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Masruri
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Departemen Kimia, Fakultas MIPA, Universitas Brawijaya, Jl. Veteran 65145 Malang
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The Journal of Pure and Applied Chemistry Research
Published by Universitas Brawijaya
ISSN : 23024690     EISSN : 25410733     DOI : http://dx.doi.org/10.21776/ub.jpacr
Core Subject : Health, Science, Engineering,
Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology Medicine & Pharmacology
The Journal of Pure and Applied Chemistry Research focuses in publishing research articles in the field of Chemistry and Applied Chemistry. The target is in exploring, investigating, and developing chemicals sources from local and/or Indonesian to increase the value. Scope of the journal is organic chemistry, analytical chemistry, inorganic chemistry, biochemistry, and physical chemistry. Included the topic also organic chemistry natural product, theoretical and computational chemistry.
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 6 Documents
 1 
Search results for , issue "Vol 12, No 1 (2023): Edition January-April 2023" : 6 Documents clear
Study Direction to Oxidize a Local Pine Rosin with Potassium Permanganate Widia Edy Kuncoro; Moh. Farid Rahman; Masruri MASRURI, Ph.D; Siti Mariyah Ulfa
The Journal of Pure and Applied Chemistry Research Vol 12, No 1 (2023): Edition January-April 2023
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2023.012.01.3298

Abstract

Pine rosin acid or Gondorukem is a solid resin obtained from pine sap. It is yielded as residue from a high temperature distillation process. In industry, rosin acid is widely used and modified as raw material in paint, ink, adhesive, resin, thermoplastic, and thermosetting polymer. Modification process generally is undergone to generate rosin acid with specific properties and for certain purposes. This paper report, potassium permanganate oxidation reaction of pine rosin acid under acidic process at low temperature. Product identified as 13,14-seco-13-oxoabiet-7-ene-dioic acid (0.52%), 7,8-dihydroxy-abietic acid (6.62%), and 7-oxo-dehydroabietic acid (1.49%). The crude product was isolated as a pale to white solid. Under high temperature a yellowish product was resulted. In overall, the yield isolated in between 46.4% and 86.0%.
Properties of Bacterial Cellulose/Polyvinyl Composite Membrane for Polymer Electrolyte Li ion Battery qolby sabrina; Hilwa Kamilah; Christin Rina Ratri; Titik Lestariningsih; Sitti Ahmiatri Saptari
The Journal of Pure and Applied Chemistry Research Vol 12, No 1 (2023): Edition January-April 2023
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2023.012.01.663

Abstract

High ionic conductivity and more porous have extraordinary significance to solid polymer electrolyte in Li ion battery application. In this study, bacterial cellulose (BC) based polymer was modified by polyvinyl pyrrolidone (PVP) and polyvinyl acetate (PVA) to get composite solid polymer electrolyte. Blending the polymer host is one more approach to work on the morphology pore and electrochemical properties of polymer electrolytes. The slurry of BC is rich in fibers that contribute to forming the pore template of the solid electrolyte membrane. Polyvinyl work to make more pore and increases the polymer segmental ion lithium mobility. Pore morphology of BC PVA composite membrane homogeneously distributed by SEM observations. The presence of many pores makes the tensile strength of the BC PVA membrane lower, for use in solid electrolytes it does not affect battery performance. The presence of pores that contribute a lot to the absorption of electrolytes. Enhancement of the conductivity upon addition of salt is correlated to the enhancement of more pore of polymer electrolyte. The conductivity of BC PVA composite 8.45 x 10-7 Scm-1 higher than PVP at room temperature. In the future, PVA can be relied on to be a mixed material for solid electrolyte membranes based on cellulose.  
Comparison of Fabrication Technique and Carrier Oil to Curcumin Nanoemulsion Properties Zubaidah Ningsih; Sepriana Puspita Dewi Syaiful; Maria L.A.D Lestari; Diah Mardiana; Budi Kamulyan
The Journal of Pure and Applied Chemistry Research Vol 12, No 1 (2023): Edition January-April 2023
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2023.012.01.701

