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All Journal Syntax Literate : Jurnal Ilmiah Indonesia Cermin Dunia Kedokteran Journal of General-Procedural Dermatology & Venereology Indonesia

Kusumawardani, Arie

Unknown Affiliation

Author-ID : 1976690

Humanities Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health

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Articles

Terapi Probiotik (Lactococcus lactis) Topikal untuk Akne Vulgaris: Kasus Serial Anggraeni, Reti; Rosita, Fiska; Kusumawardani, Arie
Cermin Dunia Kedokteran Vol 48, No 1 (2021): Penyakit Dalam
Publisher : PT. Kalbe Farma Tbk.

Latar Belakang: Akne vulgaris (AV) adalah penyakit inflamasi kulit kronik yang mengenai unit pilosebasea, mengakibatkan kelainan non-inflamasi berupa komedo dan tanda inflamasi. Mikroba kulit seperti Propionibacterium acnes (P. acnes) dan Malassezia spp. berperan dalam patogenesis AV. Laporan kasus ini mengenai efek terapi probiotik topikal terhadap perbaikan lesi AV. Kasus: Tiga pasien AV diberi terapi tabir surya (SPF 30) dan probiotik topikal selama 4 minggu tanpa terapi standar AV. Pemeriksaan swab dilakukan pada semua pasien untuk melihat jenis dan jumlah mikrobiom. Hasilnya tidak ditemukan kolonisasi P. acnes tetapi terjadi penurunan jumlah dan derajat keparahan lesi pada semua pasien. Terapi yang sama dilanjutkan selama 4 minggu pada satu pasien. Kolonisasi P. acnes hanya ditemukan pada awal terapi. Evaluasi klinis yaitu penurunan jumlah lesi AV dan kulit wajah menjadi lebih halus dan lembap. Ringkasan: Probiotik topikal memberikan hasil baik pada kasus AV.Introduction: Acne vulgaris (AV) is chronic inflammatory skin disease affecting pilosebaceous unit, resulting in non-inflammatory disorders in the form of comedones and signs of inflammation. Skin microbes such as Propionibacterium acnes (P. acnes) and Malassezia spp. play role in the AV pathogenesis. This paper reports the effects of topical probiotic on AV lesions improvement. Case: Three AV patients were given sunscreen (SPF 30) and topical probiotics for 4 weeks without standard AV therapy. Swab examination showed no P. acnes colonization but the amount and severity of lesions in all patients were decreased. One patient then continued the same therapy for 4 weeks; P. acnes colonization was only found at the beginning of therapy. Clinical evaluation resulted in decreasing lesions and smoother and moisturized facial skin. Summary: Topical probiotic gives good results in AV.

Metotreksat Intramuskular untuk Terapi Psoriasis Vulgaris: Serial Kasus Rafika Paramitasari, Anggana; Hartati, Agung Triana; Mustifah, Etty Farida; Yustin Ellista Sari, Endra; Kusumawardani, Arie
Cermin Dunia Kedokteran Vol 45, No 8 (2018): Alopesia
Publisher : PT. Kalbe Farma Tbk.

Metotreksat merupakan pilihan terapi psoriasis yang efektif. Laporan pemberian MTX parenteral pada psoriasis vulgaris masih jarang. Kami melaporkan 8 kasus psoriasis vulgaris dengan terapi injeksi MTX dosis inisial 10mg/minggu dan dinaikkan menjadi 15mg/minggu. Dalam evaluasi 8-12 minggu, terdapat perbaikan klinis yang dievaluasi menggunakan Psoriasis Activity and Severity Index (PASI), luas Body Surface Area (BSA) dan Dermatology Life Quality Index (DLQI). Bioavailabilitas MTX parenteral lebih baik dibandingkan peroral. Tidak ditemukan efek samping selama pemberian injeksi MTX.Methotrexate (MTX) is the commonly prescribed for psoriasis. Reports on parenteral MTX for psoriasis in Indonesia are still scarce. We reported eight psoriasis patients treated with intramuscular MTX 10mg/week increased to 15mg/week. The clinical improvement was remarkable demonstrated with Body Surface Area (BSA), Psoriasis Activity and Severity Index (PASI) and Dermatology Life Quality Index (DLQI) scores. Bioavailability of parenteral MTX is better than oral MTX. No adverse effect was found and the clinical improvement was good.

