metode penelitian yang digunakan adalah experimental design. Kelompok perlakuan dibagi menjadi lima kelompok yaitu: Kontrol positif (Hidrokortisone), Formula 0 (Basis Gel), Formula 1 (Konsentrasi Ekstrak 10%), Formula 2 (Konsentrasi Ekstrak 15%), dan Formula 3 (Konsentrasi Ekstrak 20%). Hewan uji yang digunakan masing-masing kelompok perlakuan 5 ekor. Data yang didapat dianalisis menggunakan ANOVA satu arah dengan tingkat kepercayaan 95%. Hasil penelitian menunjukkan bahwa semakin banyak ekstrak maka semakin baik efek antiinflamasinya. Namun berdasarkan data evaluasi sediaan pada penelitian sebelumnya tentang formulasi gel maka disimpulkan bahwa formula 2 merupakan formula terbaik dengan efek yang secara statistic hampir sama dengan formula 3 serta memiliki stabilitas gel yang baik dalam formulasi. Kata Kunci: Daun Ekor Naga, Gel, Inflamasi, Air Pouch
Hubungan Kuantitatif Struktur-Aktivitas dan Desain Senyawa Novel Phenyl Benzimidazoles sebagai Penghambat Wnt/?-Catenin untuk Terapi Pancreatic Ductal Adenocarcinoma: Quantitative Structure-Activity Relationship and Design of Novel Phenyl Benzimidazoles as Wnt/?-Catenin Inhibitors for Pancreatic Ductal Adenocarcinoma Therapy Dwi Syah Fitra Ramadhan; Rusli Rusli; Taufik Muhammad Fakih
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1713

Abstract

In the pancreatic ductal adenocarcinoma (PDAC) initiation and progression, the Wnt/β-Catenin signaling pathway showed a very important role. Earlier study showed that novel phenyl benzimidazoles have inhibiton activity in Wnt/?-Catenin pathway. The purpose of the present study was to design novel phenyl benzimidazoles as a Wnt/?Catenin inhibitor on PDAC based on the Quantitative In the pancreatic ductal adenocarcinoma (PDAC) initiation and progression, the Wnt/?-Catenin signaling pathway showed a very important role. Earlier study showed that novel phenyl benzimidazoles have inhibiton activity in Wnt/?-Catenin pathway. The purpose of the present study was to design novel phenyl benzimidazoles as a Wnt/?Catenin inhibitor on PDAC based on the Quantitative Structure Activity Relationship (QSAR) method. The molecule structures were built optimized by semi empirical AM1 using Gaussian. 12 Descriptors were selected which represented electronical, hydrophobic, and steric parameters using MOE 2014.0901. The compounds suspected as an outlier were then removed from the data set based on XZ-score value, i.e. compounds with XZ-score above 2.5. The data set were then classified into two parts, i.e. training set and test set. Validation was performed using Leave One Out (LOO) method and F test. The new derivatives were designed using topliss scheme, in which parent compound with the lowest IC value was used as a 50 template. The statistical analysis showed that there were two most influential descriptors of Wnt/?-Catenin inhibition activity: mr and LogS. The LOO validation gave Q2 = 0.7363. Six new derivatives, predicted to have lower IC that of parent compound. Keywords: Benzimidazoles, PDAC, QSAR, Wnt/?-Catenin Abstrak Jalur pensinyalan Wnt/?-Catenin sangat penting dalam inisiasi dan perkembangan dari pancreatic ductal adenocarcinoma (PDAC). Studi sebelumnya menunjukkan bahwa fenil benzimidazol baru memiliki aktivitas penghambatan di jalur Wnt/?-Catenin. Tujuan dari penelitian ini adalah untuk merancang fenil benzimidazol baru sebagai penghambat Wnt/?Catenin pada PDAC berdasarkan metode Hubungan Kuantitatif Struktur-Aktivitas (HKSA). Struktur molekul dibangun dan dioptimalkan dengan metode AM1 semi empiris menggunakan Gaussian. Sebanyak 12 Deskriptor dipilih yang mewakili parameter elektronik, hidrofobik, dan sterik menggunakan MOE 2014.0901. Senyawa-senyawa yang diduga outlier kemudian dikeluarkan dari kumpulan data berdasarkan nilai XZ-score, yaitu senyawa-senyawa dengan XZ-score di atas 2,5. Kumpulan data kemudian diklasifikasikan menjadi dua bagian, yaitu training set dan test set. Validasi dilakukan menggunakan metode statistik Leave One Out (LOO). Turunan baru dirancang menggunakan skema topliss, dimana senyawa induk dengan nilai IC terendah digunakan sebagai template. Analisis statistik menunjukkan bahwa ada dua deskriptor paling berpengaruh dari aktivitas penghambatan Wnt/?-Catenin: mr dan LogS. Validasi LOO menunjukkan niali Q2 = 0,7363. Enam turunan baru, diprediksi memiliki IC yang lebih rendah dari senyawa induknya. Kata Kunci: Benzimidazoles, PDAC, HKSA, Wnt/?-Catenin
Pengaruh Motivasi terhadap Kinerja Perawat di Rumah Sakit: The Effect of Motivation on Nurse Performance in the Hospital Azzilla Nur Layli; Chriswardani Suryawati; Wulan Kusumastuti
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1758