Abstract

Turmeric (Curcuma longa L.) is included in the rhizome plant containing curcumin which has various therapeutic properties. However, curcumin has poor bioavailability. The manufacture of nanoemulsion is expected to increase curcumin bioavailability. This study aims to compare 3 methods (wet-ball milling, ultrasonication and microfluidic) and 3 carrier oils (soybean, virgin coconut, and olive oil) in the production of curcumin nanoemulsion. Wet-ball milling reduces particle size through grinding process using milling beads in liquid medium. Microfluidic decreases the particle size via collision of emulsion components in microchannel while ultrasound utilizes sound-wave energy to break down the particle size. Parameters compared were particle size, polydispersity index and entrapment efficiency. Particle size and polydispersity index were observed using Particle Size Analyzer with Dynamic Light Scattering technique while entrapment efficiency was measured based on the curcumin absorbance in UV-Visible spectrophotometer at 420 nm. Our study concludes that microfluidic is the most effective and efficient fabrication method which produces the smallest particle size and polydispersity index compared to ultrasonication and microfluidic. The resulting particle sizes using microfluidic are 154, 140 and 132 nm with polydispersity index of 0.224; 0.200and 0.208 insoybean,virgin coconut, and oliveoil respectively. However, entrapment efficiency is best achieved using wet-ball milling method with the average value of 49±10%. Soybean oil appears to be the most curcumin solubilizing oil compared to olive and virgin coconut oil. Thus, it can be concluded that fabrication methods and carrier oils determine curcumin nanoemulsion properties.
Potential Cytotoxic Activity of Methanol Extract, Ethyl Acetate, and n-Hexane Fraction from Clitoria ternatea L. on MCF-7 Breast Cancer Cell Line and Molecular Docking Study to P53 Rollando Rollando; Marsha Anggita Amelia; Muhammad Hilmi Afthoni; Kestrilia Rega Prilianti
The Journal of Pure and Applied Chemistry Research Vol 12, No 1 (2023): Edition January-April 2023
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2023.012.01.705

Abstract

Breast cancer is a condition where the cells in breast tissue lose control and multiply uncontrollably. In this study, MCF-7 breast cancer cells were tested for cytotoxic activity using the MTT assay and the active compound's interaction with the p53 protein was tested in silico. The most active fraction was found to be the ethyl acetate fraction, with an IC50 value of 1.730 μg/mL and a selectivity index of 2.485. However, the selectivity index was less than 3, and Vero cells showed changes in morphology with the addition of the ethyl acetate fraction. GC-MS was used to identify 19 compounds in the ethyl acetate fraction, and in-silico tests were performed on 5 potential anticancer compounds. Lipinski's Rule of Five test showed that only 3 of these compounds could undergo molecular docking. The results indicated that Anethole compound can interact with p53 protein, while Cinnamaldehyde, (E)- can interact with p21 protein.
Sargassum aquifolium Extract Prevents Elevated Cholesterol Levels and Blood Vessel Thickening in Rats Fed an Atherogenic Diet Muhamad Firdaus; Rahmi Nurdiani; Aulia Savira; Firyal Hanifah
The Journal of Pure and Applied Chemistry Research Vol 12, No 1 (2023): Edition January-April 2023
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2023.012.01.711

Abstract

Hypercholesterolemia is a health disorder in which cholesterol in the blood increases beyond normal limits. This disorder chronically can cause atherosclerosis. Sargassum aquifolium contains bioactive that can prevent an increase in blood cholesterol levels. This study aimed to prevent the increasing cholesterol levels and changes in the blood vessel profile of rats fed an atherogenic diet by S. aquifolium extract. S. aquifolium was obtained from Ekas Bay. Rattus norvegicus 2-3 months ages used in this study. Normal rats were fed an atherogenic diet for four months to produce an animal hypercholesterolemia model. The phytochemical profile was screened based on the Harborne method. Identity of bioactive determined by HPLC-HRMS. The parameters observed were cholesterol levels and blood vessel profiles. The juice of S. aquifolium contained steroids, saponins and tannins and their bioactive showed anticholesterolemic. Rats given an atherogenic diet had increased cholesterol levels. Administration S. aquifolium juice twice a day can reduce cholesterol levels and prevent the thickening of the aorta and arteries. In conclusion, S. aquifolium juice contains bioactive compounds and administration of S. aquifolium juice twice a day prevents an increase in cholesterol and damage to the aortic and arterial profiles.
Antibacterial Activity of Legundi Leaf (Vitex trifolia) Essential Oil Using In-Vitro and In-Silico Methods Retno Indriatie; Masruri Masruri; Warsito Warsito
The Journal of Pure and Applied Chemistry Research Vol 12, No 1 (2023): Edition January-April 2023
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jpacr.2023.012.01.738

Abstract

Staphylococcus aureus causes many severe diseases, such as meningitis, lung infection, and hematogenous osteomyelitis. The prolonged use of antibiotic drugs leads to antimicrobial resistance (AMR), decreasing their effectiveness against S. aureus. Therefore, novel drugs isolated from natural products have been the focus of many researchers to solve that problem. The essential oils isolated from Vitex trifolia leaf have many pharmacological activities, including antibacterial and antifungal activities. In this research, essential oil was isolated by distillation, followed by GC-MS analysis. The antibacterial activity of the essential oil was conducted using a disk diffusion test (Kirby-Bauer) and by molecular docking study. The essential oil yield from distillation was 0.13%, containing major compounds such as sabinene, eucalyptol, terpinen-4-ol, α-terpineol, limonene, and caryophyllene. The essential oil gave intermediate inhibition against S. aureus with a 6.91 ± 0.03 mm inhibition zone in 20 mg/mL of the sample. Using molecular docking study, caryophyllene and α-terpineol were the key compounds for inhibiting the active site of tyrosyl-tRNA synthetase, sortase A, and dihydrofolate reductase that are responsible for the S. aureus growth and development.

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