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All Journal Jurnal Pengabdian UntukMu NegeRI ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry JURNAL PHOTON Molekul: Jurnal Ilmiah Kimia Acta Chimica Asiana Makara Journal of Science Molekul: Jurnal Ilmiah Kimia
Syahri, Jufrizal
Department Of Chemistry, Universitas Muhammadiyah Riau
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Energy Environmental Science Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Nursing Physics Social Sciences

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Design of Trolox Compounds as Antioxidant and Their Analysis Using Quantitative Structure Activity Relationship Hasmalina Nasution; Nur Enizan; Nurlaili Nurlaili; Jufrizal Syahri
Acta Chimica Asiana Vol. 3 No. 2 (2020)
Publisher : Chemistry Education Program, the University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v3i2.40

Abstract

Antioxidant compound can inhibit the oxidation of lipids and other biomolecules. The role of antioxidants is very important in neutralizing and destroying free radicals that can cause the damage to cells in the body. This research was carried out to design trolox derivate compounds as antioxidants using the QSAR method. The semi empirical AM1(Austin Model 1)method was used to generate the QSAR model. The statistical analysis result using multiple linier regression methods revealed thet antioxidant activity was influenced by the descriptors of qC1, qC4, qO7, qC13 and qO18. The QSAR equation model obtained was log IC50 = 0.821 + 7.067 (qC1) + 2.585 (qC4) + 4.812 (qO7) – 5.363 (qC13) – 0.887 (qO18) with the best predicted IC50 value was 4.699 µM. Keywords: Antioxidants, QSAR, semi empirical AM1, trolox
Bio-insecticide’s Extract of Scented Root (Polygala paniculata) in Controlling the Mosquito Aedes aegypti (L.) Wahyuni, Denai; Sari, Nila Puspita; Jasril, Jasril; Syahri, Jufrizal
Makara Journal of Science Vol. 26, No. 2
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Controlling Aedes aegypti mosquitoes with chemical insecticides causes resistance on humans, environmental residues, and contaminates food and water. Polygala paniculata is a potential alternative to insecticides in controlling Ae. aegypti. This study aimed to determine the effect of the Insecticide Score of P. paniculata extracts on the mortality of Ae. aegypti mosquitoes based on KT50. A total of 20 mosquitoes for each concentration were used to examine the effectiveness of 10%, 15%, 20%, and 25% concentration of P. paniculata extracts compared to a positive and a negative control with four replications. The results showed that P. paniculata extracts had an effect on Aeaegypti mosquito mortality. There were significant differences in mortality rate between concentrations (Kruskal-Wallis test, p = 0.001). Spearman Correlation test gave a p-value of 0.008 < 0.05. Similarly, there was a weak but significant correlation between plant extract concentration and mortality (Spearman correlation: r = +0.312, p = 0.008). The 10% and 15% concentrations had KT50with Insecticide Scores of 1 and 2, respectively, implying that both had no knockdown effect. A 20% concentration had a KT50 with an Insecticide Score of 3, indicating a weak knockdown effect, whereas a 25% concentration had KT50with an Insecticide Score of 5, signifying a quick knockdown effect. These results show that a 25% concentration has a quick knockdown time on Ae. aegypti mosquitoes. Therefore, extract P. paniculata extract at a concentration of 25% has a potential for use as a bio-insecticide in controlling Ae. aegypti mosquitoes.
Evaluation of the Antibacterial Activity of the Jackfruit Parasite Leaf Plant Extract (Macrosolencochinchinensis (Lour.) van Tiegh) with Vitro and In Silico approach Rahmiwati Hilma; Suma Rahmani Harahap; Jufrizal Syahri
Acta Chimica Asiana Vol. 5 No. 2 (2022)
Publisher : The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v5i2.141

