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Hang Tuah Medical Journal
Published by Universitas Hang Tuah
ISSN : 16931238     EISSN : 25984861     DOI : https://doi.org/10.30649/htmj.v19i2
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Nursing Public Health
Hang Tuah Medical Journal: is published by Faculty of medicine, Universitas Hang Tuah with p-ISSN: 1693-1238 e-ISSN: 2598-4861. Its disciplinary focus is medical science and speciality in bio marine science. Hang Tuah Medical Journal is published in English and Indonesia for May and November. Each 90-100 page edition contains between nine and eleven scientific articles on research, case reports and study literature. Contributors of Hang Tuah Medical Journal included: medical researchers, dental practitioners, lecturers, and students drawn from Indonesia and a wide range of other countries. Hang Tuah Medical Journal as the open-access journal has been indexed by SINTA-Science and Technology Index, Garuda, Google scholar Hang Tuah Medical journal has been certificated as a Scientific Journal by Sinta (Science and Technology Index) S5 . valid until Volume 17 No.1, 2017.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 117 Documents
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Pengaruh Pemberian Terapi Oksigen Hiperbarik Terhadap Kadar Kolesterol Total Pada Tikus Putih (Rattus novergicus) Jantan Galur Wistar Yang Diinduksi Diet Tinggi Lemak AZRUL HILDAN SAFRIZAL
HANG TUAH MEDICAL JOURNAL Vol 16 No 1 (2018): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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ABSTRACT BACKGROUND: The pattern and lifestyle of today's society with the presence of an interner facility makes people spend more time sitting out than on exercise and increased consumption of high-fat foods may increase the risk of cardiovascular disease. An effective therapy is needed in preventing the occurrence of cardiovascular disease. Hyperbaric oxygen now starts to develop for the treatment of several diseases, which in turn can increase the gene forming antioxidant enzymes and ROS.To determine effect of hyperbaric oxygen therapy on total cholesterol levels of wistar white rats (Rattusnovergicus) induced by high fat. METHOD: The study was carried out in an experimental post test only group of three groups. First group was given standard feed. Second group was given high-fat diet. Third group was given high fat diet and hyperbaric oxygen therapy with a dose 2 ATA 3 x 30 minutes for six days. On day 7 total cholesterol levels were measured. RESULT: One way Anova test showed that high fat diet incresed total cholesterol level (p = 0.03) and oxygen hyperbaric therapy significantly decreased total cholesterol level (p=0,015). CONCLUSION : hyperbaric oxygen therapy significantly decreased total cholesterol level because can increase the gene forming antioxidant enzymes and ROS
Aliskiren: Direct Renin Inhibitor Baru Pada Terapi Hipertensi N. P. U. S. DEWI; I. G. A. A. E. AMANDARI; M. W.KRISNAYANTI; M. A. SARASMITA
HANG TUAH MEDICAL JOURNAL Vol 16 No 1 (2018): Hang Tuah Medical Journal
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Abstract Hypertension is a condition when blood pressure increases chronically. Referring to the results of Riset Kesehatan Dasar (Riskesdas), Bali has a proportion of hypertension of 19.9%. Several epidemiological studies suggest that the risk of damage to various vital organs directly correlates with an increase in blood pressure. Therefore, it takes regularity in controlling and also taking antihypertensive drugs. The most common antihypertensive drugs currently used are angiotensin converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARBs). However, previous findings suggest that ACEI and ARB have not been fully effective in lowering blood pressure. To overcome these weaknesses, found a new direct renin inhibitor that is aliskiren. Aliskiren can block the renin-angiotensin-aldosterone system (RAAS) at the highest level, so the ability of aliskiren in lowering blood pressure can not be doubted. Aliskiren able to inhibit the conversion of angiotensinogen to angiotensin I, so it can lower blood pressure in a sustainable manner.
