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Ophthalmologica Indonesiana
Published by Perhimpunan Dokter Spesialis Mata Indonesia
ISSN : 01261193     EISSN : 2460545X     DOI : 10.35749
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
Ophthalmologica Indonesiana is an open accessed online journal and comprehensive peer-reviewed ophthalmologist journal published by the Indonesian Ophthalmologist Association / Perhimpunan Dokter Spesialis Mata (PERDAMI). Our main mission is to encourage the important science in the clinical area of the ophthalmology field. We welcome authors for original articles (research), review articles, interesting case reports, special articles, clinical practices, and medical illustrations that focus on the clinical area of ophthalmology medicine.
Arjuna Subject : Kedokteran - Ophthalmology
Articles 511 Documents
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Search results for , issue "Vol 49 No S2 (2023): Supplement Edition" : 511 Documents clear
COMPARISON OF ANGLE OPENING DISTANCE AND TRABECULAR IRIS SPACE AREA BEFORE AND AFTER LASER PERIPHERAL IRIDOTOMY IN ANGLE CLOSURE DISEASE: Abstract Only Rizki Fasa Ramdhani; R. Maula Rifada; Irawati Irfani; Elsa Gustianty; Sonie Umbara
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/p64vmm95

Abstract

Introduction and Objective: Laser peripheral iridotomy (LPI) is the standard first-line therapy in angle closure disease to increase anterior chamber angle width. Spectral Domain Anterior Segment Optical Coherence Tomography (SD AS-OCT) is an instrument that has a quantitative parameter to measure anterior chamber angle. Angle opening distance (AOD) and trabecular iris space area (TISA) are quantitative parameters in SD AS-OCT. The purpose of this study is to compare AOD and TISA before and one week after LPI in angle closure disease. Methods: This is an analytical prospective study with a cross-sectional study design. Twenty-two eyes with angle closure disease that met inclusion and exclusion criteria underwent LPI and SD AS-OCT before and one week after LPI. Analysis was performed using SD AS-OCT parameters, such as AOD (AOD500, AOD750) and TISA (TISA500, TISA750) in the temporal, nasal quadrants, and average. Results: Twenty-two eyes with angle closure are divided into nine eyes with primary angle closure suspect, seven eyes with primary angle closure, and six eyes with primary angle closure glaucoma. The mean age of participants was 57.86±7.63 years. There was a significant increase in AOD500, AOD750, TISA500, and TISA750 in the temporal and nasal quadrants, as well as in the average (P=0.0001) based on a paired t test or Wilcoxon as an alternative. Average AOD750 had the highest T-value (T= 6.329) with a mean 0.20±0.096 before LPI and 0.31±0.144 one week after LPI. Conclusion: There was a significant increase in AOD and TISA after one week LPI in angle closure disease.
Spontaneous Globe Rupture due to Neglected Glaucoma: How can it be? Poster Presentation - Case Report - General practitioner Asri Ayu Firdausi; Cosmas Hascaryanto Kunhermawan; Chindhia Rima Rochmatika Bunga Lestari
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/amhbb109

Abstract

IntroductionGlobe rupture is usually associated with spontaneous traumatic processes with the worst prognosis.The occurrence without prior trauma is only reported in small numbers of cases. This paper willdescribe a globe rupture in glaucomatous eye and share our experience with its management. Case IllustrationA 66-year-old male presented to the emergency department (ED) with reddish and progressive painin the right eye (RE) followed by severe headaches for the last three days. On history taking, thepatient complained of a progressive blurry vision to total blindness of his RE for 1 year. The patientadmitted to having a history of glaucoma on previous primer examination but did not routinelycontrol it. On initial examination, the patient was hypertensive , and suddenly began bleeding within10 minutes upon arrival at ED. The diagnosis of globe rupture was made and he underwentemergency evisceration. DiscussionSpontaneous globe rupture is very rare, with an incidence of 3 per 100.000 in the United States,while no definite number is found in Indonesia due to the rarity. In glaucoma patients, spontaneousglobe rupture is postulated to occur due to suprachoroidal hemorrhage. Our patients had multiplerisk factors such as advanced age, systemic hypertension, and chronic untreated glaucoma.Evisceration went down to reduce pain, stop bleeding and prevent the spread of infection.Performing surgery within 10 days of the initial injury suggests a lower risk of post-operativeendophthalmitis or sympathetic ophthalmia. ConclusionSpontaneous globe rupture in neglected chronic glaucoma has a very poor outcome but preventable.
AGREEMENT OF MELBOURNE RAPID FIELDS PERIMETRY PARAMETERS TO HUMPHREY FIELD ANALYZER IN MODERATE-SEVERE GLAUCOMA PATIENTS: RELATIONSHIP BETWEEN VISUAL ACUITY AND MELBOURNE RAPID FIELDS ACCURACY: Oral Presentation - Observational Study - Resident Yuri Dwi Mayasari; Virna Dwi Oktariana; Dewi Yunia Fitriani
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/cewap317

