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All Journal Folia Medica Indonesiana Jurnal Farmasi Sains dan Komunitas Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Jurnal Farmasi Indonesia RANDANG TANA - Jurnal Pengabdian Masyarakat Jurnal Ilmiah Medicamento Prosiding SIMKESNAS Parapemikir Jurnal Ilmiah Farmasi
Anak Agung Ngurah Putra Riana Prasetya
Sekolah Tinggi Farmasi Mahaganesha
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Effectivity of Erythropoietin Alpha Compared to Erythropoietin Beta in Patients with Chronic Kidney Disease-Anemia on Hemodialysis Anak Agung Ngurah Putra Riana Prasetya; Budi Suprapti; Bayu Dharma Shanti
Folia Medica Indonesiana Vol. 55 No. 2 (2019): June
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (288.652 KB) | DOI: 10.20473/fmi.v55i2.24461

Abstract

Anemia in patient with chronic kidney disease could cause a lot of complication. The first line therapy of this condition is by treating with erythropoiesis-stimulating agents (ESA) or called erythropoietin. The erythropoietin alpha and beta were two types of the human recombinant erythropoietin that are usually used in Indonesia. The aim of this study was to determine the effectivity of erythropoietin alpha compared to erythropoietin beta especially in haemoglobin and haematocrit level. This prospective observational study was conducted in March – September 2016. The inclusion criteria were CKD stage 5 patients with a minimum of 3 months of regular hemodialysis, Hb <10 g/dL with enough iron status ST > 20% and FS > 200ng/mL. The methology of this study had been approved by the Health Research Ethics Committee of the Bhayangkara H.S. Samsoeri Mertojoso Hospital, Surabaya. Patients received 2000 IU subcutaneous erythropoietin twice a week on both groups. Blood sample was withdrawn in pre-treatment and after 4 weeks of post erythropoietin therapy treatment for measurement of haemoglobin and haematocrit. Target for this erythropoietin therapy are increase of Hb 0.5 – 1.5 g/dL (not to exceed 12 g/dL) and increase of Hct level 2 – 4 % in 4 weeks. Based on the inclusion criteria, there were 20 patients in this study (10 patient each of both erythropoietin alpha either beta group) that consist of 7 women and 13 men. After the treatment, the mean of increased haemoglobin level for erythropoietin alpha group was 1.28 ± 0.80 g/dL (p=0.001) and erythropoietin beta was 0.37 ± 0.95 g/dL (p=0.254). The mean of increased haematocrit level for erytropoietin alpha group was 3.56 ± 3.46 % (p=0.010) and erythropoietin beta was 1.34 ± 2.71 % (p=0.152). In comparison of haemoglobin and haematocrit achievement in both groups showed that erythropoietin alpha gave better achievement in haemoglobin parameter (p=0.033), but there were no differences in both groups on haematocrit parameters (p=0.127).
Evaluasi Rasionalitas Penggunaan Antidiabetes Oral pada Pasien Diabetes Melitus Tipe 2 Rawat Inap di Rumah Sakit Nasional di Dili Putu Dian Marani Kurnianta; Gracia Isabel Baptista Soares; Anak Agung Ngurah Putra Riana Prasetya; Agustina Nila Yuliawati
Jurnal Farmasi Indonesia Vol 19 No 1 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i1.1338

