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JOURNAL OF CHEMICAL NATURAL RESOURCES (JCNaR)

JCNaR
Website

Published by TALENTA PUBLISHER

ISSN : - EISSN : 26561492 DOI : https://doi.org/10.32734/jcnar.v4i1.9353

Core Subject : Science,

Biochemistry, Genetics & Molecular Biology Chemistry Materials Science & Nanotechnology

Journal of Chemical Natural Resources (JCNaR) is a peer-reviewed biannual journal (February and August) published by TALENTA as an open access journal. The aim of the journal is to provide a medium to exchange ideas and information related to research and knowledge in disciplines of organic chemistry, biochemistry, analytical chemistry, inorganic chemistry and physical chemistry. The journal also receives systematic reviews, meta- analysis and review article on the new issues in the fields of chemistry and natural sciences. Submission to this journal implies that the manuscript has not been published or under consideration to be published in another journal.

Arjuna Subject : Kimia(semua kategori) - Kimia Organik

Articles 65 Documents

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The Characterization of Active Compound of Pedada Magrove Plants (Sonneratia caseolaris) Which HaveThePotential as Natural Antioxidants Madyawati Latief
Journal of Chemical Natural Resources Vol. 1 No. 1 (2019): Journal of Chemical Natural Resources
Publisher : Talenta Publisher

The present research aimedto isolate the compound from the acetone fractions of pedada leaves (Sonneratia caseolaris) and test its antioxidant activity. The extraction wasperformed usinga multi-stage maceration method. The separation and purification were done using a vacuum and gravitational column chromatography whereasthe antioxidant activity was tested with theDPPH method. The structural elucidation of the compound was performed by spectroscopy data of UV, IR, alsoone- and two-dimensional NMR. The appearance of the pure isolate was odorless yellow crystal. Based on the spectroscopy data, the compound wasstigmasta-5,22-dien-3-ol. The activity testing of the extract antioxidant and pure isolate with IC50showed a value of 166.2 ppm dan 134.4 ppm, respectively.

Antibacterial Activities of Rough Lemon (Citrus jambhiri Lush) Rind Essential Oil Helmina Sembiring
Journal of Chemical Natural Resources Vol. 1 No. 1 (2019): Journal of Chemical Natural Resources
Publisher : Talenta Publisher

The isolation of rough lemon (Citrus jambhiri Lush) rind essential oil has been done by using hydrodistillation method and paper disk diffusion test for antibacterial activity test. 2.3 gram (1.51%) of essential oil was obtained from 450 gram of dried rough lemon rind powder. Based on the analysis using GC-MS, the essential oil from rough lemon rind contains 5 chemical compounds, but only 4 of them can be interpreted. They are Limonene (71.88%), 1,4-cyclohexadiene (13.93%), β-Pinene (10.57%) and β-Ocimene (2.37%). Antibacterial activity was tested to Bacillus cereus and Escherichia coli at 40% concentration (v/v) with 12.7 mm and 12.9 mm of clear zones respectively.

Synthesis of Polyurethane from Diphenyl Methane 4,4 Diisocyanate (Mdi) Polymerization with Hydroxilated Avocado Oil Polyol Herlince Sihotang
Journal of Chemical Natural Resources Vol. 1 No. 1 (2019): Journal of Chemical Natural Resources
Publisher : Talenta Publisher

Polymerization between polyol and isocyanate compounds produces polyurethane in different forms. Polyol used in this study utilized spoiled avocado as the oil source for polyol to produce polyurethane. Avocado oil was epoxidized with formic acid (HCOOH) and H2SO4 catalyst at 40 – 45oC followed by hydrolysis reaction to produce polyol reaction. Next polyol was purified and structure confirmation was done using FT-IR spectroscopy analysis. Polyol was then reacted with diphenylmethane 4,4 diisocyanate (MDI) with ratios of (polyol : MDI) 9:1; 8:2; 7:3; 6:4; and 5:5 (v/v) in a total volume of 10 mL with open air stirring at 40 – 45oC to produce polyurethane. Characterization for the form was observed visually followed by the determination of gel content, density and structure using FT-IR spectroscopy. The results of polyol from avocado oil reacted with diphenylmethane 4,4 diisocyanate for each of the mixing ratio to produce polyurethane is gel content of 74.63% to 99.80% where the higher MDI ratio is, the higher gel content becomes. Density determination from the polyurethane produced is between 0.1341 g/cm3 to 0.7220 g/cm3. FT-IR spectrometer analysis to polyurethane produced is marked with the peaks at 3400 – 3300 cm-1, 2270 – 1940 cm-1, 1700-1600 cm-1 and 1590 – 1540 cm-1 wavelengths which are the characteristic of urethane functional groups.

