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Rafika Paramitasari, Anggana
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Health Professions Medicine & Pharmacology Public Health

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Diagnosis Luka Tungkai Kronis Rafika Paramitasari, Anggana; Risman, Muhammad; Rahman, Aulia; Rieka Sulaikha, Khalida; Kariosentono, Harijono; Mulianto, Nurrachmat
Cermin Dunia Kedokteran Vol 46, No 1 (2019): Obstetri - Ginekologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1096.883 KB) | DOI: 10.55175/cdk.v46i1.534

Abstract

Luka kronis adalah luka yang tidak dapat mengalami proses penyembuhan luka sesuai urutan dan dalam rentang waktu normal. Mayoritas luka kronis didapatkan di ekstremitas inferior dengan penyebab antara lain insufisiensi vena (45-60%), insufisiensi arteri (10-20%), diabetes (15-25%), ulkus dekubitus (1-5%), dan lain-lain (10-15%). Masing-masing penyebab memberikan gambaran klinis berbeda, begitu pula terapinya. Oleh karena itu gambaran klinis, patogenesis, dan diagnosis banding penting diketahui.Chronic wounds are characterized by failure to progress through a proper timely sequence of wound repair or without restoring to normal anatomy and function. Chronic wounds in lower leg including foot is a condition caused by venous insufficiency (45-60%), artery insufficiency (10-20%,) diabetes mellitus (15-25%), decubitus ulcer (1-5%), or other causes (10-15%). Each etiology has different clinical manifestations and therapy. Treatment of leg ulcers needs evaluation of many different etiologies. 
Metotreksat Intramuskular untuk Terapi Psoriasis Vulgaris: Serial Kasus Rafika Paramitasari, Anggana; Hartati, Agung Triana; Mustifah, Etty Farida; Yustin Ellista Sari, Endra; Kusumawardani, Arie
Cermin Dunia Kedokteran Vol 45, No 8 (2018): Alopesia
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (821.515 KB) | DOI: 10.55175/cdk.v45i8.627

Abstract

Metotreksat merupakan pilihan terapi psoriasis yang efektif. Laporan pemberian MTX parenteral pada psoriasis vulgaris masih jarang. Kami melaporkan 8 kasus psoriasis vulgaris dengan terapi injeksi MTX dosis inisial 10mg/minggu dan dinaikkan menjadi 15mg/minggu. Dalam evaluasi 8-12 minggu, terdapat perbaikan klinis yang dievaluasi menggunakan Psoriasis Activity and Severity Index (PASI), luas Body Surface Area (BSA) dan Dermatology Life Quality Index (DLQI). Bioavailabilitas MTX parenteral lebih baik dibandingkan peroral. Tidak ditemukan efek samping selama pemberian injeksi MTX.Methotrexate (MTX) is the commonly prescribed for psoriasis. Reports on parenteral MTX for psoriasis in Indonesia are still scarce. We reported eight psoriasis patients treated with intramuscular MTX 10mg/week increased to 15mg/week. The clinical improvement was remarkable demonstrated with Body Surface Area (BSA), Psoriasis Activity and Severity Index (PASI) and Dermatology Life Quality Index (DLQI) scores. Bioavailability of parenteral MTX is better than oral MTX. No adverse effect was found and the clinical improvement was good.
Co-Authors Aulia Rahman Hartati, Agung Triana Kariosentono, Harijono Kusumawardani, Arie Mustifah, Etty Farida Nurrachmat Mulianto Rieka Sulaikha, Khalida Risman, Muhammad Yustin Ellista Sari, Endra