Garuda - Garba Rujukan Digital

p-Index From 2019 - 2024

1.006

P-Index

This Author published in this journals

All Journal Jurnal Kedokteran Diponegoro Medica Hospitalia Generics: Journal of Research in Pharmacy

Hardian Hardian

Department Of Anatomy And Physiology, Faculty Of Medicine, Diponegoro University Jl. Prof. Sudarto, SH, Tembalang, Semarang, Indonesia 50275 Pharmacy Study Program, Faculty Of Medicine, Universitas Diponegoro, Jl. Prof. Sudarto, SH, Tembalang, Semara

Author-ID : 2668084

Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

Published : 6 Documents Claim Missing Document

Claim Missing Document

Articles

Efektivitas Ozonated Virgin Coconut Oil Dosis Bertingkat Terhadap Penyembuhan Luka Full Thickness Skin Graft Autolog Ditinjau Dari Jumlah Fibroblas Dan Ekspresi Vascular Endothelial Growth Factor Pada Tikus Sprague Dawley Johan Rinto Even Napitupulu; Hardian Hardian; Najatullah Najatullah
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 1 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Abstract Background: Now, Skin grafts are one of the therapies of choice in the wound healing process. And this is still developing today. The process of formation fibroblas and the formation of vascular endothelial growth factor have an important role in healing skin graft wounds. Ozonated virgin coconut oil has an important role in wound healing. Objective: To prove the effect of ozonated virgin coconut oil in various doses in increasing number of fibroblas and expression of vascular endothelial growth factor of skin graft wounds. Methods: This study is an experimental study with "Randomized parallel study with controlled group design" on 40 Sprague Dawley rats which are performed an autologous skin graft at the same time. Samples were divided randomly into 8 groups (K1 and K2 = without ozonated VCO), (A1 and A2 = ozonated VCO 50,4 mg/ml), (B1 and B2 = ozonated VCO 103,2 mg/ml), (C1 and C2 = ozonated VCO 204 mg/ml). Evaluation of the amount of fibroblas was done by staining hematoxylin & eosin after the 6th day and the expression of vascular endothelial growth factor was done by staining immunohistochemistry after the 12th day after skin graft. Results: Statistical analysis of the amount of fibroblas after the 6th day was found to be significantly different between the K1 vs A1 group (p = 0.029), K1 vs B1 (p = 0.004), K1 vs C1 (p = 0.000), on the 12th day was found significantly different the amount of fibroblast between K2 vs A2 ( p = 0,029 ), K2 vs B2 ( p = 0,010 ), K2 vs C2 ( p = 0,001 ). The expression of vascular endothelial growth factor on the 6th day was found a significant difference between the K1 vs A1 group (p = 0.024), K1 vs B1 (p = 0.005), K1 vs C1 (p = 0.001), on the 12th day was found significantly different the expression of vascular endothelial growth factor between K2 vs A2 ( p = 0,011 ), K2 vs B2 ( p = 0,036 ), K2 vs C2 ( p = 0,004 ) . Conclusion: Ozonated VCO can increase the amount of fibroblas and expression of vascular endothelial growth factor in the wound healing process of autologous skin graft in Sprague Dawley rats. Keywords: Ozonated VCO, full thickness skin graft, fibroblas, VEGF.

EFEKTIVITAS OZONATED VIRGIN COCONUT OIL TERHADAP PENYEMBUHAN LUKA FULL THICKNESS SKIN GRAFT AUTOLOG TIKUS SPRAGUE DAWLEY Ditinjau dari Ekspresi TGF-? dan Jumlah Neutrofil Nauval Marta Kusuma; Hardian Hardian; Najatullah Najatullah; Renni Yuniati; Neni Susilaningsih
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 3 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

Abstract Introduction : Skin grafts are now one of treatment option in wound healing process that is always developing. TGF-bexpression and the number of neutrophils have an important role in healing skin graft wounds. Ozone (O3) has disinfecting properties that are effective in wound healing. Objective : Proving the effectiveness of Ozonated VCO for Full Thickness Skin Graft wound healing using parameter of TGF-b expression and neutrophil number. Method : This study is an experimental study with a post-test only design group of 40 Sprague Dawley rats performed autologous skin graft at the same time. Samples were divided randomly into 8 groups (K1 = without Ozonated VCO), (A1 = Ozonated VCO 50 mg / ml), (B1 = Ozonated VCO 100 mg / ml), (C1 = Ozonated VCO 200 mg / ml), ( K2 = without Ozonated VCO) (A2 = Ozonated VCO 50 mg / ml), (B2 = Ozonated VCO 100 mg / ml), (C2 = Ozonated VCO 200 mg / ml). Assessment of TGF-b expression and neutrophil number of tissue was performed by staining hematoxylin & eosin and immunohistochemistry on days 6 and 12 after skin graft. Results : There were significant differences (p <0.05) TGF-b expression and neutrophils number of tissue between the control group and the administration of Ozonated VCO doses of 50 mg / ml, 100 mg / ml and 200 mg / ml on days 6 and 12 post skin graft. Conclusion : The administration of Ozonated VCO effectively improve Full Thickness Skin Graft wound healing seen from macroscopic wounds, increase TGF-b expression and decrease the number of neutrophils.

