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All Journal Medical Journal of Indonesia Jurnal Kesehatan Andalas The Indonesian Biomedical Journal Sari Pediatri Journal of Dentomaxillofacial Science JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Endurance: Kajian Ilmiah Problema Kesehatan Journal of Midwifery JIK- JURNAL ILMU KESEHATAN The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Majalah Kedokteran Andalas Health and Medical Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Ilmu Kesehatan Indonesia
Ellyza Nasrul
Andalas University
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Role of nuclear factor kappa beta, tumor necrosis factor α, and cyclooxygenase-2 in preterm labor Darwin, Eryati; Nasrul, Ellyza; Effendi, Jusuf S.
Medical Journal of Indonesia Vol 23, No 4 (2014): November
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (669.766 KB) | DOI: 10.13181/mji.v23i4.1005

Abstract

Background: The pathway of tumor necrosis factor alpha (TNFα), nuclear factor kappa beta (NF-κB), and cyclooxygenase-2 (COX-2) activation in releasing prostaglandins is suggested to be crucial for initiating labor in the pathogenesis of preterm labor. The aim of the study was to know whether there were mean differences of NF-κB, TNFα, and COX-2 expressions between preterm and term labor and also to know the correlation among them in preterm labor.Methods: A case-control study was performed from May 2013 to February 2014 in Arifin Achmad Hospital, Pekanbaru. There were 30 subjects with preterm labor as cases and 30 with normal labor as controls. All subjects had singleton gestation with maximum parity was three, age limit of 35 year-old, and spontaneous labor in both groups. Placental tissue was collected from all subjects and evaluated with hematoxylin eosin staining. The expressions of TNFα, NF-κB, and COX-2 in the tissue were assessed with immunohistochemical staining by counting the percentage of smeared cells by two experts. The expressions of TNFα, NF-κB, and COX-2 between case and control were compared using t-test and the correlation was analyzed with Pearson correlation coefficient.Results: Mean (SD) of expressions of TNFα (93.05% [12.68] vs 49.11% [27.33]), NF-κB (42.46% [27.29] vs 13.66% [17.77]), and COX-2 (88.75% [10.86] vs 46% [30.36]) were significantly higher in the preterm labor compared to term labor (p = 0.001). There was significant correlation between TNFα and NF-κB expression (r = 0.385; p = 0.036) and no correlation was found between NF-κB and COX-2 (p = 0.982) in preterm labor.Conclusion: High expressions of TNFα, NF-κB, and COX-2 in preterm labor showed to contribute in the onset of preterm labor. High TNFα may suggest that infection was a leading cause of preterm labor. This is supported with an increase in NF-κB activation will increase COX-2 and subsequently prostaglandins that result in premature labor.
Perbedaan Kadar Brain Derived Neurotropic Factor Neonatus Dari Ibu Hamil Normal Dan Anemia Defisiensi Besi Mardiah, Ainal; Amir, Arni; Friadi, Andi; Nasrul, Ellyza
Jurnal Endurance Vol 3, No 3 (2018): Jurnal Endurance: Kajian Ilmiah Problema Kesehatan
Publisher : Lembaga Layanan Pendidikan Tinggi (LLDIKTI) Wilayah X

