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INDONESIA
Berkala Ilmu Kesehatan Kulit dan Kelamin
Published by Universitas Airlangga
ISSN : 19784279     EISSN : 25494082     DOI : 10.20473
Core Subject : Health, Science,
Immunology & microbiology Public Health
Arjuna Subject : -
Articles 409 Documents
 1   2   3   4   5 
Susceptibility test of Griseofulvin, Ketoconazole, Itraconazole, and Terbinafine to Dermatophyte Species Using Microdilution Method Anggarini, Dyah Ratri; Sukanto, Hari; Astari, Linda; Endraswari, Pepy Dwi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 1 (2015): BIKKK APRIL 2015
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (130.616 KB) | DOI: 10.20473/bikkk.V27.1.2015.55-62

Abstract

Backgroud: Dermatophytosis is common disease in tropical countries such as Indonesia. The prevalence of dermatophytosis in general population also high (20%). The dermatophyte fungi are the etiologic agents that cause this disease, some of them had already reported to be resistant to some anti-fungi. Purpose: To determine dermatophyte species causing dermatophytosis and the resistancy of griseofulvin, ketoconazole, itraconazole, dan terbinafine to dermatophyte species. Methods: Isolates of dermatophyte from patient who met the inclusion criteria in outpatient clinic of dermato-venereology Dr. Soetomo Hospital Surabaya during October until December 2014 were analyzed with respect to their susceptibility to four anti-fungal agents (griseofulvin, ketoconazole, itraconazole, and terbinafine) using microdilution methode. Results: Thirthy patients were included in inclusion criteria, with T. mentagrophytes var. Interdigitale was the most common cause of dermatophytoses. According to MIC all 30 isolates were already resistant to all anti-fungal agent, except T. rubrum that still sensitive to ketoconazole and 80,  itraconazole.  Conclusion: According to MIC 16.7% isolates sensitive to griseofulvin, 23.3% to ketoconazole, 16.7% to 80 itraconazole and 20% to terbinafine.Key word: dermatophyte species, susceptibility test of anti-fungal, microdilution.
Retrospective Study: Atopic Dermatitis in Childhood Sihaloho, Kristina; Indramaya, Diah Mira
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 3 (2015): BIKKK DESEMBER 2015
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (115.231 KB) | DOI: 10.20473/bikkk.V27.3.2015.176-182

Abstract

Background: Atopic dermatitis is a chronically and relapsing inflammatory skin disease affecting individuals with atopic history or their families. Atopic dermatitis affects all ageswith percentage 15-30% in children and 1-2% in adults. Chronic pruritus, skin infection, sleep disorder, and growth disorder are signs and symptomps commonly found in childhood atopic dermatitis. Evaluation of the profile and management of DA were needed to improve the management of atopic dermatitis. Purpose:To evaluate the profile of childhood atopic dermatitis. Methods: A retrospective study of all new cases of childhood atopic dermatitis who visited the Pediatric Division, Dermatology and Venereology Outpatient Clinic, Dr. Soetomo General Hospital, Surabaya from January 2007 to Desember 2011. Results: Numbers of chilhood atopic dermatitis increased from 2007 to 2011. Itchy was the main complaint of DA, but redness patches (32,3%) and xerosis cutis (9,1%) were also found. Atopic history in patients and or their families were found in 842 patients (74,3%). Treatment was antihistamin in 879 patients (77,5%). Conclusions: Chilhood atopic dermatitis are still increasing by years. Determining and avoiding trigger factors are education for DAs patients and their families in preventing it recurrency.Key words: atopic dermatitis, childhood, retrospective study.
Eritema Induratum Bazin pada Pasien Tuberkulosis Paru Miryana, Windy; Nurainiwati, Sri Adila; Hidayat, Taufiq; Moedjiwijono, Moedjiwijono
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 1 (2014): BIKKK APRIL 2014
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1519.05 KB) | DOI: 10.20473/bikkk.V26.1.2014.1-5

