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All Journal Jurnal Ilmiah Farmasi Natural Science: Journal of Science and Technology Pharmaciana: Jurnal Kefarmasian The Journal of Pure and Applied Chemistry Research Jurnal Farmasi Klinik Indonesia Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Indonesian Journal of Chemistry Jurnal Aplikasi Teknologi Pangan Jurnal Kimia dan Kemasan
Dion Notario
Universitas Katolik Indonesia Atma Jaya
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Penelusuran aktivitas antibakteri, antioksidan, dan sitotoksik fungi endofit genus fusarium sp. diisolasi dari daun meniran (Phyllantus niruri Linn.) rollando, Rollando; Aditya, Martanty; Notario, Dion; Monica, Eva; Sitepu, Rehmadanta
Pharmaciana Vol 7, No 1 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (350.762 KB) | DOI: 10.12928/pharmaciana.v7i1.5644

Abstract

Endophytic fungi used as a new resource to produce bioactive compounds such as antibacterial, antioxidant and anticancer. This study aimed to analyze the antibacterial, antioxidant, cytotoxic fraction of the separation ethyl acetate extract of mycelium of endophytic fungi genus Fusarium sp. Diethyl ether fraction showed high antibacterial activity in E.coli (20,75 µg/mL), S.typhi (35,08 µg/mL), and S.aureus (51,96 µg/mL). Test showed that the antioxidant activity of ethanol 96% fraction has highest antioxidant activity and total phenolic content (75,85 ± 0.87 mg GAE). Cytotoxic test on T47D breast cancer cells showed that the fraction of diethyl ether have highest activity with IC50 of 10,16 ± 0,88 µg /mL.
ANALISIS FAKTOR PERLINDUNGAN MATAHARI (FPM) DARI SEDIAAN TABIR SURYA SECARA SPEKTROFOTOMETRI DENGAN METODE KUADRAT TERKECIL SEBAGIAN JACK-KNIFE Notario, Dion; Aditya, Martanty; Rollando, Rollando; Prilianti, Kestrilia Rega
Natural Science: Journal of Science and Technology Vol 6, No 1 (2017): Volume 6 Number 1 (March 2017)
Publisher : Univ. Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (437.851 KB)

Abstract

Penentuan nilai Faktor Perlindungan Matahari (FPM) dengan metode spektrofotometri sangat dibutuhkan untuk melakukan penapisan awal kandidat bahan aktif tabir surya. Meskipun demikian, ditemukan kesalahan yang relatif besar ketika dilakukan penentuan SPF secara spektrofotometrik terhadap beberapa sediaan tabir surya yang beredar secara komersial. Oleh karena itu, dalam penelitian ini dilakukan analisis FPM secara spektrofotometrik pada panjang gelombang 290 ? 320 nm yang dilanjutkan dengan regresi multivariat yaitu kuadrat terkecil sebagian jack-knife untuk meningkatkan akurasi estimasi nilai prediksi FPM secara in vitro. Selanjutnya, model matematik yang diperoleh, digunakan untuk melakukan penapisan bahan aktif tabir surya dari beberapa sampel botani. Hasil penelitian menunjukkan bahwa model matematik yang dihasilkan mempunyai nilai kesalahan prediksi yang lebih rendah daripada metode sebelumnya (RMSECV = 3,15; r = 0,915) dan dapat diaplikasikan untuk penapisan kandidat bahan aktif tabir surya dari tanaman.
The risk of Angiotensin Converting Enzyme Inhibitor (ACEI) and Calcium Channel Blocker (CCB) used on Obstructive Sleep Apnea (OSA) incidence in hypertension patients Fibe Yulinda Cesa; Martanty Aditya; Rehmadanta Sitepu; Dion Notario
Jurnal Ilmiah Farmasi 2022: Special Issue
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.specialissue2022.art1