Synthesis of 2-(4-Allyl-2-Methoxy Phenoxy)-N,N-Bis(2- Hydroxyethyl) Acetamide from the Transformation of Eugenol Isolated from Clove Oil mimpin ginting
Journal of Chemical Natural Resources Vol. 1 No. 1 (2019): Journal of Chemical Natural Resources
Publisher : Talenta Publisher

Eugenol as the main component of clove oil has been isolated through NaOH salting procedure followed by H2SO4hydrolysis, n-hexane partitioning and purification with vacuum distillation. 71% (v/v) eugenol was produced with purity of 97.70% based on gas chromatography analysis. 2-(4-allyl-2-methoxy phenoxy)-N,N-bis(2-hydroxyethyl) acetamide compound has the potential as antibacterial or substances for medicine in pharmaceutical can be synthesized from eugenol isolated through alkoxylation, esterification and followed by amidase. Alkoxylation was done using Williamson method through NaOH transformation of hydroxyl functional group in eugenol to form sodium eugenolate then with α-monochloroacetate substitution in reflux condition, eugenyl acetate was produced. The acid produced was extracted with ether/Na2CO3, followed by recrystallization using hot water and produced 70.52% solid form. Eugenyl acetate esterification with methanol in benzene solvent with H2SO4 catalyst in reflux condition produced methyl eugenol acetate liquid with 81.36% of yield. Amidase of methyl eugenol acetate with diethanolamine and sodium methoxide catalyst with methanol solvent in reflux condition. After purification, 2-(4-allyl-2-methoxy phenoxy)-N,N-bis(2-hydroxyethyl) acetamide compound in solid form is produced with 72.99% yield. Eugenol isolated, eugenyl acetate and methyl eugenol acetate had their structures analyzed with FT-IR spectroscopy while 2-(4-allyl-2-methoxy phenoxy)-N,N-bis(2-hydroxyethyl) acetamide compound was analysed using FT-IR and H1-NMR.

The Isolation and Characterization of Phenolic Compound of Euphorbia Plant/Patikan Cina (Euphorbia thymifolia Linn) Hilda Amanda
Journal of Chemical Natural Resources Vol. 1 No. 1 (2019): Journal of Chemical Natural Resources
Publisher : Talenta Publisher

Euphorbia plant, Euphorbia thymifolia Linn, is one the Euphorbiaceae families that still need to be developed due to its benefits. An effort to be able to use this plant maximumly is by studying the active component in the plant. This study aims to isolate and characterize phenolic compound in euphorbia plant extract using ethyl acetate. 500 gram of euphorbia plant (Patikan Cina) powder was macerated using methanol. Then, the macerated extract was evaporated to eliminate excess solvent and as a result, a solvent-free extract was obtained. Next, the result was partitioned with a solution of methanol : ethyl acetate (1:1) in order to get methanol and ethyl acetate extracts. The ethyl acetate extract of the partition was evaporated to get concentrated ethyl acetate extract. Next, it was isolated in a vacuum liquid and gravitational column chromatography to get pure isolate. Silica gel 60 (0.040 – 0.063 mm) and n-hexane motion phase were used in the separation of concentrated ethyl acetate in vacuum liquid chromatography. There were 16 fractions produced from the yield. Then the fractions were put in TLC. With silica gel 60 (0.2 – 0.5 mm) mesh and n-hexane mobile phase, ethyl acetate gave 5 fractions in gravitational column chromatography and fraction 3 produced a single spot. UV and IR spectroscopy were used to determine the constituents in the isolate. From UV spectrum, max is 268.97 nm. While IR data shows the presence O-H group in 3521.38 cm-1, C – H (alkane) presents at wave number 2926.45 cm-1 reinforced by the appearance of 5 other alkanes absorption at 2857.00 cm-1, 1447.31 cm-1, 1370.18 cm-1, 868.774 cm-1 and 757.887 cm-1 wavelengths. There is also C = O (carbonyl) groups in wave number 1693.19 cm-1. The identification of structures based on UV and IR spectra data has shown that the isolate is a phenolic compound.

