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Jurnal Farmasi Sains dan Praktis
Published by Universitas Muhammadiyah Magelang
ISSN : 25499068     EISSN : 25794558     DOI : -
Core Subject : Health, Science,
Immunology & microbiology Medicine & Pharmacology Public Health
Jurnal Farmasi Sains dan Praktis aims to serve the updated scientific knowledge for international researchers in pharmaceutical sciences. Jurnal Farmasi Sains dan Praktis (JFSP) publishes review article, original article, as well as short communication in the all scopes of Pharmaceutical Science such as Pharmaceutics, Biopharmaceutics, Drug Delivery System, Physical Pharmacy, Pharmaceutical Technology, Pharmaceutical Microbiology and Biotechnology, Pharmacology and Toxicology, Pharmacokinetics, Pharmaceutical Chemistry, Pharmaceutical Biology, Community and Clinical Pharmacy, Pharmaceutical Marketing, Alternative Medicines, Pharmaceutical Management, Pharmacoeconomic, Pharmacoepidemiology, Social Pharmacy, Pharmacy Policies.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 24 Documents
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Search results for , issue "Vol 7 No 3 (2021): Supplementary Issue (The 4th National Pharmacy Conference 2021 Universitas Halu O" : 24 Documents clear
THE CLOZAPINE EFFECT ON BLOOD GLUCOSE LEVELS, LEUKOCYTES AND PLATELETS IN SCHIZOPHRENIC PATIENTS IN THE MENTAL SERVICE UNIT OF BANYUMAS HOSPITAL Ikhwan Yuda Kusuma
Jurnal Farmasi Sains dan Praktis Vol 7 No 3 (2021): Supplementary Issue (The 4th National Pharmacy Conference 2021 Universitas Halu O
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i3.5190

Abstract

Schizophrenia is a disorder of strange and disordered thoughts, delusions, hallucinations, inappropriate influences, and disorders of psychosocial functioning. One of the management of schizophrenia therapy is the administration of atypical antipsychotic drugs, namely clozapine. Clozapine is an antagonist of serotonin (5-HT2) and dopamine type 2 (D2) receptors. However, the risk of using clozapine provides a risk of side effects in the form of metabolic syndromes such as impaired blood glucose regulation and disorders of blood elements such as leukocytes and platelets. This study aims to determine the effect of using clozapine on blood glucose, leukocyte, and platelet levels in schizophrenia patients at Banyumas General Hospital. This research method was carried out by cross-sectional study in outpatient schizophrenia at Banyumas General Hospital who received clozapine therapy and had met the inclusion and exclusion criteria, taken by consecutive sampling, then examined blood glucose levels, leukocyte counts, and platelet counts before and after giving clozapine therapy. Samples were taken on day 1 and day 10 of drug use. Paired t-test statistical analysis was used to see the effect of using clozapine on glucose, leucocyte, and platelet levels. In the T-test, it was found that there was a relationship between the use of clozapine on the patient's blood glucose levels, the use of clozapine did not have a significant effect on the increase in leukocyte levels and there was also a relationship between the use of clozapine and the patient's platelet levels. The results showed that the patient had an increase in blood glucose levels by a percentage (100%), the patient had leukopenia by a percentage (63.5%), the patient had thrombocytopenia by a percentage (75%), while the other patients had thrombocytosis. Patients with hyperglycemia, leucopenia, and thrombocytopenia were those who used clozapine> 12 months
FORMULATION AND PHYSICAL STABILITY TEST OF NANOEMULGEL CONTAINING Petrosia Sp. ETHANOLIC EXTRACT Muhammad Hajrul Malaka; Astrid Indalifiany; Sahidin Sahidin; Adryan Fristiohady; Rina Andriani
Jurnal Farmasi Sains dan Praktis Vol 7 No 3 (2021): Supplementary Issue (The 4th National Pharmacy Conference 2021 Universitas Halu O
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i3.6080

