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Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy)

Farmasi
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Published by Universitas Wahid Hasyim Semarang

ISSN : 16937899 EISSN : 27163814 DOI : 10.31942

Core Subject : Health,

Medicine & Pharmacology

Selamat datang di situs e-Publikasi Ilmiah Fakultas Farmasi Unwahas (Universitas Wahid Hasyim) Semarang. Situs ini berisi kumpulan publikasi ilmiah yang diterbitkan oleh Fakultas Farmasi Unwahas. Publikasi berasal dari jurnal-jurnal serta hasil prosiding seminar yang dilaksanakan oleh Fakultas Farmasi Unwahas.

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PENGARUH PERBEDAAN KONSENTRASI EKSTRAK ETANOLIK UMBI BENGKUANG (Pachyrrhizus erosus, Urb) DALAM SEDIAAN KRIM TERHADAP SIFAT FISIKNYA yulias ninik windriyati; diah pitaloka wahyuningrum; mimik murukmihadi
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 4 NO. 1 JUNI 2007
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTPeople has been used juicy tuber as food and cosmetic for delicated skin. Juicy tuber extract was formulated in cream in order to practical and effective. The aim of this research is to know the influence of difference concentration of juicy tuber extract in cream and storage duration to its physical properties. Extract was obtained from juicy tuber by remaceration method using 70% ethanol. Cream were made in five formulas with extract concentration 0,5 %, 1,0 %, 1,5 %, 2,0 % and 2,5 % w/w using standard formula cold cream. The physical stability of the cream was tested such as homogeneity, creaming and cracking, stickness, and spreadibility for 4 weeks storage. The data obtained were statistically analyzed using Friedman test with the 95 % confident level, followed by Mann Whitney test. Result of this research indicate that the cream of juicy tuber extract homogeneous and no creaming for 4 weeks storage. The difference of extract concentration and storage duration had not influence to physical stability of cream. Keyword: Extract of Juicy tuber, Cream, Physical TestPENDAHULUANPerawatan kesehatan dan kecantikan dengan memanfaatkan bahan alamiah selain lebih murah juga lebih aman dan tidak menimbulkan efek samping yang membahayakan. Berbagai hasil penelitian dibidang kosmetik mengungkapkan bahwa perawatan kecantikan kuno dengan bahan alamiah bisa dibuktikan secara ilmiah (Surtiningsih, 2005).Kosmetika pada prinsipnya adalah obat namun tujuan pemakaiannya sedikit mengalami perubahan bila dibandingkan dengan tujuan pemakaian obat-obatan pada umumnya. Kosmetika dirancang untuk tujuan estetika yaitu mempercantik, memperbaiki, dan mengubah penampilan seseorang (Depkes RI., 2003).Tanaman bengkuang (Pachyrrhizus erosus, Urb) biasa dimanfaatkan sebagai buah atau bagian dari beberapa jenis masakan. Bengkuang juga dimanfaatkan sebagai penghalus kulit, dan berkhasiat sebagai obat beri-beri, demam, diabetes, sariawan dan wasir. Sifat kimiawi dan efek farmakologis tanaman bengkuang adalah manis, dingin, sejuk dan berkhasiat mendinginkan. Kandungan kimianya adalah Pachyrhiton, rotenone, vitamin B1 dan C (Anonim, 2003).Bengkuang supaya mudah digunakan sebagai penghalus kulit perlu dilakukan pengembangan formulasinya dalam sediaan krim. Penelitian ini bertujuan untuk mengetahui pengaruh perbedaan konsentrasi ekstrak etanolik umbi bengkuang dalam sediaan krim dan lama penyimpanan terhadap sifat fisiknya.METODOLOGIAlat

