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Contact Name
Assyifa Junitasari
Contact Email
assyifajunitasari@uinsgd.ac.id
Phone
+6281287749909
Journal Mail Official
alkimiya@uinsgd.ac.id
Editorial Address
Department of Chemistry, Faculty of Science and Technology Building, UIN Sunan Gunung Djati Bandung, A.H. Nasution Street No. 105 Bandung 40614
Location
Kota bandung,
Jawa barat
INDONESIA
al Kimiya : Jurnal Ilmu Kimia dan Terapan
ISSN : 24071897     EISSN : 24071927     DOI : http://doi.org/10.15575/ak
The scope of al Kimiya Jurnal Ilmu Kimia dan Terapan s publication included general studies and special studies The general studies are pure chemistry in general and in specific fields as follows Study of inorganic organic and biochemical substances materials that have traditionally been successively entered into studies of inorganic chemistry organic chemistry and biochemistry. Some examples of specific topics from the study of these substances are bioanorganic bioorganic organometallic heterogeneous catalysts transition metal chemistry and coordination chemistry (complex) metabolism enzymology natural material chemistry and solids. Study of the physical and chemical properties of matter and their changes that have traditionally entered into the study of physical chemistry. Some examples of specific topics from this study are reaction kinetics and mechanisms surface chemistry polymers dyes, thermo dynamics chemistry theoretical chemistry and computation membrane catalysis radiochemistry electrochemistry photochemistry and spectroscopy. Experimental studies and chemical instrumentation that have traditionally entered into analytic chemistry studies. Some examples of specific topics from this study are spectroscopy microscopy and chromatography. Specific studies that can be raised in the publication of al-Kimiya in general are as follows Study of applied chemistry in the field of food. Some examples of specific topics from this study are proteins lipids carbohydrates vitamins minerals enzymes additives food coloring agents and food chemical technologies related to these topics. Study of applied chemistry in the energy field. Some examples of specific topics from this study are photochemistry cell chemistry fuel biomass petroleum and natural gas fuels renewable chemical energy sources and chemical energy conversion Study of applied chemistry in the field of environment. Some examples of specific topics from this study are soil chemistry aquatic chemistry atmospheric chemistry green chemistry toxicology and water treatment. Pure chemistry studies as well as applied in the problem of local wisdom. This study was inspired by the lack of habits traditions in local tribe customs or culture related to the use of substances from nature. Back to Nature can be the ultimate term to describe the contribution of culture to modern traditions that are more prudent in managing nature. Pure and applied chemistry studies to understand the universality values of Islam rahmatan lil alamin.
Articles 113 Documents
Sintesis dan Karakterisasi Selulosa Termetilasi sebagai Biokomposit Hidrogel Neng Rita Nurjannah; Tety Sudiarti; Lena Rahmidar
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol 7, No 1 (2020): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v7i1.6490

Abstract

Penggunaan biomaterial di bidang klinis semakin banyak dilakukan, karena biomaterial lebih aman digunakan (tidak toksik) serta ketersediaannya di alam sangat banyak. Salah satu pemanfaatan  biomaterial ini adalah yang berasal serat batang pisang. Serat batang pisang ini merupakan prekursor untuk disintesis menjadi Metil Selulosa (MS) yang bisa digunakan sebagai bahan hidrogel untuk proses penyembuhan luka dan iritasi kulit. Penelitian ini dimulai dari sintesis selulosa mikrobial dari batang pisang dengan menggunakan starter Acetobacter xylinum yang diinkubasi selama 9 hari. Nata yang diperoleh dimurnikan dan dihasilkan selulosa mikrobial. Selulosa mikrobial yang dihasilkan kemudian disintesis menjadi metil selulosa. Metil selulosa disintesis secara swelling, kemudian ditambahkan pelarut dan metilen klorida untuk proses metilasi. Selulosa dan metil selulosa dianalisis FTIR dan dilakukan pengujian pada metil selulosa meliputi warna, titik leleh serta kelarutan, sehingga dapat diperkirakan nilai DS-nya. Hasil karakterisasi FTIR pada selulosa mikrobial terdapat gugus –OH pada bilangan gelombang 3388,93 cm-1 dan gugus -CH pada bilangan gelombang 2931,80 cm-1. Karakterisasi metil selulosa dengan FTIR dapat diketahui dengan munculnya puncak daerah serapan gugus  –CH yang semakin tajam, yaitu pada MS-air dan MS-aseton terdapat gugus –CH masing-masing pada panjang gelombang 2918,30 cm-1 dan 2900,94 cm-1. Metil selulosa hasil sintesis dari batang pisang tidak dapat larut dalam pelarut air dingin (0-15°C), NaOH 4% dan asam asetat glasial. Nilai Derajat Substitusi (DS) MS-aseton 0,912 dan MS-air 0,834, sehingga pelarut aseton lebih baik untuk mengoptimalkan nilai DS pada metil selulosa.
Kajian Farmakoinformatika Senyawa Brazilin dan 3-O-Methyl Brazilin Caesalpinia sappan Sebagai Terapi Demam Berdarah Dengue Dewi Ratih Tirto Sari; Heny Yusuf; Laily Sifaiyah; Nur Dina Camelia; Yohanes Bare
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol 9, No 1 (2022): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v9i1.17613

