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INDONESIA
IDJP (Indonesian Journal of Pharmaceutics)
Published by Universitas Padjadjaran
ISSN : -     EISSN : 25978748     DOI : -
Core Subject :
The Indonesian Journal of Pharmaceutics (IdJP) is an established international journal for pharmaceutical scientists concerned in all fields of pharmaceutical sciences, including pharmaceutical preformulation, formulation, manufacturing technologies, drug delivery systems, biopharmaceutics, and pharmacokinetics for drugs, vaccines and biologicals. IdJP also includes pharmaceutical engineering and industrial pharmacy topics.
Arjuna Subject : -
Articles 5 Documents
 1 
Search results for , issue "Vol 4, Issue 1, Jan - April 2022" : 5 Documents clear
Review: Methods for Enhancing Solubility of Carvedilol Iyan Sopyan; Rania Talinta L; Nurdiani Adiningsih; Norisca Aliza Putriana; Sandra Megantara2 Megantara
Indonesian Journal of Pharmaceutics Vol 4, Issue 1, Jan - April 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i1.39321

Abstract

The oral route of administration is the most frequently used route of drug administration and is generally the most convenient for patients. For an oral drug to be effective, a therapeutic concentration in the blood must be achieved. Solubility in water and permeability of active pharmaceutical ingredients are often used as the main conditions for rapid and complete absorption and high bioavailability. Carvedilol is beta blockers that works as an antihypertensive drug and included in biopharmaceutical classification system (BCS) class II with high permeability but low solubility. Due to this, the goal of this review is to go through a few different methods for increasing solubility of carvedilol. dissolution, and bioavailability. Various solubility enhancement techniques have been applied to carvedilol, including co-crystallization, liquidsolid technique, cyclodextrin inclusion complex, nanoparticles, hydrotrophy, nanosuspension, solid dispersion, nanoemulsion, and dendrimers. These techniques have been shown to increase the solubility and dissolution rate of carvedilol thereby increasing its bioavailability.Keyword: carvedilol, solubility enhancement, BCS class II
Review: Implementation of Overall Equipment Effectiveness (OEE) Based on Lean Manufacturing Tools in the Indonesian Pharmaceutical Industry Prilly Mutiara Sandy; Nasrul Wathoni
Indonesian Journal of Pharmaceutics Vol 4, Issue 1, Jan - April 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i1.38707

Abstract

Increasing production in the industry is important to face the current global competition. Therefore, a performance measurement system is needed for the manufacturing process. Overall Equipment Effectiveness (OEE) is a method for monitoring and improving the efficiency of manufacturing processes. In this article, overall equipment effectiveness (OEE) is described as one of the performance measurement tools that measure different types of production losses and shows areas of process improvement. The analysis is done on how OEE evolved leads to other tools such as the performance of the total equipment effectiveness, such as the effectiveness of production equipment, the effectiveness of the overall plant, and the effectiveness of the asset as a whole. OEE consist of three metric measurement; availability, performance, and quality. Purpose of review articles is to apply these metrics to compare the efficiency and effectiveness of production activity in pharmaceutical industry and to categorize the highly occurence of loss productivity in the production activity that takes place in industry, especially pharmaceutical industry. This review included studies published in ScienceDirect database with the keyword “Lean Manufacturing” and “Overall Equipment Effectiveness”. The results obtained from study of the primary source is the OEE can be used to optimize the production process in the industry, especially the pharmaceutical industry, because this method can produce products efficiently and with the good quality of products that leads to consumer’s satisfactory.
Effect Of The Stopping Stripping Production Line To OEE (Overall Equipment Effectiveness) Of The Stripping Machine On The Primary Packaging Processes In The Pharmaceutical Industry Kelvin Fernando Pratama; Anis Yohana Chaerunisaa
Indonesian Journal of Pharmaceutics Vol 4, Issue 1, Jan - April 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i1.39062

