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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Journal of Tropical Pharmacy and Chemistry Jurnal Mandala Pengabdian Masyarakat Borneo Journal of Pharmacy
Kamaruddin, Harni Sartika
Program Studi Farmasi, Fakultas Sains Dan Teknologi, Universitas Sembilan Belas November Kolaka
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Aktivitas Antioksidan dan Penghambatan Xantin Oksidase Kulit Batang Songi (Dillenia serrata Thunb.): Antioxidant and Xanthine Oxidase Inhibitory Activity of Stem Bark of Songi (Dillenia serrata Thunb.) Carla Wulandari Sabandar; Juriyati Jalil; Norizan Ahmat; Nor-Ashila Aladdin; Harni Sartika Kamaruddin; Retno Wahyuningrum
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 6 No. 1 (2020): (March 2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (431.256 KB) | DOI: 10.22487/j24428744.2020.v6.i1.15008

Abstract

Songi (Dillenia serrata) is a tree endemic to Southeast Sulawesi and its stem bark been used in folk medicine. Nonetheless, only a handful scientific knowledge regarding chemistry and biological activities has been investigated on the plant. The present study aimed to investigate the antioxidant and xanthine oxidase (XO) inhibitory activity of the stem bark of the plant. Methanol extract and organic fractions (petroleum ether, ethyl acetate, and methanol) of the dried powdered stem bark of songi were evaluated for phytochemical screening, total phenolic (TPC), total flavonoid contents (TFC), DPPH, FRAP, and XO in vitro assays. Flavonoids, tannins, terpenoids, steroids, and saponins present in the extract. TPC and TFC in extract were 59.2 mg GAE/g and 23.4 mg QE/g. The contents in organic fractions were in solvent-dependent manner (methanol>ethyl acetate>petroleum ether). Extract and fractions scavenged DPPH radicals (48.2–59.7%) at 100 μg/mL compared to ascorbic acid, trolox, and gallic acid (90.3–93.8%). FRAP values varied from 0.8–3.4 μg/μg equivalent trolox amount (quercetin and gallic acid were 25.7 dan 32.4 μg/μg, respectively). They also inhibited xanthine oxidase (15.3–50.3%) at 100 μg/mL (allopurinol, 98.2%). The study concluded the potential of methanol extract and organic fraction of the stem bark of songi, thus highlighted the prospect of songi to be used in herbal and drugs development from nature.
Determination of Polyphenol Content in Sawo Fruit (Manilkara zapota) Based on Geographical Location Harni Sartika Kamaruddin; Angriani Angriani; Carla Wulandari Sabandar
Journal of Tropical Pharmacy and Chemistry Vol. 5 No. 3 (2021): Journal of Tropical Pharmacy and Chemistry
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v5i3.300

Abstract

Background: Sawo fruit (Manilkara zapota (L.) P.Royen) is rich in antioxidant compounds like polyphenols, and has long been used to treat diarrhea and thypoid by natives of Toari and Langori villages of Kolaka district of Southeast Sulawesi Province. Both villages located at different geographical location according to their altitudes from the sea level. The polyphenols content of sawo fruit from these villages that has a correlation with its antioxidant activity has yet investigated and thus need more research. Objective: This study was aimed to determine the content of polyphenols in sawo fruit based on geographical growth difference, that are Toari and Langori villages. Material and Methods: The fruits were collected from two locations of the Kolaka district that are Langori and Toari villages. The polyphenols content in the methanol extract of Sawo fruit was determined qualitatively using FeCl3 and quantitatively using the Folin-Ciocalteu reagent measured by UV-Visible spectrophotometry. Gallic acid was used as the standard polyphenol of the assay. Results: The polyphenols content of sawo fruit from Langori found to be 1.48113 mg/g, while fruits from Toari contained 1.55747 mg/g of polyphenolics. Conclusion: The study showed that there was an influence of the geographical growth on the content of polyphenolics of sawo fruits.
Inventarisasi dan Penanaman Bibit Tanaman Obat Bagi Masyarakat di Kelurahan Mangolo, Kabupaten Kolaka Carla Sabandar; Muh. Syahruddin; Rina Rembah; Harni Sartika Kamaruddin; Retno Wahyuningrum; Evodius Nasus; Abdul Gani Baeda; Rizki Kumalasari; Megawati Megawati; Muhamad Jalil Baari; Ica Aprilia Seleng; Khafidzah Yusuf; Muh. Ansar Azali; Muhammad Rayzhal Faturahman; Nun Ainun Arap; Nur Afifa; Nurliana Nurliana; Rezkiya Nur Insani; Rina Hardianti Pratiwi; Sri Gita Handayani; Susianti Susianti; Wahyuni Hakim; Yayang Rahmadani
Jurnal Mandala Pengabdian Masyarakat Vol. 3 No. 2 (2022): Jurnal Mandala pengabdian Masyarakat
Publisher : Progran Studi Farmasi STIKES Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1238.09 KB) | DOI: 10.35311/jmpm.v3i2.78

