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Journal : Medula

The ROLE OF OBESITY IN BREAST CANCER METASTASIS Fadila Gustiani Daraz; Indri Windarti; Putu Ristyaning Ayu Sangging
Medula Vol 13 No 1 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i1.562

Abstract

Breast cancer is the most common type of cancer in women worldwide. One of the factors that are believed to have a role in the development and growth of breast cancer is nutritional status which can be associated with the body mass index of adult patients. It is estimated that overweight and obesity are risk factors for the spread of breast cancer to distant metastases. Mechanism of spread through two ways, estrogen and leptin. Aromatase is an enzyme in estrogen biosynthesis that promotes tumor growth through its expression in breast adipose stromal cells. Meanwhile, leptin is produced by adipocytes. Adipocytes that experience hypertrophy and hyperplasia cause pathophysiological changes that affect the development of breast cancer. Various case studies show that a diet high in fat and calories is associated with breast cancer. The high risk of obesity for breast cancer metastases. This is important to be studied further because of the large number of cases of breast cancer both globally, in Indonesia and in Lampung. This review article is important to know the relationship between obesity and breast cancer metastases, as scientific information and knowledge, and can be used as material for dietary intervention in obese breast cancer patients.
Anemia pada Pasien Tuberkulosis Inna Kurniaji; Waluyo Rudiyanto; Indri Windarti
Medula Vol 13 No 1 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i1.592

Abstract

Tuberculosis (TB) is one of the most common causes of health problems in the world. The prevalence of TB in the world is estimated at 10.6 million, and 1.6 million of them died from TB, in Indonesia the incidence of TB reached 503,712. Tuberculosis is a chronic infectious disease caused by Mycobacterium tuberculosis, which is known to cause complex hematological disorders. The hematopoietic system is thought to be affected during TB infection, so that Hb levels tend to decrease along with bacterial increase, which eventually causes anemia. The article aims to determine the incidence of anemia in TB patients and the mechanism of anemia in TB patients. Based on the results of a literature review conducted on references found from 2012–2022, it shows that anemia is a common condition in TB. The mechanism that causes anemia in TB patients is due to its pathogenesis as a chronic inflammatory disease. Anemia is an indicator in providing clues to diagnosis, prognosis, complications and response to TB therapy. Nutritional intake and adherence to TB therapy need to be done properly to prevent the development of severe disease and improve the patient's quality of life.