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All Journal Jurnal Wiyata : Penelitian Sains dan Kesehatan Journal Of Holistic Nursing Science Jurnal Farmasi dan Sains Indonesia (JFSI) Medical Sains : Jurnal Ilmiah Kefarmasian Pharmacy Genius Ad-dawaa: Journal Of Pharmacy Jurnal Kesehatan Bakti Tunas Husada Daarul Ilmi: Jurnal Pengabdian Kepada Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian
Davit Nugraha
STIKes Muhammadiyah Ciamis
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Formulation and Evaluation of Catfish ( Calias Sp ) Albumin Extract Ointment with Variations of Basis Erik Risnawan; Davit Nugraha
Ad-Dawaa : Journal of Pharmacy Vol. 1 No. 1 (2023): Ad-Dawaa: Journal of Pharmacy (May 2023)
Publisher : LPPM STIKes Muhammadiyah Ciamis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52221/dwj.v1i1.220

Abstract

Catfish (Clarias sp) contains albumin which is an important protein needed by the human body, especially in the process of healing diseases. Giving this catfish extract functions as a nutrient, it is hoped that this nutrition can improve nutrition, increase the immune system and speed up the wound healing process or post surgery. This research is an experimental research, in which the albumin ointment formulation of catfish (clarias sp) extract was carried out, with variations of vaselin flavum and adeps lanae ointment bases in three formulations namely formulation 1, formulation 2 and formulation 3. The results of catfish extract (clarias sp) were then formulated in the form of an ointment. Then an evaluation of physical properties was carried out including organoleptic evaluation, homogeneity test, spreadability test, adhesion test, pH test. The results showed that the albumin extract ointment for catfish (Clarias sp) with variations in ointment base made a difference to the evaluation of albumin extract for catfish (Clarias sp) which included organoleptic tests (soft shape, white to yellow), homogeneity test (has round particles, irregular, no foreign particles), spreadability test (FI, 5.16cm: FII, 5.23cm: FIII, 5.06cm), adhesion test (FI, 3.19 seconds, FII 2.27 seconds, FIII 3.24 seconds), pH test (FI 6, FII 6, FIII 6). The conclusion that the vaseline flavum ointment combined with adeps lanae from catfish albumin extract meets the quality consists of an evaluation. homogeneity test, organoleptic test, adhesion test, spreadability test and pH test.
Albumin Identification in Catfish ( Clarias sp ) Using Spectrophotometry UV-VIs Perti Fitriani; Davit Nugraha
Ad-Dawaa : Journal of Pharmacy Vol. 1 No. 1 (2023): Ad-Dawaa: Journal of Pharmacy (May 2023)
Publisher : LPPM STIKes Muhammadiyah Ciamis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52221/dwj.v1i1.223

Abstract

Albumin is a simple protein with globular protein molecules. Albumin is water soluble and can be coagulated with heat. Albumin solution in water can be precipitated by adding ammonium sulfate until saturated. Albumin functions to regulate the osmotic pressure in the blood, maintain the presence of water in the blood plasma so that it can maintain the volume of blood in the body and as a means of transportation and transportation. Catfish contains 15.6 grams of high-quality protein in each fish so that it can meet the needs of the amino acids needed by the body. The high-quality protein in catfish helps the body build lean brain mass and the protein content in catfish also helps increase the effectiveness of immune function. The purpose of this study was to determine albumin levels in catfish by extracting catfish meat using the oven method and determining the maximum albumin wavelength. In the identification test with the heating method and UV-Vis spectrophotometry test. This research method uses the experimental method. The extraction results were then heated in an oven to observe coagulation and determine the wavelength using UV-Vis spectrophotometry using Bovine Serum Albumin (BSA) as a reference solution and Bromocressol green as a reagent. The conclusion of this study is that catfish meat extract was coagulated using the oven method and maximum absorption was obtained at a wavelength of 625 nm using UV-Vis spectrophotometry.
Formulation and Evaluation of Gel Mask Peel Off Moringa Leaf Extract (Moringa oleifera Lam) Santi Agustina; Anna L Yusuf; Davit Nugraha
Ad-Dawaa : Journal of Pharmacy Vol. 1 No. 1 (2023): Ad-Dawaa: Journal of Pharmacy (May 2023)
Publisher : LPPM STIKes Muhammadiyah Ciamis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52221/dwj.v1i1.224