Abstract

AbstractBackground: The administration of angiotensin-converting enzyme inhibitor (ACEI) and calcium channel blocker (CCB) therapy is known to have a side effect of a dry cough that would trigger OSA. Further research is needed to compare the effect of these two drugs on the side effects of OSA, which could trigger high-risk patient conditions.       Objective: To determine the risk of using ACE and CCB on the incidence of OSA using a case-control study method at Dau Primary Health Center.Methods: Demographic data were collected on 207 respondents aged 40-60 years by collecting Data Collection Sheets and Berlin questionnaires to determine the risk of OSA in respondents. Then, statistical analysis was carried out by determining the odds ratio (OR).Results: The results showed that one of the factors BMI (obese BMI; OR=1.33; 95% CI=0.11-15.70) induces OSA with the highest OR value compared to other factors.Conclusion: Obese patient has a 1.33 times greater risk of OSA with ACEI and CCB therapy than non-obese. It is necessary to conduct further research with a larger sample size related to OSA’s assessment associated with this therapy to improve patients’ quality of life.Keywords: Obstructive sleep apnea, ACE inhibitors, calcium channel blockers, hypertension IntisariLatar belakang: Obtructive Sleep Apnea (OSA) yang terjadi pada pasien hipertensi dapat disebabkan karena efek samping dari penggunaan antihipertensi angiotensin converting enzyme inhibitor (ACEI) dan calcium channel blocker (CCB), namun analisis hubungan keduanya belum diketahui dengan pasti.Tujuan: Penelitian ini bertujuan untuk mengetahui risiko penggunaan ACE dan CCB terhadap kejadian OSA dengan metode case control study di Puskesmas Dau.Metode: Pengambilan data demografi pada 207 responden usia 40-60 tahun dilakukan dengan mengumpulkan Lembar Pengumpul Data (LPD) dan kuesioner Berlin untuk mengetahui risiko OSA pada responden kemudian dilakukan analisis statistik dengan penentuan odds ratio (OR).Hasil: Hasil penelitian menunjukkan bahwa pasien yang menjalani pengobatan dengan antihipertensi ACEI dan obesitas memiliki risiko lebih besar mengalami OSA (OR=1,33; CI 95%=0,11-15,70)  yaitu 1,33 kali dibandingkan pada pasien yang tidak obesitas.Kesimpulan: Obesitas menjadi factor risiko terhadap kejadian OSA pada pasien hipertensi yang mendapatkan antihipertensi golongan ACEI dan CCB.Kata kunci: Obstructive sleep apnea, ACE inhibitor, calcium channel blocker, hipertensi
Sintesis Senyawa Koordinasi Astaxanthin Dengan Bantuan Gelombang Ultrasonik Rokiy Alfanaar; Dion Notario
Jurnal Kimia dan Kemasan Vol. 41 No. 2 Oktober 2019
Publisher : Balai Besar Kimia dan Kemasan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24817/jkk.v41i2.3366

Abstract

Astaxanthin merupakan senyawa turunan karotenoid xantofil yang sangat potensial dalam pengobatan kanker. Salah satu upaya meningkatkan aktivitas anti kanker dari astaxanthin adalah dengan menggabungkan senyawa astaxanthin dengan ion logam. Upaya sintesis senyawa koordinasi astaxanthin dengan ion logam Fe3+, Mn2+, dan Zn2+ telah dilakukan dengan bantuan gelombang ultrasonik. Panjang gelombang maksimal senyawa kompleks Mn(II)-Astaxanthin adalah 473 nm, Fe(III)-Astaxanthin adalah 355 nm, dan Zn(II)-Astaxanthin adalah 473 nm. Hasil FTIR menunjukan munculnya gugus fungsi khas astaxanthin pada semua kompleks dan munculnya serapan pada 535 cm-1, untuk kompleks Mn(II)-Astaxanthin, 397 cm-1 untuk Fe(III)-Astaxanthin, dan 535 cm-1 untuk Zn(II)-Astaxanthin yang mengindikasikan adanya ikatan logam dengan atom donor dari Astaxanthin.
Antimicrobial, antioxidant, and cytotoxic activities of endhopitic fungi Chaetomium sp. isolated from Phyllanthus niruri Linn: in vitro and in silico studies Rollando Rollando; Dion Notario; Eva Monica; Martanty Aditya; Rehmadanta Sitepu
The Journal of Pure and Applied Chemistry Research Vol 6, No 1 (2017): Edition of January - April 2017
Publisher : Chemistry Department, The University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1433.715 KB) | DOI: 10.21776/ub.jpacr.2017.006.01.317