Abstract

Latar belakang: Eritema induratum Bazin (EIB) atau yang disebut dengan Nodular Vaskulitis merupakan tuberkulosis kutis jenis tuberkulid, ditandai dengan erupsi nodular kronik pada tungkai bawah terutama menyerang wanita usia pertengahan. Eritema Induratum Bazin merupakan bentuk panikulitis lobular dengan vaskulitis. Gambaran klinis berupa nodul, nyeri, yang akan membentuk ulkus dan skar, bersifat kronis dan rekuren. Penyakit ini jarang dijumpai. Tujuan: Memaparkan kasus EIB pada pasien tuberkulosis paru yang merupakan kasus yang jarang ditemukan. Kasus: Wanita, 24 tahun dirujuk oleh dokter spesialis paru dengan keluhan luka dan nyeri pada kedua tungkai sejak 4,5 tahun yang lalu yang hilang timbul. Pemeriksaan dermatologis terdapat nodul dan plak eritematus, multipel, ireguler, ulkus multipel tertutup krusta kehitaman, dan skar atrofi. Pemeriksaan histopatologis menunjukkan adanya epitel histiosit, radang granulomatus dan vaskulitis. Tes Mantoux positif dan foto Thorax menunjukkan gambaran tuberkulosis paru. Penatalaksanaan: Pasien diberikan regimen obat anti tuberkulosis kategori I, yaitu Rifampisin 600 mg/hari,Isoniazide 300 mg/hari, Pirazinamide 1500 mg/hari dan Etambutol 800 mg/hari selama 2 bulan, dilanjutkan dengan Rifampisin 600 mg/hari dan Isoniazide 300 mg/hari selama 4 bulan berikutnya. Simpulan: Diagnosis EIB ditegakkan berdasarkan anamnesis dan gambaran klinis ditunjang dengan pemeriksaan histopatologi. Sesuai hasil tes Mantoux dan foto thorax menunjukkan bahwa etiologi kasus ini berkaitan dengan tuberkulosis. Patogenesis EIB berkaitan dengan reaksi imun kompleks. Pasien diterapi dengan obat anti tuberkulosis dan memberikan hasil yang memuaskan setelah pengobatan selama 3 bulan. Kata kunci: Eritema induratum Bazin, panikulitis, tuberkulosis, obat anti tuberculosis.
Penggunaan Kalsineurin Inhibitor sebagai Imunomodulator Topikal pada Terapi Dermatitis Atopik Wirantari, Nadia; Prakoeswa, Cita Rosita Sigit
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 2 (2014): BIKKK AGUSTUS 2014
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (491.525 KB) | DOI: 10.20473/bikkk.V26.2.2014.1-7

Abstract

Latar belakang: Dermatitis atopik (DA) adalah inflamasi kronis yang kambuh-kambuhan pada kulit. Kortikosteroid topikal adalah terapi topikal lini pertama pada DA tetapi terdapat efek samping dalam penggunaan jangka panjang seperti atrofi kulit. Akhir-akhir ini kalsineurin inhibitor topikal (KIT) digunakan sebagai terapi DA. Tujuan: Memberikan pengetahuan tentang profil, mekanisme kerja, efektivitas, dan efek samping topikal kalsineurin inhibitor sebagai imunomodulator terapi DA. Tinjauan pustaka: Manifestasi klinis DA adalah gatal dan lesi kulit eksematus kronik dan kambuh-kambuhan. Pengobatan DA tergantung keparahan gejala. Kebanyakan kasus membutuhkan emolien untuk kulit kering dan kortikosteroid topikal saat kambuh. Kalsineurin inhibitor sebagai imunomodulator topikal telah disetujui oleh FDA sebagai terapi DA. Sediaan KIT terdapat dua macam, yaitu salep takrolimus sediaan 0,1% dan 0,03%, serta krim pimekrolimus 1%. Cara kerjanya melalui inhibisi kalsineurin, yang menghambat aktivasi sel T dan produksi sitokin proinflamasi. Banyak penelitian yang membandingkan KIT dengan plasebo, kortikosteroid topikal dan satu sama lain, dan telah menunjukkan efektivitas dan keamanan KIT sebagai terapi DA. Simpulan: KIT efektif dan aman untuk terapi lini kedua DA. Takrolimus dan pimekrolimus memiliki efektivitas lebih tinggi dibandingkan plasebo, dan lebih rendah dibandingkan kortikosteroid topikal. Takrolimus lebih efektif dari pimekrolimus, dan dapat digunakan untuk DA yang lebih berat, namun dengan efek samping yang lebih besar.Kata kunci: dermatitis atopik, kalsineurin inhibitor topikal, takrolimus, pimekrolimus.
Secreted Aspartyl Proteinase[SAP] Enzyme Profile on Vulvovaginalis Candidiasis Patients isolates Nugrahaeni, Diah; Agusni, Indropo; Ervianti, Evy
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 1 (2015): BIKKK APRIL 2015
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (125.891 KB) | DOI: 10.20473/bikkk.V27.1.2015.17-23