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22216/jen.v3i3.3706

Abstract

Iron deficiency anemia is anemia caused by iron deficiency in the blood. Maternal iron deficiency affects the low iron reserves in neonates and it also influences on Brain Derived Neurotropic Factor (BDNF)  which affects cognitive function. The purpose of this study was to determine the difference mean of BDNF in neonates from normal pregnant women and pregnant women with iron deficiency. The design of this research was Cross Sectional design. This research was conducted in Community Health Center of Lubuk  Buaya, Ambacang Community Health Center, Community Health Center of Ikur Koto Health Center and Biomedical Laboratory of Andalas University on February 2017 to April 2018. There were 42 pregnant women was selected as sample e of this research. The samples were chosen by Consecutive Sampling. Then, the sample is divided into two groups: normal pregnant women and pregnant women with iron deficiency anemia. BDNF are examined by the ELISA. Next, the data were analyzed by using T test. The levels of BDNF neonates in normal pregnant group was 3.65(ng/ml) and the anemia pregnant group was 1.74(ng/ml) (p <0.05). There was significant difference of BDNF levels in neonates from normal pregnant women and pregnant women with iron deficiency anemia. The conclusion of this study is there is a difference of average BDNF in neonates from normal pregnant women and pregnant women with iron deficiency. Anemia defisiensi besi adalah anemia yang disebabkan karena kekurangan zat besi dalam darah. Defisiensi besi  maternal berdampak pada rendahnya cadangan besi pada neonatus dan berdampak terhadap ekspresi Brain Derived Neurotropic Factor (BDNF) yang berpengaruh pada fungsi kognitif. Tujuan penelitian ini adalah untuk mengetahui perbedaan rerata kadar BDNF pada neonatus dari ibu hamil normal dan ibu hamil defisiensi besi. Desain penelitian ini adalah Cross Sectional. Penelitian dilakukan di Puskesmas Lubuk Buaya, Puskesmas Ambacang, Puskesmas Ikur Koto dan Laboratorium Biomedik Universitas Andalas pada bulan Februari 2017 – Juli 2018. Sampel Penelitian adalah ibu hamil sebanyak 42 orang yang dipilih secara Consecutive Sampling, sampel dibagi menjadi dua kelompok yaitu ibu hamil normal dan ibu hamil anemia defisiensi besi. BDNF diperiksa dengan metode ELISA. Data dianalisa menggunakan uji T test. Kadar BDNF neonatus pada ibu kelompok normal adalah 3,65(ng/ml) dan kelompok ibu anemia adalah 1,74(ng/ml) (p<0,05). Terdapat perbedaan bermakna kadar BDNF pada neonatus dari ibu hamil normal dan ibu anemia defisiensi besi.
Immunocompetent Expression of CD4+ T Cell and CD8+ T Cell, TNF-alpha and INF-gamma in Patient with Chronic Hepatitis C Nasrul, Ellyza
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 7, ISSUE 2, August 2006
Publisher : The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (0.036 KB) | DOI: 10.24871/72200633-37

Abstract

Aim: To investigate the expression CD4+ T cell and CD8+ T cell as well as TNF-a and INF-g level on chronic hepatitis C. Methods: This is a cross-sectional study. Forty patients with chronic hepatitis C based on laboratory examination, who were collected from blood transfusion centers at Dr. M. Djamil Hospital. The control group used forty healthy samples. Results: There were 40 chronic hepatitis C cases satisfying the inclusion criteria. We found that CD4+ T cells count 50.35 ± 3.18%; CD8+ T cells count 59.37 ± 3.52%; TNF-a level 22.03 ± 3.72 pg/ml and INF-g level 4.47 ± 1.47 pg/ml. Conclusion: The chronic infection hepatitis C virus have given the effects on the immunocompetent cells which increased of CD4+, CD8+, TNF-a level and INF-g level. Keywords: hepatitis C virus, CD4+ T cell, CD8+ T cell, cytokines TNF-a, INF-g
RETRACTED: Pengaruh Kurang Tidur terhadap Berat Badan pada Tikus Wistar Jantan Deby Nelsya Eka Putri; Ellyza Nasrul; Machdawaty Masri
Jurnal Kesehatan Andalas Vol 6, No 1 (2017)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v6i1.655

Abstract

Artikel ini ditarik dari daftar terbitan Vol. 6 No. 1 Tahun 2017 karena terjadi kesalahan dalam pengorganisasian artikel yang diterbitkan sehingga terjadi penerbitan ulang artikel ini.Artikel ini dapat diakses melalui link berikut: http://jurnal.fk.unand.ac.id/index.php/jka/issue/view/11.
Gambaran Pemeriksaan Kadar SGOT, SGPT, Ureum dan Kreatinin Pasien Covid-19 dengan dan tanpa Komorbid Rachmi Fadillah; Ellyza Nasrul; Tuty Prihandani
Jurnal Kesehatan Andalas Vol 10, No 2 (2021): Online July 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i2.1722

