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Jurnal Kedokteran Diponegoro
Published by Universitas Diponegoro
ISSN : -     EISSN : 25408844     DOI : -
Core Subject : Health,
Medicine & Pharmacology
JKD : JURNAL KEDOKTERAN DIPONEGORO ( ISSN : 2540-8844 ) adalah jurnal yang berisi tentang artikel bidang kedokteran dan kesehatan karya civitas akademika dari Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang dan peneliti dari luar yang membutuhkan publikasi . JURNAL KEDOKTERAN DIPONEGORO terbit empat kali per tahun. JURNAL KEDOKTERAN DIPONEGORO diterbitkan oleh Program Studi Kedokteran Umum, Fakultas Kedokteran, Universitas Diponegoro Semarang.
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Articles 9 Documents
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Search results for , issue "Vol 12, No 2 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)" : 9 Documents clear
THE EFFECT OF KAFFIR LIME PEEL EXTRACT (Citrus hystrix) ON SPATIAL MEMORY OF MICE WITH DEMENTIA USING MORRIS WATER MAZE Florentina Anindita Christiyanto; Endang Mahati; Noor Wijayahadi; Yora Nindita
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 2 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i2.37788

Abstract

Background: Antioxidants are a group of chemicals that protect biological systems against the potential harmful effects of oxidation processes or its reactions. Kaffir lime peel (Citrus hystrix) contains various potential antioxidants substances those are able to protect neurons from free radical-induced damage. Objective: To evaluate the effect of kaffir lime peel extract (Citrus hystrix) on the spatial memory of mice induced by Scopolamine (SCM). Methods: This research was a true experimental study with a post-test-only controlled group design. Thirty mice were randomly divided into 5 groups. SCM was injected intraperitoneally on day 1-7 and kaffir lime peel extract was given orally on day 2-7, the spatial memory testing of mice using Morris Water Maze on day 8. Data analysis used One-Way ANOVA test (α = 0.05) and continued with Post Hoc LSD test (α = 0.05). Results: The mean spatial memory of K+, K-, P1, P2,P3 were 16,33 ± 7,42; 70,00 ± 32,24; 25,66 ± 24,43; 23,00 ± 19,39; 25,00 ± 19,50 seconds respectively. There were significant differences in spatial memory in P1, P2, dan P3 to the negative control group, but there is no significant differences between treatment grups. Conclusion: Kaffir lime peel extract (Citrus hystrix) can improve the spatial memory of scopolamine-induced dementia (SCM) mice. There is no dose effect relationship between the treatment groups
CORRELATION BETWEEN KNOWLEDGE AND BEHAVIOR OF USING VITAMIN C SUPPLEMENTS AMONG HEALTH AND NON-HEALTH STUDENTS IN CENTRAL JAVA DURING THE COVID-19 PANDEMIC Isnaini Nur Jannah; Eva Annisaa'; Intan Rahmania Eka Dini
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 2 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i2.37549

Abstract

Background: During the COVID-19 pandemic, 57.1% of students used vitamin C. Everyone's behavior/actions in using vitamin C are different. This is influenced by several factors, one of which is knowledge. Objective: Knowing the differences in the level of knowledge and the different levels of behavior in using vitamin C supplements and the correlation between knowledge and behavior in using vitamin C supplements among health and non-health students in Central Java. Methods: Cross sectional analytic research using a questionnaire with purposive sampling technique. Data were analyzed using Chi-Square difference test and Rank Spearman correlation test. Results: The level of knowledge of health students related to vitamin C was in the good category (75%) and non-health students was in the sufficient category (42%). The behavior level of health students related to the use of vitamin C was in the good category (83.3%) and non-health students was in the poor category (58%). Chi-Square test showed that there were differences in the level of knowledge and behavior in using vitamin C between health students and non-health students with a p value = 0.000. There was a correlation between knowledge and the behavior of using vitamin C with a p value = 0.000. The Spearman correlation coefficient (r) obtained was 0.612. Conclusion: There were differences in the level of knowledge and different levels of behavior between health students and non-health students. There was a correlation between knowledge and behavior in using vitamin C supplements among health and non-health students in Central Java.
Case Report: Non-Cirrhotic Hepatoma BCLC-C With Vertebrae Metastasis Bonfilio Neltio Ariobimo; Nurun Nujum Nujum; Daniel Ponco Harto Saputro
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 2 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i2.36748