Abstract

Content Nurses are one of the professions that have the most human resources in hospitals which is 50% and has an important role in the provision of health services. A work boost is needed in hopes of improving and delivering optimal performance. Providing work motivation is a way to improve performance in nurses and encourage to carry out activities in order to achieve their goals and to meet their needs. Without motivation, the task carried out will not be carried out according to the standards because what has become his motive and motivation in working is not fulfilled. From 10 motivational variables, found 9 variables that can affect the performance of nurses in the hospital include achievement, self-employment, responsibility, development of individual potential, policy and administration, incentives/salaries, working relationships, working conditions, and quality of supervision. Incentive/salary variables are more dominant to influence motivation towards hospital nurse performance. Keywords: Motivation, Job Performance, Nurse   Abstrak Perawat adalah salah satu profesi yang memiliki sumber daya manusia paling  besar di rumah sakit yaitu sebesar 50% dan memiliki peranan penting dalam pemberian pelayanan kesehatan. Dorongan kerja sangat diperlukan dengan harapan dapat meningkatkan dan mewujudkan kinerja yang optimal. Memberikan motivasi kerja merupakan cara untuk meningkatkan kinerja pada perawat serta mendorong untuk melaksanakan kegiatan agar mencapai tujuan serta dapat memenuhih kebutuhannya. Tanpa motivasi, tugas yang dilaksanakan tidak akan dijalani sesuai standar sebab apa yang telah menjadi motif dan motivasinya dalam bekerja tidak terpenuhi. Dari 10 variabel motivasi, ditemukan bahwa 9 variabel mempengaruhi kinerja perawat di rumah sakit diantaranya adalah prestasi, pekerjaan itu sediri, tanggung jawab, pengembangan potensi individu, kebijakan dan administrasi, insentif/gaji, hubungan kerja, kondisi kerja, dan kualitas supervisi. Variabel insentif/gaji lebih dominan untuk mempengaruhi motivasi terhadap kinerja perawat. Kata Kunci: Motivasi, Kinerja, Perawat
Perbandingan Aktivitas Antioksidan Infusa Simplisia Segar dan Simplisia Kering Daun Buni (Antidesma bunius L. Spreng) dengan Metode DPPH: Comparison of Antioxidant Activity of Infused from Fresh Simplicia and Dried Simplicia of Buni Leaves (Antidesma bunius L. Spreng) with DPPH Method Indah Permata Sari; Agriana Rosmalina Hidayati; Handa Muliasari
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1792

