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All Journal UG Journal Jurnal Kesehatan Reproduksi Medical Journal of Indonesia
Jusuf S. Effendi
Department of Obstetrics and Gynecology, Padjadjaran University, Bandung
Civil Engineering, Building, Construction & Architecture Computer Science & IT Economics, Econometrics & Finance Education Health Professions Medicine & Pharmacology

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Role of nuclear factor kappa beta, tumor necrosis factor α, and cyclooxygenase-2 in preterm labor Darwin, Eryati; Nasrul, Ellyza; Effendi, Jusuf S.
Medical Journal of Indonesia Vol 23, No 4 (2014): November
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (669.766 KB) | DOI: 10.13181/mji.v23i4.1005

Abstract

Background: The pathway of tumor necrosis factor alpha (TNFα), nuclear factor kappa beta (NF-κB), and cyclooxygenase-2 (COX-2) activation in releasing prostaglandins is suggested to be crucial for initiating labor in the pathogenesis of preterm labor. The aim of the study was to know whether there were mean differences of NF-κB, TNFα, and COX-2 expressions between preterm and term labor and also to know the correlation among them in preterm labor.Methods: A case-control study was performed from May 2013 to February 2014 in Arifin Achmad Hospital, Pekanbaru. There were 30 subjects with preterm labor as cases and 30 with normal labor as controls. All subjects had singleton gestation with maximum parity was three, age limit of 35 year-old, and spontaneous labor in both groups. Placental tissue was collected from all subjects and evaluated with hematoxylin eosin staining. The expressions of TNFα, NF-κB, and COX-2 in the tissue were assessed with immunohistochemical staining by counting the percentage of smeared cells by two experts. The expressions of TNFα, NF-κB, and COX-2 between case and control were compared using t-test and the correlation was analyzed with Pearson correlation coefficient.Results: Mean (SD) of expressions of TNFα (93.05% [12.68] vs 49.11% [27.33]), NF-κB (42.46% [27.29] vs 13.66% [17.77]), and COX-2 (88.75% [10.86] vs 46% [30.36]) were significantly higher in the preterm labor compared to term labor (p = 0.001). There was significant correlation between TNFα and NF-κB expression (r = 0.385; p = 0.036) and no correlation was found between NF-κB and COX-2 (p = 0.982) in preterm labor.Conclusion: High expressions of TNFα, NF-κB, and COX-2 in preterm labor showed to contribute in the onset of preterm labor. High TNFα may suggest that infection was a leading cause of preterm labor. This is supported with an increase in NF-κB activation will increase COX-2 and subsequently prostaglandins that result in premature labor.
Hubungan Umur Ibu, Paritas dan Penolong Persalinan dengan Kematian Neonatal di Wilayah Kerja Puskesmas Kabupaten Banjarnegara tahun 2013 Rofiqoch, Isnaeni; Effendi, Jusuf S.; Bratakoesoema, Dinan S.
JURNAL KESEHATAN REPRODUKSI Vol 3, No 1 (2016)
Publisher : Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (285.116 KB) | DOI: 10.22146/jkr.36193