Abstract

  Background: Hepatocellular carcinoma (HCC) can arise from either cirrhosis or non-cirrhosis of the liver. HCC in non-cirrhotic livers is still uncommon and can present insidiously in patients. HCC may develop in people with non-cirrhotic chronic liver illness, such as chronic hepatitis B virus infection and chronic HCV infection. More than half of non-cirrhotic individuals with HCC may not exhibit any symptoms, and the disease is frequently detected when it is advanced and incurable. Case Report: Here we presented a 47-year-old man went to the emergency room complaining of upper right side abdominal discomfort that suddenly arose and spread to the back and right shoulder. He also experiencing upper right abdominal fullness for the past two months, along with a sense of a lump growing larger and harder. Hepatic stigmata were not discovered, whole blood revealed a thrombocytosis and significant rising AFP from the expected result of 71,000 ng/dL, with hepatitis B testing was positive. Abdominal ultrasound revealed hepatomegaly and several hypo-hyperechoic nodules. CT scan revealed multiple solid lesions and lytic lesions of the vertebrae bodies. The patient recieved palliative treatment.. Conclusion: This case study demonstrates a non-cirrhotic hepatoma that came at an80 tan advanced stage and was more likely to be asymptomatic than a cirrhotic hepatoma that showed signs of liver failure, such as hepatic stigmata and other physiologic abnormalities. This case report demonstrates the This case study demonstrates the importance of strengthening general HHC preventative measures in order to lower non-cirrhotic HHC's incidence and fatality rate.
Comparison of Caffeine Intake and Brain Training Effect on Performance Intelligence Gianina Dinda Pamungkas; Hardian Hardian; Tanjung Ayu Sumekar; Ainun Rahmasari Gumay; Innawati Jusup
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 2 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i2.36921

Abstract

Background: Intelligence is the ability to comprehend complex ideas and reasoning. Caffeine is a psychoactive substance that is known to possess an effect on improving cognitive function, memory, and attention. Brain training is a digital training process which holds the purpose of enhancing cognitive function.Objective: This study aimed to compare the effect of caffeine and brain training on performance  intelligence.Methods: This research is an experimental study with two groups pre test and post test design. The research sample was the college students of Faculty of Medicine, Universitas Diponegoro (n=42) aged between 18-22 years old, which then categorized into: the caffeine group (n=21) which received 50 ml once daily of caffeinated beverage for two weeks, and brain training group (n=21) which received 30-minute-session of NeuroNationTM brain training every day for two weeks. Performance intelligence was measured before and after treatment by using The Raven Progressive Matrices test. The statistical analysis used was The Mann-Whitney test and The Wilcoxon test.Results: The average score of performance intelligence on the group caffeine treatment increased from 48,81±9,30 to 55,90±2,95 (p<0,001). In brain training group, increased from 54,95±1,91 to 57,29±1,68 (p<0,001). The two groups were tested for Mann-Whitney Test and it was found that the caffeine group's performance intelligence score was significantly higher than brain training (p = 0.005).Conclusion: There was a significantly higher increase performance intelligence score shown in the caffeine group rather than in the brain training group.Keywords: brain training, caffeine, NeuroNationTM, performance intelligence, Raven Progressive Matrices test
CASE REPORT: PANCYTOPENIA IN SEVERE MALARIA WITH SUSPECTED HEMOPHAGOCYTIC SYNDROME AT ATAMBUA HOSPITAL Krisdianto Putra Lainy; Geraldo Laurus; Yosef Samon Sugi
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 2 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i2.36945

