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OPTIMASI FORMULA TABLET PIROKSIKAM MENGGUNAKAN EKSIPIEN LAKTOSA, AVICEL PH-101, DAN AMPROTAB DENGAN METODE SIMPLEX LATTICE DESIGN Kusuma, Ikhwan Yuda; Prabandari, Rani
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.9176

Piroxicam solubility in water is very small this cause problem in the process of absorption so that it?s required an optimal formula to establish the physical properties of tablet quality for piroxicam tablets. The purpose of this research was creating formulas with the optimal combination of excipients lactose, Avicel pH 101, and piroxicam amprotab to obtain tablets with good physical properties and disolution. Seven piroxicam tablet formulas were made with a combination of lactose, avicel PH-101, and Amprotab on 2 batches. Method for making tablets piroxicam was established by direct compression. Tests included were the physical properties of piroxicam tablets tablets weight uniformity, uniformity of size, hardness, brittleness, disintegration test, as well as dissolution test, and content uniformity. Based on the simplex lattice design method, lactose is a dominant factor to improved the uniformity of tablet?s concentartions. Interaction of two components avicel PH-101 and amprotab is a dominant factor to reduced vulnerability. Interaction of three components lactose, avicel PH-101 and amprotab is a dominant factor to lowered the value coefisien variation of weight uniformity, increased hardness, decreased the disintegration, and improved dissolution of tablets. Selection of the optimum formula was determined by the method of simplex lattice design through diagrams superimposed contour plots and contour plots for obtaining the optimal proportions of each ingredient as follows: lactose (85,154?100%), avicel PH-101 (0?12,437%), and amprotab (0?5,425%).

Perbandingan randemen minyak atsiri sereh (cymbopogon citratus) yang umur panennya 6 bulan Dan 9 bulan dengan metode destilasi air) Rani Prabandari
Viva Medika Vol 11 No 1 (2017)
Publisher : Universitas Harapan Bangsa Purwokerto

AbstractIndonesian nature is very rich in plants containing essential oils. Essential oils can be produced from various parts of plants such as roots, stems, leaves, flowers, or fruit. There are 50-200 species of essential oil producing plants. In Indonesia there are around 40 types of essential oils producing plants. One of the essential oils producing plants is lemongrass (Taufiq, Tuhana, 2008 p: 2). This study aims to determine the comparison of essential oils in Lemongrass (Cymbopogon citratus) which are harvested at 6 months and 9 months with a water distillation method. The procedure for selecting samples and research samples, directly with the object of research, is the citronella plant whose harvest age is 6 months taken from 1 clump and 9 months taken from 1 clump. The results of this study indicate that lemongrass plants with a harvest age of 6 months produce more essential oils compared to lemongrass plants with a harvest age of 9 months. This is influenced by several factors, including climate, harvest age. Lemongrass plants aged 6 months are the optimal age to be harvested, so that they get a higher yield of essential oils, besides that the factors of soil fertility and the intensity of sunlight also affect the content of essential oils of lemongrass.From the results of the research that has been done on the test sample, it can be concluded that the results of the essential oil ration on citronella (Cymbopogon citratus), which has 6 months of harvest age, obtained an average yield of 0.46% v / b and 9 months. 0.35% v / b with the results of the t-test obtained by the price t-count (2.984)> t-table (2.776). So that H0 is rejected and Ha is accepted and it can be concluded that there is a significant difference between lemongrass with 6 months and 9 months of harvest. Keywords: lemongrass, essential oil, age of harvest, water distillation

PROFIL KROMATOGRAFI LAPIS TIPIS MINYAK ATSIRI SEREH (Cymbopogon citratus) Rani Prabandari
Viva Medika Vol 11 No 1 (2017)
Publisher : Universitas Harapan Bangsa Purwokerto

Abstract. Rhodinol has been isolated from citronella oil. Isolation of lemongrass oil is done by using the distillation method. Samples used were citronella harvested for 6 months and 9 months. Silent phase used TLC plate slika gel F254 with a size of 2 x 10 cm and the mobile phase used was Toluen: Ethyl Acetate (93: 7). Results of Thin Layer Chromatography HRF profile obtained for experiment I (citronella harvesting age 6 months) 32, 77, 87 and Experiment II (lemongrass harvest age 9 months) respectively 25, 73, 81.

