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All Journal CERATA Jurnal Ilmu Farmasi Jurnal Farmasi Sains dan Praktis Urecol Journal. Part D: Applied Sciences Prosiding University Research Colloquium MOTORIK CERATA
Anita Agustina Styawan
Program Studi D3 Farmasi, STIKES Muhammadiyah Klaten
Humanities Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Energy Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health

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Analisis Logam Merkuri (Hg) dalam Krim Pemutih Herbal Temulawak (Curcuma zanthorrhiza) dengan Metode Mercury Analyzer Anita Agustina Styawan; Lenny Apriyaningsih; Dwi Joko Yulianto
CERATA Jurnal Ilmu Farmasi Vol 10 No 1 (2019): Cerata Jurnal Ilmu Farmasi
Publisher : STIKES MUHAMMADIYAH KLATEN

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Temulawak herbal whitening cream is one of the herbal whitening creams containing curcumin rhizome extract containing curcumin, demetoksikurkumin and bidemetoksikurkumin which can reduce hyperpigmentation (the skin becomes too dark). Mercury is a dangerous metal that in even small concentrations can be toxic. The use of mercury in whitening creams can cause a variety of things, ranging from changes in skin color which will eventually cause black spots on the skin, allergies, skin irritation and can be carcinogenic. The results of the study qualitatively indicated that sample A was positive containing mercury marked by an orange-red precipitate. Quantitatively, using Mercury Analyzer in sample A, the levels of mercury were 7,470.52 mg / kg or 7,470.52 ppm. The conclusions indicate that sample A is inappropriate or should not be used because it contains more than 1 mg / kg or 1 ppm of mercury.
Analisis Kandungan Asam Retinoat Pada Sediaan Krim Malam Yang Beredar Di Toko X Kota Klaten Dengan Spektrofotometri UV-Vis Yenni Kusuma Wardhani; Anita Agustina Styawan; Choril Hana Mustofa
CERATA Jurnal Ilmu Farmasi Vol 10 No 2 (2019): Cerata Jurnal Ilmu Farmasi
Publisher : STIKES MUHAMMADIYAH KLATEN

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Abstract

Whitening cosmetics are cosmetics that contain an active whitening ingredient to brighten the skin. Retinoic acid is prohibited from being used in whitening creams because it can cause dry, burning, carcinogenic and teratogenic skin. The purpose of this study was to determine the levels of retinoic acid contained in night creams. The sample in this study were 5 night cream products circulating in Klaten City X Store. This study was conducted to determine the content of retinoic acid in night creams using thin layer chromatography (TLC). Five positive samples contained retinoic acid by giving dark green spots and the concentration was determined by UV-Vis spectrophotometry.The results of this study indicate that in 5 samples of night cream circulating in Store X in the City of Klaten all positive for retinoic acid, that is, the average for sample A was 0.021%; sample B 0.014%; sample C 0.016%; sample D 0.025% and sample E 0.023%.
Uji Stabilitas Formula Optimum Masker Gel Peel Off Ekstrak Buah Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl) Nurul Hidayati; Anita Agustina Styawan; Ida Naim Muslimah
CERATA Jurnal Ilmu Farmasi Vol 11 No 2 (2020): Cerata Jurnal Ilmu Farmasi
Publisher : STIKES MUHAMMADIYAH KLATEN

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Mahkota Dewa fruit (Phaleria macrocarpa (Scheff.) Boerl was effective as an anti-acne agent and an optimization formula of Mahkota Dewa fruit extractpeel off gel mask has been carried out but the stability test has not been carried out. This study aims to determine the stability of the optimum formula of Mahkota Dewa fruit extract (Phaleria macrocarpa (Scheff.) Boerl)peel off gel mask. The fruit simplicia of Mahkota Dewa was extracted by soxhletation with 70% ethanol. The thick extract is made into a peel off gel mask with 13.09%PVA and 2.97% HPMC. Stability tests were carried out in 3 cycles using the freeze and thaw method. The evaluations carried out included organoleptic, homogeneity, pH, viscosity, dispersibility, adhesion and drying time. Analyzed data by One Way Anova followed by the LSD (Least Significance Difference) test. The results showed that the peel off gel mask optimization formula stable in storage for 3 cycles which overall meet the requirements of physical properties. The preparation was brown with rose aroma, thick, homogeneous with a pH value of 6 ± 0 and a viscosity value of 400 ± 0. The results of the drying time and spreadability test showed no difference in all cycles. Although the results of the adhesion test showed a significant difference, it was still within the range of good adhesion values.
Penetapan Kadar Tanin Dari Bunga Telang (Clitoria ternatea L.) Secara Permanganometri Choiril Hana Mustofa; Anita Agustina Styawan; Nofia Putri Lestari
CERATA Jurnal Ilmu Farmasi Vol 12 No 2 (2021): Cerata Jurnal Ilmu Farmasi
Publisher : STIKES MUHAMMADIYAH KLATEN

