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All Journal MNJ (Malang Neurology Journal) Medicra (Journal of Medical Laboratory Science/Technology)
Arista, Devi Maya
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Health Professions Neuroscience Public Health

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Predictive Analysis of NLR, Absolute Lymphocyte Count, and CT-Value on The Severity of Covid-19 Patients Bastiana; Donastin, Adyan; Arista, Devi Maya; Surya, Prima Ardiansah
Medicra (Journal of Medical Laboratory Science/Technology) Vol 5 No 1 (2022): July
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v5i1.1625

Abstract

Laboratory parameters in Covid-19 patients may have a relationship with the clinical severity of the patient on arrival. This study aims to Analyzing the relationship between NLR, ALC, and CT values with the clinical severity of Covid-19 patients on arrival. A total of 101 subjects were collected from medical records of RSI Jemursari Surabaya from April to September 2020. The correlation laboratory parameters (NLR, ALC, and CT-value) with the severity of Covid-19 patients (mild, moderate, severe and critical) were analyzed using One Way Anova and Kruskal Wallis. The relationship of NLR with severity (p-value=0.143), ALC with severity (p-value=0.165), and CT-value with severity (p-value= 0.987). Patients with COVID-19 tend to have a high NLR in all clinical conditions. The mean value of the ALC was within normal limits for all degrees of severity. There is no significant relationship between NLR, ALC, CT-value with the severity of Covid-19 patients.
DOES THE COMBINATION OF ROSMARINUS OFFICINALIS AND CENTELLA ASIATICA NANOEMULSIONS AFFECT BDNF EXPRESSION IN THE GESTATIONAL DIABETES MELLITUS MODEL IN ZEBRAFISH LARVAE Khotimah, Husnul; Lamadi, Sutini; Amelia, Rizki; Arista, Devi Maya; Prastiwi, Fajar Dwi; Raras, Tri Yudani Mardining
MNJ (Malang Neurology Journal) Vol. 10 No. 2 (2024): July 2024
Publisher : PERDOSSI (Perhimpunan Dokter Spesialis Saraf Indonesia Cabang Malang) - Indonesian Neurological Association Branch of Malang cooperated with Neurology Residency Program, Faculty of Medicine Brawijaya University, Malang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mnj.2024.010.02.08

Abstract

Background: Pancreatic β-cells compensate for the increased insulin demand due to increasing glucose levels during pregnancy or in gestational diabetes mellitus (GDM). The enzyme that regulates the rate of gluconeogenesis production is PEPCK. Circulatory and metabolic disturbances in the brain caused by hyperglycemia could affect brain-derived neurotrophic factor (BDNF) expression as an agent for neurodevelopment. Objective:  The purpose of this work is to ascertain the impact of combining nanoemulsions of Rosmarinus officinalis and Centella asiatica on the expression of BDNF and PEPCK. Methods: This study was a true experimental laboratory using zebrafish larvae. The larvae were exposed to 3% glucose and a combination of nanoemulsion extracts. The study sample of zebrafish larvae at 72 hpf (hour post fertilization) was divided into control, glucose, treatment 1, 2, and 3, with the combination of Rosmarinus officinalis and Centella asiatica nanoemulsions at 2.5 μg/ml, 5 μg/ml, and 10 μg/ml, respectively. PEPCK and BDNF expression were measured by the real-time PCR method. Results: The expression of PEPCK increased significantly in the glucose group (3.05 ± 0.27). The combination of Rosmarinus officinalis and Centella asiatica nanoemulsions significantly decreased PEPCK (p-value 0,001 < 0.05). The BDNF level did not significantly differ (p-value 0.253 >0.05) among groups, but the highest level (1.06 ± 0.60) was gained in the T2 group, which received an embryonic medium (EM), 3% glucose, and the combination of Rosmarinus officinalis and Centella asiatica nanoemulsions at 5μg/ml. Conclusion: The combination of Rosmarinus officinalis and Centella asiatica nanoemulsions significantly reduces PEPCK expression but does not affect BDNF expression.
Co-Authors Bastiana Donastin, Adyan Husnul Khotimah Lamadi, Sutini Prastiwi, Fajar Dwi Rizki Amelia Surya, Prima Ardiansah Tri Yudani MR