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All Journal PROSIDING SEMINAR NASIONAL Pharmaciana: Jurnal Kefarmasian Unisia
Achmad Mursyidi
Unknown Affiliation
Religion Humanities Economics, Econometrics & Finance Education Medicine & Pharmacology Social Sciences

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The determination of metal content, microbial contamination and dissolution assessment of the ethanol extract of pasak bumi root Laela Hayu Nurani; Eka Kumalasari; Zainab Zainab; Achmad Mursyidi; Sitarina Widyarini; Abdul Rohman
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (315.452 KB) | DOI: 10.12928/pharmaciana.v7i2.6751

Abstract

 The Eurycoma longifoliais bitter therefore, to address this problem, it is prepared in a capsule form. The capsule dosage form  must has  the parameters of good quality, thus expected to increase the potential use of biodiversity and the interest of the community in consuming the medicine from the natural materials. The purpose of this research is to get the capsule product of ethanol extract of the Eurycoma longifolia root of quality through the test of total plate value and yeast yeast contamination, the determination of the metal content of Pb, Hg, Cd and the level of flavonoids released in the capsule dissolution test of ethanol extract Eurycoma longifolia root. The result of this research shows that the dissolution efficiency (DE120) capability of ethanol extract of Eurycoma longifolia root is 81,04±2,38%. Test of heavy metal content in capsule of  of ethanol extract of Eurycoma longifolia root found level of Pb equal to 4,132 ppm and not detected content of Cd and Hg in capsule. This indicates that the capsule meets the requirements set by BPOM RI. Tests for total plate numbers (ALT) and yeast capsule ethanol extract of the E. longifolia root were each obtained data of 70 x 102 colonies / g and 4 x 102 colonies / g. It also shows that the capsules meet the requirements by BPOM RI.
PENGARUH PEMBERIAN KOMBINASI FRAKSI ETIL ASETAT AKAR PASAK BUMI DAN DOXORUBICIN TERHADAP BERAT BADAN DAN JUMLAN NODUL TIKUS SPRAGUE DAWLEY BETINA YANG DIINDUKSI 7,12 DIMETILBENZ(α) ANTRASEN (DMBA) Laela Hayu Nurani; Achmad Mursyidi; Sitarina Widyarini
Pharmaciana Vol 6, No 1 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (458.079 KB) | DOI: 10.12928/pharmaciana.v6i1.3093

Abstract

Pasak Bumi roots contain quasinoid compounds that have carcinogenesis inhibitory, imunomudulator, antiulcer, and antimalaria effects. This study aims to determine the effect of a combination of ethyl acetate fraction of Pasak Bumi roots and doxorubicin on DMBA-induced white mice by weight and palpation observation. The mice were divided into 8 groups. Each group consisted of 7 female Sprague Dawley mice. Group 1 (normal) was only given food and drink, Group 2 was given fraction of ethyl acetate of Pasak Bumi roots (100 mg/kg body weight, Group 3 (positive control) was given doxorubicin (1.17 mg/kg body weight) 1 times a week for 5 weeks, Group 4 was given DMBA (20 mg/kg) two times a week for 5 weeks, Groups 5 was given DMBA (20 mg/kg) + doxorubicin (1.17 mg/kg), Group 6 was given DMBA (20 mg / kg) + ethyl acetate fractions of Pasak Bumi roots (100 mg / kg), Group 7 was given DMBA (20 mg / kg) + doxorubicin (1.17 mg / kg) + ethyl acetate fraction of Pasak Bumi roots (100 mg / kg) and Group 8 doxorubicin ( 1.17 mg / kg body weight) + ethyl acetate fraction of Pasak Bumi roots (100 mg / kg). Observations were made on the basis of body weight of mice and tumor incidence by palpation at week 6 of treatment. The result of  this research shows that the administration of ethyl acetate fraction of Pasak Bumi roots and doxorubicin combination can increase body weight of the mice and decrease the number of tumors compared to single doxorubicin.
UJI AKTIVITAS ANTIFUNGI FRAKSI ETANOL INFUSA DAUN KEPEL (Stelechocarpus burahol, Hook F&Th.) TERHADAP Candida albicans Edwin Daru Anggara; Dwi Suhartanti; Achmad Mursyidi
PROSIDING SEMINAR NASIONAL & INTERNASIONAL 2014: PROSIDING SEMINAR NASIONAL HASIL - HASIL PENELITIAN & PENGABDIAN
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (260.281 KB)

Abstract

Tanaman kepel (Stelechocarpus burahol, Hook F&Th.) dikenal oleh masyarakat untukmengobati banyak penyakit. Tujuan dari penelitian ini adalah mengetahui aktivitas antifungifraksi etanol infusa daun Kepel terhadap Candida albicans, dan mengetahui kandungan kimiayang terdapat dalam fraksi etanol infusa daun Kepel (Stelechocarpus burahol, Hook F&Th.).Simplisia daun Kepel diekstraksi dengan metode infundasi kemudian difraksinasi menggunakanpelarut etanol 70%. Uji antifungi dilakukan dengan metode dilusi cair dan zona hambat .Metode dilusi cair menggunakan uji pendahuluan menggunakan konsentrasi bertingkat 50%,25%, 12,5%, 6,25%. Hasil  Uji pendahulan kemudian diperkecil dengan skalaperbandingan 5%(25% b/v, 30% b/v, 35% b/v, 40% b/v, 45% b/v, 50% b/) untuk menentukan KBM. Zona hambatdengan menggunakan cawan petri yang dibuat dengan sumuran. Uji Kromatografi Lapis Tipisdilakukan untuk mengetahui senyawa yang terdapat dalam fraksi etanol infusa daun Kepel.Hasil dari penelitian ini menunjukkan bahwa KBM ekstrak etanol daun Kepel terhadap Candidaalbicans adalah 45% b/vv sedangkan KHM tidak dapat ditentukan karena sampel keruh danberwarna coklat pekat. Zona hambat fraksi etanol infusa daun kepel menunjukan luas zonahambat dengan diameter rata-rata 2cm.Berdasarkan kromatografi lapis tipis menunjukkanbahwa fraksi etanol infusa daun Kepel mengandung golongan senyawa flavonoid. Berdasarkanhasil penelitian ini menunjukan bahwa fraksi etanol infusa daun kepel memiliki aktivitassebagai antifungi terhadap Candida albicans dengan kandungan utama flavonoid.Kata Kunci : Fraksi etanol, daun kepel, Antifungi, Candida albicans
Pestisida Efek Toksik dan Nasibnya di Lingkungan Achmad Mursyidi
Unisia No. 23: Tahun XIV Triwulan III 1994
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/unisia.v0i23.5420

Abstract

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Co-Authors Abdul Rohman Dwi Suhartanti Edwin Daru Anggara Eka Kumalasari Laela Hayu Nurani Sitarina Widyarini Sitarina Widyarini Zainab Zainab