Abstract

Antidesma bunius L. Spreng is one of the plants that can use for antioxidants. The antioxidant activity of buni leaves caused by the presence of flavonoid compounds that potentially scavenge free radicals. This study aimed to identify the flavonoid compounds in buni leaves and compare the antioxidant activity between infusions of dried and fresh simplicia of buni leaves. This research procedure includes the collection of materials, determination of plants, made simplicia and infusions, identification of flavonoid compounds, and quantitative antioxidant activity test using the DPPH free radical method (1,1-diphenyl-2-picrylhydrazyl). The result obtained in the IC50 values from the linear regression equation between % inhibition and the concentration of the test solution. The IC50 values have been analyzed by a non-parametric statistical test with a 95% confidence level. The result of flavonoid identification showed the infusion contains flavonoid. The IC50 values of infusion from dried and fresh simplicia of buni leaves were 197,344±0,819 ppm and 303,646±3,731 ppm. Dried simplicia on antioxidant classification have weak antioxidant activity, while fresh simplicia have very weak antioxidant activity. The infusion from fresh and dried simplicia of buni leaves has significantly different antioxidant activity (p?0,05). Dried simplicia is more recommended for making infusions for an antioxidant. Keywords: Antidesma bunius, antioxidants, infusion   Abstrak Daun buni atau Antidesma bunius L. Spreng merupakan salah satu tanaman yang dapat dimanfaatkan sebagai sumber antioksidan. Tujuan penelitian ini adalah untuk mengidentifikasi kandungan senyawa flavonoid daun buni dan mengetahui perbandingan aktivitas antioksidan sediaan infusa simplisia kering dan simplisia segar daun buni. Prosedur penelitian ini meliputi pengumpulan bahan, determinasi tanaman, pembuatan simplisia, pembuatan infusa, identifikasi senyawa flavonoid, serta uji aktivitas antioksidan secara kuantitatif dengan metode radikal bebas DPPH (1,1-diphenyl-2-picrylhydrazyl). Data yang didapatkan berupa nilai IC50 yang diperoleh dari persamaan regresi linier antara % inhibisi terhadap konsentrasi larutan uji. Nilai IC50 dianalisis dengan uji statistik non parametric dengan taraf kepercayaan 95%. Hasil identifikasi senyawa flavonoid menunjukkan infusa daun buni positif mengandung senyawa flavonoid. Nilai IC50 infusa simplisia segar dan infusa simplisia kering daun buni berturut-turut 303,646±3,731 ppm dan 197,344±0,819 ppm. Infusa simplisia segar memiliki aktivitas antioksidan sangat lemah, sedangkan infusa simplisia kering memiliki aktivitas antioksidan lemah. Infusa simplisia segar dan infusa simplisia kering daun buni memiliki aktivitas antioksidan yang berbeda signifikan (p?0,05). Berdasarkan data yang diperoleh simplisia kering daun buni lebih direkomendasikan dalam pembuatan infusa sebagai antioksidan dibandingkan simplisia segar. Kata Kunci: Daun buni, antioksidan, infusa
Analisis Faktor yang Berhubungan dengan Potensi Interaksi Obat Pasien Covid-19 di Salah Satu Rumah Sakit Kalimantan Selatan: Factors Associated with Potential Drug Interactions in Covid-19 Hospitalized Patients Okta Muthia Sari; Aditya Maulana Perdana Putra; Yusrinie Wasiaturrahmah; Nahdiya Rahmah
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1811