Abstract

Introduction & ObjectivesPerimetric examination is vital for measuring visual field defects and predicting the progression ofglaucoma. The Covid-19 pandemic prompted the use of perimetry at home. Tablet or website-basedperimetry becomes an option due to unavailability of Humphrey Field Analyzer (HFA). MelbourneRapid Fields (MRF) is affordable, portable and reliable, even provide the same benefits as HFA. Thisstudy aimed to assess the agreement of MRF results to HFA in moderate-severe glaucoma patientswith impaired visual acuity. MethodsObservational study using a cross-sectional design to assess the relationship between visual acuityand the agreement of MRF vs HFA in moderate-severe glaucoma patients. Subjects were groupedinto two groups based on visual acuity. Each subject was examined with MRF and HFA, the order ofexamination was randomized using block randomization. ResultsThe test durations were shorter on MRF than HFA (265.7±26.6 vs 384.4±46.7, P<0.001). There wasno significant difference in the reliability index of the two perimetry. MRF showed a high level ofconcordance in its outcomes with HFA (R=0.931, intraclass correlation coefficient (ICC)=0.957 formean defect (MD) and R=0.941, ICC=0.974 for Visual Field Index (VFI)). MRF also showed levels oftest-retest repeatability comparable to HFA (R=0.948, ICC=0.989 for MD and R=0.946, ICC=0.989for Visual Capacity (VC)). There was no correlation between visual acuity and MRF accuracy,p>0.05. ConclusionThe perimetry results from MRF have a very stong correlation to the HFA outcomes. MRF also hastest-retest repeatability comparable to HFA. The accuracy of the MRF results does not correlate withvisual acuity.
PUPIL CYCLE TIME AND PERIPAPILLARY PERFUSION IN ANGLE CLOSURE GLAUCOMA: Oral Presentation - Observational Study - Resident Muhammad Alfin Kamal; Fifin Luthfia Rahmi; Denti Puspasari; Maharani Cahyono
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/3hjtkn18

Abstract

Introduction & ObjectivesOne of important roles in the pathogenesis of glaucoma is vascular condition. To enhance glaucomamanagement, the clinical assessment of ocular perfusion is required. The pupillary light reflex'safferent or efferent pathways may become impaired as a result of pupil cycle time (PCT) elongation.PCT is a simple objective method to measure the function of optic nerve, including glaucoma. Thepurpose of this study is to evaluate the connection between pupil PCT and peripapillary perfusion. MethodsA cross-sectional study from Kariadi Hospital included 26 eyes with angle closure glaucoma and 26eyes of healthy patients. Complete ophthalmologic examinations, PCT measurements, and OCTperipapillary angiography were performed on each patient. Patients with history of drugs use thatcan affect pupillary reflexes such as barbiturates, methyldopa, anaesthetics, and antidepressant, andpatients with history of glaucoma attack are excluded. The comparisons between the two groupswere examined, with a p<0.05 indicating statistical significance. ResultsThe mean PCT of normal subjects was 943,4ms (882,4ms – 993,4ms) and angle closure glaucomasubject was 1789,5ms (1060ms – 4600ms). There were statistically significant difference of PCTvalue in angle closure glaucoma compared to normal subjects (P<0,05). Peripapillary flow index andperipapillary vessel density in closed angle glaucomatous eyes were lower than normal eyes(P<0.05). There is a significant relationship between PCT with peripapillary flow index andperipapillary vessel density. (P<0,05). ConclusionIn angle closure glaucoma, prolonged PCT associated with decreased peripapillary perfusion asshown by decreases in peripapillary flow index and peripapillary vascular density.
EARLY POSTOPERATIVE COMPLICATION FOLLOWING FILTRATION SURGERY IN DR. KARIADI GENERAL HOSPITAL SEMARANG 2020-2022: Oral Presentation - Observational Study - Resident Mazidah Zulfa; Denti Puspasari; Maharani; Fifin L Rahmi
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/742jnq25