Abstract

Background: The neonatal mortality rate is Banjarnegara district is high compared with a target of IMR in Central Java province. In 2012 the neonatal mortality rate in Banjarnegara reached 316 cases, whereas in 2013 there were 115 cases in all health centers working area. The high neonatal mortality rate in Banjarnegara influenced by the persistence of early marriage in woman, birth attendant by non skilled health worker (dukun bayi) and women’s parity more than 4.Objective: The purpose of this study is to analyze the correlation between maternal age, parity and birth attendants with the incidence of neonatal mortality and examine the most dominant factors influencing the incidence neonatal mortality in the Health Center working area in Banjarnegara.Method: This study is a case control study design with retrospective approach. The data consists of perinatal verbal autopsy and medical records as many as 136 respondents consisting of 68 mothers who gave birth to her child and neonatal death and 68 maternal and child alive. Subjects were mothers who gave birth a baby who died aged 0-28 days.Result and Discussion: Statistical analysis using Chi Square, Mann Whitney, and multiple logistic regression. The results showed maternal age and parity variables were not significantly corerelated with neonatal mortality (p> 0.05), the variables significantly corerelated with neonatal mortality was birth attendants with p = 0.001. The results of logistic regression showed the strength of the corerelation from the most dominant variable to the smallest variable were birth attendants with OR: 5.64 (95% CI: 1.81 to 17.4), maternal age OR 3.97 (CI 95%, from 1.54 to 10.22), and parity OR: 0.32 (CI 95% 0.12 to 0.87).Conclusion: In conclusion, there was no relationship between maternal age and parity with neonatal mortality but there was a relationship between birth attendants with neonatal mortality. Based on the results of the multivariable analysis, birth attendants’ effect on the incidence of neonatal deaths was 5 times greater than mother’s age and parity.Keywords: Neonatal mortality, maternal age, parity, birth attendants
PENGARUH PROGRAM PENCEGAHAN PENULARAN HIV (HUMAN IMMUNODEFICIENCY VIRUS) DARI IBU KE ANAK TERHADAP KEJADIAN HIV PADA ANAK DI RSUD R. SYAMSUDIN, SH KOTA SUKABUMI Rochmawati, Rochmawati; Effendi, Jusuf S.; Susanto, Herman; Susiarno, Hadi; Widjadjakusumah, Tony; Anwar, Anita Deborah
UG Journal Vol 14, No 3 (2020)
Publisher : Universitas Gunadarma

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Abstract

Pada tahun 2015 terdapat 36,9 juta orang dengan HIV di seluruh du nia. Sebanyak 50% di antaranya adalah perempuan dan 2,1 juta anak berusia kurang dari 15 tahun. Penularan infeksi HIV dari ibu ke anak merupakan penyebab utama infeksi HIV pada anak usia di bawah 15 tahun. Penularan HIV dari ibu ke anak dapat dicegah denga n intervensi Pencegahan Penularan HIV dari Ibu ke Anak (PPIA). Penelitian ini menggunakan desain cohort retrospective nested cross sectional. Populasi dalam penelitian ini adalah data ibu hamil, bersalin, nifas dengan diagnosis HIV positif dan anaknya di RSUD R. Syamsudin, SH pada tahun 2011 - 2015. Analisis data menggunakan Chi Square dan Uji regresi logistik. Hasil penelitian didapatkan karakteristik subjek penelitian menunjukkan bahwa tidak terdapat perbedaan yang bermakna antara umur dan pekerjaan dengan diagnosis anak HIV positif dan anak HIV negatif karena kedua nilai p > 0,05 (0,770 dan 0,308). Hasil analisis didapatkan bahwa terdapat pengaruh pemeriksaan ANC terpadu dan pengobatan ARV terhadap kejadian HIV pada anak (p < 0,05). Ibu yang menjalani pemeriksaan ANC terpadu yang tidak sesuai berisiko 10 kali (RR 10,5 IK 95% 1,510 -72,92) menularkan HIV pada anak dibandingkan yang menjalani ANC terpadu sesuai. Ibu yang mendapat pengobatan ARV yang tidak sesuai berisiko 12 kali (RR 12,139 IK 95% 1,742 -84,09) menularkan HIV pada anak dibandingkan dengan ibu yang mendapat pengobatan ARV yang sesuai. Faktor yang paling berpengaruh dalam program pencegahan penularan HIV dari ibu ke anak terhadap kejadian HIV pada anak yaitu pengobatan ARV
Co-Authors Anita Deborah Anwar Bratakoesoema, Dinan S. Ellyza Nasrul Eryati Darwin Herman Susanto Rochmawati, Rochmawati Rofiqoch, Isnaeni Susiarno, Hadi Widjadjakusumah, Tony