Physical Stability Test of Ethanol Extract Cream of Bajakah Wood as Topical Antiaging Cream Prasetyorini, Budi Eko; Kusumawardani, Arie; Ellistasari, Endra Yustin
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : CV. Ridwan Publisher

The barakah ethanolic extract (Spatholobus littoralis Hassk) contains antioxidants that function as antiaging. The use of barakah wood ethanolic extract cream as a cosmetic preparation requires a long preparation time, so it is necessary to formulate a preparation that is practical and durable in storage. Cream components affect the physical stability of the preparation. Physical stability tests need to be carried out to ensure the quality, safety, and benefits of the cream meet the expected specifications and are stable during storage. This study aims to make the physical stability of the formulation of the cream preparations of barakah wood ethanol extract at concentrations of 7.5%, 15%, and 30%. The design of this study was an experimental laboratory. The stability test was carried out using the cycling test method for 6 cycles by re-testing its physical properties. Physical evaluation includes organoleptic tests, homogeneity, pH, dispersion, and adhesion. Preparation of cream formula 7.5%, 15%, and 30% of the results of testing physical properties (cycle 0) namely organoleptic test (smell: typical of wood; color: dark brown; texture: semi-solid), homogenity (homogeneous arrangement), pH F1, 2 and 3 p = 0.524; 0.350 and 0.745 adhesion F1, 2 and 3 p = 0.209; 0.207 and 0.377 spreadability F1, 2 and 3: p = 0.690; 0.207 and 0.395 the results of statistical values in formula 1, 2 and 3 which show the value of Sig(2-tailed) where this value is p > 0.05 which means there is no significant difference before and after the cycling test. In the cream stability during the cycling test (cycles 1-6) there was no significant difference. There was no statistically significant difference in any physical evaluation of the cream stem ethanolic extract barakah 7.5%, 15%, and 30% so the three concentrations of cream were stable creams.

The Difference In Transepidermal Water Loss (TEWL) Values Between Sun-exposed and Non-sun-exposed Skin Among Male Medical Students Prihadi, Ihsany Arafiasetyanto; Ellistasari, Endra Yustin; Kusumawardani, Arie
Journal of General - Procedural Dermatology & Venereology Indonesia
Publisher : UI Scholars Hub

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Background: Transepidermal Water Loss (TEWL) is the amount of water released from the human body into the atmosphere through a diffusion process per unit of time. Changes in TEWL indicate impaired skin barrier function. Exposure to ultraviolet light for an extended period can cause photoaging, characterized by rough and dry skin (xerosis cutis). TEWL will increase significantly in the skin exposed to ultraviolet radiation. This study aims to determine the difference in the TEWL values among male medical students in the sun-exposed and non-sun-exposed skin areas. Methods: An analytical observational cross-sectional study was conducted at the Dermatology and Venereology Department of RSUD Dr. Moewardi Surakarta in January-March 2021. Sampling was carried out through consecutive sampling and 25 samples were obtained. TEWL examination was performed on the dorsal area of the forearm and the medial area of the upper arm using the Tewameter TM300. The mean value of TEWL was analyzed using the non-parametric Wilcoxon signed rank test and Spearman's correlation test. Results: Based on the Wilcoxon signed rank test, there was a significant difference in the value of TEWL (p = 0.000). Spearman correlation analysis shows the coefficient value of r = 0.599, with p = 0.002. Conclusion: There is a significant difference in TEWL values in the sun-exposed skin area compared to the non-sun-exposed skin area, with a moderate positive correlation.

The relationship between increased body mass index with transepidermal water loss: a comparative study Yudhistira, Muhammad Yurizar; Kusumawardani, Arie; Widhiati, Suci; Mulianto, Nurachmat
Journal of General - Procedural Dermatology & Venereology Indonesia
Publisher : UI Scholars Hub

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Background: Obesity affect significant populations on all ages. The relationship between obesity and metabolic diseases is known but a dermatological link is rarely explained. Transepidermal water loss (TEWL) is one of the measurement tools used to define the skin’s barrier function by measuring the amount of water that evaporates through the skin in aspecific amount of time. Although several studies on TEWL are available but discussion about the correlation between TEWL and body mass index (BMI) is still limited. This study aims to evaluate the correlation between TEWL and BMI. Methods: This research is a single-center study with analytical cross-sectional design that includes healthy subjects among medical students aged 18 to 23 years old in Universitas Sebelas Maret. A questionnaire was used to ensure that all subjects met the criteria. Chi-square and Pearson were used to analyze the observed variables.Results: The total sample in this study was 62 participants, with a majority of female (59.7%) and ranged from 21 to 23 years (74.2%). The ratio of normoweight and overweight/obese was 1:1. The results demonstrated significant difference and positive correlation between increased BMI with TEWL (pConclusion: This study showed a significant correlation between increased body mass index and transepidermal water loss. Overweight participants tend to develop high values of TEWL which reflect a disruption of skin barrier. Further research on other influencing factors with larger samples and more study centers are needed.

Co-Authors Anggraeni, Reti Ellistasari, Endra Yustin Hartati, Agung Triana Mulianto, Nurachmat Mustifah, Etty Farida Prasetyorini, Budi Eko Prihadi, Ihsany Arafiasetyanto Rafika Paramitasari, Anggana Rosita, Fiska Widhiati, Suci Yudhistira, Muhammad Yurizar Yustin Ellista Sari, Endra

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