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Hang Tuah Medical Journal
Published by Universitas Hang Tuah Surabaya
ISSN : 16931238     EISSN : 25984861     DOI : https://doi.org/10.30649/htmj.v19i2
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health
Hang Tuah Medical Journal: is published by Faculty of medicine, Universitas Hang Tuah with p-ISSN: 1693-1238 e-ISSN: 2598-4861. Its disciplinary focus is medical science and speciality in bio marine science. Hang Tuah Medical Journal is published in English and Indonesia for May and November. Each 90-100 page edition contains between nine and eleven scientific articles on research, case reports and study literature. Contributors of Hang Tuah Medical Journal included: medical researchers, dental practitioners, lecturers, and students drawn from Indonesia and a wide range of other countries. Hang Tuah Medical Journal as the open-access journal has been indexed by SINTA-Science and Technology Index, Garuda, Google scholar Hang Tuah Medical journal has been certificated as a Scientific Journal by Sinta (Science and Technology Index) S5 . valid until Volume 17 No.1, 2017.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 106 Documents
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Infark Serebri Tipe Kardioemboli pada Pasien dengan Fibrilasi Atrium ERIC HARTONO TEDYANTO; KEN CHRISTIAN KAWILARANG; FEISAL TANJUNG
HANG TUAH MEDICAL JOURNAL Vol 17 No 2 (2020): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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Abstract Background: Stroke is the leading cause of disability and the second most common cause of death in the world. Atrial fibrillation (AF) is the major risk factor for embolic stroke. Patients with atrial fibrillation have a 5 times much more risk of stroke to those who do not have atrial fibrillation. Case Report: A 40-year-old woman came to the Emergency Unit with chief complaints the left-sided limbs suddenly weakened while cooking. On ECG examination there is an irregular rhythm (irregular P-P), leading to an atrial fibrillation. CT scan revealed hypodense lesions on the temporal part of the left side, leading to a cerebral infarction. Discussion: AF puts patients at an increased risk for stroke because blood cannot be properly pumped, which caused stagnation and formed a blood clot. This clot can be released from ventricle and travel to the other organ via artery, including brain and block the blood flow which can result a infarct stroke. Conclusion: Close supervision and routine control are needed for patients with heart rhythm disorders, especially atrial fibrillation to prevent embolic stroke
Potensi Daun Kastuba (Euphorbia Pulcherrima) Sebagai Antimalaria Plasmodium Falciparum ELVINA VERONICA; NI KADEK SINTA DWI CHRISMAYANTI
HANG TUAH MEDICAL JOURNAL Vol 18 No 1 (2020): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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Abstract Introduction: Around 41% of people in the world at risk of malaria due to plasmodium infection. Plasmodium falciparum is the most dangerous malaria infection compared to another plasmodium because it causes 90% of total malarial deaths. ACT (Artemisinin Combination Therapy) is the gold standard of malaria medicine, is starting to become resistant, so other alternatives are needed. Poinsettia plants (Euphorbia pulcherrima) are ornamental plants and contain compounds that potential as anti-parasites. Objective: To aims the potential of poinsettia leaves as an antimalarial alternative to Plasmodium falciparum in malaria treatment. Methods: Literature studies using in vivo, in vitro, in silico research articles, and literature reviews from national and international journals accessed from Google Scholar, Elsevier, Science Direct, and Pubmed in the last 10 years using malaria, antioxidants, anti-malaria, Plasmodium falciparum, and Euphorbia pulcherrima as keywords. There were 22 relevant articles used in this literature review. Results: Antioxidants in poinsettia leaves inhibited plasmodium growth by inhibit nutrient transport at new permeation pathways and prevent hemozoin ban. Terpenoids in poinsettia inhibit schizont and trophozoite in an earlier asexual phase of Plasmodium falciparum by inhibiting isoprenoid biosynthesis. Conclusion: Poinsettia (Euphorbia pulcherrima) has the potency to be an antimalarial alternative against Plasmodium falciparum. Need further research about the dosage and side effects of the usage
Acute Cerebellar Ataxia As A Parotitis Complication: Clinical Evaluation And Management OKKY PRASETYO; ERNY PRASETYO; DENNY PRASETYO
