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Prodi S1-Farmasi, Fakultas Ilmu Kesehatan Jl. KH Samanhudi, No.93 Sondakan, Laweyan, Surakarta, Jawa Tengah. Kode Pos 57145. Telp : (0271) 712826
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Duta Pharma Journal
Published by Universitas Duta Bangsa Surakarta
ISSN : 28307054     EISSN : 2829811X     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology
Duta Pharma Journal berisikan hasil penelitian di bidang Farmasi sebagai upaya untuk memberikan informasi mengenai perkembangan ilmu farnasi yang didasarkan pada bukti. Penelitian dalam jurnal ini mencakup berbagai aspek ilmu farmasi, yang bermanfaat untuk meningkatkan pengetahuan bagi masyarakat, sejawat tenaga kesehatan dan membantu memecahkan masalah serta memberikan inovasi terbaru di dunia farmasi dalam mewujudkan kualitas pelayanan kesehatan yang lebih baik. Duta Pharma Journal merupakan kumpulan jurnal publikasi dari berbagai aspek ilmu Farmasi,seperti Ekstrak dan Standarisasi Herbal, Teknologi dan Formulasi Sediaan Farmasi, Analisis Farmasi, Kimia Farmasi, Mikrobiologi Farmasi, Penentuan aktivitas Farmakologis dari Natural Product serta Farmasi Klinis dan Komunitas.
Arjuna Subject : Pharmacology, Toxicology and Pharmaceutics - Ilmu Farmasi
Articles 34 Documents
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UJI AKTIVITAS EKSTRAK ETANOL HERBA KROKOT (Portulaca oleracea L.) TERHADAP Salmonella typhi SECARA IN VITRO Youniarista Ayu
Duta Pharma Journal Vol. 1 No. 2 (2021): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (288.939 KB) | DOI: 10.47701/djp.v1i2.1281

Abstract

Salmonella typhi merupakan bakteri yang dapat menginfeksi usus manusia. Bakteri ini dapat tumbuh dan memproduksi endotoksin penyebab infeksi yang ditandai dengan gejala gastroenteritis, seperti sakit perut, mual, diare, disertai dengan demam. Salah satu tanaman yang berkhasiat sebagai anti bakteri adalah herba krokot (Portulaca oleracea L.) yang memiliki kandungan senyawa kimia seperti saponin, tanin, alkaloid, dan polifenol. Sehingga peneliti tertarik untuk melakukan penelitian tentang uji aktivitas anti bakteri ekstrak etanol herba krokot terhadap Salmonella typhi. Metode penelitian ini adalah penyiapan sampel, metode maserasi secara ECC menggunakan pelarut etanol 96% untuk mendapatkan ekstrak kental, standarisasi spesifik dan non spesifik, skrining fitokimia, uji aktivitas anti bakteri dengan konsentrasi 10%, 50%, 100% dengan kontrol positif kloramfenikol 30 µg/disk secara difusi cakram. Data hasil penelitian dianalisis menggunakan uji one way anova.Hasil penelitian uji aktivitas antibakteri diperoleh ekstrak etanol herba krokot konsentrasi 10%, 50%, dan 100% memiliki rata-rata zona hambat 16,02 ± 6,21 mm, 19,54 ± 5,23 mm, 26,52 ± 6,47 mm. Hasil uji one way anova p=0,000 (sig.<0,05) menunjukkan bahwa terdapatnya perbedaan yang signifikan antara kelompok perlakuan dengan kontrol positif. Kesimpulan dari penelitian ini adalah ekstrak etanol herba krokot memiliki aktivitas antibakteri dengan konsentrasi terbesar 100% dengan rata-rata zona hambat 26,52 ± 6,47 mm, dalam kategori kuat.
PENGARUH KOMBINASI GELLING AGENT CARBOPOL 934 DAN NATRIUM CARBOXYMETHYLCELLULOSE (Na-CMC) TERHADAP STABILITAS FISIK GEL GETAH JARAK PAGAR (Jatropha curcas) SEBAGAI PENYEMBUH LUKA INSISI ari budi santoso
Duta Pharma Journal Vol. 2 No. 1 (2022): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

