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INDONESIA
Jurnal Penyakit Dalam Indonesia
Published by Universitas Indonesia
ISSN : 24068969     EISSN : 25490621     DOI : https://doi.org/10.7454/
Core Subject : Health,
Jurnal Penyakit Dalam Indonesia contains the publication of scientific papers that can fulfill the purpose of publishing this journal, which is to disseminate original articles, case reports, evidence-based case reports, and literature reviews in the field of internal medicine for internal medicine and general practitioners throughout Indonesia. Articles should provide new information, attract interest and be able to broaden practitioners insights in the field of internal medicine, as well as provide alternative solutions to problems, diagnosis, therapy, and prevention.
Articles 9 Documents
Search results for , issue "Vol. 9, No. 3" : 9 Documents clear
Dampak Pandemi COVID-19 terhadap Mahasiswa Kedokteran P. Utari, Amanda
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 3
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Outcome Result of Acute Myeloid Leukemia Undergoing Treatment in Semi-Isolation Chemotherapy Ward Irawan, Cosphiadi; Steven, Ricci; Gunarsa, Ralph Girson; Tenggara, Jeffry Bela
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 3
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Introduction. Standard positive pressure isolation room is not yet widely available in Indonesia. In several private hospitals, current best practice is admitting patients to semi-isolation room with additional protective measures. Despite the limitation, this practice is considered safe and might benefit Acute Myeloid Leukemia (AML) patients. This study aimed to analyze the leukemic profile and survival in AML patients admitted to semi-isolation room. Methods. A retrospective cohort study was conducted using secondary data from medical record of AML patients diagnosed in Mochtar Riady Comprehensive Cancer Center between 2018 – 2020. Patients were divided into semi-isolation room group and not admitted to semi-isolation room group. Semi-isolation room patients who received standard chemotherapy regimen were further analyzed according to complication, outcome, and survival.Results. We included 45 AML patients, 53.3% were females, 42.2% in the 40-59 years age group, and 28.9% were AML-M2. Fifteen patients received standard chemotherapy regimen including D3A7, FLAG, ATRA-Daunorubicin-Cytarabine in semi-isolation room, 60% of them had complete remission after treatment completion. Patients who not admitted to semi-isolation room received conservative treatments including hydroxyurea, mercaptopurine, cytarabine cytoreduction, and decitabine. Among patients in semi-isolation room, 41.2% had sepsis and 29.4 % had septic shock, with most of the sources coming from bloodstream infection (80%), Acinetobacter baumannii remained the most prevalent microorganism. Treatment outcomes showed median Progression Free Survival (PFS) of 11 months, 1-year survival was 47%, and 2-year survival was 27%.Conclusions. In countries with limited standard isolation room, treatment of AML patients in semi-isolation room with infection control protocol could be considered in order to give the standard induction chemotherapy regimen. Although there was an infection risk, strict isolation policy produced good response (60% complete remission).
Threats of COVID-19 Reinfection: A Review of the Evidence from the Literature Adnan, Muhammad Luthfi; Fauziyati, Ana
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 3
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Case of COVID-19 reinfection are related to immune factors in patients who have recovered by the natural course of the infecting pathogen. However, the chance of COVID-19 reinfection are still not well established. This review aimed to discuss about reinfection-related studies, including causes and clinical manifestations, and reinfection management. Reinfection happens when a patient is infected by the SARS-CoV-2 virus, which has a different genome from previous infection. Although the comparison of clinical manifestation between reinfection and the previous infection is not clear, it is believed that vulnerable populations may have worse outcomes. Vaccination is the main option to reduce the severity of reinfection. Further studies are needed to understand the mechanisms and management of COVID-19 reinfection. Thus, the development of COVID-19 treatment and vaccine can be more effective.