SGLT-2 Inhibitor: Pilihan Terapi Baru Untuk Penderita DM Tipe 2 I GUSTI A. A. E. AMANDARI; MADE ARY SARASMITA; NI PUTU U. S. DEWI; MADE WINDA KRISNAYANTI
HANG TUAH MEDICAL JOURNAL Vol 16 No 1 (2018): Hang Tuah Medical Journal
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ABSTRACT Type 2 diabetes mellitus (DMT2) is a medical condition characterized by an increase in blood glucose levels exceeding normal limits. World Health Organization (WHO) states that the number of DMT2 patients in Indonesia has increased from 8.4 million patients in 2000 to 21.3 million patients in 2030, which is 90% of them are patients with DMT2. Pathophysiology of DMT2 is a complex process and involves many factors. The ominous octet concept proposed by Ralph DeFronzo plays an important role to explain the pathophysiology of DMT2. The kidneys are organs that have a significant role to control blood glucose to stay within normal limits, thus being considered to be targets of new drug therapies. Sodium glucose co-transporters (SGLTs) such as SGLT-2 facilitate the reabsorption of glucose into plasma. Pharmacokinetics of the SGLT-2 inhibitors generally show good bioavailability when administered orally. DMT2 is a risk factor for chronic kidney disease (CKD) and cardiovascular disease (CVD). The presence of an inhibitory mechanism in SGLT-2 will benefit the reno-cardiovascular system through decrease in blood glucose, weight, and blood pressure. SGLT-2 inhibitors have some favorable adjunctive effects for metabolic syndrome, such as weight loss, decreased blood pressure (especially systolic), as well as decreased serum uric acid
Hubungan Konsumsi Makanan Kariogenik Dan Kebiasaan Menggosok Gigi Dengan Timbulnya Karies Gigi Pada Anak Usia 4-6 Tahun FEBRI ENDRA BUDI SETYAWAN; PERTIWI FEBRIANA CHANDRAWATI; NATALIA MULYADI
HANG TUAH MEDICAL JOURNAL Vol 16 No 1 (2018): Hang Tuah Medical Journal
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ABSTRACT The initial factor of the dental caries initiator is cariogenic food. In previous research states there is a relationship between eating patterns and the habit of brushing teeth with dental caries prevalence. This study aims to determine the relationship between the consumption of cariogenic foods and the habit of brushing teeth with the onset of dental caries disease in children aged 4-6 years in kindergarten Tunas Mekar at village Mlajah Bangkalan District. The research method is Descriptive Observational Analytic with Cross Sectional approach. The population in this study is all children aged 4-6 in the village Mlajah Bangkalan District. Samples taken by a total of 68 children using Total Sampling technique. Primary data obtained from observation and questionnaire, processed using Chi-Square test statistic and Discriminant test with degree of significance (α) = 0,05. The result showed that 49 children (84,5%) had dental caries on cariogenic food consumption ≥3x daily with habit of brushing teeth <2x a day. On the results of the Contingency Coefficient test obtained the value of r = 0.61 with a significance value in the Discriminant test. The conclusion of this study is a relationship between the consumption of cariogenic foods and the habit of brushing teeth with the dental caries at the time of children 4-6 years in TK Tunas Mekar, Mlajah village, Bangkalan District. The habit of giving cariogenic food which is more meaningful to make teeth compared to the eyes of brushing teeth
Peta Isolat Bakteri Dan Sensitifitasnya Pada Penderita Gangren Diabetik Di Rumah Sakit Angkatan Laut Dr. Ramelan Surabaya NI LUH AYU MADE INTAN EDYASSARI PUTRI UTAMI
HANG TUAH MEDICAL JOURNAL Vol 16 No 1 (2018): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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Abstract Background: Diabetic gangrene is one of the complications of Diabetes Mellitus (DM) characterized by open wounds on the skin surface to the dermis layer. One of the complicating factors of the wound healing process is the infection of germs. Infection therapy in diabetic gangrene often associated with the use of antibiotics. The purpose of this study was to determine the germs that found in diabetic gangrene and its sensitifity to antibiotic in diabetic gangrene patients at Naval Hospital Dr. Ramelan Surabaya. Methods: This study is a retrospective descriptive study using 60 data samples that have fulfilled the inclusion criteria and obtained from the result of pus culture in diabetic gangrene at the Clinical Pathology Laboratory of Naval Hospital Dr. Ramelan Surabaya. Results: The results obtained from this study indicate the presence of 13 types of germs found in pus culture of diabetic gangrene patients and the most common found were Escherichia coli (33,3%). While the results on the sensitifity test showed that antibiotics with the highest sensitifity were Cefoperazone/ Sulbactam, Meropenem, and Levofloxacin (92.3%), whereas the lowest sensitifity antibiotic was Ampicilin (15.3%). Conclusion: Diabetic gangrene is often followed by the occurrence of infections that can be caused by various germs, and each germ has a different sensitifity to antibiotics. The culture of gangrene must be done because it is used to determine the type of antibiotic used for the treatment of diabetic gangrene based on the type of germs that infects. However, Cefoperazone/ Sulbactam, Meropenem, and Levofloxacin antibiotics may be the primary antibiotic choice because they have a high level of sensitifity