Abstract

Endophytic fungi Chaetomium sp isolated from Phyllanthus niruri Linn. Mycelium powder was extracted by using ethyl acetate. Extract was fractionated using n-hexane, dichloromethane and ethanol 96%. The antimicrobial test was carried out using disc diffusion and microdilution methods. The antioxidant activity of the fraction was determined using hydrogen peroxide free radical scavenging and reducing power capacity activities. The cytotoxicity assay of the fraction against T47D breast cancer cell was carried out using dimethylthiazol-2-yl-2,5-diphenyltetrazolium bromide method (MTT). The in silico prediction of chemical substances which are reported exist in Chaetomium sp. performed using AutoDockVina embedded in PyRx version 8.0. Dichloromethane fraction was found as the most active sample against Escherichia coli (IC50 20.76 mg/mL), Staphylococcus aureus (IC50 70.15 mg/mL), Salmonella typhi (49.13 mg/mL) and was found as the most high phenolic content with value 47.44 mg GAE/g fraction, whereas the best antioxidant activity was performed by ethanol 96% fraction (85%). Cytotoxicity assay against T47D cell line showed dichloromethane fraction have highest activity with IC50 10.76 mg/mL. The docking studies showed that compounds bearing xanthone structure were potential for maltose binding periplasmic and human aromatase associating with their potencies as antibacteria and anticancer. Endophytic fungi Chaetomium sp. was isolated from Phyllanthus niruri using n-hexane, dichloromethane and ethanol fractions was studied its various biological activities as antimicrobial, antioxidant and cytotoxic agent against breast cancer cell. 
Pengukuran Risiko Gangguan Tidur pada Penggunaan Angiotensin Converting Enzyme Inhibitor dan Calcium Channel Blocker: Case Control Study di Puskesmas Dau, Malang Martanty Aditya; Rehmadanta Sitepu; Dion Notario; Fibe Y. Cesa
Indonesian Journal of Clinical Pharmacy Vol 8, No 3 (2019)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (755.386 KB) | DOI: 10.15416/ijcp.2019.8.3.166