Abstract

Peel-off gel mask is a practical mask, after drying the mask can be directly removed or removed without causing pain. This mask can also restore freshness and softness of the skin, even with regular use it can reduce fine wrinkles on facial skin. Moringa plants contain antioxidants, especially the leaves that contain flavonoids, causing Moringa leaves to be used as a source of natural antioxidants. The research method used is an experimental method with peel off gel mask preparation samples of Moringa leaf extract with various concentrations of 0% (F0), 5%(F1), 10%(F2), and15% (F3). Data analysis using One Way Anova test with 95% confidence level of significance = 0.05. Evaluation of the peel off gel mask preparation includes organoleptic test, homogeneity test, pH test, viscosity test, dispersibility test, adhesion test, dry time test and syneresis test. The results of the research F0, F1, F2 and F3 met the standard of the tests carried out such as organoleptic tests, pH tests, dispersibility tests, adhesion tests, dry time tests, and syneresis tests. The results of the One Way Anova statistical test for the pH test obtained a P-Value value of 0.63> 0.05, the dispersion test obtained a P-Value value of 0.02 0.05, the drying time test obtained a P-Value value of 0.00 (0.05) while the test dispersion and syneresis test there is an effect of giving concentration variations with a significance value of P < (0.05).
Narrative Review: Optimation of Ethanol as a Solvent for Flavonoid Compounds in Papaya Leaf Extraction Davit Nugraha; Anna L Yusuf; Panji Wahlanto
Ad-Dawaa : Journal of Pharmacy Vol. 1 No. 2 (2023): Ad-Dawaa: Journal of Pharmacy (November 2023)
Publisher : LPPM STIKes Muhammadiyah Ciamis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52221/dwj.v1i2.496

Abstract

Ethanol is widely used as a distiller of secondary metabolite compounds. Ethanol very well dissolves secondary metabolite compounds including flavonoids group compounds including for papaya (Carica papaya L.) leaf extraction. This review was conducted to examine solvent optimization that has been used in various original studies. The method of searching scientific journal article using PubMed and MDPI using keyword “extraction and ethanol and flavonoid and carica papaya leaf” with the inclusion criteria of 2018 – 2023 article, free full text and not review articles, the number of article obtained was 3 articles. The optimal concentration of ethanol as a flavonoid extract solven is 70 % ethanol at temperatures from 30 °C – 50°C with a time range of 10 – 48 hours of immersion.
IDENTIFIKASI VARIAN GENETIK TERKAIT KEJADIAN INFARK MIOKARD MELALUI PENDEKATAN BIOINFORMATIK Rafiastiana Capritasari; Muhammad Irham; Fara Azzahra; Davit Nugraha; Anna Lesmanasari Yusuf; Febriana Astuti; Zulkifli Zulkifli; Anggoro Wicaksono; Andhika Nor Hendryawan; Tiyas Putri Nurgraheni; Kusmini Kusmini; Ilham Alifiar; Dona Suzana
Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-ilmu Keperawatan, Analis Kesehatan dan Farmasi Vol 23, No 1 (2023)
Publisher : LPPM Universitas Bakti Tunas Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36465/jkbth.v23i1.1307

