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All Journal Medical Laboratory Technology Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) UMI Medical Journal Journal of Health Science Community Ebers Papyrus
Mansyur Arif
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Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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MULTIPLE MYELOMA IN A YOUNG ADULT (Mieloma Multipel di Dewasa Muda) Hendra Rasubala; Agus Alim Abdullah; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 3 (2016)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v22i3.1248

Abstract

Mieloma Multipel (MM) merupakan penyakit tertentu di individu yang berusia lanjut. Kejadian mieloma multipel di pasien berusia dibawah empat puluh tahun adalah sangat jarang. Mieloma multipel merupakan kasus keganasan sel plasma yang mengenai banyak tulangdengan gejala peningkatan protein monoklon di serum/air kemih atau keduanya. Hal ini harus dibedakan dengan kasus peningkatanprotein monoklon yang lain seperti plasmasitoma soliter yang hanya terjadi di satu tulang. Dalam kasus ini dipaparkan pasien mielomamultipel laki-laki dewasa muda berumur 34 tahun, dengan hasil memeriksa laboratorik dan radiologis yang mendukung diagnosismieloma multipel tertentu. Keluhan utama berupa nyeri punggung yang disertai dengan kondisi tulang yang rapuh di gambaranradiologik. Pasien dirawat di rumah sakit selama tujuh belas hari di ruang perawatan bagian Bedah Ortopedi Rumah Sakit WahidinSudirohusodo, Makassar. Pasien meninggal pada hari ke-17 sesaat setelah menjalani kemoterapi pertama. Gambaran laboratorik yangmenonjol dan khas selama perawatan di rumah sakit seperti pemeriksaan hapusan aspirasi sumsum tulang, pemeriksaan elektroforesisserum protein, hematologik rutin, laju endap darah, zat kimia klinik (seperti kalsium, asam urat, uji fungsi hati, ureum dan kreatinin)dan pemeriksaan radiologik berupa foto polos tulang. Dalam makalah ini akan dipaparkan secara jelas, sampai akhirnya penyakit inididiagnosis beserta derajat dan perjalanan penyakitnya. Penanganan dan pengobatan pasien mieloma multipel selama perawatan inapdi rumah sakit juga akan dipaparkan dengan jelas dalam makalah ini.
WAKTU PENYIMPANAN TROMBOSIT TERKAIT JUMLAH DI KONSENTRAT TROMBOSIT Raehana Samad; Agus Alim Abdullah; Kusriny A.P.; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 3 (2014)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i3.481

Abstract

The transfusion of thrombocyte concentrate is one of the important medical approaches to make the platelet count raised in patients with thrombocytopenia. The TC could change during the storage process, so the in vitro storaging should be considered to minimalize the alterations on the platelet count. The study was aimed to know the impact of storage time to maintain the platelet count stability in TC of transfusion blood by evaluating it. A study with Time Series design was performed in 30 samples of TC of transfusion blood collected from 30 blood donors. The samples was collected from the bag tube of TC and the test is performed as soon as possible by using haematological analyzer (Sysmex KX-21) with an impedance method, the rest of the samples was stored in an agitator on 22±2°C to perform a repeated count on day 5th and 7th. The collected data was analyzed with “Paired T Test”. The results of this study showed that the platelet count in TC of transfusion blood was decreased in the fifth day compared to the first day, but the decreased matter is insignificant, statistically (p=0.13). While after seventh (7) day, the platelet count is decreased significantly (p=0.00). The researchers concluded that the storage of TC for seven (7) days could not maintain the stability of the platelet count of the transfusion blood. There fore is suggested, a further study to evaluate the impact of storage time on platelets viability. So the quality of platelets in TC of transfusion blood can be evaluated.
PENENTUAN KADAR LIPOPROTEIN RAPATAN TINGGI (HIGH DENSITY) DENGAN DUA PEREAKSI (REAGEN) BERBEDA MENGGUNAKAN HITACHI 902 I. Hutagalung; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 15, No 2 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v15i2.941

Abstract

Reagent selection is one of the factors that could influence the quality of laboratory results. The use of open system tools gives thepossibility to choose the best reagents, including the reagent for high density lipoprotein (HDL) determination. The aim of this studywas to compare HDL level determination using two different reagents measured by Hitachi 902. A cross sectional study was done fromJanuary to February 2007 in Ratulangi Medical Centre Laboratory, Makassar. From 47 samples we found that the mean HDL levelusing Daichi reagent was 50.47 mg/dl ranging from 45.99 mg/dl to 54.94 mg/dl and the mean using Roche reagent was 56.23 mg/dlranging from 50.93 mg/dl to 61.53 mg/dl with p = 0.098, and Pearson Correlation was 0.900 with p = 0.000. There was no significantdifference between HDL level measured by Hitachi 902 using Daichi and Roche reagents.
Association between Soluble Transferrin Receptor with Central Obesity Muh Taufiq; Liong Boy Kurniawan; Mansyur Arif
Journal of Health Science Community Vol. 2 No. 3 (2022): February
Publisher : Institut Ilmu Kesehatan STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (176.448 KB)