Perbandingan latihan plyometrics dengan aerobik terhadap memori Yohana Novelia Christin; Yuriz Bakhtiar; Hardian Hardian; Endang Kumaidah
Medica Hospitalia : Journal of Clinical Medicine Vol. 8 No. 2 (2021): Med Hosp
Publisher : RSUP Dr. Kariadi

ABSTRACT Background: Problems of a person's desire to exercise is still a major highlight in the realm of health, both in Indonesia and in the world. Lack of exercise affects brain work, which is a smaller brain volume in people who are not actively exercising, so doing plyometrics and aerobic exercises can be a solution to these problems because exercise can be easily done for health and increased cognitive abilities. Aim: To understand which exercises are more effective at improving one's short-term memory. Methods: This study is a quasi-experimental study with 54 subjects, all of whom are students of the Faculty of Medicine Diponegoro University, aged between 15-25 years. Subjects were divided into three groups, namely the plyometrics group, the aerobic group and the control group. Subjects were selected by purposive sampling method and participated in the measurement of short-term memory at the time before exercise and after exercise for 6 weeks. Statistical analysis in this study using paired t-test and independent t-test. Results: There was a significant difference in the short-term memory measurement results between the treatment and control groups, but a higher increase was found in the plyometrics group, with p value <0.001. Conclusion: Plyometrics and aerobic exercises improve short-term memory in students of the Faculty of Medicine Diponegoro University. A more significant improvement was found in the plyometrics group. Keywords: plyometrics exercise, aerobic exercise, short term memory.

IN VITRO TESTING OF CLOVE EXTRACTS IN INHIBITING AND KILLING STAPHYLOCOCCUS AUREUS AND ESCHERICHIA COLI Nadia Dwi Rahmawati; Tri Nur Kristina; Endang Sri Lestari; Hardian Hardian
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 10, No 1 (2021): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v10i1.29420

Background: Diarrhea that could be caused by Staphylococcus aureus and Escherichia coli can be prevented by increasing hand hygiene using alcohol-based hand rub, but frequent use might cause skin irritation. Replacing alcohol with herbs could avoid this side effect. Cloves have been proved to have antibacterial properties. However, most researches used complex extraction methods that might not be applicable on a household scale.Objective: To prove that clove extracts have ability to inhibit and to kill S. aureus and E. coli.Methods: This is an experimental study by using post-test only control group design. Clove extract was obtained with simple aqueous maceration. Samples were Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 allocated into six groups: clove extracts at concentrations of 12.5%, 25%, 50%, 100% respectively; 70% alcohol as a positive control; and aquadest as a negative control. Each group was given 5 repetitions of intervention. MIC was measured with dilution method, while MBC with streak method. Negative controls were only used to monitor the quality of this work.Results: MIC of S. aureus was started at 50% concentration of clove extract, while MBC of S. aureus was started at 25 % concentration of the same extract. MIC and MBC of E. coli was both started at 25% concentration of clove extract. MIC and MBC of 100% concentration of clove extract were equal with 70% alcohol.Conclusion: Concentration of 100% clove extracts have similar ability with 70% alcohol to inhibit and to kill S. aureus and E. coli. Keywords: Clove Extracts, Escherichia coli, MBC, MIC, Staphylococcus aureus

Evaluasi Kualitas Penggunaan Antibiotik pada Pasien Pediatri dengan Diare Akut Spesifik di RSND Semarang Diah Ayu Oktaviani; Intan Rahmania Eka Dini; Hardian Hardian
Generics: Journal of Research in Pharmacy Vol 2, No 1 (2022): Generics : Journal of Research in Pharmacy, Volume 2, Edisi 1, 2022
Publisher : Diponegoro University