Abstract

Petrosia sp. is one of the sponges from the demospongia class that has biological activity as anti-inflammatory, antimalarial, cytotoxic agent, and can be used in nanoemulgel formulation. Nanoemulsion system is thermodynamically stable and produces globule size that can increase the permeability and diffusibility of Petrosia sp. The presence of gelling agent in the nanoemulgel gives the viscosity and spreadability of Petrosia sp nanoemulsion optimally to increase the effectiveness of the active substances on the skin. This study aims to determine the formulation, characterization, and physical stability of nanoemulgel ethanol extract of sponge Petrosia sp. with carbopol 940 as the gel base. Nanoemulsion characterization included transmittance value, particle size, polydispersity index, and type of emulsion formed. The physical stability test of nanoemulgel included centrifugation and freeze thaw tests with organoleptic, pH, viscosity, and dispersibility evaluation. Nanoemulsion of Petrosia sp ethanolic extract with a composition of 1% VCO, 7% Tween-80, and 2% PEG-400 produced an oil-in-water (O/W) nanoemulsion, transmittance value of 94.84%, droplet size of 23.9 nm and particle size distribution of 0.176. The optimum formula for nanoemulgel is F1 with a nanoemulsion concentration of 75 mL and 25 g of gel base produced a clear and transparent nanoemulgel, semi-solid, soft texture, distinctive aroma, pH value of 5, viscosity of 28,000, dispersibility of 5.7 cm and the shape/color did not change after freeze thaw stability test. Based on the data above, it can be concluded that the F1 nanoemulgel formula with carbopol 940 as the base gel produced an optimal nanoemulgel.
COMPARISON OF ANTHOCYANIN STABILITY OF ETHANOL EXTRACT Etlingera elatior (Jack) R.M. Sm. WITH COOPIGMENTATION OF TARTRIC ACID AND GALIC ACID Lilis Tuslinah; Firman Gustaman; Desi Silviani; Mira Rohimah
Jurnal Farmasi Sains dan Praktis Vol 7 No 3 (2021): Supplementary Issue (The 4th National Pharmacy Conference 2021 Universitas Halu O
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i3.6081

Abstract

Anthocyanins are unstable compounds mainly due to the influence of pH and temperature, including those sourced from the Honje Laka fruit (Etlingera elatior (Jack) R.M.Sm), to increase its stability, copigmentation method is used. In this study, the stability of anthocyanins was compared after being copigmented with tatric acid and gallic acid through the value of % color retention of anthocyanins using the UV-VIS Spectrophotometry method. Based on the test results, copigmentation with tartaric acid ratio 1: 75 mmol and gallic acid 1: 100 nmol is the optimal ratio to stabilize anthocyanins at pH 2 at 300C. Optimal conditions of copigmentation with tartaric acid and gallic acid did not give a significant difference at pH 2 temperature 300C
ANTIHYPERURICEMIA ACTIVITY OF WUALAE FRUIT (Etlingera elatior Jack R. M. Smith) ETHANOL EXTRACT IN VIVO Asriullah Jabbar; Wahyuni Wahyuni; Mesi Leorita; Muhammad Ilyas Yusuf; Sahidin Sahidin
Jurnal Farmasi Sains dan Praktis Vol 7 No 3 (2021): Supplementary Issue (The 4th National Pharmacy Conference 2021 Universitas Halu O
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i3.6083