Abstract

Among several types of diabetes mellitus (DM), type-2 DM seemed to demonstrate the highest prevalence. Appropriate management in type-2 DM should follow rational use of antidiabetic agents to prevent any unfavorable impacts. In fact, due to the limited guidelines and medication resources, medication process for patients with type-2 DM has not been evaluated in Timor-Leste, especially at a national hospital in Dili. This was the first study which aimed to evaluate the use of oral antidiabetic agents (OAD) in hospitalized patients with type-2 DM at a national hospital, Dili Timor-Leste.This study was conducted retrospectively under cross-sectional design to describe the rational drug use evaluation based on indicators: right patient, right dose, right indication, right drug, and cautious to adverse events according to guideline from American Diabetes Association (2020). The included patients were diagnosed as type-2 DM, hospitalized during year 2020, and received OAD. Data were calculated (%) for each indicator of rational drug use.A total number of 83 hospitalized patients with type-2 DM at a national hospital in Dili had taken metformin (62.65%), gliclazide (12.15%), and combination of both metformin and gliclazide (22.89%), respectively. The evaluation results of OAD use according to ADA guideline comprised of right indication 100%, right patient 100%, right drug 72.28%, right dose 100%, and cautious to adverse events 93.7%. Despite favorable results in rational medication, enhancement for limitation of OAD use at a national hospital in Dili, Timor-Leste is compulsory.
PENGGUNAAN STATIN DAN ANTIPLATELET SEBAGAI PENCEGAHAN SEKUNDER KOMPLIKASI KARDIOVASKULER PADA PASIEN DIABETES MELITUS TIPE 2 Pande Made Desy Ratnasari; Putu Dian Marani Kurnianta; Anak Agung Ngurah Putra Riana Prasetya
Majalah Farmasi dan Farmakologi Vol. 24 No. 2 (2020): MFF
Publisher : Faculty of Pharmacy, Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/mff.v24i2.10384

Abstract

Resistensi insulin pada pasien diabetes melitus (DM) tipe 2 dapat meningkatkan risiko terjadinya komplikasi kardiovaskuler yang selanjutnya dapat berkontribusi sebagai penyebab utama kematian. Resistensi insulin meningkatkan kerentanan pasien mengalami aterosklerosis dan menimbulkan gangguan pada fungsi platelet di pembuluh darah yang dapat berdampak pada peningkatan risiko komplikasi kardiovaskuler. Sebagai salah satu upaya untuk mencegah dan mengurangi risiko tersebut, Canadian Cardiovascular Society Guidelines tahun 2011 dan American Diabetes Association tahun 2019 merekomendasikan penggunaan golongan statin dan antiplatelet sebagai upaya pencegahan sekunder komplikasi kardiovaskuler pada pasien DM tipe 2. Penelitian ini bertujuan untuk mengetahui gambaran penggunaan statin dan antiplatelet sebagai pencegahan sekunder pada pasien DM tipe 2 dengan komplikasi kardiovaskuler. Penelitian ini bersifat observasional dengan desain cross sectional yang dilakukan pada 110 pasien di RSU Puri Raharja Denpasar Bali periode November 2019. Hasil penelitian menunjukkan bahwa dari 110 pasien yang memenuhi kriteria penggunaan statin, hanya 42 pasien (38,1%) yang menggunakan statin (simvastatin 20 mg; 95,2%). Selain itu, dari total 96 pasien yang memenuhi kriteria penggunaan antiplatelet, hanya 52 pasien (47,3%) yang menggunakan antiplatelet (aspirin 80 mg; 82,7%). Penelitian ini merefleksikan penggunaan statin yang masih rendah dalam upaya pencegahan sekunder komplikasi kardiovaskuler pada pasien DM tipe 2. Meskipun terdapat kecenderungan tingkat penggunaan antiplatelet aspirin yang lebih tinggi daripada statin dalam penelitian ini, pemberian aspirin selanjutnya masih perlu ditingkatkan lagi bersama-sama dengan peningkatan pemberian statin.
Penyuluhan Kesehatan Mengenai Pemanfaatan Tanaman Obat Keluarga (TOGA) untuk Kesehatan di Desa Gunung Salak Anak Agung Ngurah Putra Riana Prasetya; Ni Luh Putu Silvia Andaresta; I Gusti Ayu Putu Priyanti; Ni Ketut Kristina Dewi; Adinda Amalia; Ni Kadek Ayu Widhyanti; Ni Luh Putu Damayanti; Ni Luh Sukma Widiastuti
Randang Tana - Jurnal Pengabdian Masyarakat Vol 5 No 3 (2022): Randang Tana - Jurnal Pengabdian Masyarakat
Publisher : Unika Santu Paulus Ruteng