The Assossiation Between Stress During the COVID-19 Pandemic and the Incidence of Dyspepsia Syndrome in The First Year Medical Students Rahmi, Wahida; Yulistini, Yulistini; Murni, Arina Widya
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 3
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Introduction. Dyspepsia syndrome is a collection of symptoms in the upper digestive tract associated with dysregulation of the hypothalamus-hypophysis axis that is triggered by stress. One of the problems faced in the world today is the COVID-19 pandemic which can be a new stressor, especially for students with many changes in the learning process. This study aimed to examine the relationship between stress during the COVID-19 pandemic and the incidence of dyspepsia syndrome.Methods. An analytic obsevasional with cross-sectional design was conducted in April-June 2021 at the Faculty of Medicine, Andalas University. The subjects of this study were the first batch of medical students which were selected by total sampling. Level of stress was measured using a questionnaire adapted from DASS-42, meanwhile dyspepsia syndrome was examined using ROME IV questionnaire. Bivariate analysis was conducted by using Chi-square and Fisher exact test.Results. 68 of 238 students experienced stress with the most stress levels was mild-moderate stress (85.3%) and severe-very severe stress (14.7%). There were 44 students who experienced dyspepsia syndrome from a total of 68 respondents (64.7%). There was no relationship between stress and the incidence of dyspepsia syndrome (p=1,00). However, child’s status were found to be a risk factor for stress stres [p=0.006; OR=13.46 (95%CI 2.134-84.894)].Conclusions. There is no significant relationship between stress during the COVID-19 pandemic and the incidence of dyspepsia syndrome in first-year medical students. However, the results of this study indicate that first child status is a risk for stress to dyspepsia.
Prevalence of Geriatric Syndromes in Elderly Undergoing Chemotherapy Rizka, Aulia; Helda, Helda; Prasetyawaty, Findy; Hanjani, Arcita
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 3
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Introduction. Geriatric syndromes is associated with poor survival, poor quality of life and increased chemotoxicity risk in elderly receiving chemotherapy. Geriatric syndromes is currently not routinely evaluated in pre-chemotherapy clinical setting. This study aimed to identify the prevalence of some geriatric syndromes in elderly patients undergoing chemotherapy.Methods. This study is part of primary study investigating geriatric syndromes in elderly with cancer. A descriptive cross sectional study during March 2020 – March 2021 was conducted to elderly patients before chemotherapy administration in Cipto Mangunkusumo Hospital, a national referral hospital in Jakarta. Patients were recruited consecutively. Patients underwent Comprehensive Geriatric Assesment (CGA), including nutritional, depression, sarcopenia risk assessment, frailty, cognitive assessment, as well as medication review.Results. Total of140 elderly subjects were recruited with mean age of 66 years old. 52% subjects were women and 67% with solid tumor. As many as 80% subjects were having malnutrition, 40,6% were frailt, 40,3% were at high risk of sarcopenia, 14,1% with depression, and 19,1% were having cognitive impairment. Of all subjects, 24,1% have more than 3 diagnosis of geriatric syndromes.Conclusion. As geriatric syndromes are prevalent among elderly subjects receiving chemotherapy, routine identification would be useful to improve cancer treatment result.
Lactate/Albumin Ratio as a Predictor of Mortality in Patients with Sepsis and Septic Shock: A Meta-Analysis Study Baihaqi, Fahri Ahmad; Delarosa, Dinda Olinda; Ramadhan, Rezki
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 3
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Introduction. The lactate/albumin ratio is an inflammatory biomarker that has been widely used and suggested as a predictor of mortality in patients with sepsis and septic shock. However, the results are inconsistent. This meta-analysis aimed to evaluate the prognostic value of lactate/albumin ratio as a predictor of mortality in patients with sepsis and septic shock.Methods. The study protocol was registered with PROSPERO (CRD42021286242). A literature search was performed using PubMed, Ovid EMBASE, Ovid MEDLINE, SCOPUS, and Web of Sciences to find all studies evaluating the association between lactate/albumin ratio and mortality in patients with sepsis and septic shock. Meta-analysis was performed to synthesize the overall Standardized Mean Difference (SMD) of the lactate/albumin ratio and the pooled Odds Ratio (OR) for mortality with 95% confidence intervals (95% CI). Heterogeneity was assessed using I2. Publication bias was assessed quantitatively with Egger’s test. Analysis was performed using Stata version 16.Results. Seven studies (n=10,264 patients) were included in the meta-analysis. The meta-analysis results showed that non-survivor had a higher lactate/albumin ratio than survivor (random-effects model; SMD 1.47; 95% CI 0,91-2,04; p <0.001). Higher lactate/albumin ratio was associated with an increased mortality in sepsis and septic shock patients (fixed-effects model; OR 1.49 (95% CI 1.37-1.62); p <0.001).Conclusions. High lactate/albumin ratio was associated with mortality in sepsis and septic shock patients. Thus, lactate/albumin ratio can be used as a predictor biomarker in predicting mortality for sepsis and septic shock patients.
