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All Journal BioWallacea Journal of Biological Research Indonesia Chimica Acta Saintifik : Jurnal Matematika, Sains, dan Pembelajarannya JKPK (Jurnal Kimia dan Pendidikan Kimia) Dimasejati: Jurnal Pengabdian Kepada Masyarakat Jurnal Mandala Pengabdian Masyarakat Borneo Journal of Pharmacy
Megawati Megawati
Universitas Sembilanbelas November Kolaka
Agriculture, Biological Sciences & Forestry Humanities Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Veterinary Other

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Uji Toksisitas Ekstrak Metanol Etlingera calophrys Dengan Metode Brine Shrimp Lethality Test (BSLT) Megawati Megawati; Muhamad Jalil Baari; Carla Wulandari Sabandar
BioWallacea : Jurnal Penelitian Biologi (Journal of Biological Research) Vol 8, No 2 (2021): Biodiversitas Wallacea
Publisher : University of Halu Oleo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (588.681 KB)

Abstract

Pada penelitian ini, dilakukan skrining fitokimia utuk menganalisis kandungan metabolit sekunder/senyawa aktif dalam ekstrak metanol bagian-bagian tumbuhan Etlingera calophrys yang meliputi daun, buah, batang, dan rimpang, yang dilanjutkan dengan pengujian aktivitas sitotoksisitasnya. Skrining fitokimia dilakukan untuk memastikan adanya kandungan senyawa aktif, sedangkan uji sitotoksisitas dilakukan dengan metode Brine Shrimp Lethality Test menggunakan larva Artemia salina. hasil skrining menunjukkan adanya senyawa alkaloid, flavonoid, fenolik, terpenoid/steroid, dan saponin yang tersebar di seluruh bagian Etlingera calophrys dengan bagian batang mengandung paling banyak senyawa metabolit sekunder. Sementara itu, berdasarkan hasil analisis sitotoksisitas, diketahui nilai LC50 pada jaringan daun, buah, batang, dan rimpang masing masing yaitu 65.2 ± 8.9 ppm, 65.7 ± 6.4 ppm, 132.3 ± 12.8 ppm, dan 84.1 ± 10.3 ppm. Hasil tersebut menunjukkan bahwa Etlingera calophrys berpotensi sebagai antioksidan/antikanker alami sekaligus menjadi pilihan alternatif obat di masa yang akan datang.
Synthesis Of Glycerol Carbonate From Glycerol And Urea Using Limestone As Catalyst Source Megawati Megawati
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 12, No 2: December 2019
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v12i2.8096

Abstract

Synthesis of Glycerol carbonate from glycerol and urea using limestone as a catalyst has been conducted. This study aims to make glycerol carbonate from glycerol and urea by utilizing scattered natural limestone widespread in Southeast Sulawesi as a catalyst source. The catalyst was obtained from the calcination of natural limestone to decompose CaCO3 to CaO. This condition added to glycerol and urea to test the catalyst activity. Synthesis of glycerol carbonate was carried out through the carbamoylation reaction of glycerol with urea. The advantage of this method is the reaction carried out with free solvents and running in ambient pressure (1 atm). The stages of catalyst testing in the reaction of glycerol carbonate formation were carried out by reacting glycerol, urea, and calcined limestone  with  1: 1 substrate mole ratio with a catalyst concentration of 5% mass over glycerol. Characterization used was Fourier Transform Infrared Spectroscopy (FTIR) and supported by Gas Chromatography (GC) data. Optimization catalysis reaction was obtained at a temperature of 140oC for 4 hours and  using a catalyst mole ratio to 5% substrate
Review: Phytochemical Screening, Secondary Metabolites and Biological Activities of Southeast Sulawesi Plants Megawati Megawati
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 13, No 2: December 2020
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v13i2.11138