Abstract

Patients with COVID-19 are treated with antivirals, supportive therapy, and symptomatic therapy. COVID-19 patients who use multiple drugs may experience drug interactions. The purpose of this study is to investigate factors associated with potential drug interactions in COVID-19 patients who are hospitalized. This cross-sectional retrospective observational study was carried out in a hospital in the Indonesia. The sample consists of medical records from COVID-19 patients who received therapy and were hospitalized between January and March 2021. The IBM Micromedex website, DrugBank Interaction Checker, and Stockley Drug Interactions 9th Edition are research tools used to assess the potential and mechanism of drug interactions. The results were 82 medical records that were analyzed for potential drug interactions. The proportion of patients who have potential drug interactions is 69.5%. in hospitalized COVID-19 patients. The drug interaction mechanism in COVID-19 patients is potentially in the pharmacokinetics phase. Age (p=0.034; OR 0.327, CI 0.11-0.94), number of drugs used during treatment (p=0.002; OR 14.00, CI 1.76-111.11), and length of stay (p=0.000; OR 0.009, CI 0.001-0.07) were factors associated to potential drug interactions. Subsequently, factors associated with potential drug interactions in COVID-19 hospitalized patients include age, number of drugs used during treatment, and length of stay. Keywords: COVID-19, drug interactions, factors associated, potential Abstrak Tatalaksana pengobatan pada pasien COVID-19 diberikan antivirus, terapi suportif dan terapi simptomatik. Penggunaan beberapa jenis obat tersebut membuat pasien COVID-19 berpotensi mengalami interaksi obat. Penelitian ini bertujuan menganalisis faktor yang berhubungan dengan potensi interaksi obat pada pasien COVID-19 rawat inap di rumah sakit. Penelitian obeservasional retrospektif cross sectional ini dilaksanakan di salah satu rumah sakit Kalimantan Selatan. Sampel yakni rekam medis pasien COVID-19 yang mendapat terapi dan rawat inap di rumah sakit periode Januari-Maret 2021 Instrumen penelitian mengkaji potensi dan mekanisme interaksi obat meliputi situs IBM Micromedex , DrugBank Interaction Checker dan Stockley Drug Interactions 9th Edition. Hasil diperoleh sebanyak 82 rekam medis dianalisis potensi interaksi obat. Persentase pasien mengalami potensi interaksi obat sebesar 69,5%. pada pasien COVID-19 rawat inap di rumah sakit. Mekanisme interaksi obat pada pada pasien COVID-19 pada berpotensi pada fase farmakokinetika. Faktor berhubungan potensi interaksi obat pasien COVID-19 yakni usia (p=0.034; OR 0.327, CI 0.11-0.94), jumlah obat yang digunakan selama dirawat (p=0.002; OR 14.00, CI 1.76-111.11) dan lama dirawat (p=0.000; OR 0.009 , CI 0.001-0.07). Kesimpulan, faktor berhubungan potensi interaksi obat pada pasien COVID-19 rawat inap di rumah sakit meliputi usia, jumlah obat yang digunakan selama dirawat dan lama dirawat. Kata Kunci: COVID-19, faktor berhubungan, interaksi obat, potensi
Uji Reliabilitas the Functional Reach Test untuk Pengukuran Keseimbangan Statis pada Penderita Osteoarthritis Lutut: Reliability Test of the Functional Reach Test for Measuring Static Balance in Patient with Knee Osteoarthritis Dwi Rosella Komalasari; Hafiza Amalia
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1861