Abstract

Background: Vulvovaginalis candidiasis (VVC) is an infection caused by various types of Candida, themost is Candida albicans. Candida produces two main enzymes that play a role in virulence, the secreted aspartyl proteinase (SAP) enzyme and the phospholipase enzyme. SAP is most widely produced by Candida albicans,which is one of the main pathogenicfactor of Candida infection. SAP is often found in cases of recurrent candidiasis vulvovaginalis (RVVC) Purpose: To evaluatethe SAP activity produced by VVC patients isolates. Methods: Descriptive observational cross-sectional study was conducted on 21 VVC patients to determine the SAP enzyme levels in VVC patients in Sexually Transmitted Infection (STI) Division, Outpatient Clinic Of Dermatology and Venerology, Dr. Soetomo General Hospital, Surabaya.Vaginal smear was examined to determine levels of SAP and culture examination to determine the kind of candida spesies that causes VVC. Results: Total subject of study are 21 patients. Twelve of  21 patients had SAP > 20 mm in diameter, 7 patients with SAP < 20 mm in diameter, and 2 patients with negative results of SAP. Fifty patients due to Candida albicans, 6 patients caused by non-albicans. Nine patients were accompanied by diabetes mellitus (DM), 1 patients by genital affection, 2 patients by condylomata acuminata. Additionally obtained in 10 patients who had previously received treatment with the results diameter SAP > 20 mm and 7 patients with of SAP diameter < 20 mm, 2 patients showed negative results of SAP. Conclusions: SAP was mainly produced by Candida albicans. SAP became more active in VVC patients that accompanied by diabetes melitus, affectiogenitalis, condylomata acuminate, and also in some patients who have received prior antifungal therapy.Key words: secreted aspartyl proteinase, vulvovaginalis candidiasis, Candida albicans,
Retrospective Study: Type 1 Leprosy Reaction Pratamasari, Meita Ardini; Listiawan, M. Yulianto
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 2 (2015): BIKKK AGUSTUS 2015
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (110.205 KB) | DOI: 10.20473/bikkk.V27.2.2015.137-143

Abstract

Background: Type 1 reaction (T1R) of leprosy occurs due toaltered balance between cell mediated immunity and M. leprae bacilli in the skin and nerves, with upgrading/reversal or downgrading as final result. Leprosy subpolar types have unstable immunity, this cause them often experience recurrence T1R, especially BB type.Clinical findings of T1R are inflammation in the skin or nerves, and can lead to disability if not treated properly. Aim: To evaluate the distribution, diagnosis, trigger factors, and therapy of T1R. Methods: Retrospective study using medical record of leprosy new patients in Dermatology and Venereology Outpatient Clinic, Dr Soetomo General Hospital, Surabaya, during 2010 – 2013. Database, anamnesis, examination, and T1R therapy were recorded. Results: The total of new leprosy patients with T1R within 2010-2013 were 117 patients (19,7% of all new leprosy  patients). Most of them were men (70,1%), aged between 15–34 years (42,8%), with BB as the most frequent type (70,9%). Skin symptom of T1R could be thickening of old lesion (52,1%). T1R most occurred when patients still consume MDT (71,8%). NSAID (37,6%) andcorticosteroid (38,5%)were prescribed as T1R therapy. Conclusions: T1R diagnosis should established accurately by history taking and physical examination.For recurrent T1R,trigger factors should be considered.Key words: type 1 reaction, CMI, reversal, downgrading.
Studi Retrospektif: Faktor Pencetus Akne Vulgaris Ayudianti, Prida; Indramaya, Diah Mira
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 1 (2014): BIKKK APRIL 2014
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (316.542 KB) | DOI: 10.20473/bikkk.V26.1.2014.1-7