Abstract

Introduction & ObjectivesFiltration surgery is the most frequent surgery in managing glaucoma. Although trabeculectomy isgenerally a safe and effective procedure, complications can occur. The purpose of the study was todescribe the early postoperative complications in patients who had undergone filtration surgery. MethodsThis study was a retrospective study that uses secondary data from electronic medical records ofpatients who had filtration surgery between January 1, 2020, and December 31, 2022, in KariadiHospital Semarang. Preoperative data include age, gender, visual acuity, intraocular pressure, andtype of glaucoma. The incidence of early postoperative complications was described up to 3 weeks offollow-up. Results287 eyes were obtained from 266 patients who underwent filtration surgery. 168 eyes (58.5%) hadphaco-trabeculectomy, 117 eyes (40.77%) had trabeculectomy and 2 eyes (0.7%) had ECCEtrabeculectomy.Primary angle closure glaucoma (126 eyes, 43.9%) was the most common type ofglaucoma treated with filtration surgery. During the 3-week follow-up period, 93 eyes (32.4%)experienced an early complication with trabeculectomy being more common (17.42%) thancombined surgery. The commonest complication found was hypotony in 69 eyes (24%). Othercomplications include hyphema (3.14%), transient intraocular pressure elevation (3.14%), blebleakage (2.09%), suprachoroidal haemorrhage (0.7%), subhyaloid haemorrhage (0.35%) and retinalhaemorrhage (0.35%). ConclusionThis study found the most common early postoperative complication of filtration surgery washypotony. This complication occurs frequently after trabeculectomy.
CORRELATION BETWEEN CHANGES IN INTRA OCULAR PRESSURE AND MEAN ARTERIAL PRESSURE BEFORE AND AFTER DIALYSIS IN REGULAR DIALYSIS PATIENTS: Oral Presentation - Observational Study - Resident Anak Agung Ayu Surya Nirmala Dewi; I Made Agus Kusumadjaja; Cokorda Istri Dewiyani Pemayun
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/t91xn416

Abstract

Introduction & ObjectivesGlaucoma is an eye disorder characterized by glaucomatous optic neuropathy with a typical visualfield defect and increased intraocular pressure (IOP).The incidence of glaucoma in dialysis patient is8.18/10,000 person. The dialysis process may change the IOP and Mean Arterial Pressure (MAP)which may lead to glaucoma. The aims of this study are to determine whether there was a change inIOP and MAP and to determine the correlation between changes in IOP and MAP due to dialysis. MethodsThis is an observational study with cross sectional approach using stratified sampling method. Thesubjects were all regular dialysis patient at the Dialysis Unit in Sanglah Hospital period April-May2021 with total 63 people. The data taken are age,gender ,duration of dialysis, fasting blood sugar,urea and serum creatinine level before dialysis. Subjects were measured IOP and calculated MAPbefore and after dialysis. ResultsMean of age of this study was 47,03±12,06 years old and dominated by male. Paired T-Test showedno significant changes IOP after dialysis but there were significant decreased on systolic, diastolicand MAP. Pearson correlation showed no correlation between changes of IOP and MAP afterdialysis. Multivariate analysis shows significant correlation between changes of IOP with urea levelbefore dialysis. ConclusionIOP after dialysis was not increased in this study. Systolic, diastolic and MAP were decreased afterdialysis compared to before dialysis. There is no correlation between changes in IOP and MAP afterdialysis compared to before dialysis. Urea level before dialysis may be associated with increased IOPafter dialysis.
Inhibition of Caspase-3 Provides Neuroprotection for Retina Ganglion Cells againts NMDA-induced Exitotoxicity in Wistar Rats: Oral Presentation - Observational Study - Resident Andriati Nadhilah Widyarini; Maharani; Fifin L Rahmi; Trilaksana Nugroho; Arnila Novitasari Saubig; Hermawan Istiadi
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/fs7v9v35