Antimicrobial Activity of Dadap Serep (Erythrina subumbrans (Hassk.) Merr.) Leaves Extract Diah Tri Utami
Journal of Chemical Natural Resources Vol. 1 No. 1 (2019): Journal of Chemical Natural Resources
Publisher : Talenta Publisher

The leaves of Erythrina has been used in Indonesia as a remedy for rheumatism, stomach-ache, asthma, dysentery, contact dermatitis, eczema and skin infections. However, there have been limited phytochemical or biological studies on the leaves of E. subumbrans and there are not studies that align with its traditional medicinal uses. The aim of this study was to assess the antimicrobial activity of the leaves of E. subumbrans to support its topical use in the treatment of skin infections. Disc diffusion agar assays were used to determine the antimicrobial activities of ethanol extracts of the leaves of E. subumbrans.The ethanol extracts showed the most significant activity with MIC values of 0,5 µg/mL. against a sensitive strain of Staphylococcus epidermidis. Extract concentration of 0,5 mg/ml, 1 mg/ml, 5 mg/ml and 10 mg/ml showed inhibition zone continuously as high as 1,83 mm; 3,42 mm; 5,17 mm, and 8,00 mm. The ethanol extracts of the leaves of E. subumbrans also showed significant activity against Candida albicans with MIC values of 0,5 µg/mL. Extract concentration of 0,5 mg/ml, 1 mg/ml, 5 mg/ml and 10 mg/ml showed inhibition zone continuously as high as 4,00 mm; 4,17 mm; 5,25 mm, and 6,50 mm. Bioactive substance test showed that alkaloid, flavonoid, saponin, and triterpenoid were found in E. subumbrans extract indicates potential activity as antimicrobial agent. These results provide support for the customary (traditional and contemporary) use of E.subumbrans leaves for the treatment of nosocomial infections.

Bacterial Cellulose-BasedBiodegradable Plasticfrom Pineapple (Ananassativus) Skin Waste: The Effectof Sorbitol On The QualityOf The Biodegradableplastic Ananda Putra
Journal of Chemical Natural Resources Vol. 1 No. 1 (2019): Journal of Chemical Natural Resources
Publisher : Talenta Publisher

The aim of this research was to investigate the effect of sorbitol on the quality ofbacterial cellulose-based biodegradable plastic from pineapple skin waste. Various concentrations of sorbitol as the plasticizer were added into a fermentation medium in the synthesis of bacterial cellulose-sorbitolcomposite (BCSC). The BCSCobtainedwas purified by soaking it into a cycled water-NaOH-water. The purified BCSC wasthen compressed using a hot press with the pressure of 300 psi to obtain BCS plastic. The BCS plasticwas characterized in the aspect of physical properties (water content,the degree of swelling), mechanical properties (tensile strength,elongation, elasticity), molecular structure (functional groups, thedegree of crystallinity), and biodegradability. The results showed that the percentage ofwater content anddegree of swelling of theBCS plastic increased with the addition of sorbitol concentrations. The maximum tensile strength was obtained with the addition of 10.5% sorbitol (%v/v). The degrability of the BCS plastic was up to 59% until the 9th day. TheFTIR results showed that functional groups appeared in the BCS plastic were similar to those of the BC. The degree of crystallinity of the BCSplastic decreased with the increasing concentration of sorbitol.