Abstract

Osteoarthritis (OA) is a chronic degenerative disease characterized damages the cartilage causing swelling, pain, muscle weakness, joint stiffness and reduced postural balance. The Functional Reach Test (FRT) is one of tests that can be used to measure static balance, unfortunately the reliability of FRT in Indonesia has not published as well including in patient with knee OA. The aim of this research is to determine test retest and inter rater reliability of FRT to measure static balance in patients with knee OA. This study used an observational study method with a methodological research approach. There were 58 participants who taken by purposive sampling. This study conducted in test retest and inter rater reliability of FRT. Test retest and inter rater reliability showed high internal consistency (?=0.82, ICC=0.69, p<0.0001, r=0.64) dan (?=0.84, ICC=0.72, p<0.0001, r=0.67). FRT is reliable in terms of test retest and inter rater reliability to measure static balance in patients with knee OA. Keywords: Functional reach test, Knee Osteoarthritis, Realiability   Abstrak Osteoarthritis (OA) adalah penyakit degeneratif kronis ditandai kerusakan tulang rawan pada sendi, menyebabkan bengkak, nyeri, penurunan kekuatan otot, kekakuan sendi serta keseinbangan tubuh yang mengakibatkan peningkatan resiko jatuh. Functional Reach Test (FRT) merupakan salah satu tes yang dapat digunakan untuk memeriksa keseimbangan statis, tetapi laporan tentang reliabilitas tes ini di Indonesia masih sangat terbatas terutama bagi pasien dengan OA lutut. Tujuan penelitian ini untuk mengetahui reliabilitas test retest dan inter rater reliability dengan pada FRT sebagai alat ukur untuk keseimbangan statis pada penderita osteoarthritis lutut. Penelitian ini menggunakan metode observational study dengan pendekatan methodological research. Terdapat 58 responden dalam penelitian ini yang diambil  dengan purposive sampling. Test retest dan inter rater reliability FRT dievaluasi dalam penelitian ini. Hasil Test retest dan inter rater reliability FRT menunjukkan internal consistency tinggi (?=0.82, ICC=0.69, p<0.0001, r=0.64) dan (?=0.84, ICC=0.72, p<0.0001, r=0.67). FRT reliabel dalam hal test retes dan inter rater sebagai alat ukur keseimbangan statis pada penderita osteoarthritis lutut. Kata Kunci: Functional reach test, Osteoarthritis lutut, Reliabilitas
Uji Efektivitas Diuretik Kombinasi Rebusan Rimpang Alang-alang (Imperata cylindrical L.) dan Daun Kumis Kucing (Orthosiphon aristatus Benth.) pada Mencit Jantan (Mus musculus): Diuretic Effectiveness Test of Combination of Alang-alang (Imperata cylindrical L.) and Kumis Kucing Leaves (Orthosiphon aristatus Benth.) Decoction in Male Mice (Mus musculus) Andi Fadillah; Rusdiaman Rusdiaman; Hendra Stevani
Jurnal Sains dan Kesehatan Vol. 5 No. 5 (2023): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v5i5.1864

Abstract

Rhizomes of reeds (Imperata cylindrical L.) and leaves of kumis Kucing (Orthosiphon aristatus Benth.) are traditional medicines used as diuretics. The flavonoids contained in these two plants have biological activity as a diuretic. In this study, 15 mice were separated into 5 groups, each containing 3 mice as test subjects. Group 1 was given aquadest. Group 2 was given furosemide 20 mg/kg BW, boiled reeds with a concentration of 60%: 40% cat's whiskers leaves was given to group 3, reed rhizome decoction with a concentration of 50%: 50% cat's whiskers leaves was given to group 4, and group 5 was given reed rhizome decoction with a concentration of 40%: 60% cat whiskers leaves. The treatment group was studied for 4 hours and the volume of urine was recorded every 30 minutes. The results of the study showed that boiled cat's whisker leaf alang-alang rhizomes from the third concentration group had a diuretic effect where the mice excreted urine for the first time in the 60th minute. The group showing positive controls and negative controls excreted urine for the first time at 30 minutes. Keywords:          Diuretics, reeds, cat whiskers, mice   Abstrak Rimpang alang-alang (Imperata cylindrical L.) dan daun kumis kucing (Orthosiphon aristatus Benth.) merupakan salah satu obat tradisional yang digunakan sebagai diuretik. Flavonoid yang terkandung dalam kedua tanaman inilah yang mempunyai aktivitas biologis sebagai diuretik. Pada penelitian ini, 15 ekor mencit dipisahkan menjadi 5 kelompok yang masing-masing berisi 3 ekor mencit sebagai subjek uji. Kelompok 1 diberikan akuades. Kelompok 2 diberikan larutan furosemide 20 mg/kg BB, rebusan alang-alang dengan konsentrasi 60% : 40% daun kumis kucing diberikan pada kelompok 3, rebusan rimpang alang-alang dengan konsentrasi 50% : 50% daun kumis kucing diberikan pada kelompok 4, dan kelompok 5 diberikan rebusan rimpang alang-alang dengan konsentrasi 40%: 60% daun kumis kucing. Kelompok perlakuan tersebut diteliti selama 4 jam dan dicatat volume urin tiap 30 menit. Hasil penelitian menunjukkan bahwa rebusan rimpang alang-alang daun kumis kucing dari ketiga kelompok konsentrasi memiliki efek diuretik dimana mencit mengeluarkan urin pertama kali pada menit ke-60. Kelompok mencit kontrol positif dan kontrol negatif mengeluarkan urin pertama kali pada menit ke-30. Kata Kunci:         Diuretik, alang-alang, kumis kucing, mencit

