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Antidiabetic activities of 96% ethanol extract of Abelmoschus esculentus on Balb-C mice strain Aditama, Agnis Pondineka Ria
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 4, No 2 (2019): November
Publisher : University of Muhammadiyah Malang

Diabetes mellitus (DM) is a progressive metabolic disease that continues to increase every year. Treatment therapy using oral hypoglycemic drugs to treat DM has side effects, and alternative approaches must be taken. Abelmoschus esculentus has been known to be used as an alternative to DM because it has antioxidant activity due to its high flavonoid content. The purpose of this study was to determine the antidiabetic activity of 96% ethanol extract of Okra leaves against male mice of balb-c strain. Male mice were acclimatized for seven days and divided into five test groups and then fasted for 18 hours. Then the mice were induced with 150 mg / 20 g BW alloxan and measured on the 3rd day. Ethanol extract 96% okra leaves were then given in a dose of 5.6 mg / 20g BW; 11.2 mg / 20g BW; 22.4 mg / 20g BW, CMC Na 0.5% as negative control and glibenclamide 0.026 mg / 20g BBs as positive control for 14 days. The results of therapy with 96% ethanol extract of okra leaves can reduce blood glucose levels in mice so that the okra leaves contain flavonoid compounds that have antioxidant activity and can reduce blood glucose levels.

Antidiabetic activities of 96% ethanol extract of Abelmoschus esculentus on Balb-C mice strain Agnis Pondineka Ria Aditama
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol. 4 No. 2 (2019)
Publisher : Universitas Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22219/farmasains.v4i2.10718

Diabetes mellitus (DM) is a progressive metabolic disease that continues to increase every year. Treatment therapy using oral hypoglycemic drugs to treat DM has side effects, and alternative approaches must be taken. Abelmoschus esculentus has been known to be used as an alternative to DM because it has antioxidant activity due to its high flavonoid content. The purpose of this study was to determine the antidiabetic activity of 96% ethanol extract of Okra leaves against male mice of balb-c strain. Male mice were acclimatized for seven days and divided into five test groups and then fasted for 18 hours. Then the mice were induced with 150 mg / 20 g BW alloxan and measured on the 3rd day. Ethanol extract 96% okra leaves were then given in a dose of 5.6 mg / 20g BW; 11.2 mg / 20g BW; 22.4 mg / 20g BW, CMC Na 0.5% as negative control and glibenclamide 0.026 mg / 20g BBs as positive control for 14 days. The results of therapy with 96% ethanol extract of okra leaves can reduce blood glucose levels in mice so that the okra leaves contain flavonoid compounds that have antioxidant activity and can reduce blood glucose levels.

AKTIVITAS ANTIOSTEOPOROSIS EKSTRAK ETANOL 96 % DAUN Abelmoschus manihot L. MEDIK SECARA IN VITRO MENGGUNAKAN SEL PREOSTEOBLAS MC3T3-E1 Agnis Pondinekaria Aditama; Mangestuti Agil; Hening Laswati
Majalah Obat Tradisional Vol 21, No 3 (2016)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Osteoporosis is a disease characterized by low bone mass and structural deterioration of bone tissue. Estrogen deficiency causes loss of bone mineral density which causes osteoporosis. Phytoestrogen is a potential alternative of estrogen that can be used as Hormone Replacement Therapy on osteoporosis with minimum side effects. Many edible plants contain phytoestrogens that are believed to promote bone health. Abelmoschus manihot (L.) Medik has been known as a plant that is empirically used in the traditional medicine and has potency to prevent osteoporosis. The aim of this research is to determine whether the Abelmoschus manihot (L.) Medik leaves have the potential to increase bone formation in an in vitro assays using preosteoblast cell line MC3T3-E1. The results showed an increasing activity of Alkaline phosphatase using confocal laser scanning microscopy technique.