Pengaruh konsentrasi air dalam formula salep minyak cengkeh (syzigium aromaticum) Rani Prabandari
Viva Medika Vol 11 No 3 (2018)
Publisher : Universitas Harapan Bangsa Purwokerto

Abstract The clove flower essential oil (Syzygium aromaticum) with the active compound eugenol has been widely investigated and is known to be efficacious as an anti-inflammatory agent, and further research on its formulation continues. The formula developed in this study was a topical ointment dosage form using a water soluble base (oleic acid enhancer and propylene glycol). This study aims to determine the physical and irritant properties of the clove flower essential oil ointment (MABC) if a hydrocarbon base is used. The ointment is made by the smelting method with a concentration of 5% (F1), 10% (FII) and 15% (FIII). The ointments of the three formulas were then evaluated for their physical properties, including dispersion, adhesion and pH. The results of statistical tests with the LSD test showed that there were significant differences between formulas. The higher the concentration of MABC, the greater the spread (p0.05). The results of the Simplex Lattice Design irritation test also show that water-soluble base ointment with a concentration of 5%, 10% and 15% MABC does not cause an irritating effect. Keywords: Syzygium aromaticum, base of water soluble ointment, anti-inflammatory.

EVALUASI SIFAT FISIK SEDIAAN SALEP MINYAK CENGKEH (SYZIGIUM AROMATICUM) DALAM BASIS LARUT AIR Rani Prabandari
Viva Medika Vol 11 No 3 (2018)
Publisher : Universitas Harapan Bangsa Purwokerto

The clove flower essential oil (Syzygium aromaticum) with the active compound eugenol has been widely investigated and is known to be efficacious as an anti-inflammatory agent, and further research on its formulation continues. The formula developed in this study was a topical ointment dosage form using a water soluble base (oleic acid enhancer and propylene glycol). This study aims to determine the physical and irritant properties of the clove flower essential oil ointment (MABC) if a hydrocarbon base is used. The ointment is made by the smelting method with a concentration of 5% (F1), 10% (FII) and 15% (FIII). The ointments of the three formulas were then evaluated for their physical properties, including dispersion, adhesion and pH. The results of statistical tests with the LSD test showed that there were significant differences between formulas. The higher the concentration of MABC, the greater the spread (p0.05). The results of the Simplex Lattice Design irritation test also show that water-soluble base ointment with a concentration of 5%, 10% and 15% MABC does not cause an irritating effect. Keywords: Syzygium aromaticum, base of water soluble ointment, anti-inflammatory.

Optimasi sediaan salep minyak cengkeh (syzigium aromaticum) dalam basis larut air Rani Prabandari
Viva Medika Vol 11 No 3 (2018)
Publisher : Universitas Harapan Bangsa Purwokerto

Abstract The clove flower essential oil (Syzygium aromaticum) with the active compound eugenol has been widely investigated and is known to be efficacious as an anti-inflammatory agent, and further research on its formulation continues. The formula developed in this study was a topical ointment dosage form using a water soluble base (oleic acid enhancer and propylene glycol). This study aims to determine the physical and irritant properties of the clove flower essential oil ointment (MABC) if a hydrocarbon base is used. The ointment is made by the smelting method with a concentration of 5% (F1), 10% (FII) and 15% (FIII). The ointments of the three formulas were then evaluated for their physical properties, including dispersion, adhesion and pH. The results of statistical tests with the LSD test showed that there were significant differences between formulas. The higher the concentration of MABC, the greater the spread (p0.05). The results of the Simplex Lattice Design irritation test also show that water-soluble base ointment with a concentration of 5%, 10% and 15% MABC does not cause an irritating effect. Keywords: Syzygium aromaticum, base of water soluble ointment, anti-inflammatory.

Formulasi dan uji stabilitas sediaan lulur dari rimpang kunyit (Curcuma longa linn) Rani Prabandari
Viva Medika Vol 11 No 3 (2018)
Publisher : Universitas Harapan Bangsa Purwokerto

ABSTRACT Lulur is a type of cosmetics made from flowers and other plant ingredients that are very useful for maintaining beauty, health, smoothness and brightness of the skin of the body. Lulur can help clean the dirt that sticks to the skin due to the influence of weather and pollution factors so that the skin becomes healthy, clean and beautiful. The contents of the substance include turmeric: curcuminoid which consists of curcumin, desmetoksikumin and bisdesmetoksikurkumin and other beneficial substances, such as volatile essential oils of oil, fat, carbohydrates, protein, starch, vitamin C, iron, phosphorus, and calcium. Curcumin is a yellow substance contained by turmeric, on average 10.29%, has broad spectrum biological activity including antihepototoxic, antibacterial and antioxidant so that turmeric is able to be used for traditional medicine both to maintain health and skin beauty of the body, The method used is study experimental scrubs and tested the stability of scrubs containing turmeric rhizome powder. The best scrubs are formula 1 which uses the ratio of turmeric powder to light brown scrub, homogeneous and perfectly fused body scrub, has a pH of 5, spread of 10,321 cm2, has a viscosity consistency of 99,000 mPa.s and adhesion for 4 seconds. Keywords: formulations, scrubs, turmeric.