Abstract

Plants Etlingera elatior (Wualae) is a family Zingiberaceae of ​​the genus Etlingera which has a large population in the world. The E. elatior plant is widely used empirically in the community to increase endurance and seasoning in fruit. In this study, ethanol extract was used to determine its potential and effectiveness as an antihyperuricemia (in vivo) was tested pharmacologically on Rattus novergicus L. In this study, twenty-four rats were grouped into six groups, namely the ethanol extract of wualae fruit at a dose (100 mg/kgBW, 200 mg/kgBW, 300 mg/kgBW, 400 mg/kgBW), and the negative control group Sodium CMC 0 .5%, and the positive control group used Allopurinol 10 mg/kgBW. Furthermore, To increase the value of uric acid levels, the rats were first induced with 250 mg/kgBW Potassium Oxonate via intraperitoneal (i.p). Furthermore, the preparation according to the treatment was given orally one hour later after the administration of potassium oxonate. At the hour (1, 2, 3), the blood was taken intravenously (i.v) through the rat's tail, and then the uric acid level was analyzed with a photometer. All doses used in this study, namely 100, 200, 300, and 400 mg/kgBW, showed that they could reduce uric acid overall. The effective dose used is the dose (300 mg/kgBW, 400 mg/kgBW). This research can be concluded that the ethanol extract of the fruit of Etlingera elatior (Jack) R.M. Smith (Wualae) has potential as an antihyperuricemia (uric acid) and can be developed as a traditional medicine
ANTIOXIDANT ACTIVITY OF PURSLANE PLANT (Portulaca oleracea L.) EXTRACT AS AN ANTIAGING SERUM IN SPRAY GEL USING DPPH METHOD Desy Ayu Irma Permatasari; Tatiana Siska Wardani; Ikrima Rahmasari; Kezia Putri Maha Dewi
Jurnal Farmasi Sains dan Praktis Vol 7 No 3 (2021): Supplementary Issue (The 4th National Pharmacy Conference 2021 Universitas Halu O
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i3.6084

Abstract

Skin aging is a problem for women caused by external factors, namely exposure to free radicals such as sunlight, antiaging cosmetic products containing antioxidants have been widely circulated to maintain skin health from the effects of free radicals. The content of antioxidant chemical compounds in the purslane plant (Portulaca oleracea L.) is believed to be able to prevent free radicals. Purslane plant extract serum preparations were made by formulating preparations with ingredients such as HPMC, chitosan, tween 80. Furthermore, antioxidant testing of extracts and preparations of serum spray formulas was carried out using the DPPH method, after which evaluation of the preparations included homogeneity, pH, adhesion, viscosity, and hedonic. The preparation of purslane plant extract serum in the spray gel preparation produces a brownish green color, has a slightly sour smell and has a soft texture. The resulting viscosity in the serum ranged from 1330 - 1362 cPs with a pH value in the range of 5.67 - 5.72. From the hedonic test carried out, the results obtained were that the color and aroma were less favored by the panelists while for the convenience of using spray gel the panelists liked the texture of all purslane (Portulaca oleracea L.) plant extract formulas. Based on this research, the IC50 value of purslane (Portulaca oleracea L.) plant extract was 132.87 ppm, while the formula had an IC50 value of 83.91 ppm. Therefore, antiaging serum in spray gel formulation has stronger antioxidant activity than purslane (Portulaca oleracea L.) plant extract.
ACTIVITY TEST OF A LIQUID HAND SANITIZER WITH LIME EXTRACT (CITRUS AURANTIFOLIA) AND ALOE VERA (ALOE VERA) AGAINST ESCHERICHIA COLI BACTERIA Lukky Jayadi; Sandry Kesuma
Jurnal Farmasi Sains dan Praktis Vol 7 No 3 (2021): Supplementary Issue (The 4th National Pharmacy Conference 2021 Universitas Halu O
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i3.6091

Abstract

One of the ways to prevent the spread of disease is to clean your hands using a hand sanitizer. Hand sanitizers are currently sterile hand sanitizers, usually as an alternative to washing the skin surface with a cleanser and air. Washing hands and skin with hand sanitizer is an action to maintain hand and skin hygiene to avoid infection that causes microbes, for example Escherichia coli microorganisms. The purpose behind this examination is make liquid hand sanitizer preparations with lime (Citrus aurantifolia) and aloe vera (Aloe vera) extracts that can kill Escherichia coli bacteria. In this study, the pH of the preparation was measured, the pH was 5 and for determining the specific gravity, the specific gravity was 0.9736 g/ml. The test is carried out using the percentage kill method at two contact times, namely 30 and 60 seconds. The percentage kill results for liquid hand sanitizer with lime (Citrus aurantifolia) and aloe vera (Aloe vera) extracts at the two contact times, with a percentage kill value of 99.9%. There is an impact using hand sanitizer with alcohol as an active ingredient with active alcohol ingredients with the addition of lime extract (Citrus aurantifolia) and aloe vera (Aloe vera) on pH, specific gravity and germicidal power.
THE EFFECT OF HPMC AS A GEL BASE AND TWEEN 80 SPAN 80 COMBINATIONS AS EMULGATORS IN ACETOSAL TRANSDERMAL EMULGEL PREPARATIONS Nirwati Rusli; Muhammad Azdar Setiawan; Nur Hikmawati
Jurnal Farmasi Sains dan Praktis Vol 7 No 3 (2021): Supplementary Issue (The 4th National Pharmacy Conference 2021 Universitas Halu O
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i3.6093