Gambaran X-Foto Schuller Pada Pasien Otitis Media Kronis Di Rumah Sakit Angkatan Laut Dr. Ramelan Surabaya Periode 20152016 SALSABILA IRBAH AZHARI; SRI MULYATI
HANG TUAH MEDICAL JOURNAL Vol 16 No 1 (2018): Hang Tuah Medical Journal
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Background: Chronic Otitis Media is an infection of the middle ear marked by discharge from the middle ear. A survey conducted in seven provinces in Indonesia in 1996 found the prevalence of chronic suppurative otitis media was 3% of the population of Indonesia. OMSK can cause complications such as mastoiditis, meningitis and epidural abscess. The presence of complicationscan be examined one with a Schuller photo. Objective: To determine how many cases of mastoiditis in patients with chronic otitis media. Methods: This research was a descriptive study. The research was held between December 2016-Januari 2017 at Dr. Ramelan naval hospital Surabaya. The samples used were chronic otitis media patients with and without complications of mastoiditis who had Schuller photo examination at Dr. Ramelan naval hospital Surabaya in 2015-2016 that met the inclusion criteria. Results: The samples consisted of 72 patients. The highest proportion of samples were in the group of 41-50 years as many as 17 samples (23,61%), 37 patients were male (51.39%) and 35 patients were female (48.61%). Complications of mastoiditis was found in 69 patients (95.83%) and kolesteatom in 5 patients (6.94%). Chronic Mastoiditis was found in 48 patients (66.67%), Acute Mastoiditis in 21 patients (29.17%) and 3 patients (4.16%) were normal. Conclusion: Chronic Mastoiditis was the most common complication in patients with chronic otitis media
Pengaruh Pemberian Ekstrak Jambu Biji (Psidium guajava) Terhadap Kadar Trigliserida Darah Tikus Putih (Rattus norvegicus) Jantan Galur Wistar Yang Diinduksi Deksametason MARIA EVANE NAVY CAHAYA PUTRI; NITA PRANITASARI
HANG TUAH MEDICAL JOURNAL Vol 16 No 1 (2018): Hang Tuah Medical Journal
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Abstract Background Dexamethasone induction may result in increased of both triglyceride synthesis and VLDL plasma level, which contribute to the increase in triglyceride level. Guava (Psidium guajava) consists flavonoid (quercetin) compounds that can inhibit triglyceride synthesis and decrease blood triglyceride level. Method This research used 24 rats divided into 3 groups: group of rats fed with standard food, group of rats induced by 0.13 mg/kgBW dexamethasone for 14 days starting from day 8, and group of rats induced by 0.13 mg/kgBW dexamethasone for 14 days starting from day 8 and received 3 gr/kgBW guava extract for 21 days. On day 22, blood triglyceride level was measured with glycerol blanking method. Result The result of Mann-Whitney U test showed that blood triglyceride level of group of rats induced by dexamethasone ( X =198.25±55.296 mg/dl) was significantly higher (p=0.001) than group of rats fed with standard food ( X =68.50±16.062 mg/dl). Blood triglyceride level of group of rats induced by dexamethasone and received guava extract ( X =98.75±26.778 mg/dl) did not significantly decreased (p=0.487) compared to group of rats induced by dexamethasone ( X =198.25±55.296 mg/dl). Conclusion The conclusion of this research showed that dexamethasone significantly increased blood triglyceride level and guava extract tend to decrease blood triglyceride level because guava consists flavonoid (quercetin) compounds.
Gambaran Karakteristik ODHA Berdasarkan Lingkungan di Minangkabau Tahun 2018 SRI HANDAYANI; ELIZA ARMAN; INGE ANGELICA
HANG TUAH MEDICAL JOURNAL Vol 16 No 1 (2018): Hang Tuah Medical Journal
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Abstract Background Ranah Minang (West Sumatra Province) ranked 8 from 34 provinces in Indonesia with HIV/AIDS case rate of 18.8, above national case rate (17.2). Minang is a tribe that uphold Adat Basandi Syarak, Syarak Basandi Kitabullah custom or the custom of Minangkabau that based on Islam Sharia law. Islam religion in The Koran already stated haram (forbidden) of sexual activities or wrongdoings outside norm/ marriage such as: LBGTQ, drinking alcoholic beverages and using narcotics. These things are HIV transmission sources. This study aims to describe ODHA (Orang Dengan HIV/AIDS; HIV/AIDS patients) characteristics based on Ranah Minang location. Methods This study is an analytic observational study with cross-sectional design. This study was conducted in Ranah Minang (West Sumatera Province). Data are obtained by conducting questionnaire survey with quota sampling technique for a total of 28 ODHA (patients). Data were analyzed using univariate analysis with SPSS software. Results The result showed the role of peers’ influence in risky behaviors accounted for 96.4%, while the role of family accounted for 60.7% and the role of custom leader in the occurrence of HIV/AIDS incidence in cases accounted for 60.7%. Conclusion The number of risky behaviors prevalence in ODHA were found still quite high, based on the role of peers’ influence, as well as family and custom leaders’ influence. This study concluded that the environment still plays important role in the management of HIV/AIDS occurrences in Ranah Minang.
