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All Journal Indonesian Journal of Pharmaceutical Science and Technology Pharmacon Journal of Pharmacopolium Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan Jurnal Dunia Farmasi Jurnal Farmasi dan Sains Indonesia (JFSI) Journal of Nursing and Health (JNH) Akper Yakpermas Banyumas Jurnal Ilmiah Farmasi Akademi Farmasi Jember Jurnal Pengabdian Masyarakat Pharmacy Genius SEMINAR NASIONAL PENELITIAN DAN PENGABDIAN KEPADA MASYARAKAT

Desy Nawangsari

Universitas Harapan Bangsa

Author-ID : 4074222

Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Isolation and Phisicochemical Characterization of Microcristalline Cellulose from Ramie (Boehmeria nivea L. Gaud) Based on Pharmaceutical Grade Quality Nawangsari, Desy; Yohana Chaerunisaa, Anis; Abdassah, Marline; Sriwidodo, Sriwidodo; Rusdiana, Taofik; Apriyanti, Linda
Indonesian Journal of Pharmaceutical Science and Technology Vol 5, No 2 (2018)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Microcrystalline cellulose is the most used material for medicine, which able to be found in fibrous plants. Microcrystal celluloses are being used as filler or binder in dosage formulas in tablets and capsules. This research aimed to produce microcrystalline cellulose from ramie based on pharmaceutical grade parameters. Research method include hemp fiber preparation, Î±-cellulose isolation, microcrystalline cellulose production, and microcrystalline cellulose characterization which compare with AvicelÂ® PH 102 . Result shown microcrystalline cellulose yield is 57.26%. The result of physicochemical characterization that can comply the specifications of pharmaceutical grade as a pharmaceutical excipient.Â Keywods :Â Microcrystalline cellulose, Ramie, physicochemical, pharmaceutical grade.

ISOLASI DAN KARAKTERISASI SELULOSA MIKROKRISTAL DARI AMPAS TEBU (SACCHARUM OFFICINARUM L.) Nawangsari, Desy
Pharmacon: Jurnal Farmasi Indonesia Vol 16, No 2 (2019)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v16i2.9150

Microcrystalline cellulose is the result of isolation from alpha cellulose. Woody plants are generally the source of microcrystalline cellulose production. One of the natural ingredients that can be used to make microcrystalline cellulose is bagasse (Saccharum officinarum L.). Bagasse contains 37.65% of cellulose which can be isolated by the delignification stage using a base solution, the process of bleaching and hydrolysis of alpha cellulose by high temperature heating using dilute dilute acid. The yield of microcrystalline cellulose from bagasse 26.03% and fulfilling the characterization based on the literature.

UJI STABILITAS SEDIAAN SALEP EKSTRAK ETANOL RIMPANG KENCUR (Kaempferiae galanga L.) DALAM BERBAGAI BASISt Of Ethanol Extract Ointment of Kaempferiae galanga L. Rhizome Extract In Various Bases Nawangsari, Desy; Sunarti, Sunarti
Journal of Pharmacopolium Vol 4, No 2 (2021)
Publisher : P3M STIKes Bakti Tunas Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36465/jop.v4i2.737

Kencur (Kaempferiae galanga L.) merupakan jenis tanaman rempah dan obat yang telah dikenal secara luas oleh masyarakat Indonesia. Secara empiris kencur digunakan sebagai penambah nafsu makan, infeksi bakteri, obat batuk, disentri, ekspektoran, masuk angin, sakit perut serta meredakan peradangan (inflamasi). Manfaat kencur sebagai anti inflamasi memerlukan pengembangkan dalam bentuk sediaan farmasi untuk meningkatkan penggunaannya. Salah satu sediaan farmasi yang dapat memudahkan dalam penggunaannya adalah salep. Pembuatan salep secara umum dibagi menjadi 4 basis. Penelitian ini bertujuan untuk mengevaluasi sifat fisik dan stabilitas dari salep dengan berbagai basis yang digunakan.Hasil penelitian ini menunjukkan perbedaan tipe basis salep yang digunakan pada formulasi salep ekstrak rimpang kencur berpengaruh pada sifat fisik sediaan yang dihasilkan. Warna, pH, daya sebar dan daya lekat dari sediaan salep berbeda-beda untuk tiap jenis basis yang digunakan, tetapi bau dan homogenitas sediaan yang dihasilkan sama.Â Hasil ujian stabilitas fisik menunjukan salep ekstrak rimpang kencur dengan basis tercuci air termasuk stabil selama penyimpanan dengan (p value > 0,05).