Abstract

Southeast Sulawesi is one of the provinces in Indonesia which has a variety of medicinal plants that have been used by its people in treating diseases. The results of research on phytochemical screening and isolation of secondary metabolites from local researchers indicated that the plants from Southeast Sulawesi have the potential to be studied further. Plants from Southeast Sulawesi show pharmacological potential activities that can be developed for the purpose of treating diseases caused by bacteria, fungi, cancer, and as an antioxidants. There are Southeast Sulawesi endemic plants from the Etlingera genus that are interesting to explore (phytochemical screening, isolation of pure compounds and pharmacological studies) considering that of the 14 species of Etlingera plants scattered in Southeast Sulawesi, 2 (two) of which have recently been reported, namely E. elatior and E. calophrys
Komposisi Kimia Batu Kapur Alam dari Indutri Kapur Kabupaten Kolaka Sulawesi Tenggara Megawati Megawati; Alimuddin Alimuddin; Laode Abdul Kadir
SAINTIFIK Vol 5 No 2 (2019): Saintifik: Jurnal Matematika, Sains, dan Pembelajarannya
Publisher : Universitas Sulawesi Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (427.482 KB) | DOI: 10.31605/saintifik.v5i2.230

Abstract

Potensi sumber daya mineral kabupaten Kolaka hampir tersebar diseluruh kecamatan. Ini dibuktikan dengan adanya beberapa perusahaan tambang yang beroperasi di kabupaten Kolaka. Salah satu mineral yang ada di kabupaten Kolaka adalah batu kapur atau yang biasa dikenal dengan istilah batu gamping. Batu kapur ialah jenis batuan sedimen yang umumnya mengandung senyawa karbonat terutama Kalsium Karbonat (CaCO3). Pada umumnya batu kapur diolah untuk bahan campuran bangunan, industri, serta bahan kimia bagian sektor katalis. Analisis komposisi batu kapur dari kabupaten Kolaka telah dilakukan dalam penelitian ini. Hal ini dilakukan untuk mengetahui kualitas batu kapur alam Kolaka agar kedepannya bisa menjadi bahan pertimbangan untuk dimanfaatkan lebih lanjut. Hasil analisis menggunakan X-Ray Fluorescence (XRF) menunjukkan komposisi mineral yaitu CaO, CaCO3 , Al2O3, SiO2, CaO, Fe2O3, MgO , Cr2O3 , Fe2O3, K2O, MnO, Na2O, P2O5, ZnO, SO3 dan TiO2.
Inventarisasi dan Penanaman Bibit Tanaman Obat Bagi Masyarakat di Kelurahan Mangolo, Kabupaten Kolaka Carla Sabandar; Muh. Syahruddin; Rina Rembah; Harni Sartika Kamaruddin; Retno Wahyuningrum; Evodius Nasus; Abdul Gani Baeda; Rizki Kumalasari; Megawati Megawati; Muhamad Jalil Baari; Ica Aprilia Seleng; Khafidzah Yusuf; Muh. Ansar Azali; Muhammad Rayzhal Faturahman; Nun Ainun Arap; Nur Afifa; Nurliana Nurliana; Rezkiya Nur Insani; Rina Hardianti Pratiwi; Sri Gita Handayani; Susianti Susianti; Wahyuni Hakim; Yayang Rahmadani
Jurnal Mandala Pengabdian Masyarakat Vol. 3 No. 2 (2022): Jurnal Mandala pengabdian Masyarakat
Publisher : Progran Studi Farmasi STIKES Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1238.09 KB) | DOI: 10.35311/jmpm.v3i2.78