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Abstract

Background: Jatropha sap (Jatropha curcas) is one of the herbal plants that contain tannins and saponins which are responsible for wound healing. Purpose: This study aims to determine the effect of the combination of Carbopol 934 and Na-CMC as a gelling agent on the physical stability of Jatropha curcas (Jatropha curcas) latex as a wound healing agent. Method: The method used in this study was to compare the combination of carbopol 934 and Na-CMC with different concentrations in the three formulations. The concentration used is 1%:4%, 1.5%:3,5% and 2%:3%. The three formulations will be tested for physical quality and tested for physical stability for 4 weeks. Then the formulation will be tested for primary irritation and incision wound healing test. Result: The results of the study showed that formulation I with a concentration of 1%:4% had a good physical quality test based on the results of tests carried out according to standards. Based on the results of the physical stability test, it showed stable adhesion results, while the pH, dispersibility and viscosity tests showed a change in storage for 4 weeks. Jatropha (Jatropha curcas) latex gel formulation did not cause primary irritation to rabbits. The three formulations have the ability to heal fast wounds on the 9th day.
Anthelmintic Test of Combination of Carrot Peels (Daucus carota L.) and Pineapple Peels (Ananas comusus) Juice Against Silkworms (Tubifex sp) Yossy Febryarti; Yetti Hariningsih; Oktaviarika Dewi H
Duta Pharma Journal Vol. 2 No. 1 (2022): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

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Abstract

Background: Anthelmintics is a treatment used as an anti-worm that can eradicate worms in the human and animal bodies, one of which is against silk worms (Tubifex sp). One of the plants that may be used as anthelmintics is carrot skin (Daucus carota L.) and pineapple skin (Ananas comusus). Carrot peel contains flavonoids, quercetin, and tannins as anthelmintics and pineapple peel contains flavonoids, bromealin enzymes and tannins, so researchers are interested in making a combination of carrot peel juice and pineapple peel juice as an anthelmintic against silk worms (Tubifex sp). Objective: This study aims to determine the effectiveness of the combination of carrot peel and pineapple peel juice in eradicating silk worms (Tubifex sp). Methods: The method used is the squeeze method, specific specific standardization, lethal time test, paralysis time test. , the anthelmintic activity test of the combination of carrot peel juice and pineapple peel extract with concentrations of F1 25%: 75%, F2 50%: 50%, F3 75%: 25% using positive control Albendazole 0.06% w/v. The research data were analyzed using the Oneway Anova test. Results: The results of this study showed that the combination of carrot peel extract 75%: pineapple peel 25% had the best anthelmintic effectiveness against the lethal time. The anthelmintic effectiveness test obtained from the combination of carrot juice 25%: pineapple juice 75% showed the best results during paralysis time. The lethal time test of the combination of carrot peel and pineapple juice obtained an average time of death in F1 of 15.32 minutes. In F2, the average time of death was 18.155 minutes, while in F3 it was 20.37 minutes and the Oneway Anova result was p=0.000 (p<0.05). The paralysis time test for the combination of carrot peel and pineapple juice was found to have an average paralysis time of 13.625 minutes in F1. In F2, the average paralysis time was 13,733 minutes, while in F3 18,712 minutes and the Oneway Anova result was p=0,000 (p<0,05). Conclusion: The best combination of juice for the time of death is F1 with a concentration of 25% carrot juice: 75% pineapple juice, while the best combination for paralysis time is F1 with a 25% carrot juice concentration: 75% pineapple juice.                                                                          Keywords : Carrot Peels (Daucus carota L.), Pineapple Peels (Ananas comosus), Anthelmintics, Tubifex sp
TINGKAT KEPUASAN PELAYANAN PENDEKAR OBAT PADA PASIEN RAWAT JALAN DI MASA PANDEMI COVID-19 RSUD KOTA MADIUN: farmasi komunitas alvintya indira
Duta Pharma Journal Vol. 1 No. 2 (2021): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (159.376 KB) | DOI: 10.47701/djp.v1i2.1284

Abstract

Kepuasan pasien merupakan salah satu tolak ukur yang digunakan untuk mengukur keberhasilan layanan pendekar obat.Pasien yang puas terhadap pelayanan yang diberikan menunjukkan bahwa pelayanan yang diberikan tersebut sesuai dengan yang diharapkan pasien atau bahkan lebih baik. Penelitian ini bertujuan untuk mengetahui tingkat kepuasan pelayanan pendekar obat pada pasien rawatdi masa pandemi COVID-19 RSUD Kota Madiun terhadap dimensi Kehandalan (Reliability), Ketanggapan (Resposiveness), Jaminan (Assurance), Kepedulian (Empathy), dan Bukti Fisik (Tangible). Metode yang digunakan adalah metode penelitian Cross Sectional dengan teknik Purposive sampling menggunakan sebanyak 100 pasien rawat jalan di RSUD Kota Madiun. Pengumpulan data dilakukan dengan mengisi kuisioner yang telah diuji Validitas dan uji Reliabilitas. Berdasarkan hasil penelitian kepuasan pasien terhadap pelayanan pendekar obat diketahui pada dimensi kehandalan pasien merasa puas (68,3%), dimensi ketanggapan pasien merasa puas (66,6%), dimensi jaminan pasien merasa puas (67,5%), dimensi kepedulian pasien merasa puas (64,5%) dan dimensi bukti fisik pasien merasa puas (70,2%). Rata-rata hasil kepuasan pasien di Instalasi Farmasi RSUD Kota Madiun pasien merasa puas (67,4%).
UJI DIURETIK INFUSA DAUN TEH HIJAU (Camellia sinensis L.,)PADA TIKUS PUTIH JANTAN GALUR WISTAR ( Rattus norvegicus ) Fadista Kurnia Dewi
Duta Pharma Journal Vol. 1 No. 2 (2021): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (243.497 KB) | DOI: 10.47701/djp.v1i2.1361