FORMULASI SEDIAAN PASTA GIGI DENGAN ARANG AKTIF TEMPURUNG KELAPA (Cocos nucifera L) SEBAGAI PEMUTIH GIGI Febrianti, Liana; Nawangsari, Desy; Silvia F, Adita
Jurnal Farmasi & Sains Indonesia Vol 4 No 2 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol4no2p50-57

Teeth are one of the important aesthetic factors for a person, including tooth color. The effect of tooth discoloration can cause a person's lack of self-confidence. The use of teeth whitening materials can cause side effects in the oral cavity so that the use of natural ingredients is chosen as a tooth whitener, one of which is activated charcoal. Activated charcoal has an absorption capacity of 25-100%. The purpose of this study was to determine the activity of coconut shell-activated charcoal toothpaste as a teeth whitener. This study used 20 dentures and then soaked them in coffee solution for 17 days to change the color of the teeth. Tooth color was measured using a classical Vitapan shade guide. Teeth whitening activity test was carried out for 14 days. Toothpaste was made in 4 formulas with different concentrations of coconut shell-activated charcoal in formula 1 (0%), formula 2 (6%), formula 3 (10%), and formula 4 (12%). The results of the observation showed that the preparation of coconut shell-activated charcoal toothpaste can give tooth discoloration. A statistical tests showed that coconut shell-activated charcoal toothpaste had a significant difference in activity as a natural ingredient for whitening teeth.

FORMULASI, SIFAT FISIK DAN UJI AKTIVITAS ANTIOKSIDAN MASKER GEL PEEL OFF TEPUNG BERAS HITAM (Oriza sativa L. var Indica) Nastiti, Mely; Nawangsari, Desy; Febrina, Dina
Jurnal Farmasi & Sains Indonesia Vol 4 No 2 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol4no2p58-67

Black rice (Oriza sativa L. var Indica) is a local variety that contains anthocyanin pigments. Anthocyanins are antioxidants that have a positive effect on health. Peel off face mask is a face mask that has the advantage that it is easy to remove like an elastic membrane. This study aims to determine the physical evaluation of the peel off gel mask preparation, antioxidant activity and stability of the peel off gel mask. This research method was carried out experimentally, the data were analyzed using the One Way ANOVA method with sig > 0.05. The conclusion of this study was that the black rice flour peel off mask preparation had a significant significant difference to the f1 dispersion test, but there was no significant difference between f2 and 3. There was no significant difference in the antioxidant test. Based on data analysis using one way ANOVA after the cycling test, the formulation was good for 6 cycles, namely formulations 2 and 3. Keywords: Antioxidant, Black rice, dan Peel off mask.

FORMULASI SEDIAAN GEL SCRUB WAJAH SERBUK BIJI KOPI ARABIKA (Coffee arabica) DENGAN KONSENTRASI KARBOPOL 940 SEBAGAI GELLING AGENT Putri, Natasha Faruqi Andrian; Nawangsari, Desy; Sunarti, Sunarti
Jurnal Farmasi & Sains Indonesia Vol 4 No 2 (2021)
Publisher : LPPM Sekolah Tinggi Ilmu Farmasi Nusaputera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52216/jfsi.vol4no2p68-73