Abstract

Demam berdarah Dengue (DBD) merupakan penyakit tropis yang diakibatkan oleh gigitan nyamuk yang terinfeksi oleh virus DENV. Beberapa tanaman herbal dapat digunakan untuk mengatasi demam berdarah baik upaya preventif maupun kuratif. Kayu secang merupakan salah satu tanaman herbal kayu yang memiliki berbagai aktivitas biologis, utamanya sebagai immunomodulator dan antivirus. Penelitian ini bertujuan untuk mengidentifikasi aktivitas brazilin dan 3-O-methyl brazilin sebagai obat terapi demam berdarah melalui kajian komputasi. Pendekatan molecular docking digunakan dalam studi penelitian ini. Senyawa brazilin dan 3-O-methyl brazilin diunduh dari database PubChem dan diinteraksikan dengan protein non- structural-5 (NS-5) yang didapatkan dari database PDB. Pemodelan docking dilakukan dengan Molegro virtual Docker versi 5.0 dan dianalisis dengan PyMol 2.2 dan Discovery studio versi 21.1.1. Hasil interaksi menunjukkan bahwa brazilin dan 3-O-methyl brazilin berikatan dengan protein NS-5 di sisi aktif guanosine triphosphate dan daerah RNA dependent RNA polymerase (RdRP). Pengikatan kedua senyawa aktif ini menyebabkan tidak terjadinya replikasi virus DENV pada sel inang dan berpotensi sebagai penghambat infeksi DENV. Berdasarkan analisis in silico, disimpulkan bahwa brazilin dan 3-O-methyl brazilin berpotensi sebagai agen terapi demam berdarah, studi in vitro perlu dilakukan untuk pembuktian lebih lanjut. 
Molecular Docking of Brazilin from Secang Wood Plant (Caesalpinia sappan L.) as an Anti-Breast Cancer Dewi Astriany; Umi Baroroh; Khotibul Umam
al Kimiya: Jurnal Ilmu Kimia dan Terapan Vol 11, No 1 (2024): al Kimiya: Jurnal Ilmu Kimia dan Terapan
Publisher : Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/ak.v11i1.35590

Abstract

Breast cancer is a disease characterized by abnormal cell growth, which can invade adjacent tissues or metastasize to other organs. Secang (Caesalpinia sappan L.) is a plant that has been used as an alternative medicine for a variety of health conditions, including some types of cancer. This study aims to determine whether the brazilin compound found in secang wood can interact with the target receptors estrogen alpha, 17-β-HSD-1, and NUDT5, potentially serving as an anticancer candidate. Molecular docking simulations were employed to identify the molecular interactions of brazilin against estrogen receptor alpha (ERα) (PDB ID: 3ERT), 17β-HSD-1 (PDB ID: 3HB5), and NUDT5 (PDB ID: 5NQR) using AutoDockTools software. The results showed that the best free-binding energy (ΔG) value obtained for brazilin against the 17-β-HSD-1 receptor was -9.16 kcal/mol, with an inhibition constant of 192.45 nM. The ΔG value of brazilin with estrogen alpha was -6.68 kcal/mol, and the ΔG value for brazilin against NUDT5 was -4.8 kcal/mol. Brazilin has a higher potency compared to innate ligands based on the docking result of estrogen alpha receptor and NUDT5. Some structural similarities and interactions occurred between the amino acids GLY186 and TYR155 in brazilin with the binding of amino acids formed in the innate ligand against the 17-β-HSD-1 receptor, thus showing similar affinity to the 17-β-HSD1 receptor. In silico approaches provided valuable insights into the potential of brazilin as an anti-breast cancer agent.

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