Effectivity of Acupuncture Therapy in Reduction of Pain Intensity in Cancer Pain Affadhia, Hanna Lianti; Cahyanur, Rahmat; Wahdini, Sri; Rachman, Andhika
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 3
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Pain is one of the most common complaints and interferes with the quality of life of cancer patients. Several studies recommend multimodal interventions that combine pharmacological and non-pharmacological therapies. Acupuncture therapy is one of the non-pharmacological treatment options that could be considered. This evidence-based case report aimed to examine the effectiveness of acupuncture therapy in reducing pain intensity in patients with cancer pain. Literature searching was performed on three databases (PubMed, Scopus, and Embase). The keywords used are cancer pain, malignant pain, acupuncture, acupuncture therapy, pain intensity, pain assessment, pain scale. The critical review was carried out using guidelines from the University of Oxford Center for Evidence-based Medicine. Four articles relevant to the clinical question were included in the study. Acupuncture therapy has been consistently shown to reduce pain intensity, shorter pain onset time, reduced dose and number of analgesics used, and better quality of life with minimal side effects, compared to drug therapy alone. Acupuncture therapy should be considered as a complementary therapy in the management of cancer pain, but not to replace standard regiment of pain protocols. Clinical decisions in applying acupuncture therapy need to assess patient preferences, accessibility, and cost-effectiveness.
Risk Factors Analysis for Gastroesophageal Reflux Disease in COVID-19 Pandemic Era on Resident Physicians Faculty of Medicine Brawijaya University Sakti, Pandu Tridana; Mustika, Syifa
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 3
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Introduction. Resident physicians have a high risk of GERD due to excessive fatigue especially during a COVID-19 pandemic. However, research on resident physicians risk factors for the incidence of GERD in the COVID-19 pandemic era has never been conducted. This study aimed to analyze the risk factors for GERD in the era of the COVID-19 pandemic on resident physicians. Methods. This study used an analytic observational design with a cross sectional approach. Subjects were resident physicians in clinical and pre-clinical stage at the Faculty of Medicine Brawijaya University which were selected using random sampling method. Questionnaires were given to subjects using google forms, consisted of education burden, diet, psychosocial-economic, and GERDQ quiestionnaire. Risk factor analysis was performed using chi-square and logistic regression with a significance level of p Results. Out of 230 subjects, most of them were female (54.5%) and mean of age was 30.32 (SD 2.60) years. The risk factors for GERD in resident physicians at Brawijaya University are hypertension (p=0.035), smoking (p=0.019), educational burden [total working hours ≥40 hours/week (p Conclusion. Education burden, diet, and psychosocial-economic factors are associated with the incidence of GERD in resident physicians in the pandemic era.
Kasabach-Merritt Syndrome in Liver Hemangioma: A Case Report Frastica, Michelle; Putranto, Rudi; Jasirwan, Chyntia Olivia Maurine; Adhiatma, Kresna
Jurnal Penyakit Dalam Indonesia Vol. 9, No. 3
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Hemangioma is the most common congenital benign liver tumor. It affects mostly female, with the incidence of 0.4- 20%. Giant liver hemangioma induce the Kasabach Merritt syndome, a life threathening coagulation disorder which occur due to consumptive coagulopathy: trombocyte sequestration and agregation inside the hemangioma. The mortality rate is around 60%, with the most common cause is multiorgan complication which may end up with sepsis. The core management is hemangioma decompression by surgical measure. However, this often considered as a very risky procedure leading to massive bleeding. In most cases, conservative treatment is the preferred option. It is important to consider Kasabach Merritt syndome as one of the differential diagnosis when facing cases with enlarged abdomen in order to plan for its treatment as well as educate the patients regarding the prognosis.

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