Abstract

Coronavirus disease (COVID-19) causes damage through mechanisms: cytotoxic to the bile duct, liver and renal tubular epithelial cells; severe inflammatory response due to excessive pro-inflammatory cytokines (cytokine storm); tissue anoxia; and drug-induced liver and kidney damage. AST and ALT enzymes are used to determine liver damage, while kidney damage is examined from increased urea and creatinine levels. Objectives: To know AST, ALT, urea and creatinine levels in COVID-19 patients with and without comorbidity in RSUP Dr. M. Djamil Padang. Methods: A retrospective descriptive study was conducted by taking chemical data for COVID-19 patients with and without comorbidity for March-August 2020. AST and ALT levels were examined by using an automatic chemistry analyzer with NADH method (without P-5'-P), urea with enzymatic colorimetry, and creatinine with Jaffe's modification. The data was presented in table and average (standard deviation). Results:  A study of 76 patients found 28 with comorbidity and 48 without comorbidity. Patients with comorbidity AST in average was 33.0 (20.3) U/l; SGPT 29.0 (23.4) U/l; urea 58.3 (66.9) mg/dl; and creatinine 3.0 (5.1) mg/dl. Patients without comorbidity AST in average 31.9 (28.7) mg/dl; SGPT 28.8 (21.4) mg/dl; urea 24.6 (20.1) mg/dl; creatinine 0.9 (0.4) mg/dl. In average, AST and ALT in patients with and without comorbidity were in the normal range. Urea and creatinine in patients with comorbidity were higher than normal. Conclusion: Covid-19 patients with comorbidity at admission had urea and creatinine levels in average higher than normal values.Keywords: aminotransaminase, COVID-19, creatinine
IDENTIFIKASI BAKTERI GRAM NEGATIF DAN UJI SENSITIVITAS ANTIBIOTIK ULKUS KAKI DIABETES DI RSUP DR. M. DJAMIL PADANG Dendy Dendy; Ellyza Nasrul; Eugeny Alia
Jurnal Kesehatan Andalas Vol 8, No 4 (2019): Online December 2019
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v8i4.1111

Abstract

AbstrakUlkus kaki diabetes merupakan komplikasi kronik diabetes melitus yang dapat menyebabkan terjadinya infeksi bakteri. Bakteri yang umum diisolasi dari infeksi ulkus kaki diabetes adalah Gram-positif dan Gram-negatif. Pemakaian antibiotik pada terapi ulkus kaki diabetes pada setiap rumah sakit berbeda sehingga terjadi perbedaan sensitivitas antibiotik. Tujuan: Mengidentifikasi bakteri gram negatif dan uji sensitivitas pada ulkus kaki diabetes di RSUP Dr M Djamil Padang. Metode: Penelitian deskriptif retrospektif telah dilakukan pada seluruh swab dari ulkus kaki diabetes di bangsal penyakit dalam yang dikultur menggunakan agar darah di Laboratorium Sentral RSUP Dr M Djamil periode Agustus 2015 sampai Juli 2016. Identifikasi bakteri dengan pewarnaan Gram dan tes biokimia. Uji  sensitivitas antibiotik menggunakan metode Kirby-Bauer sesuai dengan standar CLSI. Hasil: Bakteri yang ditemukan dari swab Ulkus kaki diabetes adalah Proteus sp (36%), Klebsiella sp (34%), Pseudomonas sp (21%), dan Acinetobacter sp (9%). Proteus sp sensitif terhadap meropenem (90%) dan resisten terhadap erithromycin (100%). Klebsiella  sp resisten terhadap ampicilin (94,7%) dan sensitif terhadap Meropenem (36.8%). Pseudomonas sp sensitif terhadap meropenem (83.3%) dan sebagian besar resisten terhadap antibiotik yang diuji. Acinetobacter sp sebagian besar resisten terhadap antibiotik yang diuji, hanya 40% sensitif terhadap meropenem. Simpulan: Bakteri terbanyak penyebab ulkus kaki diabetes di bangsal penyakit dalam pada periode Agustus 2015 sampai Juli 2016 adalah Proteus sp, yang sensitif terhadap meropenem dan resisten terhadap erithromycin. 
Korelasi Kadar Protein C-Reaktif dengan Rasio Kolesterol Total / HDL pada Penyandang Obes di RSUP Dr M Djamil Padang Nanda Oktavia; Ellyza Nasrul; Efrida Efrida
Jurnal Kesehatan Andalas Vol 10, No 2 (2021): Online July 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i2.1714