Abstract

Pemanfaatan tanaman obat secara tradisional oleh masyarakat Kolaka telah berlangsung selama turun-temurun. Namun, hingga saat ini upaya pembinaan asuhan mandiri pemanfaatan taman obat keluarga masih belum giat dilakukan. Sebagai langkah awal program pembinaan, pengabdian ini bertujuan untuk melakukan inventarisasi tanaman obat dan penanaman bibit tanaman obat yang digunakan oleh masyarakat di Kelurahan Mangolo yang secara geografis merupakan wilayah taman wisata alam Kolaka. Kegiatan yang dilakukan meliputi survei potensi wilayah, identifikasi permasalahan, koordinasi dan perizinan, inventarisasi tanaman obat, pelatihan pembuatan pupuk alami, perbanyakan bibit dan pemeliharaan tanaman obat, penanaman bibit secara serentak, monitoring, dan evaluasi kegiatan. Kegiatan pengabdian menghasilkan inventarisasi tanaman obat sebanyak 49 tanaman dan penanaman bibit tanaman obat sebanyak 297 bibit oleh masyarakat Kelurahan Mangolo. Melalui kegiatan ini, masyarakat memperoleh pengetahuan, keterampilan, dan motivasi untuk membudidayakan tanaman obat secara mandiri dan berkelanjutan sebagai wujud kesadaran terhadap kesehatan bagi diri sendiri dan keluarga.
Chemical Constituents and Antioxidant Activity of Melothria scabra Naudin Fruits Harni Sartika Kamaruddin; Megawati Megawati; Nurliana Nurliana; Carla Wulandari Sabandar
Borneo Journal of Pharmacy Vol. 4 No. 4 (2021): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v4i4.2890

Abstract

The fruit of Melothria scabra Naudin is traditionally used by natives of South East Sulawesi and has economic values in the local markets. Nonetheless, little scientific information was gained from this plant to support its development for nutraceutical and pharmaceutical aspects. This study aimed to investigate the phytochemicals contained in the ethanol extract and organic fractions (methanol, ethyl acetate, and hexane) of the fruits using specific reagents and an LC-MS/MS analysis, as well as to evaluate their total phenolics, total flavonoids, and DPPH radical scavenging activity using a dot-blot staining and spectrophotometric assays. Results showed that the fruits of M. scabra contained alkaloids, tannins, flavonoids, terpenoids, and saponins. Six compounds were successfully identified from the ethanol extract of the fruits for the first time that is D-1-[(3-carboxypropyl)amino]-1-deoxyfructose (1), fructose-C3H5NO (2), valine (3), 1β, 3α, 9β-trihydroxyeudesma-5,11(13)-dien-12-oic acid (4), Cucurbitacin B-2-O-α-L-rhamnopyranosyl-β-D-glucopyranoside (5), and 2-heptyl-3-hydroxy-4(H)-quinolone (6). Total phenolics in the extract and organic fractions were in the range of 54.2 ± 2.4 to 259.1 ± 8.4 mg GAE/g, while total flavonoids were in the range of 1.6 ± 0.2 to 22.4 ± 0.2 mg QE/g. The ethanol extract and its organic fractions (methanol and ethyl acetate) were potent radical scavengers with SC50 values ranging from 20.7 to 37.5 µg/mL when compared with ascorbic acid, gallic acid, and quercetin (SC50 of 2.8 to 9.4 µg/mL). This study concludes that M. scabra fruits could be developed as a source of natural antioxidant agents for nutraceuticals and pharmaceuticals purposes.
Tentative Identification of Compounds, Antioxidant, and Antimicrobial Activity of the Edible Part of Benincasa hispida L. fruit (Cucurbitaceae) Carla Wulandari Sabandar; Harni Sartika Kamaruddin; Reskiya Nur Insani; Rana Triana Amin; Zulkifli Zulkifli; Tien Tien
Borneo Journal of Pharmacy Vol. 6 No. 2 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i2.4350

Abstract

The edible part of Benicasa hispida (Thunb.) Cogn. fruit is traditionally used in Southeast Sulawesi to treat high blood pressure, typhoid fever, and body cooling. The present study evaluated the chemical compounds present in the 80% ethanol of the edible part of the plant using phytochemical screening and an LC-MS analysis, antioxidant activity based on assays on total phenolics content (TPC), total flavonoids content (TFC), and DPPH, and antimicrobial activity towards Salmonella typhi, Escherichia coli, Staphylococcus aureus, and Candida albicans. Phytochemical screening revealed the presence of tannins, flavonoids, terpenoids, steroids, and saponins in the extract. As many as eighteen compounds (1-18) were tentatively identified in the extract, including sugars, a simple phenolic, a tricarboxylic acid, a peptide, flavonoids, quinic acid derivatives, phytosterols, triterpenoids, and saponins. The extract exhibited remarkable antioxidant activity with an SC50 value of 23.4 µg/mL, although its TPC (1.1±0.1 mg GAE/g extract) and TFC (1.0±0.1 mg QE/g extract) values were considered in low amounts. The extract was found inactive to inhibit the microbial growths of all tested microbes. However, raffinose (3) present in the extract might be beneficial as a prebiotic to promote a healthy human gut. The study concludes that the 80% ethanol extract of the edible part of B. hispida fruit could be used to develop natural antioxidant agents and nutraceuticals.
Co-Authors Abd Gani Baeda Angriani Angriani Carla Sabandar Carla Wulandari Sabandar Evodius Nasus Ica Aprilia Seleng Juriyati Jalil Khafidzah Yusuf Megawati Megawati Muh Syahruddin Muh. Ansar Azali Muhamad Jalil Baari Muhammad Rayzhal Faturahman Nor-Ashila Aladdin Norizan Ahmat Nun Ainun Arap Nur Afifa Nurliana Nurliana Nurliana Nurliana Rana Triana Amin Reskiya Nur Insani Retno Wahyuningrum Rezkiya Nur Insani Rina Hardianti Pratiwi Rina Rembah Rizki Kumalasari Sri Gita Handayani Susianti Susianti Tien Tien Wahyuni Hakim Yayang Rahmadani Zulkifli Zulkifli