Abstract

ABSTRACT Green tea leaves are natural materials, contains flavonoids can increase the volume of urine, This study aims to determine the diuretic effect of ethanol extract of green tea leaves in male Swiss mice. This study is an experimental post control group design using in male swiss mice were divided into 5 groups: group I negative control with CMC Na 0,5%, group II positive control with furosemide dose of 3,6mg/KgBB, and group III ethanol extract of green tea leaves dose of 250 mg/gBB, group IV ethanol extract of green tea leaves dose of 500 mg/gBB, group V ethanol extract of green tea leaves dose of 750 mg/gBB. Before treatment all mice were given warm water orally, then give it according to the group. Tests on the diuretic effect is done by measuring the urine volume, the measurements of to be conducted every 60 minutes for 6 hours. Data analysis was performed using SPSS 23 with One-way ANOVA test and continue LSD. Results of the average cumulative urine volume group I of 7,01 ml, group II of 12,98 ml, group III of 9, 13 ml, gruop IV of 12, 57 ml, and gruop V of 12, 81 ml . Furthermore, analysis of data using SPSS. LSD test results showed that the group V differ significantly with group II, ie with significant value 0,850 (p> 0.05). Based on the average volume and SPSS can be concluded that the ethanol extract of green tea leaves have a diuretic. Keywords: Diuretics, Infusa Green Tea Leaves, Green Tea Leave
Analisis Profil Fisika Kimia dan Farmakokinetik Senyawa Pentagamavunon-1 Secara Komputasi Eva Kholifah; Endah
Duta Pharma Journal Vol. 2 No. 1 (2022): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

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Abstract

Pentagamavunon-1 (PGV-1) is a curcumin analog which is known to inhibit the growth of cancer cells, bacteria and inhibit free radicals as an antioxidant agent. The purpose of this study was analyzed the pharmacokinetic profile and physicochemical properties of PGV-1 computationally. The predicted parameters were Lipinski rule of five, bioavailability, Blood Brain Barrier (BBB) ​​absorption, GI absorption, P-gp substrate, and prediction of metabolic enzymes involved in drug ADME processes. The results of this study indicate that the compound PGV-1 complies with the Lipinski rule of five with the characteristics of a molecular weight of 348.43 g/mol, hydrogen donor 2, hydrogen acceptor 3, Log P 4.71 and molar refractory 40-130. PGV-1 could absorb through the GI and can pass the blood brain barrier passively without P-gp protein. Several enzymes involved in the metabolism of PGV-1 are CYP2C19, CYP2C9, CYP 3A4. Thus, our finding suggest that PGV-1 can be developed as a drug target compound for active oral drugs.
Pengaruh Waktu Ekstraksi Pada Kadar Kafein Produk Biji Kopi Arabica Dari Kabupaten Tegal Dengan Metode Spektrofotometri Uv-Vis Yuzar Khasan Yusuf
Duta Pharma Journal Vol. 2 No. 1 (2022): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

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Abstract

Indonesia merupakan salah satu negara produsen kopi dunia, saat ini Indonesia berada pada urutan keempat negara pengekspor kopi dunia. Data BPS tahun 2018, Kabupaten Tegal memiliki lahan perkebunan kopi seluas 122,93 Ha. Sampel pada penelitian ini adalah produk kopi Arabica Wine, Fulwash, Honey dan Natural dengan perbandingan waktu ektraksi 0 jam, 1 jam dan 3 jam. Metode penerapan kadar kafein pada penelitian ini menggunakan spektrofotometri UV-Vis. Hasil penentuan kadar kafein dengan perbandingan waktu ekstraksi 0 jam (T 0), waktu ekstraksi 1 jam(T 1) dan waktu ekstraksi 3 jam (T 3) yaitu : Sampel Kopi Arabica Wine T 0 = 5.0 %, T 1 = 5.8 % dan T 3 = 8.8%. Sampel Kopi Arabica Fullwash T 0 = 5.4%, T 1 = 6.0% dan T 3 = 8.3%. Sampel Kopi Arabica Honey T 0 = 5.3%, T 1 = 6.5% dan T 3 = 7.9% dan Sampel Kopi Arabica Natural T 0 = 5.7%, T 1 = 6.8% dan T 3 = 7.9%. Analisa data hasil penelitian secara statistik dilakukan dengan metode one-way ANOVA dan dilanjutkan dengan uji pos hoc Tukey HSD dengan hasil signifikansi 0.001, maka dapat disimpulkan bahwa hasil penelitian terdapat perbedaan makna yang signifikan antara kadar kafein dengan waktu ekstraksi T 0, T 1 dan T 3. Kata kunci : 
The Relationship Between Length of Rehabilitation and Quality of Life for Psychoactive Substance Users in Yogyakarta Ani Kristiyani
Duta Pharma Journal Vol. 2 No. 1 (2022): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