Page 1 of 5 | Total Record : 41

 1   2   3   4   5 

Filter by Year

2023 2023


Reset
Filter By Issues
All Issue Vol. 6 No. 2 (2024): J. Sains Kes. Vol. 6 No. 1 (2024): J. Sains Kes. Vol. 5 No. 6 (2023): J. Sains Kes. Vol. 5 No. 5 (2023): J. Sains Kes. Vol. 5 No. 4 (2023): J. Sains Kes. Vol. 5 No. 3 (2023): J. Sains Kes. Vol. 5 No. 2 (2023): J. Sains Kes. Vol. 5 No. SE-1 (2023): Spesial Edition J. Sains Kes. Vol. 5 No. 1 (2023): J. Sains Kes. Vol. 4 No. 6 (2022): Jurnal Sains dan Kesehatan (J. Sains Kes.) Vol. 4 No. 5 (2022): Jurnal Sains dan Kesehatan (J. Sains Kes.) Vol. 4 No. 4 (2022): Jurnal Sains dan Kesehatan (J. Sains Kes.) Vol. 4 No. 3 (2022): Jurnal Sains dan Kesehatan (J. Sains Kes.) Vol. 4 No. 2 (2022): Jurnal Sains dan Kesehatan (J. Sains Kes.) Vol. 4 No. 1 (2022): Jurnal Sains dan Kesehatan (J. Sains Kes.) Vol. 4 No. SE-1 (2022): Spesial Edition J. Sains Kes. Vol. 3 No. 6 (2021): Jurnal Sains dan Kesehatan (J. Sains Kes.) Vol. 3 No. 5 (2021): Jurnal Sains dan Kesehatan Vol. 3 No. 4 (2021): Jurnal Sains dan Kesehatan Vol. 3 No. 3 (2021): Jurnal Sains dan Kesehatan Vol. 3 No. 3 (2021): Jurnal Sains dan Kesehatan (J. Sains Kes.) Vol. 3 No. 2 (2021): Jurnal Sains dan Kesehatan Vol. 3 No. 1 (2021): Jurnal Sains dan Kesehatan Vol. 2 No. 4 (2020): Jurnal Sains dan Kesehatan Vol. 2 No. 3 (2020): Jurnal Sains dan Kesehatan Vol. 2 No. 2 (2019): J. Sains Kes. Vol. 2 No. 2 (2019): Jurnal Sains dan Kesehatan Vol. 2 No. 1 (2019): Jurnal Sains dan Kesehatan Vol. 1 No. 10 (2018): Jurnal Sains dan Kesehatan Vol. 1 No. 9 (2018): Jurnal Sains dan Kesehatan Vol. 1 No. 8 (2017): Jurnal Sains dan Kesehatan Vol. 1 No. 7 (2017): Jurnal Sains dan Kesehatan Vol. 1 No. 6 (2016): Jurnal Sains dan Kesehatan Vol. 1 No. 5 (2016): Jurnal Sains dan Kesehatan Vol. 1 No. 4 (2015): Jurnal Sains dan Kesehatan Vol. 1 No. 3 (2015): Jurnal Sains dan Kesehatan Vol. 1 No. 2 (2015): Jurnal Sains dan Kesehatan Vol. 1 No. 1 (2015): Jurnal Sains dan Kesehatan More Issue