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36928/jrt.v5i3.1287

Abstract

The utilization of family medicinal plant or known as TOGA has been used as a medication since ancient time. Until now, the scientific use of TOGA has not been widely known by the Indonesian people, one of which is the community in Gunung Salak Village, Tabanan, Bali. Some people in Gunung Salak village are known to have cultivated several types of TOGA, but the majority of the people there don’t know yet the function and how to use TOGA for health. Health education activities regarding the use of TOGA are carried out with the aim of increasing public knowledge, especially Banjar Kemetug and Banjar Apit Yeh, as well as increasing responses from village officials to support efforts to cultivate and utilize TOGA scientifically and massively. The provision of questionnaires to the people in both Banjar as evaluation material for this health education activity. Statistical analysis was carried ot on each item of the questionnaire questions and the understanding of each respondent who had filled out the questionnaire, both before and after the extension using Mc Nemar test. The majority of respondents who attended were aged 41-50 years (40%) and had a high level of understanding related to TOGA both before (76%) and after health education (100%). Based on Mc Nemar analysis, it was found that there was a significant difference of each respondent who had filled out the questionnaire before and after the health education (p=0,004). Overall there was a significant difference of each question item on the questionnaire (p<0,05). This indicates that the extension activity that has been carried out can increase the understanding of the community in Gunung Salak Village and increase efforts to cultivate and use TOGA
Analisis Hubungan Pengetahuan terkait Hipertensi dengan Kepatuhan Minum Obat dan Kontrol Tekanan Darah pada Pasien Hipertensi Mahadri Dhrik; Anak Agung Ngurah Putra Riana Prasetya; Pande Made Desy Ratnasari
Jurnal Ilmiah Medicamento Vol 9 No 1 (2023): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v9i1.5470

Abstract

Hypertension is a chronic disease with a high mortality rate, and patient adherence to treatment is still low. Low patient adherence can be caused by several factors, including patient knowledge related to hypertension. In addition, medication adherence is a factor that can affect blood pressure control. This study aimed to analyze the relationship between knowledge, adherence, and blood pressure control in hypertensive patients. This research was conducted at Tk.II Udayana Hospital Denpasar with data collection time, namely February-April 2022. The research design was carried out cross-sectionally using a validated questionnaire. The level of patient knowledge was measured using the Hypertension Knowledge Level Scale (HK-LS) questionnaire, and the level of patient compliance was measured using the Probabilistic Medication Adherence Scale (ProMAS) questionnaire. The patient's blood pressure data has been seen through the patient's medical record in the past three months. The sampling technique in this study used a nonprobability sampling technique with a consecutive sampling approach. The data analysis used to determine the relationship between hypertension knowledge and adherence to taking medication is the Pearson correlation test. Differences in blood pressure control at various levels of adherence were tested with the Kruskal-Wallis test. The results of the analysis of 78 respondents showed that there was a significant relationship between knowledge and medication adherence (p=0.004; r=0.321). For drinking compliance with blood pressure control, there was no significant difference in blood pressure control values at various levels of drinking adherence (p=0.941). Thus knowledge related to hypertension affects medication adherence. However, various factors other than medication adherence are needed to produce reasonable blood pressure control.
The Association Between Medication Adherence and Blood Pressure Control in End-Stage Renal Disease Patients with Hemodialysis Pande Made Desy Ratnasari; Ketut Tia Pran Anggar Yani; Agustina Nila Yuliawati; Anak Agung Ngurah Putra Riana Prasetya
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 20, No 1 (2023)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.004141