Abstract

Pemanfaatan tanaman obat secara tradisional oleh masyarakat Kolaka telah berlangsung selama turun-temurun. Namun, hingga saat ini upaya pembinaan asuhan mandiri pemanfaatan taman obat keluarga masih belum giat dilakukan. Sebagai langkah awal program pembinaan, pengabdian ini bertujuan untuk melakukan inventarisasi tanaman obat dan penanaman bibit tanaman obat yang digunakan oleh masyarakat di Kelurahan Mangolo yang secara geografis merupakan wilayah taman wisata alam Kolaka. Kegiatan yang dilakukan meliputi survei potensi wilayah, identifikasi permasalahan, koordinasi dan perizinan, inventarisasi tanaman obat, pelatihan pembuatan pupuk alami, perbanyakan bibit dan pemeliharaan tanaman obat, penanaman bibit secara serentak, monitoring, dan evaluasi kegiatan. Kegiatan pengabdian menghasilkan inventarisasi tanaman obat sebanyak 49 tanaman dan penanaman bibit tanaman obat sebanyak 297 bibit oleh masyarakat Kelurahan Mangolo. Melalui kegiatan ini, masyarakat memperoleh pengetahuan, keterampilan, dan motivasi untuk membudidayakan tanaman obat secara mandiri dan berkelanjutan sebagai wujud kesadaran terhadap kesehatan bagi diri sendiri dan keluarga.
1H and 13C NMR Study of Oligosuccinimide Prepared by Thermal Condensation and Evaluation of Its Scale Inhibition Muhamad Jalil Baari; Megawati Megawati; Didi Prasetyo Benu
JKPK (Jurnal Kimia dan Pendidikan Kimia) Vol 7, No 3 (2022): JKPK (Jurnal Kimia dan Pendidikan Kimia)
Publisher : Program Studi Pendidikan Kimia FKIP Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jkpk.v7i3.65666

Abstract

The presence of scale is a serious problem in the petroleum industry, and some efforts should be made to control scale formation. Oligosuccinimide (OSI) is an oligomer with several repeating units of succinimide. The structure of the OSI main chain and end groups has never been comprehensively analyzed. Meanwhile, OSI is potentially a scale inhibitor due to chelating properties, high polarity, and high solubility. This study investigates the molecular structure of oligosuccinimide, focusing on the main chain and end groups. Synthesis was carried out by thermal condensation between maleic anhydride and ammonium carbonate using a 1H and 13C NMR spectroscope equipped with Distortionless Enhancement by Polarization Transfer 135, Heteronuclear Multiple Quantum Coherence, and Single Quantum Coherence. The NMR analysis results detected the presence of the main chain and several synthesized OSI end groups, such as the amino, succinimide, and maleimide end groups. However, the dicarboxylic acid end group and other irregular structures, as in polysuccinimide (various synthesis methods), were not identified. It confirmed that our thermal condensation method produced OSI with less irregular structures than previous methods. Evaluation of OSI as CaCO3 and CaSO4 scales inhibitor showed reasonably good performance in very small concentrations. The inhibition efficiency was 73.20% for the CaCO3 scale with 10 mg.L-1 and 55.29% for the CaSO4 scale with 10 mg.L-1 inhibitor concentration. Analysis of thermal stability informed OSI has good thermal stability because it started to be degraded at 353.38 °C.
Implementasi Software Hyperchem sebagai Media Praktikum Elektronik Visualisasi Struktur dan Sifat Senyawa Kimia di SMAN 1 Mawasangka Timur Muhamad Jalil Baari; L A Na’ani; Agusriyadin Agusriyadin; Megawati Megawati; Faradisa Anindita; Alfiah Alif; Salim Salim; Netty Huzniati Andas; Arif Prasetya; Sarimuddin Sarimuddin; Dian Permana
Dimasejati: Jurnal Pengabdian Kepada Masyarakat Vol 5, No 3 (2023): Penguatan Peran Perguruan Tinggi dalam Percepatan Pembangunan Sumber Daya Manusi
Publisher : IAIN Syekh Nurjati Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24235/dimasejati.202353.13507