HANG TUAH MEDICAL JOURNAL Vol 18 No 1 (2020): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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ABSTRACT Acute cerebellar ataxia is a motor control or coordination disorder that can be caused by several things, most often in children due to viral infections including paramyxovirus, head trauma, stroke and intoxication with varying prognosis. The paramyxovirus causes parotitis is highly neurotrophic with aseptic meningitis, encephalitis, hydrocephalus, decreased blood flow on the cerebellum and vasculitis. Those mechanisms implicated on many clinical symptoms, including cerebellar ataxia. Management is only limited to supportive and rehabilitative because symptoms will improve within 2-3 weeks
Pendekatan Pelayanan Kesehatan Holistik-Komprehensif Pada Kasus Menopause FEBRI ENDRA BUDI SETYAWAN; FENY TUNJUNGSARI; RETNO LESTARI
HANG TUAH MEDICAL JOURNAL Vol 18 No 1 (2020): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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Abstract Menopause is a natural process that occurs in the reproductive cycle of women aged over 40 years. These changes will affect physical and psychological state of a woman, and they are not ready to deal with this condition. Family doctors should provide information about menopause and how to manage various changes during menopause. The results of previous studies were very limited in examining various menopausal management options which were safe, comfortable and have less negative impacts. This study aimed to examine a holistic-comprehensive approach in the case of menopause. Systematic review results were obtained from 55 reference sources through Science Direct, Google Scholar, Proquest Health and Medical Complete, Proquest Nursing and Allied Health Source from 2010 to 2019. The systematic review results explain that the management of menopause cases can be optimized through a holistic-comprehensive approach. Holistic aspect includes the components of biopsychosocial and comprehensive needs which are carried out through promotive, preventive, curative and rehabilitative efforts. Menopausal women often not only experience physical symptoms, but also psychological symptoms which will impact their quality of life. It can be concluded that a holistic-comprehensive approach can be carried out as an effort by family doctors to optimize the management of menopause
Analisa Aktivitas Antibakteri Rebusan Daun Sirih Dengan Rebusan Daun Kemangi Terhadap Pertumbuhan Bakteri Streptococcus mutans ENNY WILLIANTI; THEODORA; WAHYUNI DYAH PARMASARI
HANG TUAH MEDICAL JOURNAL Vol 18 No 1 (2020): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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ABSTRACT Background: Betel leaf contains essential oils consisting of bethelphenol, kavikol, sesquiterpenes, hydroxycavikol, cavibetol, estragol, eugenol and carvacrol. Essential oils are antibacterial due to the presence of phenol compounds and their derivatives that can denature the bacterial cell proteins. Basil leaves contain compounds from essential oils, namely 1,8-cineole, ß-bisabolene, and methyl eugenol. These three ingredients are soluble to ethanol and can cause damage to the cell membranes of the Streptococcus mutans bacteria, which are members of the normal oral flora but can turn into pathogens if the balance of normal flora is disturbed. The aim of this study was to determine the difference in the activity of the antibacterial of decoction betel leaf (piper betle L. ) with a decoction of basil leaves (ocimum sanctum) against growth of bacteria Streptococcus mutans (in vitro study). Method: this observational research with disk diffusion techniques. This study observed and measured the diameter of the inhibitory zone in MHA formed by decoction of betel leaf (piper betle L) and basil leaf (ocimum sanctum) in units of millimeters (mm). There were 2 groups with 16 replications. Results: the results of the description test showed that the antibacterial activity of the betel leaf decoction and the highest decoction of basil leaf was 17 mm and the lowest was 15 mm, but the average antibacterial value of betel leaf decoction (15,81) greater than the average value of antibacterial activity of basil leaf (15.75). This is because there are chemicals contained in betel leaf similar as contained in basil leaf, namely essential oils. Conclusion: there is no difference in the antibacterial activity of decoction betel leaf with decoction basil leaf against growth of bacteria Streptococcus mutans.