Abstract

C-reactive protein is an acute-phase protein produced by the liver in response to inflammation. Dyslipidemia can trigger the inflammatory reaction in the blood vessels, causing atherosclerosis. The ratio of total cholesterol/High Density Lipoprotein (HDL) is considered as one of the sensitive predictor lipid ratio for the cardiovascular disease risk factor. Objectives: To determined the correlation of C reactive protein between cholesterol levels with total cholesterol/HDL ratio in obese people. Methods: This study was an analytical study with a cross-sectional design of 59 people who met the inclusion and exclusion criteria at the RSUP Dr. M. Djamil Padang from January to September 2019. Research subjects consisted of first degree obesity (25.0 ≤IMT <30.0 kg/m2) and second degree (≥30.0 kg/m2). C reactive protein levels were measured as high-sensitivity C-reactive protein. Total cholesterol and HDL levels were measured using automated clinical chemicals with the enzymatic colorimetric method. Data were analyzed by Pearson, significant if p <0.05. Results: The study subjects were 59 people (17 men and 22 women) with an average age was 35 (8.04) years. CRP levels in stage II obesity were slightly higher than grade I, with a mean difference between groups of 0.26 mg/L (95% CI: -1.80-1.2; p=0.74). The average ratio of total cholesterol/HDL levels in the obese group I and II was 5.13 and 4.80 (p=0.93). The correlation showed a very weak positive (r=0.12) and was statistically not significant (p=0.35). The results of the subanalysis showed relatively similar patterns between the first-degree obesity population (r=0.10; p=0.58) and second-degree (r=0.16; p=0.41). Conclusion: There is no significant correlation between protein C-reactive and total cholesterol/HDL ratio.Keywords: Obesity, C-Reactive Protein, total cholesterol/HDL ratio
Prevalensi dan Pola Sensitivitas Antibiotik Klebsiella pneumoniae dan Escherichia coli Penghasil Extended Spectrum Beta Laktamase di RSUP Dr. M Djamil Padang Suci Alillah Muztika; Ellyza Nasrul; Eugeny Alia
Jurnal Kesehatan Andalas Vol 9, No 2 (2020): Online June 2020
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v9i2.1272

Abstract

Prevalensi Escherichia coli dan Klebsiella pneumoniae penghasil Extended spectrum beta Lactamase (ESBL) meningkat dalam beberapa tahun ini. Infeksi bakteri penghasil ESBL memiliki pilihan terapi yang terbatas. Tujuan: Mengetahui prevalensi dan pola sensitivitas antibiotik dari Klebsiella pneumoniae dan Escherichia coli penghasil ESBL di RSUP Dr M Djamil Padang. Metode: Penelitian ini merupakan studi deskriptif dengan rancangan potong lintang terhadap 828 sampel mikrobiologi dengan hasil kultur positif terhadap bakteri Gram negatif pada bulan Juni 2018- Mei 2019 yang memenuhi kriteria inklusi. Identifikasi bakteri, pemeriksaan ESBL dan uji sensitivitas dilakukan dengan alat mikrobiologi otomatis dengan metode kolorimetri dan turbidimetri. Hasil: Prevalensi Klebsiella pneumoniae dan Escherichia coli penghasil ESBL di RSUP Dr M Djamill Padang  masing-masing sebanyak 70,9% dan 75,7%. Sensitivitas Klebsiella pneumoniae dan Escherichia coli penghasil ESBL adalah 96,4% dan 98,8 terhadap antibiotik meropenem, 98,9% dan 99,4% terhadap antibiotik amikasin, 53,5% dan 44,8% terhadap antibiotik sefepim, 46,2% dan 53,4% terhadap antibiotik gentamisin serta 31,5% dan 15,9% terhadap antibiotik siprofloksasin. Prevalensi Klebsiella pneumoniae dan Escherichia coli penghasil ESBL di RSUP Dr. M Djamil Padang cukup tinggi dengan rata-rata prevalensi kedua bakteri 73,2%. Simpulan: Klebsiella pneumoniae dan Escherichia coli penghasil ESBL sensitif terhadap antibiotik meropenem dan amikasin.Kata kunci: ESBL, Escherichia coli, Klebsiella pneumoniae, prevalensi
Perbedaan Rasio Kolesterol Total/ HDL Kelompok Kontrol dan Kelompok Diet Tinggi Minyak Sawit pada Tikus Wistar Yelsa Yulanda Putri; Ellyza Nasrul; Susila Sastri
Jurnal Kesehatan Andalas Vol 6, No 2 (2017)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v6i2.712