Abstract

Increased production output is the main priority in the pharmaceutical industry. Productivity of primary packaging process which plays an important role in producing output can be improved and maintained by conducting regular OEE (Overall Equipment Effectiveness) analysis of the machinery and processes. OEE is a calculation method that is carried out thoroughly to identify the level of productivity and performance of machines or equipment. The OEE consists of three main measurements, namely availability, performance, and quality. In this study, line stop activities were observed during the primary packaging process that affected the OEE value of stripping machines in one of the pharmaceutical industries in the city of Jakarta. Research is carried out by observing, recording, and processing data related to primary packaging processes such as line stops and the number of products produced. Based on our study, we found that most of the line stops in the primary packaging process are caused by the changing of the polycellonium of the primary packaging material. Thus, we conclude that reducing changing of the polycellonium time from 10 minutes to 5 minutes will be beneficial to increase the operating time by 8% and increase the OEE value by 5%.Keywords: Primary Packaging Process, Overall Equipment Effectiveness (OEE),  Stripping Machine, Net Operating Time
Utilization of 1-(3-aminopropyl)-imidazole in development of pH-sensitive nanocarrier for anticancer drug delivery Patihul Husni Husni; Norisca Aliza Putriana
Indonesian Journal of Pharmaceutics Vol 4, Issue 1, Jan - April 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i1.40691

Abstract

pH-sensitive nanocarriers have demonstrated as successful drug carriers due to the higher drug accumulation at the tumor site by pH dependent release at acidic tumor microenvironment. Imidazole can be utilized to obtain the pH-sensitive nanocarriers. One of imidazole-based compounds used by researchers in development of pH-responsive carriers is 1-(3-Aminopropyl)-imidazole. This review is focused on utilization of 1-(3-aminopropyl)-imidazole to develop pH-sensitive nanocarrier especially for delivery of anticancer drug. In addition, this review also shows research performed by researchers to develop pH-sensitive nanocarrier for anticancer drug delivery using 1-(3-aminopropyl)-imidazole to prepare imidazole-based pH-sensitive nanocarriers. The data were collected from published journals with 15 and 20 journals as primary and supporting literatures, respectively. Properties of imidazole groups to deprotonate at pH 7.4 and protonate at pH ≤ 6.5 implies that the drug release was pH-dependent, leading to limited release of drug from carriers under physiological pH conditions and diminishing the drug’s effect in blood circulation before reaching the tumor site, resulting in more effective anticancer activity.
Formulation and Evaluation Of Black Garlic (Allium Sativum L.) Lozenges As An Antioxidant Supplement Norisca Aliza Putriana; Efri Mardawati; Yoga Windu Wardhana; Ismiatun Ismiatun; Anting Wulandari; Dwi Wahyudha Wira; Nanang Masruchin
Indonesian Journal of Pharmaceutics Vol 4, Issue 1, Jan - April 2022
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v4i1.40477

Abstract

Free radicals are species of reactive chemical compounds that can cause degenerative diseases. Antioxidants work to deactivate free radicals by binding to these radicals to stabilize the radicals. One of the plants that contain antioxidants is black garlic. This study aimed to obtain the best formula from the preparation of lozenges of black garlic extract using the wet granulation method as an antioxidant supplement. The formula optimization was carried out using a statistical approach with a two-level factorial method using expert design software. The lozenges formula was made using wet granulation method. The granules and tablets were evaluated for its characteristic. Besides, the levels of polyphenols and antioxidant activity of the extracts and lozenges were also determined. The best formula is F2 obtained from a ratio of gum arabic and starch pregelatin of 3: 5 with a desirability value of 0.922. The Evaluation of black garlic extract granules is eligible, including the moisture content of 2.04%, an excellent flow rate is 18.3 g/s, and good compressibility of 9%. The uniformity of lozenge weight obtained is eligible, which is 3%. The hardness and disintegration time of  9.1 kg and 11.28 minutes, respectively. Meanwhile, the antioxidant activity of the extract and lozenges was 263 µg/mL and 323.9 µg/mL, respectively. The best formula obtained is with 3% gum arabic and 5% starch pregelatin.Keywords: Antioxidant, Black Garlic, Design expert, Lozenges 

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