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Telang flowers can be found thriving in watery areas in Indonesia, their purple flowers bloom throughout the year. Telang flowers have been studied to contain phenolic chemicals, flavonoids, anthocyanins, flavonol glycosides, kaempferol glycosides, quercetin glycosides, myristetin glycosides, terpenoids, flavonoids, tannins and steroids. Tannins are plant polyphenols that function to bind and precipitate proteins. In the world of tannin medicine serves to treat diarrhea, stop bleeding, and treat hemorrhoids. There are two main types of tannins namely condensed tannins and hydrolyzed tannins. The purpose of this study was to determine the tannin content in the extract of telang (Clitoria ternatea L.) flowers using the permanganometric method. Determination of tannin levels by permanganometric method. Permanganometry is a titration method using potassium permanganate, which is a strong oxidizing agent as a titrant. This property of KMnO4 is known as an auto-indicator. The result of the determination of the tannin content of the telang flower (Clitoria ternatea L.) by permanganometry was 13.86% b/b.
PENETAPAN KADAR β-KAROTEN PADA WORTEL (Daucus carota, L) MENTAH DAN WORTEL REBUS DENGAN SPEKTROFOTOMETRI VISIBEL Anita Agustina Styawan; Nurul Hidayati; Putri Susanti
Jurnal Farmasi Sains dan Praktis Vol 5 No 1 (2019)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v5i1.2293

Abstract

Wortel (Daucus carota, L) adalah tumbuhan sayur yang ditanam sepanjang tahun yang banyak mengandung β-karoten. Dalam tubuh, β-karoten diubah menjadi vitamin A. β-karoten dalam wortel selain dapat memenuhi kebutuhan vitamin A, juga berfungsi sebagai antioksidan melawan radikal bebas. Akan tetapi, studi mengenai pengaruh pemasakan terhadap kandungan gizinya masih terbatas. Tujuan penelitian ini adalah untuk mengetahui kadar β-karoten pada wortel mentah dan wortel rebus. Sampel sebanyak 100 gram wortel (wortel mentah maupun wortel rebus) masing masing diekstraksi dengan heksan:aseton:etanol (2:1:1) sebanyak 200 mL. Ekstrak yang didapat kemudian dianalisis secara kualitatif dan kuantitatif. Analisis kualitatif menggunakan KLT silica gel 60 F254 dengan cairan pengelusi petroleum eter:benzen (9:1). Analisis kuantitatif menggunakan Spektrofotometri Visibel pada panjang gelombang 380–780 nm. Hasil kualitatif menunjukkan antara wortel mentah dan wortel rebus positif mengandung β-karoten yang ditunjukkan dengan hasil sama dengan baku pembanding, yaitu adanya 1 bercak noda kuning dengan nilai Rf 0,5 cm. Hasil analisis kuantitatif menunjukkan kadar rata-rata β-karoten wortel mentah adalah 34,94 ± 7,810 % b/b dan pada wortel rebus adalah 23,31 ± 4,246 % b/b. Besarnya kadar β-karoten kemudian dianalisa menggunakan uji sample paired t-test dan menunjukkan hasil nilai P value 0,06 (> 0,05) yang berarti tidak terdapat perbedaan bermakna antara kadar β-karoten pada wortel mentah dan wortel rebus. Kata Kunci: β-karoten; Wortel; Spektrofotometri Visibel.
DETERMINATION OF FLAVONOID LEVELS OF AlCl3 METHODE IN THE EXTRACT OF METANOL FLOWERS (Clitoria ternatea L.) Anita Agustina Styawan; Gandis Rohmanti
Jurnal Farmasi Sains dan Praktis Vol 6 No 2 (2020)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v6i2.3912

