This research essentially examines the implications of using Pop Up Book learning tools on the results of a study on the human digestive system in fifth-grade students. The method used is a Nonequivalent Control Group Design with a Quasi-experimental approach, where data from two experimental and control groups are compared. The research sample consists of 60 students, with 28 students in the experimental group and 32 students in the control group. Data was collected using pretest and posttest multiple-choice questionnaires. The output obtained shows that the mean posttest score in the experimental group is 81.11, while in the control group it is 57.59. The results of the t-test hypothesis indicate a Sig. (2-tailed) value of 0.000 < 0.05 for both groups, which means that the null hypothesis (Ho) is rejected, and the alternative hypothesis (Ha) is accepted, indicating the effectiveness of using Pop Up Book learning tools in improving the learning outcomes of fifth-grade students in the subject of the human digestive system at SDN Sunter Agung 01.