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Media Farmasi Indonesia
Published by Sekolah Tinggi Ilmu Farmasi Yayasan Pharmasi Semarang
ISSN : 19788495     EISSN : 26551462     DOI : https://doi.org/10.53359/mfi.v17i1
Core Subject : Health, Science, Education,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Other
Media Farmasi Indonesia publishes original article in the all scopes of Pharmaceutical Science such as Pharmaceutics, Biopharmaceutics, Drug Delivery System, Chemical Pharmacy, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Pharmacokinetics, Pharmaceutical Chemistry, Pharmaceutical Biology, Community and Clinical Pharmacy, Management Pharmacy, Alternative Medicines.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Pharmacology, Toxicology and Pharmaceutics (Lain-Lain)
Articles 3 Documents
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Search results for , issue "Vol. 8 No. 1 (2013): Media Farmasi Indonesia" : 3 Documents clear
PENGARUH PROSES PENCAMPURAN TERHADAP SIFAT FISIK SEDIAAN VIRGIN COCONUT OIL(VCO) COLD CREAM Octavianus Rico Aditya Putra; Agatha Budi Susiana Lestari
Media Farmasi Indonesia Vol. 8 No. 1 (2013): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

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Abstract

Abstract The aim of the research was to investigate the significant effect among mixing time, mixing rate, and their interaction on the Virgin Coconut Oil (VCO) Cold Cream’s. In this research, the physical as properties of cold cream studied were viscosity, spreadability and viscosity shift. The result showed that mixing time, mixing rate and their interaction did not significantly affect the viscosity, spreadability, and viscosity shift responses.
ANALISIS HKSA SENYAWA TURUNAN EURIKUMANON SEBAGAI ANTIMALARIA MENGGUNAKAN PENDEKATAN REGRESI LINIER BERGANDA Hanifah Yusuf; Mustofa; Mahardika Agus Wijayanti; Ratna Asmah Susidarti; Andrian Saputra; Iqmal Tahir
Media Farmasi Indonesia Vol. 8 No. 1 (2013): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

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Abstract

Quantitative Structure Activity Relationship (HKSA) study of eurycomanone derivatives as antimalarial compound was done using multiple linear regression approaches. HKSA equation was obtained from theoretical descriptors data which involved atomic net charges (q), partition coefficient (log P), molecular volume (VM), molecular surface area (LP), molecular weight (BM), and HOMO-LUMO energy differences (EHOMO-ELUMO) versus minimum concentration to inhibit 50% of parasite growth Plasmodium falciparum (log IC50) growth. Descriptors data were obtained by applying AM1 semiempirical quantum mechanics calculation using Hyperchem 7.5 software, while the regression data processes were runned using SPSS 17.0 program. Based on multiple linear regression approaches, there is a selected quantitative relationship between log IC50 to the descriptors that was shown by HKSA equation below: Log IC50 = – 3048.930 + 5137.957qC2 – 13799.126qC5 – 1537.764qC12 + 556.313qC16 – 817.654qO29 + 4.654log P – 0.146VM + 0.270BM with n =10, r = 0.982, SE = 1.262, Fcalc/Ftable = 17.805, and PRESS = 1.593
Uji Aktivitas Hipoglikemik Ekstrak Etanolik Daun Lenglengan ( Leucas lavandufolia,smith) pada Tikus Putih Jantan yang Dibebani Glukosa sri susilowati
Media Farmasi Indonesia Vol. 8 No. 1 (2013): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53359/mfi.v8i1.219

Abstract

ABSTRACT Empirical experience-based, Lenglengan (Leucas lavandulifolia Smith) leaves have a special antidiabetic effect. This research aimed to determine the hypoglycemic effect of ethanolic extract of Lenglengan leaves in glucose induced rats. The research was conducted by dividing the experiment animals into five groups, each group had 6 rats. Three groups were given with ethanolic extract of Lenglengan leaves with 63, 126, and 252 mg/kgBB doses. One group served as the positive control were given Metformin at 189 mg/kgBB dose and the negative control were given CMC-Na 0,5%. Thirty minutes after the experiment, the animals were given D-glukosa monohydrate peroral with 2 g/kgBB dose. The measurement of the blood glucose was conducted by taking the blood at 0, 30, 60, 120, 180, 240 and 300 minutes. The blood glucose rate was measured enzymatically using GOD-PAP reagent. The evaluation on the hypoglicemic effect was done to AUC0-300 relationship curve value between blood glucose to sampling time 0-300 minute and hypoglycemic activity percentages. The statistical analysis to data AUC was done with Kruskal-Wallis test, continued with Mann-Whitney test. The result showed that the ethanolyc extract of Lenglengan leaves at 63, 126, and 252 mg/kgBB doses could decrease the blood glucose on rats glucose induced and was proven statistically to indicate high significance in comparison to the negative control (p < 0,05). The hypoglycemic activity percentage from the ethanolic extract of lenglengan leaves at 252 mg/kgBB dose was of 45,89%, where as metformin 189 mg/kgBB doses it was of 44,86%. Keywords: extract, lenglengan, hypoglichemic effect.

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