Peningkatan Soft Skill Siswa Melalui Pembuatan Sabun Ekstrak Kulit Buah Naga Merah (Hylocereus polyrhizus) di MA. Habiburrahman Jatian - Pakusari Jember Hadi Barru Hakam Fajar Siddiq; Agnis Pondinekaria Aditama
Warta Pengabdian Vol 12 No 3 (2018): Warta Pengabdian
Publisher : LP2M Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/wrtp.v12i3.9101

Community service activities undertaken by lecturers from Pharmacy Diploma III Program of Pharmacy Academy of Jember held on March, 2018, held at MA. Habiburrahman Jatian, Pakusari Jember provides benefits for students in improving students skill through soap red dragon fruit extract. MA. Habiburrahman was senior high school under the Ministry of Religious Affairs located in Jatian-Pakusari-Jember. MA. Habibirrahman also has a religious education institution that is Pondok Pesantren Habibirrahman. Nearly 70% of students of MA. Habiburrahman were santri. The results show that MA Habiburrahaman does not have a curculum that focuses on the attachment of students. Therefore, this program provides many benefits to students to add soft skills in the field of technology. In addition, this program is in great demand by all students. Keywoard: Community Servive, Soft Skill, Soap, Red Dragon Fruit

AKTIVITAS ANTIINFLAMASI FRAKSI ETANOL DAUN GEDI (Abelmoschus manihot L. Medik) PADA TIKUS PUTIH GALUR WISTAR Agnis Pondinekaria Aditama
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 2017: Desember - Vol.2 No.2
Publisher : AKADEMI FARMASI JEMBER

Gedi leaves (Abelmoschus manihot L. Medik) has been used empirically by the people of North Sulawesi to cure the disease. Flavonoids and steroids in Gedi leaves suspected to have anti-inflammatory effects. This Study aims to examine the anti-inflammatory effects of ethanol fraction from Gedi leaves (Abelmoschus manihot L. Medik) on edema of white males wistar foot induced with 1 % caragen, and to determine an effective dose of fraction to decrease the edema volume of Rat foot. The test was done using Rat Hind Paw Edeme or esthablished an artificial inflammation in left foot of white male rats. The treatments were carried out on five groups, the positive control group was administered with diclofenac sodium, the negative control group was administered with CMC Na 0,5 % solution, and the fraction groups were administered with 12 mg/Kg BB, 27 mg/Kg BB, 54 mg/Kg BB. Edema volume were measured every hour for 5 hours using a pletismometer. The average of edema volume (mL) and time (hour) were used to calculate the percentage of anti-inflammatory on each group compared to the negative control group. Obtained data were analyzed by one-way ANOVA followed by LSD test with confident level was 0,05. The result of this study indicate that gedi leaves can reduce edema volume of rat foot that induced with 1 % caragen and anti-inflammatory activity showed in ethanol fraction from Gedi leaves 12 mg/Kg BB by 55,2 %, 27 mg/Kg BB by 64,4% and 54 mg/Kg BB by 62,2%.Keywords : Daun Gedi (Abelmoschus manihot L. Medik), anti-inflammatory, edema

PENGARUH VARIASI KONSENTRASI HPMC SEBAGAI GELLING AGENT TERHADAP SIFAT FISIK GEL ANTIJAMUR EKSTRAK LENGKUAS (Alpinia galanga (L.) Swartz) Mikhania C.E., Agnis Pondinekaria Aditama, Sri Agita Ningrum
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 2019: Juli - Vol.3 No.1
Publisher : AKADEMI FARMASI JEMBER

The aim of this research was to know the influence of HPMC variation concentration as gelling agent againts physical properties antifungal extract galangal gel (Alpinia galanga (L) Swartz). Pre-experimental the one shot case study was used as the research design. Gel is formulated into three formulas with various concentration of HPMC 2% (F1), 3% (F2), and 4% (F3). The materials used in this research were galangal extract, propylenglycol, glycerin, methyl paraben, and aquadest. The result showed that the variation concentration of HPMC give influence to physical properties of organoleptic gel (form, smell and colour), viscosity, and spreadibility of gel but did not influence homogeneity and pH of the gel.Keywords: gel, galangal extract, HPMC

AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL 96% KULIT PISANG RAJA (Musa paradisiaca L) TERHADAP Escherichia coli Agnis Pondinekaria Aditama, Rizqiyah Akbar Mauliddah
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 2017: Desember - Vol.2 No.2
Publisher : AKADEMI FARMASI JEMBER

Banana peel is a material that can be used as a natural antibacterial because of its secondary metabolites content. The present study aimed to evaluate antibacterial activity of ethanol 96% extracted from banana (Musa paradisiaca L) peel against Escherichia coli. Result of phytochemical screening indicated that banana peel extract has alkaloid, flavonoid (tannin), and saponin compound that can act as antibacterial. Banana peel extract showed antibacterial activity that was proved by clear zone formed around disk paper. Sample of 64% extract concentration had the largest inhibition zone (9.6 mm) compared to sample of 16% and 32% concentration, inhibition zone of which was 4.4 mm and 6.26 respectively. One Way Anova analysis showed that sample of 64% concentration was significantly different from negative control, 16%, and 32% concentration. Nevertheless, there was no significant difference between 16% and 32% concentration.Keywords: Musa paradisiaca L, Escherichia coli, antibacterial

Efek Induksi Proliferasi Sel Osteoblas Tulang Trabekular Mencit Jantan oleh Ekstrak Etanol 96% Daun Semanggi (Marsilea crenata Presl.): Induction Effect of Proliferation of Osteoblas Cells Trabecular Bone Male Mice by 96% Ethanol Extract of Semanggi Leaves (Marsilea crenata Presl.) Agnis Pondineka Ria Aditama; Faisal Akhmal Muslikh; Izza Nailia Shirvi; Firsta Roisatul Islamiyah; Kurniawan Hidayat Perdana Putra; Fidia Rizkiah Inayatilah; Weka Sidha Bhagawan; Burhan Ma’arif; Asri Wido Mukti; Asti Rahayu
Jurnal Sains dan Kesehatan Vol. 3 No. 4 (2021): Jurnal Sains dan Kesehatan
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Osteoporosis adalah kondisi penurunan kepadatan mineral tulang dan berisiko patah tulang yang disebabkan oleh defisiensi estrogen. Fitoestrogen adalah senyawa pada tanaman yang memiliki kemampuan berikatan dengan reseptor estrogen untuk menggantikan fungsi estrogen. Daun M. crenata Presl. diketahui mengandung senyawa fitoestrogen. Tujuan penelitian ini adalah untuk membuktikan ekstrak etanol 96% daun M. crenata Presl. dapat meningkatkan jumlah sel osteoblas tulang trabekular femur dan vertebra pada mencit yang mengalami osteoporosis. Penelitian ini dilakukan dengan pemberian ekstrak etanol 96% daun M. crenata Presl. dosis 1,2; 2,4; 4,8; dan 9,6/20 g BB mencit/hari. Analisis dilakukan dengan cara pemeriksaan histomorfometri menggunakan pewarnaan HE, dan pengamatan sel osteoblas menggunakan mikroskop cahaya Olympus dengan software optilab. Data dianalisis menggunakan metode one way ANOVA. Hasil yang didapat yaitu kelompok PIV dengan dosis 9,6/20g BB mencit/hari dapat meningkatkan jumlah rerata sel osteoblas dengan nilai tertinggi yaitu 224,60 pada tulang trabekular femur dan 540,11 pada trabekular vertebra. Nilai perhitungan ED50 ekstrak etanol 96% daun M. crenata Presl. yaitu 1,908 mg pada tulang trabekular femur dan 2,878 mg pada tulang trabekular vertebra