Pengaruh Pemberian Ekstrak Teripang Pasir terhadap Hambatan Pertumbuhan Shigella Dysentriae Secara In Vitro FERIZAL NEGERI SAMUDRA; RETNO BUDIARTI; Irmawati Dikman
HANG TUAH MEDICAL JOURNAL Vol 18 No 1 (2020): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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Abstract Background; In Indonesia, most diarrhea disease in 1995 to 2001 are caused by Shigella spp. Shigella spp infection can cause various symptom dan complication. Generally, the treatment by using antibiotic can cause antibiotic resistance. Sea cucumber (Holoturia scabra) is an herb that known, available, and easy to consume by society and has an antibacterial effect. Therefore, further research to study the effect of Holoturia Scabra on Shigella Dysentriae growth in vitro is needed. Objectives: The goal of this research is demonstrate the effect of sea cucumber (Holoturia scabra) to the growth of the Shigella dysentriae bacteria in vitro. Method: The method in this research is Posttest Only Control Group. There are 6 groups, 4 types of and 2 control groups. The concentration of the treatment group is 100%,50%, 25%, and, 12.5% while for positive control tests using chloramphenicol and aquadest as a negative control. Result: The result showed there is an influence on the intake of sand cucumber to the growth of the Shigella dysenteriae. Conclusion: Sea cucumber (Holoturia scabra) inhibit the growth of Shigella dysenteriae.
Hubungan Kadar HbA1c pada Pasien Diabetes Melitus Tipe II dengan Kejadian Azotemia di Rumah Sakit Angkatan Laut Dr. Ramelan Surabaya VIOLITA PUTRI MURSANDI; SUWARNO; MOHAMMAD FATHI ILMAWAN
HANG TUAH MEDICAL JOURNAL Vol 18 No 1 (2020): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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ABSTRACT Background : Diabetes mellitus is chronic condition of elevated blood sugar levels, which can lead to complication due to uncontrolled sugar levels which is measured by HbA1c level parameters, affecting microvascular conditions, one of which is in the kidneys, which results in decreased kidney function characterized by elevated creatinine serum and BUN levels called by azotemia. In 2011 as many as 49.677 individuals began treatment for kidney failure which caused by diabetes, and around 228.934 people with various ages within kidney failer due to diabetes do dialysis and kidney transplantation. Methods : This observational analytic study was conducted by using cross sectional study design, by taking secondary data from the medical record files of diabetes mellitus type II patients who are doing outpatient care at the Diabetes Clinic Dr. Ramelan Naval Hospital Surabaya. Patients with a diagnosis of diabetes mellitus type II for at least five years will be the inclusion criteria of case samples. Bivariate analysis was performed using Spearman Correlation Test. Results : The results also showed that there were 19 people without azotemia and 21 people with azotemia. Blood sugar control which one of risk factor of azotemia by measuring HbA1c levels results 6 people with HbA1c <7; 21 people with HbA1c 7.19.0; and 13 people with HbA1c> 9.0. Spearman correlation test showed a significant value of p=0,512 with correlation coefficient 0.107. Conclusion: there is no relationship between HbA1c levels of type II diabetes mellitus patients with the incidence of azotemia
Efek Analgesik Ekstrak Etanolik Daun Mangrove Api-Api Putih (Avicennia alba) terhadap Mencit (Mus musculus L.) Jantan yang Diinduksi Asam Asetat 0,7% ANDREW THEO WILLIAM CHRIS PURMATA; LESTARI DEWI; CHOESNAN EFFENDI
HANG TUAH MEDICAL JOURNAL Vol 18 No 1 (2020): Hang Tuah Medical Journal
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ABSTRACT Background : Avicennia alba or known as mangrove api-api putih is a type of mangrove species which has many benefits and often to be used by the local Indonesians as traditional medicine. The alcaloid and flavonoid substances derived from Avicennia alba leaves could inhibit pain. This study aims to determine the analgesic effect of Avicennia alba leaves extract in male mice (Mus musculus L.) induced by acetic acid 0,7%. Method :25 mice were divided into 5 groups that were given different therapies. The therapy are 10 mL/kg bw of water, 150 mg/kg bw of acetosal, 250 mg/kg bw; 500mg/kg bw; 1000 mg/kg bw of Avicennia alba leaves extract. 0,7% acetic acid with dose of 10 mL/kg bw is given to each subject intraperitoneally 30 minutes after the therapy to induce pain. The pain is manifested as writhes in mice, the writhes then are counted repeatedly each 10 minutes for 30 minutes. Result:: mean of writhes in group treated with Avicennia alba leaves extract in 250 mg/kg bw and 500 mg/kg bw with each value 6,20 and 9,40 are less than mean of writhes in negative control group with value 31,40. %inhibition of Avicennia alba leaves extract with dose of 250 mg/kg bw and 500 mg/kg bw respectively are 80,25% and 70,06%. Conclusion : Avicennia alba leaves extract in 250 mg/kg bw and 500 mg/kg bw dosage showed analgesic effect in male mice (Mus musculus L.) induced with 0,7% acetic acid.