PENYIDIKAN EFEK SAMPING HALOPERIDOL DAN CHLORPROMAZINE : STUDI KASUS PADA PASIEN RAWAT INAP RUMAH SAKIT JIWA DAERAH Dr. AMINO GONDOHUTOMO SEMARANG PERIODE 2005 sri susilowati
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 4 NO. 1 JUNI 2007
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTHaloperidol and chlorpromazine antipsycotic were used for broad and so long time. That drugs used could shown undesire side effect. Objective of this study was to investigate haloperidol and chlorpromazine side effect, especially was to know relative risk (RR) of extrapiramidal and hypotension orthostatic side effects of haloperidol and chlorpromazine antipsycotic used in Dr. Aminogondohutomo Mental Hospital durimg 2005. Non experimental, retrospective and Case Control study design was done. Population of this study was patient ward in Dr. Aminogondohutomo Mental Hospital durimg 2005. Data was taken retrospectively from medical record. Analytical of data used Chi Kuadrat and Odds Ratio (OR) was to know relative risk (RR) of extrapiramidal and hypotension orthostatic side effects of haloperidol and chlorpromazine antipsycotic used. The results showed there were 27,17% extrapiramidal side effects of haloperidol used and 15,24 % hypotension orthostatic side effects of chlorpromazine used. That were the first rank of side effect in every that antipsycotic.The value of relative risk (RR) of extrapiramidal side effects of haloperidol used was 5 and 3 for hypotension orthostatic side effects of chlorpromazine used. That meaned patient who used haloperidol could 5 more time got extrapiramidal side effects than haloperidol unused and patient who used chlorpromazine could 3 more time got hypotension orthostatic side effects than chlorpromazine unused. Keyword : Extrapiramidal and hypotension orthostatic side effects, haloperidol and chlorpromazine antipsycotic, , Dr. Aminogondohutomo Mental Hospital

PENGARUH PENAMBAHAN SUKROSA TERHADAP STABILITAS ASETOSAL DALAM DAPAR FOSFAT ifiet pantilata; suwaldi suwaldi
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 4 NO. 1 JUNI 2007
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTAsetil salisilat acid or known as acetosal or aspirin is a class of analgetic and antipyretic medicine that used widely. In this research we used acetosal to know it stability for sucrose effect. Acetosal stability examination of temperature effect and pH that done in several sucrose concentration, they are 5,0 %; 10,0 %; and 15,0 % which pH 7,0; 8,0; 9,0 and 10,0 in the 40 0C, 50 0C and 60 0C. The result of research showed that acetosal degradation reaction the sucrose fluid in pH 7,0; 8,0; 9,0 and 10,0 at the 40 0C can speedyacetosal degradation where the speed degradation with sucrose effect has more higher value than the degradation without sucrose effect, while in the 50 0C and 60 0C sucrose made stability of acetosal where degradation value with sucrose effect that smaller than degradation speed without sucrose effect. Key words : asetosal, stability, sucrose

KERASIONALAN PENGGUNAAN OBAT BEBAS DAN OBAT BEBAS TERBATAS COMMON COLD DALAM UPAYA SWAMEDIKASI OLEH MASYARAKAT DI KECAMATAN GAJAHMUNGKUR KOTA SEMARANG aqnes budiarti; dharmika wijaya sakti; tri murti andayani
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 4 NO. 1 JUNI 2007
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTThe research about rationality of using over the counter drugs common cold for self medication in district of Gajahmungkur Semarang has been carried out. Data gotten from the result of field survey which is using the questioners that has been filled by Gajahmungkur’s people. Data will be analyzed with non analytical descriptive method. Based on the survey result, knowing that people in Gajahmungkur’s district choosing OTC drugs especially analgetic, antihistamin and decongestan (66,4%). The evaluation of rationality of using drugs for common cold has result: 1) Drugs of choice for common cold is correct. 2) Correct patient are 92,1%. 3) Correct dosage form 96,0%. 4) The most adverse drugs happens is sleepy (53,4%). Key words: Drugs rationality, common cold, self medication, people in district of Gajahmungkur Semarang

AKTIVITAS MUKOLITIK IN VITRO EKSTRAK ETANOLIK HERBA MENIRAN (Phyllanthus niruri L) TERHADAP MUKOSA USUS SAPI yulias ninik windriyati; mimik murrukmihadi; nissa ratna junita
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 4 NO. 1 JUNI 2007
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTPhyllanthus niruri L has been traditionally used by Indonesian people to treat cough. However, scientific basic of using this plant as mucolytic agent is still less observed. The aim of this research is to evaluate in vitro mucolytic activity of ethanol extract of P. niruri against bovine bowels mucose. In vitro mucolytic activity of P. niruri was tested through method as like as Haslinda (1999) and Setyawati (2004). Ethanol extract of P. niruri at various concentrations 0,25; 0,5; 0,75; 1,0; and 1,25% b/v mixed with mucose solution 50% b/v in fosfat buffer pH 7. The solution incubated at 37ºC during 30 minute. Solutions viscosity measured by stormer viscometer and evaluated its fluid flow properties. Negative control was mucosa solution without extract and positive control was asetilsistein. Mucolytic activity was shown by a concentration of extract which decrease viscosity of mucose solution. Ethanol extract of P. niruri had mucolytic activity againts bovine bowels mucose which decrease viscocity of mucose. However, statistically there was no difference between various concentrations of ethanol extract to mucolytic activity. Ethanol extract of P. niruri at concentrations 0,25; 0,5; and 0,75% in mucose solution had fluid flow properties thiksotropi pseudoplastic and at concentrations 1,0 and 1,25% had fluid flow properties pseudoplastic.