Abstract

Rasio kolesterol  total/HDL merupakan variabel lipoprotein terbaik dalam memprediksi risiko penyakit kardiovaskular. Peningkatan risiko penyakit kardiovaskular dapat disebabkan oleh tingginya kadar kolesterol serum. Minyak sawit mengandung 50% asam lemak jenuh dan 50% asam lemak tidak jenuh. Tujuan penelitian ini adalah mengetahui perbedaan rasio kolesterol total/ HDL antara kelompok kontrol dan kelompok diet tinggi minyak sawit pada tikus. Penelitian ini adalah eksperimental dengan pendekatan post test only control group design. Sampel penelitian terdiri dari 10 ekor tikus Wistar jantan yang dibagi menjadi kelompok kontrol (K) dan kelompok perlakuan (P). Diet tinggi minyak sawit (minyak sawit 42.5%, 3ml/hari) diberikan pada kelompok P selama empat minggu. Analisis data menggunakan uji t-independent. Hasil penelitian menunjukkan terdapat perbedaan peningkatan yang tidak bermakna antara kelompok P dan kelompok K pada rerata kolesterol, yaitu 63.66±9.9(P) 57.39±3.28(K) (p>0.05), rerata HDL 19.44±3.99(P) 17.64±2.00(K) (p>0.05), dan rerata rasio kolesterol total/ HDL 3.26±0.24 (P) 3.31±0.32 (K) (p>0.05). Simpulan penelitian ini adalah kadar kolesterol total, HDL, dan rasio kolesterol total/ HDL antara kelompok kontrol dan kelompok diet tinggi minyak sawit tidak berbeda.
Pola Kuman dan Uji Kepekaan pada Pasien Community Acquired Pneumonia di RSUP Dr. M. Djamil Padang Tahun 2016 Narlis Narlis; Ellyza Nasrul; Efrida Efrida
Jurnal Kesehatan Andalas Vol 8, No 3 (2019): Online September 2019
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v8i3.1041

Abstract

Community acquired pneumonia (CAP) merupakan infeksi yang paling sering menyebabkan sepsis dan dapat menimbulkan kematian. Pertimbangan pemilihan antimikroba yang tepat dan menghindari penggunaan yang berlebihan perlu dilakukan untuk mencegah terjadinya resistensi. Tujuan penelitian ini adalah mengetahui pola kuman dan uji kepekaan pasien CAP di RSUP Dr. M. Djamil Padang. Penelitian ini merupakan penelitian deskriptif retrospektif terhadap 201 sampel sputum pasien CAP yang diperiksa kultur kemudian dilanjutkan dengan pewarnaan Gram dan uji biokimia untuk mengidentifikasi bakteri. Uji kepekaan antimikroba menggunakan metode difusi cakram. Penelitian dilakukan di Laboratorium Sentral RSUP Dr. M. Djamil Padang periode Januari 2016 hingga Desember 2016. Data ditampilkan dalam bentuk tabel distribusi frekuensi. Mikroorganisme yang ditemukan adalah Klebsiella pneumonia (55,23%), Staphylococcus aureus (25,87%), Streptococcus pneumonia (7,96%), Pseudomonas aeruginosa (5,97%), Staphylococcus epidermidis (2,9%), Acinetobacter baumani (1,99%), Proteus vulgaris (0,49%). Antimikroba yang paling sensitif adalah Meropenem (78,7%), sedangkan antimikroba resisten dengan persentase tertinggi adalah Ampisilin (90%), Amoksisilin (89,4%), Eritromisin (73,5%), Amoksisilin + Klavulanat (64,6%), dan Kloramfenikol (61,7%). Mikroorganisme yang paling banyak ditemukan adalah Klebsiella pneumonia (55,23%). Meropenem merupakan antimikroba sensitif dengan persentase paling tinggi (78,7%) sedangkan antimikroba resisten dengan persentase paling tinggi adalah ampisilin (90%).
Co-Authors . Yanwirasti Amri Bakhtiar Andi Friadi Arni Amir Deby Nelsya Eka Putri Dendy Dendy Dewi Asmawati Dia Rofinda Dian Handayani Dwi Yulia Efa Ismardianita Efa Ismardianita, Efa Efrida Efrida Erizal Zaini Eryati Darwin Eugeny Alia Eugeny Alia Eva Chundrayetti Fadila Esmeralda Ilmi Fatmawati Fatmawati Ferry Sandra Fhany El Shara Fifi Harmely Hanifah Maani Hasmiwati Inggrit Anggraini Jusuf S. Effendi Lisa Ernita Machdawaty Masri Mardiah, Ainal Meri Ponda Sari Mieke Hemiawati Mieke Hemiawati, Mieke Nanda Oktavia Narlis Narlis Nasrul Zubir Rachmi Fadillah Rikarni Rikarni Rina Gustia Salman - Suci Alillah Muztika Susila Sastri Tuti Asryani Tutty Prihandani Tuty Prihandani Umar Syarif Yanwirasti Yanwirasti Yanwirasti Yanwirasti Yelsa Yulanda Putri Yufri Aldi