Abstract

End-Stage Renal Disease (ESRD) is a severe kidney disorder that contributes to an increased risk of mortality in the world. This condition is often related with hypertension. Low medication adherence was affecting uncontrolled blood pressure in ESRD. The research aimed to analyze the association between medication adherence and blood pressure control in ESRD patients. This cross-sectional study with 77 respondents was conducted in September 2020 at the Dialysis Unit of the Private Hospital “X” Buleleng Bali by purposive sampling technique. The respondents must be ≥18 years, diagnosed with ESRD and hypertension, underwent hemodialysis (HD) twice a week, received the same antihypertensive for 3 months, have complete medical record data, and signed the informed consent form. Patients with cognitive impairment, unable to communicate, pregnant or breastfeeding, and received the Erythropoiesis Stimulating Agent (ESA) treatment were excluded. Kruskal-Wallis test was used in data analysis. Most of the patients were 65 years (80.52%), male (70.13%), primary education (57.14%), without complications (57.1%), and duration of illness 5 years (89.61%). Patients were in the high adherence (61.04%) and 66.23% of patients had uncontrolled blood pressure. The association between medication adherence and blood pressure control was not significant (p=0.478). However, these results show that high medication adherence could impact on good blood pressure control.
HUBUNGAN KARAKTERISTIK SOSIODEMOGRAFI TERHADAP KEPATUHAN TERAPI PASIEN GAGAL JANTUNG KONGESTIF DI RUMAH SAKIT ARI CANTI Mahadri Dhrik; Anak Agung Ngurah Putra Riana Prasetya; Ni Ketut Apridewi
PROSIDING SIMPOSIUM KESEHATAN NASIONAL Vol. 2 No. 1 (2023): Simposium Kesehatan Nasional
Publisher : LPPM STIKES BULELENG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (300.726 KB)

Abstract

Meskipun berbagai penelitian terkait kepatuhan pengobatan telah dilakukan, hubungan karakteristik sosiodemografi terhadap kepatuhan terapi pasien GJK belum sepenuhnya dipahami kaitannya. Untuk itu dilakukan penelitian secara observasional dengan desain penelitian secara cross sectional dengan menggunakan kuesioner Probabilistic Medication Adherence Scale (ProMAS) untuk mengukur tingkat kepatuhan pasien dan kuesioner karakteristik demografi yang kemudian dicari hubungan antara kedua variable tersebut dengan analisis statistik. Hasil penelitian menunjukkan dari 63 responden memiliki tingkat kepatuhan sedang-rendah (72,41%). Uji statistik menunjukkan tidak adanya hubungan antara karakteristik sosiodemografi dengan kepatuhan terapi pasien GJK yang meliputi jenis kelamin (p=0,439), umur (p=0,091), pendidikan (p=0,078) dan pekerjaan (p= 6,527).
EFEK ANTIINFLAMASI EKSTRAK ETANOL 70% KULIT BUAH POMELO (Citrus maxima (Burm.) Merr) PADA TIKUS JANTAN GALUR WISTAR BERDASARKAN DOSIS PEMEJANAN Putu Dian Marani Kurnianta; Anak Agung Ngurah Putra Riana Prasetya; Elisabeth Oriana Jawa La; I Gede Krisna Yudiarta
PROSIDING SIMPOSIUM KESEHATAN NASIONAL Vol. 2 No. 1 (2023): Simposium Kesehatan Nasional
Publisher : LPPM STIKES BULELENG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (567.065 KB)

Abstract

Beberapa penelitian menunjukkan hasil positif terkait efek antiinflamasi ekstrak kulit buah pomelo pada model hewan uji, namun pengamatan efek berdasarkan perbedaan dosis masih terbatas. Penelitian ini bertujuan untuk membandingkan efek antiinflamasi dari beberapa dosis pemejanan ekstrak etanol kulit buah pomelo atau Citrus maxima (Burm). Merr. pada tikus putih jantan galur Wistar dengan metode carrageenan-induced hind paw edema. Volume edema berbeda secara signifikan antara kelompok ekstrak dengan kontrol negatif CMC-Na pada menit ke-120 (p=0,013). Penghambatan inflamasi terendah hingga tertinggi ditimbulkan oleh ekstrak dosis 100, 400, dan 200 mg/kg secara berturut-turut. Jadi, efek antiinflamasi berdasarkan perbedaan dosis pada penelitian ini bersifat non-linear.
PERBEDAAN EFEKTIVITAS KOMBINASI ANALGESIK OPIOID PADA PASIEN PASCA OPERASI SESAR DI RSIA PUCUK PERMATA HATI DENPASAR Anak Agung Ngurah Putra Riana Prasetya; Mahadri Dhrik; Putu Dian Marani Kurnianta
Parapemikir : Jurnal Ilmiah Farmasi Vol 12, No 2 (2023): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v12i2.4366