Abstract

Gangguan tidur atau insomnia yang muncul pada pasien hipertensi dapat disebabkan oleh efek samping obat-obat antara lain golongan Angiotensin Converting Enzyme Inhibitor (ACEI) dan Calcium Channel Blocker (CCB), namun besarnya pengaruh masing-masing golongan belum banyak diperbandingkan. Oleh karena itu, dilakukan penelitian dengan menggunakan rancangan case control untuk menilai risiko penggunaan ACEI dan CCB terhadap angka kejadian insomnia. Data demografi dan status insomnia dikumpulkan melalui Lembar Pengumpul Data (LPD) dan kuesioner Athens Insomnia Scale (AIS), kemudian dilakukan analisis univariat, bivariat, dan multivariat. Hasil analisis menunjukkan bahwa pada kelompok usia 56–60 tahun, pasien yang menjalani pengobatan dengan ACEI memiliki risiko insomnia lebih kecil yaitu sekitar 0,38 kali (p=0,026, 95% CI=0,15–0,94) dibandingkan dengan pasien lain yang menggunakan CCB, sedangkan pada kelompok kategorial yang lain tidak ditemukan hubungan yang signifikan. Dengan demikian, pemantauan efek samping insomnia menjadi penting untuk dilakukan oleh tenaga kesehatan terutama pada pasien yang menjalani pengobatan dengan CCB pada usia 56–60 tahun.Kata kunci: ACE inhibitor, calcium channel blocker, case control, gangguan tidur A Measurement of Sleep Disorder in the Use of Angiotensin Converting Enzyme Inhibitor and Calcium Channel Blocker: A Case Control Study at Dau Public Health Center, MalangAbstractSleep disorder or insomnia arisen in hypertensive patients might be derived as a side effect of antihypertensive mediations such as Angiotensin Converting Enzyme Inhibitor (ACEI) and Calcium Channel Blocker (CCB), but the influence of each group had not been much compared. Therefore, a research was conducted using case control design to assess the risk of using ACEI and CCB against the incidence rate of insomnia. Demographic data and insomnia status were collected through Data Collector Sheet and Athens Insomnia Scale (AIS) questionnaire before univariate, bivariate, and multivariate analysis was conducted. The result showed that in the age group of 56–60 years patients undergoing treatment with ACEI have a smaller risk of insomnia of approximately 0.38 times (p=0.026, 95% CI=0.15–0.94) compared to the other patients who were treated with CCB, while in other categorial groups, no significant relationship was found. Thus, the monitoring of insomnia side effects becomes important to be conducted by healthcare professional especially in patients undergoing treatment with CCB at the ages of 56–60 years.Keywords: ACE inhibitor, calcium channel blocker, case control, sleep disorder
Pemodelan Farmakokinetika Berbasis Populasi dengan R: Model Dua Kompartemen Ekstravaskuler: Population-Based Pharmacokinetics Modeling with R: Two Compartment Extravascular Model Dion Notario
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 4 No. 1 (2018): (March 2018)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (386.702 KB) | DOI: 10.22487/j24428744.2018.v4.i1.9777

Abstract

A Tutorial of two-compartment extravascular population-based pharmacokinetics modeling was performed by differential equations and non-linear mixed effect model approach. First, three-level differential equations of two-compartment pharmacokinetics were generated. Then, covariate and non-covariate models were developed by nlmeODE and nlme packages installed in R. The best model was selected according to AIC, BIC, and LogLik value. A model without covariates model was selected as the best model. The selected model showed a goodness of fit with experimental dataset and residual plot of the model revealed that no violations of model assumtions. In conclusion, nlme and nlmeODE is capable to generate an adequate predictive model of two-compartment population-based pharmacokinetics for extravascular route
Efek Penambahan Gula Kelapa dan Lemak Kakao terhadap Ekstrak Alga Cokelat yang Mengandung Fukosantin dalam Formulasi Foodbars Agustina Dwi Retno Nurcahyanti; Rianita Pramitasari; Intan Harmae Setiawan; Dion Notario
Jurnal Aplikasi Teknologi Pangan Vol 10, No 3 (2021): Agustus 2021
Publisher : Faculty of Animal and Agricultural Sciences, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17728/jatp.8366