Abstract

Acetosal or acetyl salicylic acid is a drug that has efficacy as ananalgesic,antipireic, and antiplatelet. Aacetosal undegoes cross-first metabolisism (first passeffect) causing low drug bioavailability. The smal lsolubility of acetosal will affectthe rate of absorption which later affect the intensity of treatment, so transdermaldelivery in emulgel dosage forms can be one of. In this study an experimentalmethod was used by formulating an acetosal transdermal emulgel preparation, asa gel base HPMC was used at a concentration of 4%, 4.5%, 5% also variation oftween 80 concentration 6%, 5%, 4% and variation of Span 80 concentration 4%,5%, 6% as an emulgator. Then a physical evaluation of the preparation wascarried out which included organoleptic tests, pH tests, homogeneity tests,emulsion type tests, viscosity tests, spreadability tests and irritation tests. Theresults of the study showed that the formula 1 emulgel was bone white whileformulas 2 and 3 were white, the pH of the preparation ranged from 4.83-5.57,the preparation was homogeneous with an O/A emulsion type, the viscosity valueof the preparation ranged from 126.67-290 cPa. s, the dispersion value rangedfrom 5.20-6.30 and the preparation was not irritating.
FORMULATION AND EVALUATION OF PEEL-OFF GEL MASK FROM EXTRACT OF RED SPINACH (Amaranthus tricolor L.) Nur Saadah Daud; Ade Ainun Insani; Eny Nurhikma
Jurnal Farmasi Sains dan Praktis Vol 7 No 3 (2021): Supplementary Issue (The 4th National Pharmacy Conference 2021 Universitas Halu O
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i3.6095

Abstract

Red spinach (Amaranthus tricolor L.) contains various secondary metabolites that act as antioxidants. These activities can be used to maintain the health of facial skin due to the negative impact of free radicals in the form of cosmetic preparations of peel-off gel mask. This study aims to make a peel-off gel mask preparation from red spinach extract that meets the requirements for physical evaluation of the preparation. The extraction process was carried out by maceration method using 96% ethanol as solvent. The thick extract was then made into a peel-off gel mask preparation with variations in extract concentration of 0.5% (F1), 1% (F2), and 2% (F3). Furthermore, physical evaluation of the preparation at room temperature for 4 weeks of storage, drying time test, irritation test, preference test, and cycling test was carried out. The red spinach used has been determined as Amaranthus tricolor L. The results of phytochemical screening of the thick extract showed that the extract contained positive alkaloids, saponins and flavonoids. The results of the evaluation showed that all preparations met the physical evaluation requirements and were not irritating. The higher the concentration of the extract, the darker the color of the preparation and the higher the pH and viscosity values. The preparation was stable during storage at room temperature but decreased in pH value and dispersion after passing 6 cycles of cycling test. The results of the preference test showed 60% of respondents liked F3, which is a formula with a dark green color, a distinctive aroma of red spinach, homogeneous, pH 7.54, dispersion of 6.2 cm, the viscosity of 7200 cps and drying time of 20.23 minutes.
ISOLATION AND IDENTIFICATION OF ANTIOXIDANT COMPOUNDS FROM METHANOL EXTRACT OF SAPPAN WOOD (Caesalpinia sappan) Agung Wibawa Mahatva Yodha; Muamar Abdillah; Astrid Indalifiany; Elfahmi Elfahmi; Sahidin Sahidin
Jurnal Farmasi Sains dan Praktis Vol 7 No 3 (2021): Supplementary Issue (The 4th National Pharmacy Conference 2021 Universitas Halu O
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i3.6096