Abstract

Chemistry is not merely a science that only studies theory in class. Chemistry learning requires practical or experimental activities to observe and directly apply chemical concepts during face-to-face meetings in class. Meanwhile, the unavailability of laboratory facilities is one of the factors in not carrying out chemistry practice. This causes students difficulties in understanding the concept of chemistry as a whole and can potentially reduce learning motivation. This public service activity aims to implement the Hyperchem software for teachers and students of SMA Negeri 1 Mawasangka Timur as an alternative solution for chemistry labs in the form of electronic labs. The chemical topics selected and considered suitable for this type of practice were the structure and properties of chemical compounds. This activity is carried out in the form of a workshop. Workshop materials use lectures, simulations, discussions, and question-and-answer models. The activity's results showed the workshop participants' enthusiasm to use the Hyperchem software as a chemistry lab media. This is reflected in the evaluation of the workshop implementation, which is carried out by assessing the response of the workshop participants based on indicators of relevance, the ability of the presenters, ease of use, availability, and usefulness of the Hyperchem software. The evaluation results show that the workshop and the implementation of the Hyperchem software as an electronic practice media for visualizing the structure and properties of chemical compounds received a positive response from the workshop participants.
Analisis Kualitas Air Sumur Bor Desa Sopura Kecamatan Pomalaa Kabupaten Kolaka Darlin S; Agusriyadin Agusriyadin; Megawati Megawati
SAINTIFIK Vol 9 No 2 (2023): Saintifik: Jurnal Matematika, Sains, dan Pembelajarannya
Publisher : Universitas Sulawesi Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31605/saintifik.v9i2.441

Abstract

Telah dianalisis kandungan kualitas air Desa Sopura Kecamatan Pomalaa Kabupaten Kolaka berdasarkan beberapa parameter. Tujuan penelitian ini yaitu untuk mengetahui kualitas air sumur bor Desa Sopura melalui pengujian parameter kimia, fisika, dan biologi. Parameter kimia berupa pengujian kandungan Chemycal Oxygen Demand (COD), Biologycal Oxygen Demand (BOD), Dissolved Oxygen (DO), besi (Fe), dan Nikel (Ni). Parameter Fisika berupa pengujian Total Suspended Solid (TSS), dan Total Dissolved Solid (TDS). Parameter Biologi berupa pengujian bakteri Coliform. Penelitian ini diawali dengan pengambilan sampel air sumur bor di Desa Sopura Kecamatan Pomalaa Kabupaten Kolaka. Kemudian sampel diuji di Laboratorium. Pengujian sampel dengan parameter kimia dan fisika dilakukan di laboratorum Dinas Lingkungan Hidup Kabupaten Kolaka sedangkan parameter biologi diuji di Laboratotium Dinas Kesehatan Kabupaten Kolaka. Selanjutnya, hasil yang diperoleh dibandingkan dengan Baku mutu yang ada pada regulasi Permenkes No 492 Tahun 2010 Tentang Persyaratan Kualitas Air Minum dan Peraturan Pemerintah No 22 Tahun 2021 Tentang Penyelenggaraan Perlindungan dan Pengelolaan Lingkungan Hidup. Hasil penelitian menunjukkan nilai kandungan DO, BOD, TSS, TDS, besi, dan coliform (B-641/c) pada sampel air sumur bor Desa Sopura, masih belum melewati nilai ambang batas yang ditetapkan pemerintah. Sedangkan nilai COD, nikel, dan Coliform (B-639/a & B-640/b) pada sampel air telah melewati nilai ambang batas yang di tetapkan pemerintah.
A Phytochemical Profile and Acute Toxicity of Meistera aculeata (Roxb). Skornick. & M.F. Newman Fruits (Zingiberaceae) Hendrisno Hendrisno; Megawati Megawati; Agusriyadin Agusriyadin; Sabandar Carla Wulandari
Jurnal Akta Kimia Indonesia (Indonesia Chimica Acta) Volume 16, No 1: June 2023
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/ica.v16i1.26638