Diare akut adalah defekasi dengan feses encer ≥ 3 kali sehari dan berlangsung selama ≤ 2 minggu. Antibiotik diindikasikan pada pasien disentri atau kolera. Kualitas penggunaan antibiotik menentukan lama dan hasil terapi. Penelitian ini bertujuan untuk mengetahui kualitas penggunaan antibiotik pada pasien pediatri dengan diare akut spesifik berdasarkan kriteria Gyssens di RSND Semarang periode Januari-Desember 2019. Penelitian ini merupakan penelitian observasional dengan pendekatan deskriptif. Subjek penelitian ini adalah pasien pediatri diare akut spesifik di RSND Semarang periode tahun 2019. Cara pengambilan sampel dengan teknik purposive sampling secara retrospektif. Pengumpulan data menggunakan rekam medis. Hasil evaluasi kualitas penggunaan antibiotik pada pasien pediatri diare akut spesifik di RSND pada tahun 2019 sebanyak 15 pasien, dengan jumlah peresepan sebanyak 16. Hasil evaluasi dengan metode Gyssens terdapat 21 kriteria hasil evaluasi yang terdiri dari penggunaan antibiotik yang berkualitas (kriteria 0) sebanyak 1, tidak tepat dosis (kriteria II A) sebanyak 8, tidak tepat interval (kriteria II B) sebanyak 1, penggunaan antibiotik terlalu lama (kriteria III A) sebanyak 6, penggunaan antibiotik terlalu singkat (kriteria III B) sebanyak 1, dan penggunaan antibiotik yang tidak tepat indikasi (kriteria V) sebanyak 4.

Gambaran Peresepan Metformin pada Pasien Diabetes Melitus Tipe 2 di Rumah Sakit Nasional Diponegoro Semarang Octavia Indah Cahyaningsih; Intan Rahmania Eka Dini; Hardian Hardian
Generics: Journal of Research in Pharmacy Vol 1, No 2 (2021): Generics: Journal of Research in Pharmacy, Volume 1, Edisi 2, 2021
Publisher : Diponegoro University

Diabetes melitus (DM) merupakan sekumpulan gangguan metabolisme yang ditandai oleh kondisi hiperglikemia yang berhubungan dengan abnormalitas metabolisme karbohidrat, lemak, dan protein. DM disebabkan oleh gangguan sekresi insulin, sensitivitas reseptor insulin, atau keduanya. Dalam pengobatan diabetes melitus tipe 2 telah disusun dalam pedoman pengobatan secara internasional seperti American Diabetes Association (ADA) sebagai petunjuk dan rekomendasi dalam pemilihan terapi kepada pasien. Ada berbagai golongan obat yang digunakan dalam pengobatan diabetes melitus tipe 2, salah satunya adalah Metformin.Mengetahui profil pasien yang mendapat terapi metformin dan mengetahui gambaran peresepan metformin pada pasien diabetes melitus tipe 2 sesuai pedoman pengobatan diabetes melitus tipe 2 pada ADA. Penelitian ini merupakan penelitian deskriptif kategorik. Data penelitian berupa rekam medik pasien diabetes melitus tipe 2 yang mendapat terapi metformin di Rumah Sakit Nasional Diponegoro Semarang pada bulan Januari-. Pada penelitian ini indikasi pemberian metformin mengikuti pedoman tata laksana pengobatan diabetes melitus yang diterbitkan oleh ADA. Penelitian didapatkan pada 97 jumlah subjek pasien DM Tipe 2 yang mendapatkan terapi metformin tunggal dan kombinasi tahun 2019 di Rumah Sakit Nasional Diponegoro Semarang, lebih banyak ditemukan jenis kelamin perempuan dengan usia 56-65 tahun, pasien juga memiliki diagnosis DM Tipe 2 dengan komplikasi. Ketepatan peresepan berdasarkan penelitian didapatkan tepat indikasi berdasarkan BMI pasien bebesar 76,3%, berdasarkan diagnosa dokter sebesar 100%. Tepat obat berdasarkan dosis pemberian sebesar 100%. Tepat kondisi pasien sebesar 97,94%. Evaluasi secara keseluruhan peresepan metformin telah mencapai angka 75,26%.Kata Kunci : Diabetes melitus; Metformin; American Diabetes Association

Co-Authors Diah Ayu Oktaviani Endang Kumaidah Endang Sri Lestari Intan Rahmania Eka Dini Intan Rahmania Eka Dini Johan Rinto Even Napitupulu Nadia Dwi Rahmawati Najatullah Najatullah Najatullah Najatullah Nauval Marta Kusuma Neni Susilaningsih Octavia Indah Cahyaningsih Renni Yuniati Tri Nur Kristina Yohana Novelia Christin Yuriz Bakhtiar

Title

Found 6 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 6 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 6 Documents
Search