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All Journal VALENSI Indonesian Journal of Chemistry Molekul: Jurnal Ilmiah Kimia
Yoshihito Shiono
Department of Food, Life, and Environmental Science, Faculty of Agriculture, Yamagata University, Tsuruoka, Yamagata 997-8555, Japan
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology

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Dammarane-Type Triterpenoids from The Stembark of Aglaia argentea (Meliaceae) Ace Tatang Hidayat; Kindi Farabi; Ida Nur Farida; Kansy Haikal; Nurlelasari Nurlelasari; Desi Harneti Putri Huspa; Rani Maharani; Unang Supratman; Yoshihito Shiono
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 4, No. 1, Mei 2018
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (111.204 KB) | DOI: 10.15408/jkv.v4i1.7065

Abstract

Two dammarane-type triterpenoids, 20S,24S-epoxy-3α,25-dihydroxydammarane (1) and 3α-acetyl-20S,24S-epoxy-3α,25-dihydroxydammarane (2), have been isolated from the stembark of Aglaia argentea. The chemical structure of compounds (1 and 2) were identified by spectroscopic evidences including UV, IR, 1D-NMR, 2D-NMR and MS as well as by comparing with previously reported spectral data. Those compounds were isolated from this plant for first time. Compounds (1 and 2) showed cytotoxic activity against P-388 murine leukemia cells with IC50 values of 23.96 and 8.14 mM, respectively.DOI:http://dx.doi.org/10.15408/jkv.v4i1.7065
Steroids from The Stem Bark of Dysoxylum nutans (Meliaceae) and Their Cytotoxic Effect Against MCF-7 Breast Cancer Cell Lines Tri Mayanti; Nur Insani Amir; Dewa Gede Katja; Sofa Fajriah; Ahmad Darmawan; Unang Supratman; Khlaijah Awang; Yoshihito Shiono
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 6, No. 2, November 2020
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v6i2.15976

Abstract

Three steroids, 3α-hydroxystigmast-5(6), 22-diene-7-one (1), stigmasterol (2) and 3-hydroxy-7β-methoxystigmast-5(6)-ene (3), were isolated from the stem bark of Dysoxylum nutans. The chemical structures were identified by spectroscopic data, which includes IR, 1D-NMR, 2D-NMR, and HR-TOFMS as well as by comparing previously reported spectral data. Compounds 1-3 were tested for cytotoxic effect against MCF-7 breast cancer cell lines and compound 1 showed the strongest cytotoxic activity with an IC50 value of 20.13 ± 0.06 μM.
Co-Authors Ace Tatang Hidayat Ahmad Darmawan Al Arofatus Naini Aprilia Permata Sari Asri Peni Wulandari Azmi Azhari Darwati Darwati Desi Harneti Putri Huspa Dewa Gede Katja Erina Hilmayanti Fajar Fauzi Abdullah Galih Bayu Pratama Gian Primahana Hersa Milawati Ida Nur Farida Ida Nurfarida Iqbal Wahyu Mustaqim Kansy Haikal Khalijah Awang Khlaijah Awang Kindi Farabi Kindi Farabi Kindi Farabi Mohamad Nurul Azmi Nur Insani Amir Nurlelasari Nurlelasari Purnama Purnama Rani Maharani Rani Maharani Rani Maharani Rani Maharani Ricson Pemimpin Hutagaol Sari Purbaya Shabarni Gaffar Sofa Fajriah Sofa Fajriah Sofa Fajriah Tjandrawati Mozef Tri Mayanti Tri Mayanti Unang Supratman Unang Supratman Unang Supratman Wahyu Syafriansyah Winda Sukmawati Yeni Mulyani