EVALUASI KERASIONALAN PENGOBATAN DIABETES MELITUS TIPE 2 PADA PASIEN RAWAT INAP DI RUMAH SAKIT BHAKTI WIRA TAMTAMA SEMARANG TAHUN 2006 ibrahim arifin; erna prasetyaningrum; tri murti andayani
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 4 NO. 1 JUNI 2007
Publisher : Universitas Wahid Hasyim Semarang

ASTRACTDiabetes melitus is metabolic disease characterized hiperglikemia that caused disparity of insulin secretion, insulin activity or both. WHO had predicted there were increasing of diabetes mellitus patients in next time, included in Indonesia. This study aim to know and evaluate the rational of in patients diabetes mellitus type 2 medication in Bhakti Wira Tamtama Hospital Semarang at 2006. This study is non experimental research that analyzed by non analytical descriptive method. Data were collected retrospectively from medical record comprised patient identity, diabetes melitus type 2 medication, and rational antidibetic usage. Data obtained were analysed with Standard of Perkeni 2006. The result of this study showed that 34 in-patient diabetes mellitus type 2 in Bhakti Wira Tamtama Hospital Semarang at 2006 were 40-50 years old (47,06%). Diabetes mellitus type 2 patients comprised 18 men and 16 women, 8 cases (23,52 %) were diabetes mellitus type 2 without additional diseases and 26 cases (76,47%) diabetes mellitus type 2 with additional diseases. Patients had diagnosis appropriate were 94,12 %, drug choise appropriate were 100 %, which biguanid metformin usage were 15 patients (46,87%). Dosis appropiate 100%, patient appropriate 100%, while drug interaction had happened to 1 case, that was antidiabetic and thiazid diuretic. Key words: Rational evaluation, diabetes mellitus type 2, Bhakti Wira Tamtama Hospital Semarang

Jurnal Ilmu Farmasi & Farmasi Klinik Vol.9 No.2 Desember 2012 farmasi farmasi
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol.9 No.2 Desember 2012
Publisher : Universitas Wahid Hasyim Semarang