Abstract

Background: Malaria is a parasitic infectious disease caused by Plasmodium falciparum, Plasmodium vivax, Plasmodium ovale, and Plasmodium malaria. The signs of a malaria infection include fever, chills, anemia, and splenomegaly. In the Belu district, the incidence of malaria is still high. It’s about 10,6 per 1000 population. Objective: To describe a case of Malaria in one of patient in Indonesia.Methods: Case reportResults: A 61-year-old woman with Malaria with clinical manifestations as follow, fever, body aches, and chills felt since 3 days before hospital admissions. On the 4th day of treatment, plasmodium falciparum was found.Conclusion: A combination of anti-malarial medications (OAM) is used in the treatment of malaria with the goal of reducing plasmodium resistance to anti-malarial medications.
A 52-Years Old Male Patient With Aorta Regurgitation Et Causa Rheumatic Heart Desease In Cut Meutia Regional General Hospital Yuri Savitri; Jauza Raudhatul Jannah Mendrofa
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 2 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i2.35990

Abstract

 Rheumatic heart disease (RHD) is an acquired heart disease with heart valve disorder that persists due to previous acute rheumatic fever, mainly affecting the mitral valve (75%), the aorta (25%), rarely affecting the tricuspid valve, and never affecting the valves lungs. A 52-year-old male patient, domiciled in Mutiara (Alue Awe) Lhokseumawe City, Indonesia. Come for outpatient treatment at Polyclinic of Cut Meutia Hospital. Patients are who routinely go to the polyclinic every month to take medicine. The patient complains of left chest pain, shortness of breath, heart palpitations, cough, tired easily during activities, especially during strenuous activities. History of Diabetes Mellitus is denied, history of hypertension (+). The patient admitted that he was diagnosed with rheumatic heart disease at the age of 19 years. The patient has been undergoing treatment for 33 years by routinely complete checks related to his heart every year and regularly taking medication at the polyclinic every month. The patient admitted at junior high school age he often experienced attacks of fever that went up and down accompanied by pain in the throat. Physical examination found: Compos Mentis (E4V5M6), BP:140/40 mmHg, HR : 92x/i, RR: 23x/i, T; 37.1°C, SpO2 : 95%. Chest examination showed vesicular breath sounds, Rhonki (-), Wheezing (-), Diastolic murmur (+).Echocardiography showed an EF of 70%. AR Severe, MR Moderate. AML Prolapse, Calcification (+), LV Dilatation, LVH Eccentric 
The Protective effect of Hibiscus sabdariffa on Lung Damage in Rats due to Cigarette Smoke Exposure Faizah Fulyani; Muhammad Yudhistira; Hermawan Istiadi; Puspita Kusuma Dewi; Riski Prihatningtias; Noor Wijayahadi; Desy Armalina
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 2 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i2.37435

Abstract

Background: Cigarette smoke consists of many free radicals that can reduce antioxidants in the body and further trigger oxidative stress. The state of oxidative stress can be minimized through antioxidant supplementation. Hibiscus sabdariffa (Rosella) is a herbal plant reported to be rich in antioxidants.Objective: To investigate the protective effect of Rosella extract on the microstructure of the lung and plasma Malondialdehyde (MDA) levels of rats exposed to cigarette smoke.Methods: This research is an experimental study with a post-test-only group design. A total of 36 male Sprague Dawley rats were randomly divided into six groups[L1] . Group K was given standard food and free access to water. Group K1, K2, P1, P2, and P3 were exposed to 4 cigarettes/day for 30 consecutive days. Before cigarette smoke exposure, each group received treatment with 1 mL saline (K1), vitamin E 0.2 g/kg b.w. (K2), and infused Rosella 0.25 g/kg b.w. (P1), 0.5 g/kg b.w. (P2), and 1 g/kg b.w. (P3). Plasma MDA levels were measured by the TBARS method. Statistical analysis was performed with one way ANOVA test and continued with a post hoc test.Results: Circulated MDA levels of groups K, K1, K2, P1, P2, and P3 were 1.84 ± 0.18 nmol/mL, 9.57 ± 0.27 nmol/mL, 2.24 ± 0.10 nmol/mL, 4.93 ± 0.31 nmol/mL 3.85 ± 0.55 nmol/mL, and 2.62 ± 0.37 nmol/mL respectively. Cigarette smoke exposure in group K showed significantly higher MDA levels (K versus K1; p < 0.001).  The administration of rosella infusion (P1, P2, P3) and or vitamin E supplementation (K2) can significantly suppress the plasma MDA levels due to cigarette smoke exposure ( p < 0.05). The administration of Rosella flower infusion 1 g/kg b.w. has an antioxidant effect similar to vitamin E supplementation 0.2  g/kg b.w. (p = 0.268).Conclusion: The administration of Rosella flower infusion could prevent lung damage from oxidative stress induced by cigarette smoke exposure. Keywords: Cigarette, Hibiscus sabdariffa,MDA, Oxidative stress.
EFFECTIVENESS TEST OF 0.2% CHLORHEXIDINE AND HIBISCUS (Hibiscus rosa sinensis L.) EXTRACT AGAINST Streptococcus sp BACTERIA ON DENTAL PLAQUE Athalaila Azzahrasukma Sakuntala; Arlita Leniseptaria Antari; Ira Anggar Kusuma; Yora Nindita
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 2 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i2.36720

