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All Journal EKSAKTA: Journal of Sciences and Data Analysis Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Pharmaciana: Jurnal Kefarmasian Universa Medicina Jurnal Kedokteran Anatomica (Anatomica Medical Journal) Healthy-Mu Journal Refleksi Pembelajaran Inovatif JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Zainuri Sabta Nugraha
Departemen Anatomi Fakultas Kedokteran Universitas Islam Indonesia
Humanities Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Earth & Planetary Sciences Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Propolis Menghambat Penurunan Jumlah Neuron Striatum Tikus Yang Di induksi Stres Yusi Maulina; Kuswati Kuswati; Zainuri Sabta Nugraha
ANATOMICA MEDICAL JOURNAL | AMJ Vol 5, No 3 (2022)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/amj.v5i3.12502

Abstract

Stres mengakibatkan perubahan neuroendokrin dan berdampak pada kerusakan neuron serta mengganggu fungsi kognitif. Salah satu area di otak yang dapat dipengaruhi oleh stres adalah striatum. Stres dapat mengakibatkan apoptosis dan menurunkan jumlah neuron striatum. Tujuan: Menganalisa proteksi sel dan menghambat apoptosis dari propolis. Penelitian ini akan melihat efek  terapi propolis pada jumlah neuron striatum tikus yang diinduksi stres. Metode: Penelitian ini merupakan penelitian eksperimental dengan desain penelitian post test only control group. Penelitian menggunakan bahan biologi tersimpan otak tikus yang terdiri dari 5 kelompok yaitu kelompok non stres  (K1), kelompok stres (K2), kelompok yang  stres + propolis 100, 150 dan 200 mg/kgBB (K3, K4, K5). Setiap sampel dibuat sediaan histologis dengan pewarnaan Toluidine blue. Perbandingan rerata jumlah neuron  dianalisa menggunakan one-way ANOVA dan dilanjutkan dengan uji post-hoc. Hasil: Penelitian ini menunjukkan  perbedaan signifikan jumlah neuron striatum (p=0.000). Jumlah neuron paling rendah pada kelompok stres (K2) dan berbeda signifikan dengan kelompok non stres (K1) dan kelompok stres + propolis (K3,K4,K5). Kesimpulan: Propolis dapat menghambat penurunan jumlah neuron striatum tikus yang diberi  perlakuan stres.Kata kunci: Propolis, Stres, Striatum
The Effect of Ethanol Extract of Arabica Coffee (Coffea Arabica Linn) on the Number of Adult Pyramidal Pallium Zebrafish (Danio rerio) Neurons exposed to Stress Method UCS (Unpredictable Chronic Stress) Muchamad Marwan; Zainuri Sabta Nugraha
Healthy-Mu Journal Vol. 5 No. 1 (2021)
Publisher : MBUnivPress

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35747/hmj.v5i1.33

Abstract

Chronic stress can have an adverse effect on behavior changes and damage to the pyramidal neurons of the brain. Pyramidal neurons of the brain play an important role in awareness, decision making, cognitive function, spatial memory formation and working memory. The effects of chlorogenic acid (CGA) found in arabica coffee can affect the improvement of cognitive function, working memory, and histology of brain pyramidal neurons. The content of chlorogenic acid (CGA) in coffee has active compounds that can maintain the number of brain pyramidal neurons due to stress. The aim of this study was to determine the effect of arabica coffee extract on the average number of brain pyramidal neurons exposed to UCS stress. The research method used was a post-test experimental study with controlled group design. A total of 24 adult zebrafish (3 months old) were divided into 4 groups. Four groups (KN, KP, K25, K50) were acclimatized (1 week) first, for groups K25 and K50 were given arabica coffee extract as much as 25mg / dl and 50 mg / dl for 4 days before inducing unpredictable chronic stress (UCS). The results of the study proved that the extra ethanol group of arabica coffee at a dose of 50 mg / dl could maintain the number of pyramidal neurons in zebrafish treated with modified UCS stress (P <0.05). In conclusion, giving ethanol extract of arabica coffee at a dose of 50 mg / dl has a neuroprotectant effect on zebrafish exposed to UCS stress.
Co-Authors . Harijadi Arie Nugroho Chandra Muhammad Rauf Ety Sari Handayani Ety Sri Handayani Febiawan Ismunandar Fitriyanto, Raden Edi Fuad Khadafianto Ika Fidianingsih Kinasih D S Kuswati Kuswati Kuswati, Kuswati Muchamad Marwan Muhammad Yusuf Hisyam Nurul Hidayah NURUL HIDAYAH Prilly i Raleka Pahlevawati Sahdella Sahdella Soedjono Aswin Untung Widodo Wimpy Wimpy Yusa Muhammad Thoriq Yusi Maulina