Abstract

Latar belakang: Akne vulgaris (AV) merupakan penyakit yang banyak diderita remaja, sekitar 85% remaja terkena dengan tingkat keparahan tertentu. Penyebab AV adalah multifaktorial. Faktor pencetus yang berperan antara lain faktor genetik, lingkungan, hormonal, stres emosi, makanan, trauma, kosmetik, dan obat-obatan. Tujuan: Mengidentifikasi faktor pencetus AV pada pasien di Divisi Kosmetik Medik Unit Rawat Jalan Kesehatan Kulit dan Kelamin RSUD Dr. Soetomo Surabaya. Metode: Studi retrospektif terhadap rekam medis tentang gambaran umum, faktor pencetus, diagnosis, dan penatalaksanaan pasien baru AV periode 2008-2010. Hasil: Jumlah pasien baru AV tahun 2008-2010 adalah 3448 pasien. Penderita AV perempuan (79,4%) lebih banyak daripada laki-laki. Kelompok umur terbanyak menderita AV adalah 15-24 tahun (64,3%), jenis pekerjaan pasien AV terbanyak adalah pelajar/mahasiswa (39,1%). Sebagian besar pasien menderita AV selama 1-5 tahun (46,5%). Faktor pencetus AV tersering adalah hormonal (55,6%). Tipe lesi AV terbanyak adalah papulopustular (75,6%). Terapi yang terbanyak adalah kombinasi doksisiklin oral, tretinoin dan klindamisin topikal. Simpulan: Faktor pencetus timbulnya AV pada wanita tersering adalah hormonal dan kosmetik, sedangkan pada laki-laki adalah makanan dan stres. Kata kunci: akne vulgaris, faktor pencetus, retrospektif.
Patch Test and Repeated Open Application Test (ROAT) in Allergic Contact Dermatitis Noviandini, Anggraeni; Prakoeswa, Cita Rosita Sigit
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 3 (2014): BIKKK DESEMBER 2014
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (819.13 KB) | DOI: 10.20473/bikkk.V26.3.2014.1-9

Abstract

Background: The clinical relevance of patch test reaction is often difficult to determine. Repeated Open Application Test (ROAT) have been developed to further evaluate the significance of patch test result. Purpose: Understanding methods, procedures, and reactivity of patch test and ROAT, so thatmay be used to help identify with a high risk of developing allergic contact dermatitis. Reviews: The validity of patch test is limited. Various attempts have been made at modifying the patch test, primarily in order to increase the sensitivity of the skin and thus enhance the reliability and validity of the results, such as ROAT. Several experimental studies have compare the result of patch testing with the outcome of ROATs and these have defined correlations between the threshold concentration at patch testing (MEC) and outcome of ROAT, and also shed light on some factors that may influence the outcome of ROATs. Results of patch testing with serial dilutions of colophony, cinnamic aldehyde, and isoeugenol have shown concordance with the outcome of ROATs. On the other hand, poor correlation between patch test reactivity and ROAT were demonstrated in another study on isoeugenol,hydoxycitronellal, formaldehyde dan chromium. Conclusion: Patch test and ROAT are two methods that may be used toidentify allergen exposure and MEC Allergic Contact Dermatitis reaction.Key words: patch test, repeated open application test (ROAT), allergic contact dermatitis (ACD).
Manifestation of Skin Disorders in HIV & AIDS Patients Listiana Dewi, Indah Sari; Hidayati, Afif Nurul
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 27, No 2 (2015): BIKKK AGUSTUS 2015
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (135.906 KB) | DOI: 10.20473/bikkk.V27.2.2015.97-105

