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INDONESIA
IDJP (Indonesian Journal of Pharmaceutics)
Published by Universitas Padjadjaran
ISSN : -     EISSN : 25978748     DOI : -
Core Subject :
The Indonesian Journal of Pharmaceutics (IdJP) is an established international journal for pharmaceutical scientists concerned in all fields of pharmaceutical sciences, including pharmaceutical preformulation, formulation, manufacturing technologies, drug delivery systems, biopharmaceutics, and pharmacokinetics for drugs, vaccines and biologicals. IdJP also includes pharmaceutical engineering and industrial pharmacy topics.
Arjuna Subject : -
Articles 5 Documents
 1 
Search results for , issue "Vol 3, Issue 1, Jan - April 2021" : 5 Documents clear
Mini Review : Sedem System as a Tool to Characterize Excipients in Solid Dosage Form Iyan Sopyan; Rizka Guntina Khairunisa
Indonesian Journal of Pharmaceutics Vol 3, Issue 1, Jan - April 2021
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v3i1.34038

Abstract

SeDem System is a new system that can be applied in solid dosage form preformulation studies of medicines. It have parameters to evaluates critical quality attributes of materials that have an impact on final drug product’s quality. SeDeM studies could be used as a method for identifying the best excipient and calculating the maximum amount of excipient required for formulation. SeDeM method can , providing formulation with the lowest amount of excipients as it combines the Active Pharmaceutical Ingredients (API) with only one excipient and the standard formula of lubricants, thus avoiding the used of unnecessary excipients, such as diluents, binders and agglutinants. The information given by the SeDeM system contributes to a quality by drug design development.Keywords: SeDeM System, Excipients
Veterinary Drug Development from Indonesian Herbal Origin: Challenges and Opportunities Yedi Herdiana; Nasrul Wathoni; Sriwidodo Sriwidodo; I Ketut Madite Adnyane
Indonesian Journal of Pharmaceutics Vol 3, Issue 1, Jan - April 2021
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v3i1.33632

Abstract

Herbal medicine is increasingly being used in human and veterinary medicine to reduce and prevent minor ailments and support conventional treatment using allopathic medicine. The medicinal properties of the plants used in phytotherapy are due to the large number of active compounds found in the plant kingdom. The active compounds extracted from the plant is often equivalent to a synthetic drug according to its therapeutic efficacy; thus, they are used in veterinary medicine, primarily as antibacterial, antimycotic, antiparasitic, disinfect, and immunostimulant.pharmaceutical quality, ensuring safety, specific standards of purity, and consistency. These standards apply throughout the production and formulation process. This review describes the development of herbs that can be used as veterinary drugs with the possibility of dosage form technology. Veterinary dosage forms show great promise for the future of the herbal veterinary delivery system.Keywords: Veterinary drug, herbal medicine, dosage form, drug delivery. 
Plant Extract Loaded Nanoparticles Patihul Husni; Zelika Mega Ramadhania
Indonesian Journal of Pharmaceutics Vol 3, Issue 1, Jan - April 2021
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v3i1.34032