Abstract

Meistera aculeata (Roxb). Skornick. & M.F. Newman belongs to the ginger family (Zingiberaceae) and locally known as ‘Susube’ by natives of Konawe district of Southeast Sulawesi. M. aculeata is an endemic plant and its fruit has been consumed by the locals. Until today, study on chemistry and biological activity aspects of M. aculeata has yet investigated. Hence, this research aimed to identify phytochemical contents and acute toxicity of M. aculeata fruits extracted using ethanol as the solvent. Phytochemical screening showed the accumulation of alkaloids, tannins, flavonoids, terpenoids, and saponins in the ethanol extract of M. aculeata fruits. Meanwhile, the Brine Shrimp Lethality Test (BSLT) revealed that ethanol extract of M. aculeata fruits has a weak acute toxicity (LC50 683,9 ppm) when compared with potassium dichromate as the positive control of the assay (LC50 8,3 ppm). The study concluded that M. aculeata fruits could be used in the development of drugs from natural sources.
Chemical Constituents and Antioxidant Activity of Melothria scabra Naudin Fruits Harni Sartika Kamaruddin; Megawati Megawati; Nurliana Nurliana; Carla Wulandari Sabandar
Borneo Journal of Pharmacy Vol. 4 No. 4 (2021): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v4i4.2890

Abstract

The fruit of Melothria scabra Naudin is traditionally used by natives of South East Sulawesi and has economic values in the local markets. Nonetheless, little scientific information was gained from this plant to support its development for nutraceutical and pharmaceutical aspects. This study aimed to investigate the phytochemicals contained in the ethanol extract and organic fractions (methanol, ethyl acetate, and hexane) of the fruits using specific reagents and an LC-MS/MS analysis, as well as to evaluate their total phenolics, total flavonoids, and DPPH radical scavenging activity using a dot-blot staining and spectrophotometric assays. Results showed that the fruits of M. scabra contained alkaloids, tannins, flavonoids, terpenoids, and saponins. Six compounds were successfully identified from the ethanol extract of the fruits for the first time that is D-1-[(3-carboxypropyl)amino]-1-deoxyfructose (1), fructose-C3H5NO (2), valine (3), 1β, 3α, 9β-trihydroxyeudesma-5,11(13)-dien-12-oic acid (4), Cucurbitacin B-2-O-α-L-rhamnopyranosyl-β-D-glucopyranoside (5), and 2-heptyl-3-hydroxy-4(H)-quinolone (6). Total phenolics in the extract and organic fractions were in the range of 54.2 ± 2.4 to 259.1 ± 8.4 mg GAE/g, while total flavonoids were in the range of 1.6 ± 0.2 to 22.4 ± 0.2 mg QE/g. The ethanol extract and its organic fractions (methanol and ethyl acetate) were potent radical scavengers with SC50 values ranging from 20.7 to 37.5 µg/mL when compared with ascorbic acid, gallic acid, and quercetin (SC50 of 2.8 to 9.4 µg/mL). This study concludes that M. scabra fruits could be developed as a source of natural antioxidant agents for nutraceuticals and pharmaceuticals purposes.
Co-Authors Abd Gani Baeda Agusriyadin, Agusriyadin Alfiah Alif Alimuddin Alimuddin Arif Prasetya Benu, Didi Prasetyo Carla Sabandar Carla Wulandari Sabandar Darlin S Dian Permana Evodius Nasus Faradisa Anindita Hendrisno Hendrisno Ica Aprilia Seleng Kamaruddin, Harni Sartika Khafidzah Yusuf L A Na’ani Laode Abdul Kadir Muh Syahruddin Muh. Ansar Azali Muhamad Jalil Baari Muhammad Rayzhal Faturahman Netty Huzniati Andas Nun Ainun Arap Nur Afifa Nurliana Nurliana Nurliana Nurliana Retno Wahyuningrum Rezkiya Nur Insani Rina Hardianti Pratiwi Rina Rembah Rizki Kumalasari Salim Salim Sarimuddin, Sarimuddin Sri Gita Handayani Susianti Susianti Wahyuni Hakim Yayang Rahmadani