Abstract

Introduction & ObjectivesGlaucoma is a disorder characterized by the presence of optic neuropathy. Visual impairment inglaucoma is caused by retinal ganglion cell (RGC) apoptosis associated with N-methyl-D-aspartate(NMDA)-mediated excitotoxicity. Excitotoxicity causes an increase in calcium in cells as well asactivation of caspase-3. Glaucoma therapy is currently given to reduce intraocular pressure (IOP),but the damage is still progressing progressively. Hesperidin is known as a neuroprotector that cansuppress calpain overactivation in NMDA-treated retina, thereby reducing the upregulation of TNF-,an inflammatory cytokine, inhibiting calpain activation by suppressing oxidative stress, andattenuating caspase-3 activation. The aim of this study to proving the effect of oral Hesperidin on theexpression of caspase-3 Retinal Ganglion Cell in Wistar rats model of NMDA-induced glaucoma. MethodsExperimental research with post test design only randomized control trial Wistar rats with NMDAinduction were divided into 2 treatment and control groups. The treatment group was given oralHesperidin at a dose of 100mg/kg/day while the control group was given Na-CMC 182 mg/kg/day for3 weeks. Retinal caspase-3 expression was examined by immunohistochemical staining. Data werecollected and processed and then the Mann- Whitney test was performed. (significant p<0.05) ResultsThe mean percentage and intensity of RGC caspase-3 expression in the treatment group were 4.29 ±0.49 it was significantly lower than the control group 6.29 ± 0.95 (p value = 0.003). ConclusionHesperidin provides neuroprotection for RGC againts NMDA- induced exitotoxicity by inhibition ofcaspase-3.
SURGICAL THERAPHY FOR PRIMARY GLAUCOMA IN DR. KARIADI GENERAL HOSPITAL SEMARANG DURING JANUARY 2020 TO DECEMBER 2022: Oral Presentation - Observational Study - Resident Zeta Aisyah Bestari; Maharani; Denti L. Puspasari; Fifin L. Rahmi
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/tcr6p578

Abstract

Introduction & ObjectivesGlaucoma can be treated with medicamentose, non invasive surgery, and invasive surgery. Thisstudy aim to determine the frequency and type of invasive surgery for primary glaucoma in Dr.Kariadi General Hospital during January 2020 to December 2022. MethodsThis was a descriptive research using secondary data obtained from electronic medical records,consist of gender, age, diagnosis, and type of surgery. The sample were taken with purposivesampling which are fullfill the inclusion criteria. ResultsThere were total of 395 eyes (395 patients) with primary glaucoma who underwent surgery, consistof 33% patients with open angle glaucoma (POAG) and 67% patients with angle closure glaucoma(PACG). Most common surgical theraphy for POAG was trabeculectomy (37%), followed bycombination of trabeculectomy and cataract surgery (32%), cataract surgery (16%),cyclocryotheraphy (10%), implantation of glaucoma drainage device (4%), and goniosynechialysis(1%). For PACG, most often used was combination of trabeculectomy and cataract surgery (61%),cataract surgery (13%), cyclocryotheraphy (12%), trabeculectomy (11%), combination of cataractsurgery and goniosynechialysis (2%), and implantation of glaucoma drainage device (1%). ConclusionThe most common type of surgery was trabeculectomy for primary open angle glaucoma andcombination of trabeculectomy and cataract surgery for primary angle closure glaucoma.
NEUROPROTECTIVE ROLE OF VITAMIN D3 ON GANGLION CELL-INNER PLEXIFORM LAYER THICKNESS IN NMDA-INDUCED RETINAL EXCITOTOXICITY MODEL OF GLAUCOMA: (Experimental Study on Wistar Rats Glaucoma Model with N-Methyl-D-Aspartate induction) Ezra Margareth; Trilaksana Nugroho; Andhika Guna Dharma; Fifin L Rahmi; Maharani; Hermawan Istiadi
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/6xrxsv34