ABSTRACT Coffee is a plant that is rich in benefits. Arabica coffee beans contain antioxidants that can provide benefits, one of which is preventing cell damage due to exposure to free radicals. Arabica coffee is formulated in the form of a gel scrub with the gelling agent carbopol 940. This study aims to determine the best concentration of gelling agent on the physical properties and stability of the Arabica coffee bean gel scrub and when used it causes irritation or not. Pure experimental research method to determine the effect of certain treatments by comparing with the control group that was not given treatment. Evaluation of gel scrub preparations included evaluation of the physical quality of the preparation and irritation test on 3 rabbits. The results of the evaluation of the preparations showed that all gel scrub preparations were in the form of a gel with black granules, distinctive smell, homogeneous, stable during 6 cycles of storage, pH value (4.5-7.8), adhesion (2-300 seconds), spreadability (5-7 cm) and viscosity (2000-4000 cp), irritation test in rabbits caused a slight irritating skin reaction. The results of the statistical test with the one way anova test showed that there was a significant difference between the formulas with a significance value (p < 0.05). However, the stock can still be said to be stable because it is still in the range of requirements. In conclusion, the gel scrub produced has good physical characteristics and causes a slight irritation of the skin reaction. Arabica coffee bean powder can be formulated as a gel scrub preparation which has good physical characteristics in formula IV with a concentration of carbopol 940 2%. and stable at 6 cycles of storage.

FORMULASI SEDIAAN MASKER ANTIOKSIDAN DARI EKSTRAK TEH HIJAU (CAMELLIA SINENSIS) desi nawangsari
Viva Medika Vol 11 No 3 (2018)
Publisher : Universitas Harapan Bangsa Purwokerto

Abstract Research has been carried out on the formulation of maskantioxidant preparations containing green tea leaf extract. The study begins with testing the antioxidant activity of ethanol extract of green tea leaves with a free radical reduction method of 1,1-diphenyl-2-picrylhydrazyl using visible spectrophotometry. Testing of antioxidant activity showed that the ethanol extract of green tea leaves gave an IC50 value of 3.17µg / mL. Formulations of gel masks made were F0 (base without active substances), F1 (base + concentration of ethanol extract of green tea leaves for IC50 (0,000317%)), F2 (base + concentration of ethanol extract of green tea leaves for 50xIC50 (0, 0158%)), F3 (base + concentration of ethanol extract of green tea leaves for 100xIC50 (0.0317%)), F4 (base + concentration of ethanol extract of green tea leaves for IC50), F5 (base + concentration of ethanol extract of green tea leaves worth IC50), F6 (base + concentration of ethanol extract of green tea leaves for IC50. Evaluation of gel mask preparations include, organoleptic examination and homogeneity, pH, viscosity, dry time of preparation and testing of antioxidant stability. F2 provides better and higher free radical reduction activity than products on the market. F4, F5, F6 shows an increase in free radical reduction activity. Keywords: Green tea leaves (Camellia sinensis L.), DPPh, IC50 gel mask.

EVALUASI SEDIAAN MASKER ANTIOKSIDAN DARI EKSTRAK DAUN TEH HIJAU (CAMELLIA SINENSIS) desi nawangsari
Viva Medika Vol 11 No 3 (2018)
Publisher : Universitas Harapan Bangsa Purwokerto