iJurnal Ilmu Farmasi & Farmasi Klinik Journal of Pharmaceutical Science & Clinical PharmacyPemimpin Umum/ Penanggung jawab Dekan Fakultas Farmasi Universitas Wahid HasyimPemimpin Redaksi Wakil Dekan Bidang Akademik dan Kemahasiswaan Fakultas Farmasi Universitas Wahid Hasyim Redaktur Ahli Dr. Sumantri, M.S., Apt Prof. Dr. Suwijiyo Pramono, Apt. Prof. Dr. Mustofa, MKes. Apt. Dr. Mimiek Murukmihadi, SU., Apt Redaktur Pelaksana Aqnes Budiarti, M.Sc., Apt Staf Redaksi : Maulita Cut Nuria, M.Sc., Apt Maria Ulfah, M.Sc., Apt Sugiyono, M.Sc., Apt Risha Fillah Fithria, M.Sc., Apt Ririn Lispita Wulandari., S.Farm., Apt Sekretaris Redaksi Devi Nisa Hidayati, S.Farm Distributor Rachmad Wahyudi Alamat Redaksi/Tata Usaha Fakultas Farmasi Universitas Wahid Hasyim Jl. Menoreh Tengah X/22 Sampangan Semarang Telp. 024-8505680, 8505681 Fax. 024-8505680E-mail : jurnalfarmasiunwahas@gmail.com Terbit 2 kali setahun sejak September 2004ISSN : 1693-7899Volume 9 No 2 Desember 2012iiJurnal Ilmu Farmasi & Farmasi Klinik Journal of Pharmaceutical Science & Clinical Pharmacy DAFTAR ISIUji Sitotoksisitas Fraksi n-Heksana Ekstrak Etanol Herba Alfalfa (Medicago Sativa L.) Pada Sel T27D dan Sel Hela Serta Identifikasi Kandungan Senyawa Kimianya. Sri Susilowati , Anggun Claresa, Ibrahim Arifin..........................................................1 -9Evaluasi Kandungan Vitamin C Dalam Madu Randu dan Madu Kelengkeng dari Peternak Lebah dan Madu Perdagangan di Kota Semarang. Aqnes Budiarti dan Diah Fahmisul Istyaningrum…………………………………….10 - 15Aktivitas Antidiare Ekstrak Etanol Daun Randu (Ceiba petandra L. Gaern.) Pada Mencit Jantan Galur Balb/C Yance Anas, Risha Fillah Fithria, Yulia Ayu Purnamasari, Kusuma Arum Ningsih, Andri Geger Noviantoro, dan Suharjono……………………………………………...16 - 22Uji Aktivitas Imunostimulator Fraksi Air Dari Ekstrak Etanol Kelopak Bunga Rosella (Hibiscus sabdariffa L.) Terhadap Proliferasi Sel Limposit Mencit Galur Swiss Secara In Vitro Beserta Identifikasi Kandungan Kimianya. Oktarina Heni Puspitowati, Maria Ulfah dan Ediati Sasmito………………………...23 - 31Pengaruh Variasi Kadar Amilum Garut (Maranta arundinaceae Linn) Sebagai Bahan Pengikat Terhadap Sifat Fisik dan Kimia Tablet Parasetamol Sugiyono, Pipit Murdiyani dan Yulias Ninik W...........................................................32 - 37Perbedaan Pengaruh Lama Penyimpanan Larutan Susu Bubuk Full Cream dan Larutan Susu Kental Manis Terhadap Kadar Glukosa Risha Fillah Fithria, Agus Suprijono dan Maywan Hariono.......................................38 – 42ISSN : 1693-7899Volume 9 No 2 Desember 2012iiiPENGANTAR REDAKSI Assalamualaikum Wr. Wb. Alhamdulillah seiring dengan perjalanan Fakultas Farmasi Universitas Wahid Hasyim Semarang, Jurnal Ilmu Farmasi dan Farmasi Klinik (JIFFK) telah memasuki tahun ke-lima semenjak penerbitan perdana tahun 2004. Kami tetap berharap bahwa JIFFK dapat memberikan kontribusi bagi perkembangan ilmu farmasi dan farmasi klinik. Kami berharap bahwa JIFFK ini dapat digunakan sebagai wadah bagi para peneliti, akademisi dan pemerhati ilmu farmasi dan farmasi klinik untuk mempublikasikan hasil penelitian atau pemeikirannya. Demi menjaga eksistensi dan sustainabilitas JIFFK kami senantiasa memohon sumbangan tulisan atau artikel dari para peneliti. Kami selalu berusaha untuk dapat meningkatkan kualitas dari setiap penerbitan JIFFK ini, karena kami memiliki cita-cita supaya JIFFK dapat terakreditasi dari Dikti, DepDikNas-RI Akhir kata kami sampaikan terima kasih yang sebesar-besarnya kepada semua pihak yang telah membantu terlaksananya penerbitan ini. Kritik dan saran selalu kami nantikan dari pembaca sekalian demi perbaikan dan kemajuan JIFFK. Wassalamu’alaikum Wr. Wb. Semarang, Desember 2012 Hormat kami Redaksi