Efek Penghambatan Ekspresi ER? Bebas oleh Fraksi n-Butanol Daun Semanggi (Marsilea crenata Presl.) pada Sel hFOB 1.19: Inhibitory Effect of Free-ER? Expression by n-Butanol Fraction of Semanggi (Marsilea crenata Presl.) Leaves on hFOB 1.19 Cells Burhan Ma’arif; Agnis Pondineka Ria Aditama; Faisal Akhmal Muslikh; Dewi Perwito Sari; Ira Purbosari; Hening Laswati; Mangestuti Agil
Jurnal Sains dan Kesehatan Vol. 3 No. 4 (2021): Jurnal Sains dan Kesehatan
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Wanita pascamenopause dapat menyebabkan berbagai macam masalah kesehatan, diantaranya adalah osteoporosis yang diakibatkan karena gangguan produksi hormon estrogen dalam tubuh. Salah satu alternatif yang muncul dan berpotensi untuk menggantikan hormon estrogen adalah fitoestrogen. Daun M. crenata diketahui mengandung senyawa fitoestrogen. Tujuan dari penelitian ini adalah untuk mengetahui fraksi n-Butanol daun M. crenata dalam meningkatkan aktivitas osteoblas pada proses pembentukan tulang terhadap sel hFOB 1.19. Penelitian ini menggunakan metode ICC dengan bantuan instrumen CLSM. Penelitian ini dilakukan dengan pemberian fraksi n-Butanol dengan varian konsentrasi62,5; 125; dan 250 ppm, serta pemberian genistein sebagai kontrol positif pada sel hFOB 1.19. Hasil dari penelitian ini menunjukkan bahwa fraksi n-Butanol daun M. crenata memiliki kandungan senyawa estrogenik sebagai agen untuk meningkatkan aktivitas osteoblas melalui penurunan ekspresi ER? bebas sel hFOB 1.19 dan konsentrasi 62,5 ppm sebagai konsentrasi optimal dengan nilai ekspresi 594.108 AU.

PENGARUH VARIASI KONSENTRASI GLISERIN SEBAGAI HUMEKTAN TERHADAP SIFAT FISIK SEDIAAN OBAT KUMUR DAUN ASAM JAWA (Tamarindus indica L.) Mikhania Christiningtyas Eryani; Agnis Pondineka Ria Aditama
JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER Vol 5, No 2 (2022): JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER
Publisher : AKADEMI FARMASI JEMBER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53864/jifakfar.v5i2.105

Obat kumur adalah cairan yang digunakan untuk membilas rongga mulut dengan tujuan untuk menghilangkan atau menghancurkan bakteri dan menghasilkan efek terapeutik dengan menghilangkan infeksi atau mencegah karies gigi. Daun asam jawa (Tamarindus indica L.) memiliki kandungan senyawa flavonoid dan tanin yang berfungsi sebagai anti bakteri pada rongga mulut. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh variasi konsentrasi gliserin terhadap sifat fisik sediaan obat kumur daun asam jawa. Obat kumur daun asam jawa dibuat dalam 3 formula dengan konsentrasi gliserin yang berbeda-beda yaitu F1 (10%), F2 (15%), dan F3(20%). Uji sifat fisik yang dilakukan meliputi uji organoleptis, pH, dan viskositas. Hasil penelitian menunjukan bahwa sediaan obat kumur pada ketiga formula memiliki warna kuning, rasa agak manis, dan bau khas mint. pH sediaan F1 sebesar 6,20±0,10, F2 sebesar 6,16±0,15 dan F3 sebesar 6,16±0,20. Viskositas sediaan F1 sebesar 1,47±0,04 cPs, F2 sebesar 1,49±0,04 cPs dan F3 sebesar 1,55±0,01 cPs. Kesimpulan dari penelitian ini adalah variasi konsentrasi gliserin tidak berpengaruh terhadap organoleptis, pH dan viskositas sediaan obat kumur daun asam jawa.

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