Abstract

Subclinical chronic inflammation in central obesity theoretically leads to hepcidin synthesis in large amount, which inhibits iron absorption and inhibits the release of iron stores from macrophages. This subsequently leads to an increase in soluble transferrin receptor (sTfR) levels due to inadequate cellular iron. This study aims to determine the association between sTfR levels with central obesity. The study design was cross sectional with 75 subjects selected purposively. The sTfR level was determined using ELISA technique. Descriptive statistical method and bivariate analysis were employed to determine the association between these variables. The results showed that there was a significant difference in terms of sTfR levels of central obese individuals with those of non-central obese one. In line with this finding, waist circumference also exhibited a positive correlation with sTfR levels. In addition, we found no systematic relationship between gender and age with respect to sTfR levels. From these results, it was concluded that the sTfR levels were higher in subjects with central obesity compared to non-central obesity, and the greater the waist circumference, the higher the sTfR levels.
Analisis Kadar Hemoglobin Terhadap Mortalitas Pasien Infark Miokard Akut Selama Perawatan Liong Boy Kurniawan; Uleng Bahrun; Darmawaty Rauf; Mansyur Arif
Ebers Papyrus Vol. 20 No. 1 (2014): EBERS PAPYRUS
Publisher : Medical Faculty Universitas Tarumanagara

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Abstract

Pemeriksaan darah rutin merupakan tes yang umum diperiksa pada pasien yang dirawat di rumah sakit. Sebagian pasien infark miokard akut mengalami anemia dan berpotensi menyebabkan peningkatan mortalitas selama perawatan. Penelitian in bertujuan untuk mengetahui kadar hemoglobin pada pasien infark miokard akut saat masuk rumah sakit dan menilai pengaruhnya terhadap mortalitas pasien selama perawatan di rumah sakit. Penelitian ini merupakan studi potong silang dengan mengambil data sekunder dari rekam medik 81 pasien infark miokard akut yang dirawat di Unit Perawatan Jantung Intensif Rumah Sakit    Dr. Wahidin Sudirohusodo Makassar periode Juli 2010 hingga Juni 2011. Kadar hemoglobin yang diteliti diperoleh saat pasien masuk rumah sakit dan diklasifikasikan sebagai anemia,hemoglobin normal dan polisitemia. Uji statistik dilakukan dengan Uji {Student T} dan Mann Whitney. Rerata kadar hemoglobin pada penderita infark miokard akut yang survive dan meninggal selama perawatan adalah 14,13±1,73 g/ddl an 13,59±2,59 g/d(lp=0,269). Risiko mortalitas pada pasien dengan anemia sebesar 2,96 kali dibandingkan dengan kadar hemoglobin normal (interval kepercayaan 95%, 0,71-12,25; p=0,144) dan pasien dengan polisitemia sebesar 2,37 kali dibandingkan dengan kadar hemoglobin normal (interval kepercayaan 95%,0,54-10,47; p=0,257). Pasien infark miokard akut yang disertai dengan anemia atau polisitemia memiliki kecenderungan mortalitas yang lebih tinggi dibandingkan dengan kadar hemoglobin yang normal.
Co-Authors Agus Alim Abdullah Ani Kartini Arie Yanti Asvin Nurulita Baharuddin Baharuddin Burhanuddin Bahar Cyntia Kornelius D. Daud Darmawaty Rauf Darwati Muhadi Dewi Sri Kartini Fitrie Octavia Glent Nurtanio HAM Akil Hardjoeno Hardjoeno Hendra Rasubala herlinah herlinah Hilma Yuniar Hilma Yuniar Thamrin Hj. Darmawaty E.R, I Hutagalung I. Hutagalung Ibrahim Abd. Samad Ibrahim Abdul Samad Ibrahim Labeda Ichwan Meinardi Ichwani Meinard Idham Jaya Ganda Irawaty Irawaty Irfan Idris Irna Diyana Kartika Iwan Joseph Joko Widodo Juranah . Kusriny A.P. Lince Wijoyo Liong Boy Kurniawan, Liong Boy Muh Taufiq Mutmainnah . Nur Rahmi Raehaan Nurhayana Sennang Nursin Abd. Kadir Nyoman Trisna Yustiani Rachmawati A.M Rachmawati AM Rachmawati Muhiddin Rachmawati Muhiddin Raehana Samad Reini Meilani Isbach Riesti Ekasanti Rifai Amirudin Rima Yuliati Muin Rostina Rostina Sri Wahyunie S Suci Aprianti Sukmawaty Sukmawaty Sulina Yanti Wibawa Suryani Jamal Susi Sevianty Syahraswati Syahraswati Theosobia Grace Orno Uleng Bahrun Viviyanti Zainuddin Waode Rusdiah Winni Agustiani Wiwi Payung Yedid Lebang Yosep F. Tallulembang ZK Abdurahman Baizal