Abstract

Childbirth is the culmination of a series of pregnancies, one of the delivery methods is by caesarean section with common complaints after that being pain and difficulty in the mobility of the patient. This study aimed to determine the profile and effectiveness of combination therapy with opioid analgesics used to reduce pain after caesarean section based on the value of the Visual Analogue Scale (VAS). This research was conducted at RSIA Pucuk Permata Hati Denpasar. This study was conducted in a cross-sectional manner. This study used all medical record data for pregnant women who gave birth by caesarean section and had VAS values before and 6 hours after receiving opioid analgesic combination therapy in January-December 2021. Samples were taken using a probability sampling technique with a simple random sampling approach. Data were analyzed using the Kolmogorov-Smirnov test and the Kruskal-Wallis test to see differences in the effectiveness of combination analgesics therapy. Based on 183 samples (each group 61 samples), the highest age group was 21-30 years (52.46%), with the gestational age at 40 weeks (70.49%). The combination therapy with opioid-opioid (pethidine-morphine) has better effectivity based on the mean of lowering pain intensity with a VAS scale (2.05 ± 0.59). The normality test showed that the data were not normally distributed (p 0.05). The Kruskal-Wallis test showed that there was no significant difference (p-value 0.748 0.05) in the usage of three combination analgesics therapies to reduce pain in post-caesarean patients based on VAS values
PERBEDAAN EFEKTIVITAS NIFEDIPIN DAN METILDOPA PADA PASIEN HIPERTENSI DENGAN KEHAMILAN Anak Agung Ngurah Putra Riana Prasetya; Pande Made Desy Ratnasari; Putu Dian Marani Kurnianta
Parapemikir : Jurnal Ilmiah Farmasi Vol 13, No 1 (2024): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v13i1.5748

Abstract

Hipertensi pada kehamilan merupakan peningkatan tekanan darah (TD) ≥140/90 mmHg saat hamil. Hipertensi pada wanita hamil dapat diklasifikasikan menjadi hipertensi kronik, gestasional, pre-eklamsia, dan eklamsia. Tujuan dari penelitian ini yaitu untuk mengetahui perbedaan pengaruh Nifedipin dan Metildopa dalam menurunkan tekanan darah sistolik (TDS) dan diastolik (TDD) pada kehamilan. Penelitian ini dilakukan di RSIA X di Denpasar dan merupakan penelitian non-eksperimental dengan jenis rancangan case study dengan pengambilan data secara restrospektif. Subjek penelitian adalah data rekam medis pasien hipertensi kehamilan yang mendapatkan terapi antihipertensi nifedipin atau metildopa. 20 sampel diambil menggunakan teknik non-probability sample dengan pendekatan purposive sampling. Data dianalisis menggunakan uji beda Independent sample t-test. Dari hasil penelitian ini didapatkan usia terbanyak pasien hipertensi dengan kehamilan yaitu pada rentang 30 – 39 tahun (60%). Rata-rata penurunan TD pada kelompok Nifedipin yaitu TDS sebesar 27,3 ± 14,32 mmHg dan TDD sebesar 15,3 ± 11,31 mmHg. Pada kelompok Metildopa terjadi rata-rata penurunan TDS sebesar 19,5 ± 8,37 mmHg dan TDD sebesar 11,7 ± 10,43 mmHg. Berdasarkan hasil uji beda diketahui bahwa tidak terdapat perbedaan signifikan antara pemberian nifedipin dan metildopa dalam menurunkan tekanan darah sistolik (p=0,158 0,05) maupun diastolik (p =0,469  0,05).
Co-Authors Adinda Amalia Agustina Nila Yuliawati Bayu Dharma Shanti Budi Suprapti Elisabeth Oriana Jawa La Gracia Isabel Baptista Soares I Gede Krisna Yudiarta I Gusti Ayu Putu Priyanti Ketut Tia Pran Anggar Yani Mahadri Dhrik Ni Kadek Ayu Widhyanti Ni Ketut Apridewi Ni Ketut Kristina Dewi Ni Luh Putu Damayanti Ni Luh Putu Silvia Andaresta Ni Luh Sukma Widiastuti Pande Made Desy Ratnasari Pande Made Desy Ratnasari Putu Dian Marani Kurnianta