UJI SITOTOKSISITAS FRAKSI n-HEKSANA EKSTRAK ETANOL HERBA ALFALFA (Medicago Sativa L.) PADA SEL T47D DAN SEL HeLa SERTA IDENTIFIKASI KANDUNGAN SENYAWA KIMIANYA sri susilowati; anggun claresa; ibrahim arifin
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol.9 No.2 Desember 2012
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTBreast and cervical cancers were the high prevalency, both in the world and Indonesia. This study aimed to determine the cytotoxic activities and its potentcy of n-hexane fraction of ethanol extract alfalfa herb (Medicago sativa L.) in T47D cells and HeLa cells, also identificated its chemical compounds.Extraction was done using ethanol by soxhletation method and then followed fractionation with n-hexane. Cytotoxic assay to get the value of IC50 was carried out by using MTT assay with a series of concentration of fraction 62,5; 125; 250; 500; 1000 μg/ ml. The cytotoxic activities was determined with viability cells from absorbance ELISA reader. Identification of chemical compounds of n-hexane fraction of ethanol extract alfalfa herb was done using chemical reactan and paper chromatography and then was evaluated qualitatively.The results showed that the n-hexane fraction of ethanol extract of alfalfa herb had cytotoxic activities in T47D cells and HeLa cells. The IC50 values were 523,9 μg/ml in T47D cells and 503,5 μg/ml in HeLa cells. The chemical compounds of n-hexane fraction of ethanol extract of alfalfa herb were coumarin and flavonoid.Key words : cytotoxic assay, n-hexane fraction of ethanol extract of herb alfalfa, Medicago sativa L., T47D cells, HeLa cells, flavonoid, coumarin

AKTIVITAS ANTIDIARE EKSTRAK ETANOL DAUN RANDU (Ceiba petandra L. Gaern.) PADA MENCIT JANTAN GALUR Balb/C yance yance; risha fillah fithria; Yulia Ayu Purnamasari; Kusuma Arum Ningsih; Andri Geger Noviantoro; Suharjono Suharjono
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol.9 No.2 Desember 2012
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTTraditionally, cottonwood's leaves have been used to treat diarrhea. The objective of the study was to investigate antidiarrheal properties of cottonwood’s leaves ethanol extract (EEDR). In addition, this study also wants to reveal the action mechanism of EEDR as antidiarrheal through its activities as antisecretory and antimotility in Balb/C strain male mice. An experimental study performed with randomized matched two-group post test only design approach. EEDR (200-800) mg/kg BW was administered orally to three groups of mice to evaluate the activity of extract as antidiarrheal and antisecretory on castor oil induced diarrhea model in mice. To evaluate the extract as antimotility, EEDR (1.0, 2.0 and 4.0) g/kg BW was provided orally to Balb/C strain male mice. Two other groups received NaCl 0.9 % 20 mL/Kg BW and Loperamide HCl 50 mg/Kg BW. The results showed the EEDR have pharmacological effects as antidiarrhea on Balb/C strain male mice with a mechanism of action as antisecretory and antimotility. The results of this study have been successfully providing the scientific basis of the use of cottonwood’s leaves as antidiarrhea by Indonesian people.Key words : cottonwood’s leaves ethanol extract, castor oil, antidiarrhea, antisecretory

UJI AKTIVITAS IMUNOSTIMULATOR FRAKSI AIR DARI EKSTRAK ETANOL KELOPAK BUNGA ROSELLA (Hibiscus sabdariffa L.) TERHADAP PROLIFERASI SEL LIMFOSIT MENCIT GALUR SWISS SECARA IN VITRO BESERTA IDENTIFIKASI KANDUNGAN KIMIANYA Oktarina Heni Puspitowati; Maria Ulfah; Ediati Sasmito
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol.9 No.2 Desember 2012
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTRoselle calyx has been used as traditional medicine for generations. The content of phenols and flavonoids in the roselle calyx thought to have immunostimulatory effects. This study aims to determine the immunostimulatory activity in vitro and to identified phenolic and flavonoids compounds in the water fraction of roselle (Hibiscus sabdariffa L.) calyx ethanol extract.Powder of roselle calyx macerated with 96% ethanol. The extract were obtained partitioned gradually with n-hexana, ethyl acetate, and water. Immunostimulatory activity test was done according to MTT Assay with series of water fraction at concentration 10, 20, 50,100, 200, 400 μg/mL and positive control PHA 10 μg/ml against to lymphocyte cell culture. Optical Density (OD) data was statistically analyzed by Oneway ANOVA followed Tukey test (p<0.05). Identification of phenolic and flavonoids compounds in roselle calyx done by Thin Layer Chromatography (TLC).The results of statistical analysis showed that water fraction have immunostimulatory activity against lymphocyte proliferation at a concentration of 400 μg/mL were significantly different compared to the positive control and the cells control (p<0.05). TLC test results showed that the fraction contained phenols and flavonoids.Key words : roselle (Hibiscus sabdariffa L.) calyx, MTT Assay, immunostimulatory, phenolic and flavonoid.

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