Abstract

In traditional Melayu Riau medicine, the jackfruit parasite plant, also known as Macrosolen cochinchinensis (Lour.) van Tiegh, has been utilized as a remedy for coughs, a treatment for cancer, a diuretic, and to speed up the recovery process after giving birth. Through in vitro and in silico testing, this investigation aims to learn more about the bioactive components and antibacterial activity of n-hexane, ethyl acetate, and ethanol obtained from the extracts of the jackfruit parasite plant (Macrosolen cochinchinensis (Lour.) van Tiegh. The disc diffusion method was used for the in vitro testing, and the molecular docking method was used for the in silico testing. Both were conducted against Staphylococcus aureus ATCC 12600 and Escherichia coli ATCC 25922. Each sample extract was prepared in three different concentrations (10%, 30%, and 50%), while chloramphenicol was used as the positive control. Inhibition zones of the extract against E. coli bacteria were found to be as follows: 6 mm, 8.4 mm, and 10.6 mm for the n-hexane extract; 8.2 mm, 10.7 mm, and 15.6 mm for the ethyl acetate extract; and 6 mm, 7.1 mm, and 14.1 mm for the methanol extract. The results of the test to determine the extract's antibacterial activity were as follows: The following is a list of the zones of inhibition that the extract has against S. aureus bacteria: 6 mm, 7.5 mm, and 13.7 mm in diameter for the extract of n-hexane; 12.8 mm, 14.2 mm, and 19.2 mm in diameter for the extract of ethyl acetate. Test results of 7.2 mm, 9.3 mm, and 15.3 mm were obtained for the methanol extract. In accordance with the findings of the study, the ethyl acetate extract of jackfruit parasite leaves exhibited the highest level of antibacterial activity, as measured by an inhibition zone diameter of 19.2 mm, when tested on S. aureus bacteria. In the meantime, the results of molecular docking of punicalin and rutin, which have been reported to have activity against proteins 6GOS.pdb and 1OJZ.pdb, have potential as antibacterials because they form 5 and 9 hydrogen bonds with important amino acids of the target protein, with cDOCKER values of -57.9239 and -88.3993, respectively. It suggests that punicalin and rutin can inhibit the growth of bacteria.
Workshop Sertifikasi Pranata Laboratorium Untuk Guru Sains Tingkat SLTA Se-Provinsi Riau Sri Hilma Siregar; Prasetya Prasetya; Hasmalina Nasution; Rahmiwati Hilma; Fitra Perdana; Rahmadini Syafri; Jufrizal Syahri
Jurnal Pengabdian UntukMu NegeRI Vol 7 No 1 (2023): Pengabdian Untuk Mu negeRI
Publisher : LPPM UMRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jpumri.v7i1.4932

Abstract

Saat ini banyak sekolah tingkat SLTA se-Provinsi Riau dan sekitarnya tidak memiliki pranata laboratorium pendidikan yang berkompeten dibidangnya. Hal ini menyebabkan banyak sekolah yang memiliki laboratorium tapi tidak digunakan secara maksimal, dan siswa siswi tidak dapat melaksanakan praktikum yang semestinya di laboratorium. Laboratorium hanya menjadi tempat pajangan alat peraga dan instrumentasi. Berdasarkan hal tersebut, kami merasa perlu memfasilitasi para pranata laboratorium pendidikan dengan memberikan pelatihan pengelolaan dan penggunaan laboratorium untuk praktikum siswa siswi di sekolah. Sehingga dihasilkan lulusan yang berkompeten. Kegiatan dirancang dalam bentuk pengembangan wawasan keilmuan melalui pemberian berbagai teori selama 2 hari dan dilanjutkan dengan praktik dan penugasan pada 2 hari berikutnya. Materi yang diberikan kepada peserta diantaranya tentang inovasi hasil penelitian, pengenalan dan pengelolaan laboratorium, praktikum ciri-ciri reaksi kimia, hokum kekekalan massa, reaksi zat makanan. pemahaman dan kemampuan guru terhadap materi pelatihan, yang nantinya dapat digunakan sebagai acuan dalam melaksanakan praktikum di laboratorium sekolah. Kegiatan workshop ini mendapat sambutan yang baik dari peserta dan berhasil dengan baik. Keadaan ini dapat dilihat dari kehadiran peserta yang hampir mencapai 100%. Peserta terdiri guru dan pranata laboratrium pendidikan ingkat SLTA se-Provinsi Riau.
Molecular Docking of Xanthone Derivatives as Therapeutic Agent for Covid-19 Emmy Yuanita; Sudirman Sudirman; Ni Komang Tri Dharmayani; Maria Ulfa; Saprizal Hadisaputra; Jufrizal Syahri
Molekul Vol 17 No 1 (2022)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2022.17.1.5600

Abstract

Covid-19 has caused more than 14 million confirmed cases and more than 6 hundred deaths as of 21 July 2020 globally. However, there is no approved drug to treat the disease. Xanthone is a potential therapeutic option for the virus that have been tested using molecular docking. There were 12 of xanthone compounds and its derivatives which have been docked against two protein crystals, 2GX4.pdb and 6FV1.pdb, which obtained two potential compounds of hydroxyxanthone derivatives with sulfonate and chloro substitution. These compounds are potentially developed into one of the agents for the treatment of infection COVID-19 disease. Based on energy data and interactions with amino acid residues when compared with its own native ligands, namely NOL and E8E, respectively. Energy docking and energy docking interactions are equal to - 43.3057and - 45.5805 Kcal/mol respectively, during interactions with amino acid residues in the form of Gly 142, His 163, Cys144, Glu166, Gln164 and His 41. Based on these two data, it can be concluded that trihydroxyxanthone compounds 4 and 8 with chloro and sulfonate substitution are very potential to be developed as drug agents for Covid-19 disease therapy through protease inhibition.
Ekstraksi, Fraksinasi, Dan Uji Antioksidan Daun Pakis Sawit (Davallia denticulata) Eti Norhaslinda; Jufrizal Syahri; Fitra Perdana
Sistem Informasi Vol 13 No 2 (2023): Jurnal Photon
Publisher : LPPM Universitas Muhammadiyah Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jp.v13i2.4116