Abstract

Background: Human immunodeficiency virus (HIV) can causes deficiency of cellular immunity resulting in decreased +lymphocyte T helper (CD4 T cell). Most common infections and neoplastic process of skin in HIV patients were facilitated by loss of CD4 in immune system. Skin disorders are often found in patients with HIV/AIDS, so that the necessary understanding and evaluation are needed for better management. Methods: Descriptive retrospective study using medical records of patients diagnosed with HIV & AIDS related skin disorders in Intermediate Unit Care of Infection Disease Ward, Dr. Soetomo General Hospital, Surabaya in 2013. The type of skin disorder, aged, supporting examination, transmission factors, CD4 counts, and therapy were recorded. Results: HIV & AIDS patients in 2013were about 649 patients, 301 patients (46.3%) among of them suffered from skin disorders. Most of them were in 25-44 years of age (70.8%). The most common skin disorders were oral candidiasis (81.1%). Examinations were performed (52.8%) to confirm the diagnose. Most of transmission factors were well3 known (66.1%). CD4 count cell were clearly noted only 17.3% in medical record, and 12.2% in CD4 1-100 sel/mm. There were 31.6% of patients received ARV. Conclusions: Skin disorders are most common disorders in HIV & AIDS patients and are determined by CD4 count. Oral candidiasis is most common skin and mucocal disorder in HIV & AIDS patient. Key words: HIV-AIDS, skin disorders, CD4+ T cells, oral candidiasis,retrospective study.
Uji Tempel Pasien Dengan Riwayat Dermatitis Kontak Alergi Kosmetik di URJ Kesehatan Kulit Dan Kelamin RSUD Dr. Soetomo Surabaya Miftah, Antoni; Prakoeswa, Cita Rosita Sigit; Sukanto, Hari
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 1 (2014): BIKKK APRIL 2014
Publisher : Faculty Of Medicine Airlangga University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (216.031 KB) | DOI: 10.20473/bikkk.V26.1.2014.1-7

Abstract

Latar belakang: Kasus dermatitis kontak alergi kosmetik (DKAK) relatif signifikan, diperkirakan 10% dari seluruh kasus dermatitis kontak di RSUD Dr. Soetomo Surabaya cenderung meningkat. Tahun 2008 ditemukan 24 (6%) penderita DKAK dari 267 pasien DKA, sedangkan tahun 2009 ditemukan 36 (15%) dari 230 pasien DKA yang datang berobat. Tujuan: Mengetahui bahan kosmetik penyebab dermatitis kontak akibat kosmetik dan mengetahui relevansi klinis hasil uji tempel. Metode: Penelitian retrospektif terhadap 30 sampel dengan riwayat DKAK periode November 2010 – November 2011 di Divisi Alergi Imunologi URJ Kulit dan Kelamin RSUD Dr. Soetomo. Uji tempel menggunakan 12 bahan standar alergen kosmetik. Hasil: Enam belas pasien dari 30 sampel (53,33%) didapatkan hasil positif dengan satu atau lebih alergen dan 14 pasien (46,67%) negatif terhadap alergen yang ditempelkan. Hasil uji tempel positif terbanyak dari 16 pasien tersebut adalah alergen pewarna rambut yaitu 13 pasien (43,3%), diikuti pewangi 6 pasien (20%) dan pengawet 5 pasien (16,7%). Simpulan: Uji tempel alergen standar kosmetik dapat digunakan sebagai pemeriksaan penunjang terhadap penderita dermatitis kontak alergi kosmetik di Divisi Alergi Imunologi URJ Kesehatan Kulit dan Kelamin RSUD Dr. Soetomo Surabaya. Kata kunci: dermatitis kontak alergi, alergen kosmetik, uji tempel, relevansi klinis.

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