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Journal : JURNAL ILMU KEFARMASIAN INDONESIA

 1 
Evaluasi Sediaan Gel Anti Jerawat Kombinasi Ekstrak Etanol Daun Cabai Rawit dan Ekstrak Etanol Daun Sirsak Dimas Setiyono; Deden Mulya Prayoga; Herlan Budi Kusuma; Dina Febrina
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 1 (2023): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i1.1391

Abstract

Acne is a skin disease that usually occurs near adulthood. Acne is caused by several bacteria namely Staphylococcus epidermidis, Propionibacterium acnes, and Staphylococcus aureus. The alternative acne treatment uses cayenne pepper leaves (Capsicum frutescens L.) and soursop leaves (Annona muricata L.). The research aimed to find out the best formulation and activity of the ethanol extract gel of cayenne pepper leaves combined with the ethanol extract of soursop leaves as an inhibitor for acne-causing bacteria. This research is an experimental research type with 3 formulation designs, each of which was made with concentrations of ethanol extract from cayenne pepper leaves and ethanol extract from soursop leaves, namely F1 (1% and 1%), F2 (3% and 3%), and F3 (5 % and 5%), then tested the physical properties, antibacterial test and physical stability test of the preparation then analyzed the data with one-way ANOVA p-value <0.05. The results showed that the gel preparations were stable in terms of organoleptic, homogeneity, spreadability, adhesion, and viscosity, while there was a change in pH after the physical stability test using the cycling test method. The F2 gel preparation had the best bacterial inhibition, namely Staphylococcus aureus of 10.83 mm. Then the F3 gel preparation best inhibited Staphylococcus epidermidis bacteria by 9.56 mm and Propionibacterium acnes by 10.4 mm.
Co-Authors Adita Silvia Fitriana Amelia Damayanti Deden Mulya Prayoga Desy Nawangsari Dimas Setiyono Dina Febrina Etika Anggraini Rahayu Galih Samodra Gita Rizki Saputri Herlan Budi Kusuma Hikmanti, Arlyana Iga Melasasi Ikhwan Yuda Kusuma Isti Nurfaizah Kurnia Panggih Rahayu Mely Nastiti Nur Islamiah Nur Rahmawati Rani Prabandari Rani Prabandari Riska Setyaningsih Siti Muawanah Sunarti Sunarti Yeni Pratiwi