Abstract

ABSTRACTBackground: Streptococcus sp colonies are Gram-positive coccus bacteria that play a role in the formation of dental plaque and cause dental caries. However, dental caries can be prevented with the gold standard mouthwash, namely chlorhexidine. In other studies, many mouthwashes have been developed using traditional ingredients that have antibacterial potential, one of which is hibiscus flower (Hibiscus rosa sinensis L.). This is due to the presence of chemical compounds that can inhibit the growth of Streptococcus sp in dental plaque.Objectives: Testing the effectiveness of 0.2% chlorhexidine and H. rosa sinensis L. extract against Streptococcus sp in dental plaque.Method: Laboratory experimental research with pre and post test only control group design on 6 groups. Group K- (aquades), K+ (chlorhexidine), H. rosa sinensis L. extract 6.25% (P1), 12.5% (P2), 25% (P3), 40% (P4). Each of these groups consisted of 4 subjects. Data were obtained by counting the number of Streptococcus sp colonies before and after gargling which had been streak-cultured on blood agar media. The statistical analysis used the Shapiro Wilk test showed significant results P ≥ 0.05, followed by the One Way ANOVA parametric test. While the not significant results with the Kruskall Wallis non-parametric test.Results: There was a significant difference between the 4 concentrations of H. rosa sinensis L. extract 6.25% (P1), 12.5% (P2), 25% (P3), and 40% (P4) with the control (+) (p = 0 .00), and at a concentration of 25% (P3) effectively inhibited the growth of Streptococcus sp bacteria by 12.5%.Conclusion: H. rosa sinensis L. extract was effective compared to 0.2% chlorhexidine in inhibiting the growth of Streptococcus sp. Administration of various concentrations of H. rosa sinensis L. mouthwash extract inhibited the growth of Streptococcus sp, and at a concentration of 25% (P3) effectively inhibited Streptococcus sp by 12.5%.
Case Report : Fahr’s Disease With Acute Double Hemiparese Manifestation Vania Ayu Puspamaniar; Giam, Billy Putera Kurniawan; Bonfilio Neltio Ariobimo; Lisa Puspitorini
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 12, No 2 (2023): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v12i2.37711

Abstract

Fahr's disease is a very rare disease with a prevalence of 1/1,000,000 individuals. We present a case report of a male with sudden double hemiparese and basal ganglia calcification leading to the diagnosis of Fahr's disease. A 59 years old male presented to the emergency department with a chief complaint of unable to move his upper and lower extremities in a sudden. The complaint begins with weakness of the right side of the body, followed by weakness of the left side of the body the day after. The serum levels of calcium, magnesium, phosphorus, and Parathyroid Hormonal (PTH) have not been measured due to the patient’s financial problems. CT scan of the brain showed bilateral, symmetrical, wide areas of calcification over the fossa posterior, basal ganglia, periventricular, and parietal area, which were suggested as Fahr’s disease. The patient is being treated with the injection of neuroprotectant, antibiotic, vitamin, neuropathic analgesia, and fluids. He is also being consulted with medical rehabilitation to get some physical treatments. Treatment goals include: increase and or maintain ROM, prevent contractures, strengthens weak muscles that may be underutilized, improvement and maintenance of postural stability in static postures and during mobility, and fall prevention. Our case highlight sudden double hemiparese which different from previous literature which says that neurological deficit symptoms appear with a chronic nature and the importance of combining pharmacological therapy and physical therapy as in this patient to reduce the patient's morbidity.

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