Abstract

Faktor risiko terjadinya penyakit kardiovaskuler selain faktor risiko konvensional (perokok, hipertensi, dislipidemia, diabetes militus dan obesitas) terdapat juga faktor genetik serta faktor risiko non-konvensional seperti kecemasan, stres dan depresi. Tujuan dari penelitian ini yaitu mengidentifikasi variasi genetik yang terkait dengan patogenesis infark miokard pada berbagai populasi dengan menggunakan basis data genom dan pendekatan bioinformatika. Hasil terdapat tiga varian genetik  yaitu gen APOE, ZC3HC1 dan ALDH2  yang memiliki potensi kerusakan terhadap protein DNA sehingga dapat menyebabkan kejadian infark miokard. SNP dengan kode rs7412, rs11556924 dan rs671 merupakan SNP yang paling kuat dikaitkan dengan kejadian infark miokard sehingga dapat direkomendasikan sebagai risiko genetik.
Penyuluhan Tentang Pemanfaatan Sambiloto (Andrgraphis paniculata) Untuk Mencegah dan Mengobati Penyakit Hipertensi Siti Rahmah Kurnia Ramdan; Marlina Indriastuti; Anna L Yusuf; Davit Nugraha; Panji Wahlanto
Daarul Ilmi: Jurnal Pengabdian Kepada Masyarakat Vol. 2 No. 1 (2024): Daarul Ilmi: Jurnal Pengabdian Kepada Masyarakat (Januari-Juni 2024)
Publisher : LPPM STIKes Muhammadiyah Ciamis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52221/daipkm.v2i1.564

Abstract

Introduction: Hypertension is one of the factors causing cardiovascular disease and is the main cause of death in the world. Hypertension can be influenced by various factors, including genetic factors and an unhealthy lifestyle. Preventing and treating hypertension is very important in order to reduce risk factors for death. Prevention and treatment of hypertension with traditional medicine or herbal medicine is an alternative that is currently in great demand and attention because it has minimal side effects and is quite effective. Andrographis paniculata is a medicinal plant that has been widely studied and is effective in preventing and treating hypertension. The main content of this plant is andrographolidine which is a phytochemical substance which has many benefits, including antihypertension. Objective: The aim of this outreach activity is to provide understanding to the public about the use of bitter (Androghraphis paniculata) to prevent and treat hypertension. Method: Education to the public about the use of Androghraphis paniculata is carried out through the lecture method. The material presented is an explanation of hypertension, the benefits of bitter as a medicinal plant, the benefits of bitter in preventing and treating hypertension and how to process it on a household scale. Explanation of how to process bitter for treatment, namely using the infusion method. Giving pre-tests and post-tests to counseling participants is carried out to evaluate the level of community understanding. Result: By providing education about the use of bitter to prevent and treat hypertension, it can increase public knowledge about hypertension, the causal factors, as well as the benefits of bitter and how to use it as a medicinal plant. Knowledge before and after counseling increased by 36.65%. The community is very enthusiastic in following the outreach that we do. Conclusion: With the outreach, participants know more about hypertension and the use of bitter in preventing and treating hypertension and how to process it. Participants' knowledge increased by 36.65%.
KAJIAN RESEP SECARA ADMINISTRASI DAN FARMASETIK PADA PASIEN RAWAT JALAN DI RSUD dr. SOEKARDJO KOTA TASIKMALAYA PERIODE 10 MARET-10 APRIL 2017 Anna Yusuf; Via Fitria; Davit Nugraha; Nurunnisa Mentari
Jurnal Farmasi & Sains Indonesia Vol 3 No 2 (2020)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Kajian resep merupakan aspek yang sangat penting dalam peresepan karena dapat membantu mengurangi terjadinya medication error. Penelitian ini bertujuan untuk mengetahui persentase kelengkapan resep dan kejelasan penulisan terkait obat pada resep rawat jalan di RSUD dr.Soekardjo Kota Tasikmalaya periode 10 Maret – 10 April 2017 berdasarkan Permenkes nomor 58 tahun 2014. Penelitian yang dilakukan bersifat non eksperimental deskriptif dan pengambilan data dilakukan secara prosfektif. Metode pengambilan sampel dilakukan dengan menggunakan metedo random sampling, didapatkan sebanyak 800 resep. Hasil penelitian menunjukan bahwa kelengkapan resep yang memenuhi standar Permenkes nomor 58 tahun 2014 secara administrasi adalah 12%, sedangkan secara farmasetik adalah 44%. Hasil pengkajian kelengkapan resep ini diharapkan dapat membantu meningkatkan kualitas pelayanan kepada pasien dan dapat mencegah terjadinya medication error pada fase prescribing.
AKTIVITAS ANTIBAKTERI AIR PERASAN BUAH PEPAYA (Carica papaya L.) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus: ANTIBACTERIAL ACTIVITIES OF PEPAYA JUICE (Carica papaya L.) ON THE GROWTH OF Staphylococcus aureus BACTERIA Davit Nugraha; Anna L. Yusuf; Veri Nugraha; Panji Wahlanto; Marlina Indriastuti
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 4 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i4.470