In Vitro Determination of SunProtective Factor (SPF) of Dadap Serep (Erythrina Subumbrans (Haks.) Merr.) Leaf Extract Using Spectrophotometric Method Indri Maharini
Journal of Chemical Natural Resources Vol. 1 No. 1 (2019): Journal of Chemical Natural Resources
Publisher : Talenta Publisher

Dadap serep (Erythrina Subumbrans Haks Merr) contains bioactive compounds of flavonoids, saponins, isoflavones, alkaloids, and lectins. Flavonoid compounds have a sunscreen effect. This studyaimed to determinethe value of Sun Protective Factor (SPF) using spectrophotometry method with variations in the extract concentrations, such as500 ppm,750 ppm, and 1000 ppm.The results showed that the SPF values of each concentration were11.47 ±0.583335, 17.05 ± 0.898838,21.93 ± 0.791557, respectively. In conclusion, the ethanol extract of dadap serep hastheability to become sunscreen in the maximal and ultra category.

Structure Elucidation of an Pentacyclic Triterpenoid and Phenolic from Steam Bark of Vitex Pubescens Vahl Lenny Anwar
Journal of Chemical Natural Resources Vol. 1 No. 1 (2019): Journal of Chemical Natural Resources
Publisher : Talenta Publisher

Pentacyclic triterpenoid, betulinic acid (1) and phenolic, p-hydroxybenzoic acid (2), had been isolated for the first time from the stem bark of Vitex pubescens Vahl. The structure of compounds 1 and 2 was determined based on the interpretation of spectroscopic data including UV, IR, NMR (1H-NMR, 13C-NMR, HMQC, HMBC, COSY) and MS, as well as by comparison with those reported data.

Synthesis Of 4-Alil-6- (Hydroxymethyl) -2-Methody Phenol Compounds from Eugenol Through Mannich Reaction Followed Methylation with Methyl Iodide and Subtitution Using NaOH Sabarmin Perangin-angin
Journal of Chemical Natural Resources Vol. 1 No. 1 (2019): Journal of Chemical Natural Resources
Publisher : Talenta Publisher

Eugenol derivative compound 4-allyl-6-hydroxymethyl-2-methoxy phenol was synthesized through Mannich reaction, methylation, dan nucleophilic substitution. Mannich reaction was carried out by reacting eugenol, formaldehyde 37%, and dimethylamine 40 % in reflux condition with n-heptane solvent at temperature 98o-100oC for 10 hours produced 4-allyl-6-(dimethylamino)methyl-2-methoxy phenol with yield of 83 %. The formation of dimethylaminomethyl group supported by C-N stretching vibration at 1246,16 cm-1 and ion molecule peak at 221 in GC-MS analysis. Methylation of 4-allyl-6-(dimethylamino)methyl-2-methoxy phenol was carried out with methyl iodide in ethanol solvent produced 6-((N-iodo-N-methyl-N-methyl-N-methylamino) methyl)-4-allyl-2-methoxy phenol in solid form, which then purified by recrystallization with 78,15 % yield. 4-allyl-6-(hydroxymethyl)-2-methoxy phenol was synthesized by nucleophilic substitution reaction of 6-((N-iodo-N-methyl-N-methyl-N-methylamino)methyl)-4-allyl-2-methoxy phenol with sodium hydroxide in reflux condition then purified by coloum chromatography gave liquid compound with yield of 65,05%. The formation of hydroxymethyl group supported by OH vibration at 3433,9 cm-1 and ion molecule peak at 194 in GC-MS analysis show the relative molecular mass of synthesized product.

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Irwana Nainggolan

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Irwana Nainggolan

Contact Email irwana@usu.ac.id

Phone +6261-8214290

Journal Mail Official jcnar@usu.ac.id

Editorial Address Jalan Bioteknologi No. 1 Kampus USU Pd. Bulan, Medan 20155, Sumatera Utara - Indonesia

Location Unknown, Unknown INDONESIA

Abstract

Abstract

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Abstract

Contact Name
Irwana Nainggolan

Contact Email
irwana@usu.ac.id

Phone
+6261-8214290

Journal Mail Official
jcnar@usu.ac.id

Editorial Address
Jalan Bioteknologi No. 1 Kampus USU Pd. Bulan, Medan 20155, Sumatera Utara - Indonesia

Location
Unknown,

Unknown

INDONESIA