Abstract

Pada penelitian ini telah dilakukan ekstraksi, fraksinasi, dan uji antioksidan daun pakis sawit (Davallia denticulata). Metode ekstraksi daun pakis sawit dilakukan secara maserasi menggunakan pelarut etanol dan fraksinasi dilakukan sebanyak tiga fraksi yaitu fraksi etanol, etil asetat dan n-heksan. Kemudian dilakukan uji fitokimia dari ekstrak dan fraksi daun pakis sawit yang didapat. Ekstrak etanol menunjukkan adanya senyawa flavonoid, saponin, tanin, triterpenoid dan steroid, pada fraksi n-heksan menunjukkan adanya senyawa flavonoid dan fenolik, fraksi etil asetat menunjukkan adanya senyawa flavonoid, tanin dan fenolik, dan pada fraksi etanol menunjukkan adanya senyawa flavonoid, saponin, tanin, triterpenoid dan steroid. Pengujian aktivitas antioksidan ekstrak etanol menunjukkan nilai IC50 1,406 μg/mL, fraksi n-heksan menunjukkan nilai IC50 2,91 μg/mL, fraksi etil asetat menunjukkan nilai IC50 103 μg/mL, fraksi etanol menunjukkan nilai IC50 18,99 μg/mL, dan vitamin C sebagai pembanding menunjukkan nilai IC50 2,22 μg/mL. Berdasarkan perbandingan dengan vitamin C dapat diketahui bahwa terdapat aktivitas antioksidan yang sangat kuat pada ekstrak etanol dan aktivitas sedang pada fraksi etil asetat.
Pelatihan Pembuatan Pupuk Kompos Limbah Kulit Nangka Bagi Masyarakat Desa Kualu Nenas- Kab. Kampar Rahmayani Indah Putri; Hasmalina Nasution; Rahmita Syafitri; Putri Khorely; Prasetya; Fitra Perdana; Rahmadini Syafri; Jufrizal Syahri; Rahmiwati Hilma; Sri Hilma Siregar
Jurnal Pengabdian UntukMu NegeRI Vol 8 No 1 (2024): Pengabdian Untuk Mu negeRI
Publisher : LPPM UMRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37859/jpumri.v8i1.6255

Abstract

limbah hasil produksi keripik nangka selama ini berdasarkan hasil survei tim ppk ormawa HIMAKI umumnya tidak dioptimalkan dengan baik oleh masyarakat desa, salah satunya ada di Desa Kualu Nenas. Oleh karena itu kegiatan ini dilakukan dengan tujuan untuk mensosialisasikan dan melatih keterampilan masyarakat desa bagaimana mengolah limbah kulit nangka dan menjadikannya salah satu produk UMKM Desa. Salah satu produk yang bisa dibuat dari limbah kulit nangka adalah pupuk kompos. Metode yang digunakan dalam penelitian ini yaitu dengan melakukan pelatihan dan bimbingan teknis pembuatan pupuk dari limbah kulit Nangka dan pemasaran produk yang dihasilkan di Desa Kualu Nenas. Hasil dari kegiatan ini adalah masyarakat dan mitra desa dapat memproduksi pupuk kompos dan produk dapat dikembangkan menjadi salah satu produk UMKM Desa Kualu Nenas.
Co-Authors Adel Zamri Bambang Purwono Beta Achromi Nurohmah Beta Achromi Nurohmah Chairil Anwar Denai Wahyuni Emmy Yuanita Emmy Yuanita Eti Norhaslinda Fitra Perdana Hasmalina Nasution Hasmalina Nasution Hasmalina Nasution Hasmalina `Nasution Ika Septiana Jasril Jasril Kamal Rullah Maria Ulfa Nasution, Annio Indah Lestari Netti Gustina Nur Enizan Nurlaili Nurlaili Nurlaili Nurlaili Nurlailli Nasution Nurul Hidayah Olif Syahbella Prasetya Prasetya Prasetya Putri Khorely Rahmadini Syafri Rahmadini Syafri Rahmadini Syafri Rahmayani Indah Putri Rahmita Syafitri Rahmiwati Hilma Rudi Hendra Saprizal Hadisaputra Sari, Nila Puspita Sri Hilma Siregar Sudirman Sudirman Suma Rahmani Harahap Tri Dharmayani, Ni Komang Trisiwi Kusumaningrum Wirdati Irma Yeni Yernita Yuana Nurulita Yuharmen Yuharmen Yum Eryanti