PENGARUH HbA1c TERHADAP SINDROMA MATA KERING PADA PASIEN DIABETES MELLITUS DI SURABAYA NI WAYAN WIWIN OKTORI; VARIDIANTO YUDO TJAHJONO; SRI ARIANI
HANG TUAH MEDICAL JOURNAL Vol 18 No 1 (2020): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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Abstract Background: Diabetes mellitus is a public health problem experienced by many countries and becomes a serious problem, affecting health in the world. Various complications of DM related to the surface of the eye is dry eye syndrome. Dry eye syndrome is an eye disorder with symptoms of discomfort, pain, dryness and foreign body sensation in the eye. The level of glycosylated hemoglobin (HbA1c) is one indicator of DM and it is stated that the prevalence of dry eye syndrome is significantly higher in DM sufferers than in healthy individuals. The Aim of this study to know the effect of HbA1c on dry eye syndrome in patients with diabetes mellitus Method :. This study used a cross sectional method and the sampling method used was purposive sampling. Samples taken as many as 34 people are patients with diabetes mellitus aged 18-55 years who have HbA1c results seen from medical records at the Public Health Center Jagir Surabaya. The research data was taken using the Dry Eye Questionnaire (DEQ), interviews and Schirmer Test I. The research data was then analyzed using a contingency test. Result: The significance value of the HbA1c test with the Schirmer I Test showed p = 0.026; that’s means a significant effect between HbA1c levels on dry eye syndrome with the Schirmer I Test and the significance value of the HbA1c test with the DEQ questionnaire shows p <0.001; that’s means a significant effect between HbA1c levels on dry eye syndrome and DEQ questionnaire, performed on patients with diabetes mellitus in Jagir Health Center, Surabaya City Conclusion: There is an influence of HbA1c levels on dry eye syndrome
The Efficacy of Aedes aegypti Natural Larvicide Gained from Averrhoa bilimbi and Averrhoa carambola GIANINA ANGELIA SANTOSO; NATHANIA DISA ARIESTA ANDRIANI; HEBERT ADRIANTO
HANG TUAH MEDICAL JOURNAL Vol 18 No 1 (2020): Hang Tuah Medical Journal
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Abstract Background: Dengue Hemorrhagic Fever (DHF) is an endemic disease transmitted by Aedes aegypti which is supposed to be demolished by using the Larvicidal activity. However, there are some Ae. aegypti larvae which are found resistant against the temephos in some provinces in Indonesia. Thus, this has been one of the biggest concern of The Ministry of Health Republic Indonesia. Apart from the resistance effect caused, temephos has been reported causing a water pollution which triggers the decreasing standard of human health and immune system. These factors have created a need for search of a new and natural larvicide, which one of it can be gained from Averrhoa. This research is aimed at comparing the effectiveness between the extract Averrhoa bilimbi and Averrhoa carambola towards the Ae. aegypti larvae’s mortality. Method: An experimental laboratory research involving the design of post test-only control group. Twenty five larvae Ae. aegypti third instar were carried out at 5 different concentrations (0%, 1%, 1.6%, 2.6%, 3.4%, and 4%). The larva demolition is counted within 24 hours. The mortality data is then analysed with the probit analysis. Results: The extract of Averrhoa bilimbi and Averrhoa carambola can cause the mortality of the Ae. aegypti larvae. LC99 24 hours from Averrhoa bilimbi was recorded = 1.47% (1.20-2.04%), whereas LC99 24 hours was recorded from Averrhoa carambola = 8.96% (7.59-11.31%). The major loses appeared is the stretchy necks and injured appendices. The bioactive substances which are predicted to be the causes of the mortality in this research are saponin glycoside and flavonoid. Conclusion: The extract of Averrhoa bilimbi produces the strongest and the most effective larvicide which will be potentially developed as a new larvicide

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