Abstract

Plant extract, a natural source containing complex mixture of compounds, offers many properties such as antiparasitic, antibiotic, antioxidant, anti-hypertensive, antiviral, insecticide, anticancer, antifungal, hypoglycemic properties. Recent research has been focused on developing formulation the plant extracts not only to deliver them safely but also to enhance its therapeutic efficacy. Nanotechnology-based strategies have been proposed as a system that can be used to formulate plant extracts. Plant extract loaded nanoparticles (NPs) is aimed to facilitate in crossing the biological barriers, to increase bioavailability of poorly water-soluble phytochemicals, to encapsulate mixture compounds of different phytochemicals, to provide targeted delivery of phytochemicals to specific organs resulting in low toxicity, to get effective purification process,  to mask unpleasant taste and odor, to protect sensitive phytochemicals from biological (e.g. enzyme, pH) and environmental (e.g. light, temperature, humidity) degradation, to control release of encapsulated phytochemicals, and to provide a more flexible control over the size and shape of the NPs. This review is focused on plant extract loaded NPs including its advantages, stages for developing formulation of plant extract loaded NPs, and nanosystem used to loading plant extract. In addition, this review also depicts studies which have been conducted by many researchers in developing plant extract loaded NPs. The data were collected from published journals with 21 and 39 journals as primary and supporting literatures, respectively. Plant extracts loaded NPs could be a promising delivery system for active phytochemical contained in the plant extract which is not only to deliver them safely but also to enhance its therapeutic efficacy.Keywords: plant, extract, nanoparticle
Peel Off Gel Mask containing Green Tea Leaf Extract (Camellia sinesis L) with Antioxidant Activity Anis Yohana Chaerunisaa; Emma Surachman; Zila Khuzaimah
Indonesian Journal of Pharmaceutics Vol 3, Issue 1, Jan - April 2021
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v3i1.30946

Abstract

Peel off mask has been very popular and preferred due to its ease in application. Gel base has been preferred for its cold and moist sensation during application. When herbal ingredients such as extract is  introduced into gel formulation, the stability then will become an issue. The aim of the study was to formulate the peel-off mask gels containing green tea leaves extract (Camellia sinensis L.) which effective, stable, and safe to be used. The antioxidant study was conducted by using  Diphenylhydrazylpicryl (DPPH) method. The peel-off mask gel formula were Hidroxypropyl Methylcelulosa (HPMC) as gel base at 0.5% concentration and plasticizer Polyvinyl Alcohol (PVA) at concentration of 12%. Evaluation of peel-off mask gel included observation on pH, viscosity, dispersing power, and drying time during the 90 days of storage at room temperature. The IC50 values of the green tea (Camellia sinensis L.) extract was 5.511 ppm. The concentration of green tea leaves extract in the preparation were 1x IC50 (F1); 2x IC50 (F2)  and 3x IC50 (F3). The result showed that all preparations were stable in the aspect of consistency, color, and odor. Viscosity, drying time and dispersing power remained unchanged after 90 days of storage. The pH value changed, but still in the range of acceptable pH of topical preparations. The results of antioxidant activity study showed that formula F3 (peel-off mask gels with 3 x IC50 of green tea extracts) had the highest antioxidant activity.Keywords: antioxidant, Camellia sinensis L., peel off gel masks, green tea
Pharmaceutical Industrial Waste Regulation in Five Countries in Asia Luthfia Azzahra; Nyi Mekar Saptarini
Indonesian Journal of Pharmaceutics Vol 3, Issue 1, Jan - April 2021
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v3i1.33383

Abstract

The pharmaceutical industry produces a various toxic wastes. Generated waste increases the risk of environmental and ecosystem pollution. It is necessary to have proper waste management to prevent waste pollution to the environment. In 1999, WHO published “Guidelines for the Safe Disposal of Unwanted Pharmaceuticals in and after Emergencies”, that contain treatments and safe disposal method, which is appropriate for any country. Many countries had developed and published regulations and guidelines on waste management. This article aimed to review the handling of pharmaceutical industrial waste in five countries in Asia. This review included studies from ProQuest, Crossref, and Google Scholar.  The pharmaceutical industries in Indonesia, India, Japan, Thailand, and China has their own state regulations in order to protect the environment. They also had implemented pharmaceutical industrial waste management following their regulation and guidelines. The method used to treat the waste is similar with WHO guideline. Some factors affecting the country regulations are the insufficient of land and waste management facilities, lack of awareness, low penalties, limited infrastructures, lack of waste testing facilities. The challenge in the future to handle pharmaceutical waste are increasing waste volume, decreasing land for waste management, sewer methods may contaminate water, possible air pollution due to incineration, so it is necessary to have more advanced methods in waste management that are safe for the environment and humans.Keywordz: Industry, Pharmaceutical, Waste Regulation, Asia

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