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INDONESIA
Jurnal Kedokteran Diponegoro
Published by Universitas Diponegoro
ISSN : -     EISSN : 25408844     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.
Arjuna Subject : -
Articles 13 Documents
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Search results for , issue "Vol 10, No 1 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)" : 13 Documents clear
MELASMA SHOW UP IN CONTRACEPTIVE PILLS ACCEPTORS Cahya Novenita Azzahra; Widyawati Widyawati; Liza Afriliana; Julian Dewantiningrum
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 1 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i1.29436

Abstract

AbstractIntroduction : Melasma is one of the most common hyperpigmentation disorders among womans, the common hyperpigmentation patches which commonly found on face especially on sunlight exposured area. One of the factors causing melasma is the use of oral contraceptives which cause the buildup of the hormones estrogen and progesterone on the skin.Objectives : Thus, the aim of the study is to analyze the association between duration of contraceptive pills use and melasma.Methods : This study used a cross-sectional design. The research was conducted in May-July 2020. The subjects were 36 womans aged 30-55 years old and oral contraceptive acceptors that qualify inclussion criteria and not eligible exclussion criteria. The data was collected primarily using questionnaires. Physical examinations were done through observation with a photo of the respondents. Data analysis using the Chi Square test with a significance value p <0,05.Results : Based on the results of this study, the significance of 0.017 less than 0.05 which indicates a relationship between variables duration of contraceptive pills use and melasma. Conclusions : This study shows a association between duration of contraceptive pills use and melasmaKeywords : melasma, contraceptive pills.
THE EFFECT OF GLYCOLIC ACID AND VITAMIN C TOPICAL IN FRECKLES EFFICACY Tiffani Sandradewi Wignjosoesastro; Widyawati Widyawati; Rahmat Sugianto
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 1 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i1.29346

Abstract

Abstract Background: Freckles are small dark-spot hyperpigmentation on the face, upper body, and back of the hands. This hyperpigmentation develops as a result of melanocyte activity by the combination of genetic predisposition located on the basal layer and sun exposure. Glycolic acid and vitamin C are widely used as a depigmentation agent. The component of vitamin C is unstable, hence, it is often used more effective when it binds to other depigmentation agents, such as glycolic acid to develop better depigmentationObjective: The aim of this study was to prove the efficacy of combination of glycolic acid and vitamin C in freckles.Methods: True experimental study with one group pre and post-test group design. Fifteen freckles patients with inclusion and exclusion criteria received combination therapy of glycolic acid and vitamin C topical for 30 days. Clinical evaluation using Freckles Refinement Score and photography was recorded before and after therapy. The statistical analyses used was Wilcoxon test.Results: There was a significant value (p = 0.000) for improvement of the Freckles Refinement Score after received the combination of glycolic acid and vitamin C topical.Conclusion: The combination of glycolic acid and vitamin C was effective for Freckles. 
IN VITRO TESTING OF CLOVE EXTRACTS IN INHIBITING AND KILLING STAPHYLOCOCCUS AUREUS AND ESCHERICHIA COLI Nadia Dwi Rahmawati; Tri Nur Kristina; Endang Sri Lestari; Hardian Hardian
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 1 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i1.29420

Abstract

Background: Diarrhea that could be caused by Staphylococcus aureus and Escherichia coli can be prevented by increasing hand hygiene using alcohol-based hand rub, but frequent use might cause skin irritation. Replacing alcohol with herbs could avoid this side effect. Cloves have been proved to have antibacterial properties. However, most researches used complex extraction methods that might not be applicable on a household scale.Objective: To prove that clove extracts have ability to inhibit and to kill S. aureus and E. coli.Methods: This is an experimental study by using post-test only control group design. Clove extract was obtained with simple aqueous maceration. Samples were Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 allocated into six groups: clove extracts at concentrations of 12.5%, 25%, 50%, 100% respectively; 70% alcohol as a positive control; and aquadest as a negative control. Each group was given 5 repetitions of intervention. MIC was measured with dilution method, while MBC with streak method. Negative controls were only used to monitor the quality of this work.Results: MIC of S. aureus was started at 50% concentration of clove extract, while MBC of S. aureus was started at 25 % concentration of the same extract. MIC and MBC of E. coli was both started at 25% concentration of clove extract. MIC and MBC of 100% concentration of clove extract were equal with 70% alcohol.Conclusion: Concentration of 100% clove extracts have similar ability with 70% alcohol to inhibit and to kill S. aureus and E. coli. Keywords: Clove Extracts, Escherichia coli, MBC, MIC, Staphylococcus aureus

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