Abstract Green tea (Camellia sinensis L.) has the main efficacy as an antioxidant and contains polyphenol compounds in green tea leaves with the main component of polyphenol fraction namely Epigallocatechin-3-gallate (EGCG) which has strong activity to prevent free radicals that cause premature aging. Research has been carried out on the formulation of maskantioxidant preparations containing green tea leaf extract. The study begins with testing the antioxidant activity of ethanol extract of green tea leaves with a free radical reduction method of 1,1-diphenyl-2-picrylhydrazyl using visible spectrophotometry. Testing of antioxidant activity showed that the ethanol extract of green tea leaves gave an IC50 value of 3.17µg / mL. Formulations of gel masks made were F0 (base without active substances), F1 (base + concentration of ethanol extract of green tea leaves for IC50 (0,000317%)), F2 (base + concentration of ethanol extract of green tea leaves for 50xIC50 (0, 0158%)), F3 (base + concentration of ethanol extract of green tea leaves for 100xIC50 (0.0317%)), F4 (base + concentration of ethanol extract of green tea leaves for IC50), F5 (base + concentration of ethanol extract of green tea leaves worth IC50), F6 (base + concentration of ethanol extract of green tea leaves for IC50. Evaluation of gel mask preparations include, organoleptic examination and homogeneity, pH, viscosity, dry time of preparation and testing of antioxidant stability. F2 provides better and higher free radical reduction activity than products on the market. F4, F5, F6 shows an increase in free radical reduction activity. Keywords: Green tea leaves (Camellia sinensis L.), DPPh, IC50 gel mask.

Pengaruh Bahan Pengisi Terhadap Massa Cetak Tablet Vitamin C Desy Nawangsari
Viva Medika Vol 12 No 02 (2019): Viva Medika: Jurnal Kesehatan, Kebidanan, dan keperawatan
Publisher : Universitas Harapan Bangsa Purwokerto

Avicel® PH is branded name from microcrystalline cellulose that is generally used in pharmaceutical preparations. Avicel® PH are being used as filler or binder in dosage formulas in tablets especially for direct compression because having a good flowing rate and a good compressibility. This study aims to compare the influence of the use Avicel® PH 101 and Avicel® PH 102 as a filler on of preparations a tablet of ascorbic acid. A method of the research was conducted by making granule of ascorbic acid tablet with the variation filler, then the granule was evaluate in .The results showed Avicel® PH 102 as a filler produce granule which better seen from the flowability, static angle of repose, carr’s index and hausner ratio .

PREPARASI DAN ISOLASI MIKROKRISTAL DARI AMPAS TEBU (Saccharum officinarum L.) Desy Nawangsari; Rani Pranbandari; Fenny Permatasari
Viva Medika Vol 13 No 01 (2019): VOLUME 13/NOMOR 01/SEPTEMBER/2019
Publisher : Universitas Harapan Bangsa Purwokerto

Selulosa mikrokristal merupakan hasil isolasi dari alfa selulosa. Selulosa mikrokristal banyak digunakan dalam bidang farmasi. Salah satu bahan alam yang dapat dimanfaatkan untuk membuat selulosa mikkrokristal adalah ampas tebu. Ampas tebu mengadung 45,96% selulosa yang dapat diisolasi dengan tahapan delignifikasi menggunakan larutan basa, proses pemutihan serta hidrolisis alfa selulosa dengan pemanasan suhu tinggi menggunakan larutan asam encer. Rendemen selulosa mikrokristal dari ampas tebu 26,03%.

Co-Authors Adita Silvia Fitriana Aditya Silvia Fitriana Alfaeni Salmatuzzahro Alviony Trista Hapsari dina febrina Dwi Mustikasari Dwi Syaji Wahyuningtias Ega Angelia Narki Febrianti, Liana Fenny Permatasari Galih Samodra Ikhwan Yuda Kusuma Isti Nurfaizah Khamdiyah Indah Kurniasih Kukuh Yunianto Sumargo Lina Umami LINDA APRIYANTI, LINDA Made Suandika Marline Abdassah, Marline Nastiti, Mely Nur Khasanah Pegi Erawati Peppy Octaviani Putri, Natasha Faruqi Andrian Rafi Firman Khaqiqi Rani Prabandari Rani Prabandari Rani Pranbandari Rizky Widya Ayuning Tias Silvia F, Adita Sriwidodo Sriwidodo, Sriwidodo Sunarti Sunarti Taofik Rusdiana umi sangadah Vidia Putri Kusumandari Yeni Pratiwi Yohana Chaerunisaa, Anis

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