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All Journal Nurse Media Journal of Nursing Jurnal Mahasiswa Teknik Sipil Universitas Tanjungpura Althea Medical Journal Jurnal Online Mahasiswa (JOM) Bidang Keguruan dan Ilmu Pendidikan Jurnal Kedokteran Indonesian Journal of Cancer
Budi Darmawan
Department of Nuclear Medicine Faculty of Medicine Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Bandung
Civil Engineering, Building, Construction & Architecture Education Health Professions Medicine & Pharmacology Nursing

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Journal : Jurnal Kedokteran

 1 
PEPTIDE RECEPTOR RADIONUCLIDE THERAPY Hidayatullah, Rian; Budiawan, Hendra; Darmawan, Budi; Affandi, Erwin
Jurnal Kedokteran Vol 10 No 1 (2021): volume 10 nomor 1 2021
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v10i1.480

Abstract

Peptide receptor radionuclide therapy (PRRT) is an effective and usually well-tolerated treatment for unresectable or metastatic neuroendocrine tumors expressing somatostatin receptors. Somatostatin analog which is labeled by ?- or ?-emitting radionuclide binds specifically to SSTRs abnormally expressed in NETs. The two radiopharmaceuticals most commonly used for PRRT are 90Y-DOTATOC and 177Lu-DOTATATE which have been demonstrated to provide an effective tumor response and symptom relief with positive impact on survival. Chronic side effects on the kidneys and bone marrow are generally mild. The radiopharmaceuticals is internalized into the cell for the irradiation. Furthermore, the long half-life of the analog maintains a persistent therapeutic effect. Different approaches are now under evaluation to improve PRRT efficacy, it may be expected that the use of PRRT will increase in the coming years.
Somatostatin Hidayatullah, Rian; Budiawan, Hendra; Darmawan, Budi; Affandi, Erwin
Jurnal Kedokteran Vol 10 No 2 (2021): Jurnal Kedokteran Juni 2021
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v10i2.482

Abstract

Somatostatin, also known as growth hormone-inhibiting factor (GIF) or somatotropin release-inhibiting factor (SRIF), is a peptide hormone that regulates the endocrine system and affects neurotransmission and cell proliferation. Somatostatin can be regarded as secretory pan-inhibitory,because it can inhibit secretion of almost all endocrine and exocrine glands. Somatostatin has 2 active forms (somatostatin-14 and 28), but the short half-life of the hormone was one of the reasons why the native hormone was not feasible for routine clinical practice. Somatostatin analog was synthesized for the first time in 1980-1982 and proved to be more resistant to degradation and more potent than native hormone. There are five somatostatin receptors (SSTR1-5). The genes encoding human SSTR1-5 are located in chromosome 14q13, 17q24, 22q13.1, 20p11.2 and 16p13.3. SSTR expression pattern and complex signaling make somatostatin be such an extraordinary neurotransmitter and hormone. The potent inhibitory action of SSTR on cellular processes such as secretion, proliferation, and apoptosis is the reason for somatostatin to be the target for therapy development. Radiopharmaceuticals used for therapy consist of three parts: somatostatin analog, chelator, and radionuclide (alpha or beta-emitting). Combinations of different peptides, chelators, and radionuclides have been tested in vitro and/or in vivo for their use in peptide receptor radionuclide therapy (PRRT). These compounds are able to irradiate tumors and their metastases via the internalization through a specific receptor subtype which is generally overexpressed on the cell membrane.
Co-Authors ', Ramadi Ardiah Juita Ardini S. Raksanagara, Ardini S. Berlian Isnia Fitrasanti Chairunnisa, - Diyah Fatmasari Drasthya Zarisha, Drasthya Elsa Pudji Setiawati Erwin Affandi Hendra Budiawan, Hendra KARDINAH KARDINAH, KARDINAH Pratiwi, Nana Novita Pujiastuti, Rr. Sri Endang Rian Hidayatullah ROSALINA HASAN, ROSALINA SARININGSIH HIKMAWATI, SARININGSIH Siaw Carwen, Siaw