Abstract

Alga cokelat mengandung pigmen karotenoid yang didominasi oleh fukosantin dengan aktivitas antioksidan yang tinggi. Karotenoid dari alga cokelat, termasuk fukosantin, belum sepenuhnya dimanfaatkan dalam formulasi pangan karena sifatnya yang kurang stabil. Karotenoid yang akan diaplikasikan dalam produk pangan perlu ditambah dengan bahan penstabil. Penelitian ini bertujuan untuk menganalisa kestabilan ekstrak alga cokelat dengan penambahan gula kelapa dan lemak kakao yang diformulasikan dalam bentuk foodbars, menguji aktivitas antioksidan, proksimat, tekstur, dan daya simpan produk foodbars yang mengandung fukosantin. Alga cokelat dari Pulau Sumbawa diekstrak menggunakan etanol 96% untuk memperoleh kandungan fukosantin. Analisa fukosantin dilakukan menggunakan high performance liquid chromatography (HPLC) dengan detektor diode array SPD-M20A (Shimadzu). Aktivitas antioksidan ekstrak alga cokelat dan selurruh bahan penyusun foodbars diuji aktivitas antioksidannya menggunakan metode DPPH (2,2-difenil-1-pikrilhidrazil) dan ekstrak alga cokelat menunjukkan aktivitas tertinggi. Foodbars formula 2 paling disukai oleh panelis semi terlatih melalui uji organoleptik. Selain itu, formulasi foodbars memiliki tingkat kekerasan tidak berbeda secara signifikan dengan produk komersial. Hasil uji daya simpan menunjukkan pertumbuhan mikroba yang rendah sebanding dengan aktivitas air yang juga rendah. Penelitian ini adalah pertama yang menunjukkan ekstrak alga cokelat mengandung fukosantin dapat dimanfaatkan sebagai foodbars.Brown algae contains fucoxanthine as dominant carotenoid with high antioxidant activity. However, this carotenoid, including fucoxanthine, has not been fully utilized in food formulations because of their unstable property. Carotenoid needs stabilizing ingredient to be suitably used in food products. This study aims to analyze  the stability of brown algae extract by adding coconut sugar and cocoa fat that are formulated in the foodbars product, testing the antioxidant activity, proximate, texture, and stability of foodbars product containing fucoxanthine. Brown algae from Sumbawa Island are extracted using ethanol 96% to obtain fucoxanthine. Fucoxanthine analysis was performed using high performance liquid chromatography (HPLC) with a SPD-M20A diode array detector (Shimadzu). The antioxidant activity was tested using the DPPH method and the brown algae extract showed highest activity amongst all foodbars ingredients. Foodbars formula 2 (FB2) is most preferred by semi-trained panelists through organoleptic testing. In addition, the formulation of foodbars has similar texture to commercial product.  The result of the shelf-life test show low microbial growth in proportion to low water activity. This is the first study showing brown algae containing fucoxanthine used in the foodbars product.
A Rapid and Simple High-Performance Liquid Chromatographic Method for Determination of Levofloxacin in Human Plasma Dion Notario; Sudibyo Martono; Zullies Ikawati; Arief Rahman Hakim; Fathul Jannah; Endang Lukitaningsih
Indonesian Journal of Chemistry Vol 17, No 1 (2017)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (431.483 KB) | DOI: 10.22146/ijc.23552

Abstract

A simple and rapid high-performance liquid chromatography method was developed and validated for quantifying LEV in human plasma. Chromatographic separation was performed under isocratic elution on a Luna Phenomenex® C18 (150 × 4.6 mm, 5 µm) column. The mobile phase was comprised of acetonitrile, methanol, and phosphate buffer 25 mM pH 3.0 (13:7:80 v/v/v) and pumped at a flow rate of 1.5 mL/min. Detection was performed by UV detector at a wavelength of 280 nm. Samples were pre-treated with acetonitrile followed by centrifugation, evaporation, and reconstitution step. The method proved linear (r = 0.995), sensitive (LLOQ and LOD was 1.8 and 0.6 µg/mL respectively), accurate (% error above LLOQ ≤ 12% and LLOQ ≤ 20%), precise (RSD ≤ 9%), robust in the ranges of 1.8-28.8 µg/mL, rapid (separation time not more than 10 min), and simple (use no organic additive in mobile phase). The method was showed reliable for quantifying LEV in human plasma.
Co-Authors Agustina Dwi Retno Nurcahyanti Alfanaar, Rokiy Arief Rahman Hakim Endang Lukitaningsih Eva Monica, Eva Fathul Jannah Fibe Y. Cesa Fibe Yulinda Cesa Intan Harmae Setiawan Kestrilia Rega Prilianti Martanty Aditya, Martanty Monica, Eva Rehmadanta Sitepu Rehmadanta Sitepu Rehmadanta Sitepu Rianita Pramitasari Rollando, Rollando Sitepu, Rehmadanta Sudibyo Martono Zullies Ikawati