Abstract

Introduction & ObjectivesRetinal ganglion cell (RGC) damage can affect the thinning of the GCC layers, which is the nervefiber layer, the ganglion cell layer and the inner plexiform layer. The loss of RGC and inner plexiformlayer (IPL) is strongly correlated with the loss of visual field defect. RGC and inner plexiform layerare potential targets to evaluate the progression of glaucoma. Glaucoma treatment not only focus onreducing IOP. Decreasing IOP according to the target pressure often can’t stop the process of RGCdamage and make it permanently and irreversible. Vitamin D3 is known as neuroprotector which hasthe ability to protect RGC and prevent layer thinning of GC-IPL in retina. The aim of this study is todetermine the effect of oral Vitamin D3 on the GC- IPL layer thickness in retinal of Wistar rats withNMDA-induced glaucoma model. MethodsGlaucoma Wistar rats were divided into 2 groups. The treatment group was given oral Vitamin D3 ata dose of 500 IU/kgBW/day for 10 weeks. GC-IPL layer thickness in retinal was examined byHematoxylin Eosin staining. Data were collected and processed then used with Independent T Test.(significant p<0.05) ResultsThe mean GC-IPL layer Thickness in the treatment group was 77,59 ± 15,15 ?m and 35,32 ± 4,04?m in the control group. There was a significant different between two group ( p = <0,001 ) ConclusionVitamin D3 has a neuroprotective effect on ganglion cell-inner plexiform layer Wistar rats in NMDAinducedexcitotoxicity model of glaucoma
Effect of Vitamin D3 on Caspase-3 Expression of Retinal Ganglion Cell Wistar Rats with N-Methyl-D-Aspartate-induced Model of Glaucoma Seia Mahanani; Maharani; Arnila Novitasari Saubig; Winarto; Andhika Guna Dharma; Hermawan
Majalah Oftalmologi Indonesia Vol 49 No S2 (2023): Supplement Edition
Publisher : The Indonesian Ophthalmologists Association (IOA, Perhimpunan Dokter Spesialis Mata Indonesia (Perdami))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35749/4zctdm27

Abstract

Introduction & ObjectivesIntroduction: Vitamin D is a neuroprotective neurosteroid hormone with antioxidant, antiinflammatoryand anti-ischemic properties that can reduce the entry of intracellular calcium,thereby reducing cytochrome-c, modulating inflammation, increasing Nitric Oxide production bysuppressing oxidative stress and activating caspase-3 activation. Excitotoxicity due to N-Methyl-DAspartatecauses caspase-3 activation due to increased calcium in cells and describes thepathogenesis of vascular factor glaucoma due to retinal ganglion cell (RGC) damage in the absenceof an increase in intraocular pressure. RGC damage can be assessed by the expression of caspase-3which is a proapoptotic agent that acts as the main effector caspase in the mechanism of apoptosis.Objective: Proving the effect of vitamin D3 on caspase-3 expression of retinal ganglion cells wistarrats in NMDA-induced glaucoma models. MethodsAn experimental study, using post-test only randomized controlled group design, was done on 14male NMDA-induced glaucoma wistar rats, divided into 2 groups. The treatment group was givenoral vitamin D3 500 IU/kgBW every 24 hours for 10 weeks, while the control group was givenaquadest. Immunohistochemistry was used to measured caspase-3 expression. Mann-Whitneyanalized non-parametric difference test (Significant p<0.05). ResultsCaspase-3 expression of retinal ganglion cell was significantly lower (p=0.004) in treatment group(mean=5,29 ± 0,76) compared to control group (mean=6,71 ± 0,49). ConclusionOral vitamin D3 has an effect on caspase-3 expression of retinal ganglion cells wistar rats in NMDAinducedglaucoma models. Further research is needed to investigate the protective role of vitaminD3 on glaucoma patients.

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