Pengaruh Pemberian Ekstrak Umbi Bawang Dayak (Eleutherine palmifolia L. Merr.) Terhadap Kadar Mda (Malondialdehid) Serum Tikus Putih (Rattus norvegicus) Jantan Galur Wistar Yang Diinduksi Parasetamol William Sugiharto; Tri Martini
HANG TUAH MEDICAL JOURNAL Vol 16 No 1 (2018): Hang Tuah Medical Journal
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ABSTRACT Background: Paracetamol induced hepatotoxic effect because paracetamol increased production of N-acetyl-para-benzoquinone imine (NAPQI). Dayak onion contains flavonoids that inhibits cytochrome P450 activity, increases Glutation S-transferase (GST) activity, and scavenges free radicals. Method: This study used 24 male wistar rats (Rattus norvegicus) divided into 3 groups: group of rats without paracetamol induction, group of rats induced by 1750mg/kgBW paracetamol on 14th day, and group of rats given 300mg/kgBW dayak onion bulb extract (Eleutherine palmifolia L. Merr) for 14 days and induced by 1750 mg/kgBW paracetamol on 14th day. Result: The result of One Way Anova showed that serum malondialdehyde level of group of rats induced by paracetamol ( =129,063±42,0497mg/dl) was significantly higher (p=0.006) than group of rats without paracetamol induction ( =85,688±15,9976mg/dl). Serum malondialdehyde (MDA) level of group of rats given dayak onion bulb extract induced by paracetamol ( =118,500±19,4054mg/dl) was not significantly lower (p=0,463) than group of rats induced by paracetamol ( =129,063±42,0497mg/dl). Conclusion: The conclusion of this study showed that paracetamol significantly increased serum malondialdehyde (MDA) level and dayak onion bulb extract was not significantly decreased serum malondialdehyde (MDA) level.
Hubungan antara Insomnia dengan Kualitas Hidup Mahasiswa Fakultas Kedokteran Universitas Katolik Indonesia Atma Jaya Jakarta Patricia Adelia Daton; Herlina Uinarni; Satya Joewana
HANG TUAH MEDICAL JOURNAL Vol 16 No 2 (2019): Hang Tuah Medical Journal
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ABSTRACT Association between Insomnia and Quality of Life among Students of Faculty of Medicine Atma Jaya Catholic University of Indonesia By: PATRICIA ADELIA DATON Supervised by: dr. Herlina Uinarni, Sp.Rad (K) Background: Insomnia is a worldwide health problem with high prevalence. Insomnia is defined as difficulties to sleep relating to onset, ability to maintain sleep, duration, and quality of sleep. Insomnia could lead to daytime activity dysfunction, which could further affect quality of life in a negative way. This research was conducted to analyze whether there is a correlation between insomnia and quality of life among students of Faculty of Medicine Atma Jaya Catholic University of Indonesia. Methods: This cross-sectional research was conducted on 107 students of Faculty of Medicine Atma Jaya Catholic University of Indonesia which suffice the inclusion criteria. Data were collected using research instruments Insomnia Severity Index (ISI) to evaluate insomnia grades, and World Health Organization Quality of Life - BREF(WHOQOL-BREF) to evaluate quality of life. Result: From a total of 107 respondents, 65 of the respondents have insomnia. Poor quality of life found in insomniac respondents are as follows: (49,2%) on the domain of physical, (63,1%) on the domain of psychological, (63,1%) on the domain of social relationships, and (43,1%) on the domain of environment. The p values found are 0,000 on the domain of physical, 0,000 on the domain of psychological, 0,022 on the domain of social relationships, and 0,010 on the domain of environment. Conclusion: There were a significant association between insomnia and quality of life among students of Faculty of Medicine Atma Jaya Catholic University of Indonesia. Keywords:Insomnia, Quality of Life, Medical Students.

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