Abstract

Bakteri Staphylococus aureus merupakan bakteri patogen dan dapat menyebabkan infeksi mulai dari infeksi kulit ringan sampai dengan infeksi sistemik. Sebagian besar pada awal mulanya Staphylococus aureus peka terhadap penisilin, namun setelah meluasnya penggunaan penisilin ditemukan 65% sampai 85% Staphylococus aureus menghasilkan beta laktamase sehingga menjadi resisten terhadap penisilin G.  Hal tersebut diatas mendorong pengobatan alternatif yang aman dan tidak menimbulkan resistensi untuk menanggulangi infeksi bakteri Staphylococus aureus.  Perasan buah pepaya sering terdengar penggunaan dimasyarakat untuk pengobatan jerawat secara turun temurun, ini dimungkinkan perasan buah pepaya mempunyai efek anti bakteri Staphylococcus aureus. Penelitian ini bertujuan untuk mengetahui kemampuan daya hambat air perasan buah papaya (Carica Papaya L) terhadap bakteri Staphylococcus aureus. Metode pengujian daya hambat pada air perasan buah papaya menggunakan metode difusi agar dengan konsentrasi 20%, 40%, 60% dan 80%. Air perasan buah pepaya pada penelitian ini mempunyai kemampuan daya hambat yang sedang terhadap pertumbuhan bakteri Staphylococcus aureus, serta konsentrasi yang paling efektif sebesar 60%.
PHYSICAL AND ACTIVITY ACTIVITY TONER OF ESSENTIAL OIL OF BAY LEAF (SYZYGIUM POLYANTHUM) AGAINST PROPIONIBACTERIUM ACNE Anna Yusuf; Davit Nugraha; Marlina Indriastuti; Siti Rahmah KR; Laela Tri Fadila
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1080

Abstract

Indonesian people have been using natural ingredients for generations as traditional medicines to treat various diseases or as a preventative measure. One of the plants often used is bay leaf (Syzygium polyanthum). Bay leaves (Syzygium polyanthum) contain 0.2% essential oil, with methyl chavicol, eugenol, and citral as the main compounds. The purpose of this study was to determine the physical properties of essential oil toner preparations from bay leaf plants (Syzygium polyanthum) and to understand the activity of the essential oil toner preparation from bay leaf plants (Syzygium polyanthum) against Propionibacterium acnes as an acne treatment. The physical test results produced the following data: organoleptic test, thin liquid form, distinctive bay leaf smell, clear slightly cloudy color, homogeneity test all preparations were homogeneous, pH test for average F0 5.75 ± 0.5016, F1 5.62±0.1039, F2 5.70±0.08083 and F3 5.64±0.05508 all met the requirements in the pH range of 4.5-6.5. ...
Co-Authors Ade Fitriani, Ade Andhika Nor Hendryawan Anggoro Wicaksono Anisa Firdaus, Fidya Anna L Yusuf Anna Lesmanasari Yusuf Anna Yusuf Anna Yusuf Ariyanto, Heri Chela Tiara Dewi desi karningsih Dini Umayati Dona Suzana Erik Risnawan Fara Azzahra Farah A Himah Febriana Astuti Henri Setiawan Ilham Alifiar Indriastuti, Marlina Kusmini Kusmini Laela Tri Fadila Lestari, Nina Indri Muhammad Irham Muhammad Jafar Shodiq Nantia Khaerunnisa, Reffi Nova Zahra Nurunnisa Mentari Nurunnisa Mentari panji wahlanto Perti Fitriani R, Susan Sintia Rafiastiana Capritasari Rian Ismail Santi Agustina Siti Rahmah KR Siti Rahmah Kurnia Ramdan Tiyas Putri Nurgraheni Veri Nugraha Via Fitria Via Fitria Widhy Rahmadilla Garnadi Zulkifli Halid