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Abstract

The background of this research is the use of psychoactive substances causes complex problems and becomes a threat to the state. Rehabilitation can reduce the risk of relapse of psychoactive substance abuse and the risk of crime, thereby improving quality of life. Understanding rehabilitation with quality of life has a positive impact on users of psychoactive substances. Therefore, it is essential to study the relationship between the length of rehabilitation and the quality of life of users of psychoactive substances. The purpose of this study was to determine the relationship between the size of rehabilitation and the quality of life for users of psychoactive substances. This research method is a non-experimental observational analytic study with a cross-sectional design. The subjects of the study were users of psychoactive substances who were undergoing the rehabilitation process at the Class IIA Narcotics Prison in Yogyakarta. Quality of life was measured by the World Health Organization Quality of Life BREF (WHOQOL-BREF) instrument. The significance level of the statistical test was stated at p<0.05. Data analysis used the Spearman Rank correlation test and multiple linear regression. The results of this study carried out for two months (March to April 2021) obtained a total of 77 subjects using psychoactive substances. The length of rehabilitation has a significant positive correlation with the quality of life, indicated by the value of p = 0.048 (p <0.05) and r = 0.220, which means that the longer the respondent undergoes rehabilitation, the better the quality of his life. This study concludes that there is a significant relationship between the length of repair and quality of life for users of psychoactive substances.
PENENTUAN KADAR ALKALOID TOTAL DAN FENOLIK TOTAL DALAM EKSTRAK ETANOL UMBI RUMPUT TEKI (Cyperus Rotundus L.) Yosua Kristariyanto
Duta Pharma Journal Vol. 2 No. 1 (2022): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

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Abstract

Rumput teki (Cyperus Rotundus L.) adalah rumput liar yang telah digunakan sebagai obat tradisional. Flavonoid yang terkandung dalam umbi rumput teki pernah ditetapkan kadarnya, namun alkaloid total dan fenolik total belum pernah dilakukan Penelitian ini bertujuan untuk menetapkan kadar alkaloid total dan fenolik total dalam ekstrak etanol umbi rumput teki (Cyperus Rotundus L.). Ekstrak etanol umbi rumput teki dibuat dengan cara mengeringkan umbi, menyerbukkan umbi yang kering, dan merendam serbuk selama 24 jam dengan etanol 96%, kemudian diuapkan dengan rotary evaporator hingga terbentuk ekstrak kental. Penetapan kadar alkaloid total dan fenolik total dalam ekstrak kental tersebut dilakukan dengan metode spektofotometri UV-Vis. Hasil penelitian menunjukkan bahwa kandungan alkaloid total dan fenolik total dalam ekstrak etanol umbi rumput teki adalah 3,40% dan 1,03%.
PENETAPAN KADAR FLAVONOID TOTAL, FENOLIK TOTAL, DAN ALKALOID TOTAL DALAM EKSTRAK ETANOL HERBA AKAR WANGI (Vetiveria zizanoides L.) Ellsya Rawar
Duta Pharma Journal Vol. 2 No. 1 (2022): Duta Pharma Journal
Publisher : Universitas Duta Bangsa Surakarta

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Abstract

Akar wangi (Vetiveria zizanoides L.) adalah herba yang telah diteliti berpotensi untuk mencegah erosi, fitoremediasi, dan insektisida. Namun, golongan senyawa kimia yang dikandung oleh akar wangi belum ditetapkan secara kuantitatif. Penelitian ini bertujuan untuk menetapkan kadar flavonoid total, fenolik total, dan alkaloid total dalam ekstrak etanol herba akar wangi (Vetiveria zizanoides L.). Ekstrak etanol herba akar wangi dibuat dengan cara mengeringkan herba, menyerbukkan herba, dan merendam serbuk selama 24 jam dengan etanol 96%. Setelah direndam selama 24 jam, ekstrak tersebut diuapkan dengan rotary evaporator hingga terbentuk ekstrak kental. Penetapan kadar flavonoid total, fenolik total, dan alkaloid total dalam ekstrak kental tersebut dengan metode spektofotometri UV-Vis. Hasil penelitian menunjukkan bahwa kandungan flavonoid total, fenolik total, dan alkaloid total dalam ekstrak etanol herba akar wangi adalah 1,86%, 3,3%, dan 0,41%.

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