FORMULASI SEDIAAN LULUR PENCERAH DAN PENGHALUS KULIT DARI KUNYIT (CURCUMA LONGA LINN) Rani Prabandari
Viva Medika Vol 11 No 3 (2018)
Publisher : Universitas Harapan Bangsa Purwokerto

ABSTRACT Lulur is a type of cosmetics made from flowers and other plant ingredients that are very useful for maintaining beauty, health, smoothness and brightness of the skin of the body. Scrub can help clean the dirt that sticks to the skin due to the influence of weather factors and pollution so that the skin becomes healthy, clean and beautiful. Dry skin types often tend to be more problematic than other skin types. Dry skin is caused by insufficient oil produced by the kelenjer oil, which makes the skin not moist and dry. This can cause skin problems such as: skin looks rough, wrinkled and dull. The contents of the substance include turmeric: curcuminoid which consists of curcumin, desmetoksikumin and bisdesmetoksikurkumin and other beneficial substances, such as volatile essential oils of oil, fat, carbohydrates, protein, starch, vitamin C, iron, phosphorus, and calcium. Curcumin is a yellow substance contained by turmeric, on average 10.29%, has broad spectrum biological activity including antihepototoxic, antibacterial and antioxidant so that turmeric is able to be used for traditional medicine both maintaining health and beauty of the body's skin, the method used to carry out this research is an experiment. The object in this study is the skin of the body found on dry skin in the hands. The sample in this study the author took the students of the University of Harapan Bangsa Purwokerto Pharmacy Department especially women aged 19-25 years, have the same characteristics / criteria that indicated dull, rough and not bright skin. Keywords: formulation, scrub, turmeric, lightening.

Pemberian Kombinasi Ekstrak Etanol Daun Pepaya (carica papaya l.) Pada Mencit rani prabandari
Viva Medika Vol 12 No 02 (2019): Viva Medika: Jurnal Kesehatan, Kebidanan, dan keperawatan
Publisher : Universitas Harapan Bangsa Purwokerto

The natural medicine has been known and used through out of the world. One of them is papaya. Efficacy papaya leave provide efficacy as fever, appetite enhancer, launsed menstruation and relieve pain. This study aims to determine whether the effect of aethanol extract of papaya leaf against power analgesic mefenamic acid on mice by using the method asetic acid induction. This study is an experimental study using twenty four mice. This animals were divided into six groups where each group consisting of four mice. Papaya leaves, mefenamic acid, and aquadest were give to each group as test substances and comparative solution. Observations were carried out for 10 minute using the method of asetic acid induction was a decreases of protection mechanism of the mice in of licking or stiff feet responses after the administration of test substances. There was a decrease of the response of mice to lick feet or stiff feet to the asetic acid induction were given after administration of papaya leaf extract. The extract of papaya leaves has an analgesic effect on mice.

ISOLASI DAN IDENTIFIKASI RIMPANG TEMULAWAK (Curcuma xanthorrohza Roxb.) DAN BUNGA LAVENDER (Lavandula angustifolia Mill.) rani prabandari; desy Nawangsari; Kukuh Yunianto Sumargo
Viva Medika Vol 13 No 01 (2019): VOLUME 13/NOMOR 01/SEPTEMBER/2019
Publisher : Universitas Harapan Bangsa Purwokerto

Essential oils are fragrance agents in plants. Essential oils have a volatile component in some plants with certain characteristics. At present, essential oils have been used as perfume, cosmetics, food additives and medicine. Empiric ethnopharmacology studies on aromatherapy plants show that Indonesia has 49 types of aromatic plants from 22 types of tribes, 12 of which are empirically used as aromatherapy with calming and refreshing effects (Sangat 1996 in Rahmawati, 2010). One example of aromatherapy used is the ginger rhizome (Curcuma xanthorrihza Roxb) and Lavender Flower (Lavandula angustifolia Mill.). This study aims to isolate and identify the essential oils of Temulawak rhizome (Curcuma xanthorrihza Roxb) and Lavender Flowers (Lavandula angustifolia Mill.). The essential oil isolation step uses the Steam Water Distillation method, after which the essential oil obtained is identified to ensure its purity. The results showed that Temulawak essential oil and Lavender essential oil were carried out using the water distillation method, obtained levels of 2.3% and 1.8%. Essential oils in Temulawak were identified by testing their physical properties which include specific gravity, solubility in ethanol 90%, solubility in chloroform and oil in NaCl. The identification results obtained in the Temulawak rhizome and Lavender plants are specific gravity 0.9436 and 0.8221. Solubility in ethanol 90% with a volume ratio of 1: 3.7 mL and 1: 3.3 mL. solubility in chloroform of 1: 3.3 mL and 1: 3.3 mL. on the addition of NaCl in the oil oil reduction occurs.

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