Abstract

Sappan wood extract (Caesalpinia sappan) provides better antioxidant properties than ascorbic acid. Empirically, Sappan wood is often used as traditional medicine. To support the utilization of Sappan wood, the isolation and identification of active antioxidant compounds from the methanol extract of Sappan wood had been conducted from this study. Extraction was performed with maceration and evaporation methods. The spots of active antioxidant compounds in TLC-DPPH observations were isolated using liquid vacuum chromatography to obtain two pure compounds. The results of the LC-MS/MS identification of the two compounds, respectively, exhibited peak fragmentation of molecular ions at m/z 271.09, 257.15, 167.03, 151.06, 123.12, and 104.06 at the retention time of 6.35 minutes which were translated as Alpinetine and peak fragmentation of molecular ion at m/z 287.09, 177.06, 164.05, 123.04 and 110.04 at a retention time of 5.75. minutes which were translated as 3-Deoxysappanone B. The antioxidant activity quantitatively showed that Alpinetine and 3-Deoxysappanone B were capable of scavenging DPPH radicals with IC50 values ​​of 20.11 M and 15.28 M, respectively.
PHYTOCHEMICALS AND RADICAL SCAVENGER ACTIVITY OF KAYU JAWA (LANNEA COROMANDELICA) AND SALAM (SYZYGIUM POLYANTHUM) LEAF STEEPING AND THE COMBINATED RATIONAL Nasrudin Nasrudin; Abraham Rahman; Nurlansi Nurlansi; Rahmanpiu Rahmanpiu; Damhuri Damhuri; Bilal Subchan Agus Santoso; Kismawati Kismawati; Jusna Jusna; Lulu Rahmatia
Jurnal Farmasi Sains dan Praktis Vol 7 No 3 (2021): Supplementary Issue (The 4th National Pharmacy Conference 2021 Universitas Halu O
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i3.6104

Abstract

Herbal medicine as a traditional medicine based on local wisdom in the Covid 19 pandemic is the alternative for the community to keep the health of the body. Specific drugs for the cure of Covid-19 disease have also not been found yet so the death of Covid-19 patients remainsat anytime. In this case this study aims to know the content of secondary metabolite compounds and radical scavenger activity of “kayu jawa” (L. coromandelica) leaf steeping and “Salam” (S. polyanthum) leaves from Southeast Sulawesi as well as their rational combination based on the radical scavenger activity of DPPH (2,2-difenyl-1-picrilhydrazil). The analysis of the content of secondary metabolite compounds in the steeping of DKJ (Daun Kayu Jawa) and DS (Daun Salam) is applied by phytochemical method and radical scavenger activity is determined by the DPPH method. The main focus of steeping is determined by the approach of the picnometer. The combination of DKJ and DS is made each with 6 variations based on the IC50 steeping value, then converted in the form of weight (grams) of DKJ and DS powder so that 36 combinations are obtained. The result of phytochemical analysis of DKJ and DS steeping showed the presence of flavonoids, saponins and polyphenols, except tannins only exist in the steeping of DS. The radical scavenger activity of DKJ and DS steeping showed IC50 values of 408.95 ± 0.075 µg/mL and 259.05 ± 0.092 µg/mL. The combination that showed the highest DPPH radical scavenger activity of 88.050.03% occurred in the combination of E1 with a ratio of 2IC50 DK: 1/8IC50DS (1,089: 0.128) grams. DPPH radical scavenger activity approaching 50% occurs in the combination of A2 and B1 with a ratio of 1/8IC50 DKJ: ¼IC50DS (0.068:0.256) grams and ¼IC50 DKJ: 1/8IC50DS (0.136:0.128) grams with values of (49.11 0.04) % and (52.87 0.05) % respectively.

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