Abstract

Telang flowers is one of the medicinal plants that can grow well in Indonesia, but have not been widely used. Previous research stated that methanol extract of telang flowers had secondary metabolite compounds such as tannin, saponin, flavonoid and alkaloid. Flavonoid are natural compounds that have the potential as antioxidants that can capture free radicals that play a role in the emergence of degenerative diseases throught the mechanisme of damage to the body’s immune system, lipid oxidation and protein.The purpose of this study was to determine whether telang flowers content was determined whether by the AlCl3 method and measured by using UV-Vis Spektrophotometry from the methanol extract of telang flowers.The results of this study indicate that the methanol extract of telang flowers contains flavonoid with red color. The level of flavonoids intended is 4.65%.
Tannin Analysis of Red Roselle Petals (Hibiscus Sabdariffa, L.) using Permanganometry Method Anita Agustina Styawan; Aristhasari Putri; Refida Ramadhani Nur Cholifa
Urecol Journal. Part D: Applied Sciences Vol. 1 No. 1 (2021): January - June
Publisher : Konsorsium LPPM Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (159.316 KB) | DOI: 10.53017/ujas.31

Abstract

Red roselle (Hibiscus sabdariffa L.) is a plant that can be used by the community as traditional medicine. Rosella flower petals contains protein, fat, minerals, alkaloids, flavonoids, and tannins. Red rosella is effective in preventing vertigo, antihypertension, antidiabetic, anticancer, and antioxidants. Tannins are known as one of the active ingredients contained in the petals of red rosella flowers. Tannins are polyphenolic protein. This study aims to determine the levels of tannin in the extract of red rosella flower petals using permanganometry titration. The research method used was observational. This study used a sample of red roselle flower petals. The sample was tested qualitatively using FeCl3 1%. Analyzed quantitatively using permanganometry titration. The results showed that qualitatively the positive sample contained tannins which was marked by a change in color to dark blue dark. Quantitatively the sample was titrated with KMnO4, the tannin content in red roselle flower petals was 13,73 % b/b.
Gel Formulation for Hand Sanitizer from Ethanol Extract of Mulberry Leaf (Morus Alba L.) Sutaryono Sutaryono; Hendra Budiman; Anita Agustina Styawan; Nurul Hidayati; Dayah Ainus
Urecol Journal. Part D: Applied Sciences Vol. 1 No. 1 (2021): January - June
Publisher : Konsorsium LPPM Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (160.556 KB) | DOI: 10.53017/ujas.37

Abstract

During the Covid 19 pandemic, a handsanitizer product has emerged which functions as a hand washing disinfectant for the prevention of the Covid 19 virus. One of the ingredients that can be made handsanitizer gel is the mulberry plant (Morus alba L.) because it contains many flavonoids which act as antiseptics against bacteria. The research objective was to determine the handsanitizer gel formulation with the concentration of carbopol and propylenglycol which can produce good physical properties. The research design used an experiment, with the mulberry leaf preparation material macerated using 70% ethanol. Mulberry leaf ethanol extract (Morus alba L.) as the active substance and made 3 formulas with variations in the concentration of carbopol: propylenglycol formula I (0.5%: 15%), formula II (1.25%: 12.5%), formula III (2%: 10%). The three formulas were tested for physical properties and analyzed by ANOVA with a confidence level of 95%. The results showed that the handsanitizer gel formulation with carbopol increased viscosity and stickiness, while propylenglycol increased the dispersibility. The 1.25% formula: 12.5% ??produces the best physical properties, with a pH test of 6, a viscosity test of 150 dPas, a spreadability test of 6.5 cm, a sticky power test of 2.39 seconds and a protective power test without red stains.
Penetapan Kadar Kafein pada Teh Oolong (Camellia Sinensis) dengan Metode Titrasi Bebas Air Dian Irawati; Anita Agustina Styawan; Rahmi Nurhaini
Prosiding University Research Colloquium Proceeding of The 7th University Research Colloquium 2018: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

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Abstract

Teh telah dikonsumsi sebagai minuman selama hampir 2000 tahunyang lalu dimulai di Cina, minuman ini dibuat dengan menyeduh daundan kuncup muda pohon teh (Camellia sinensis) didalam air panas.Teh mengandung banyak senyawa yang berkhasiat untuk tubuh sepertikafein. Teh Oolong adalah teh hasil semioksidasi enzimatis atau tidakbersentuhan lama dengan udara saat diolah. Penelitian ini bertujuanuntuk menganalisis dan mengetahui kadar kafein pada teh oolong.Metode penelitian yang digunakan adalah observasional. Variabelyang digunakan adalah variabel tunggal yaitu kadar kafein dalam tehoolong (Camellia sinensis). Perlakuan untuk menetapkan kadar kafeinpada teh oolong dengan menggunakan metode titrasi bebas air.Sampel yang digunakan dalam penelitian ini adalah ekstrak kafeindari ekstraksi 100 gram simplisia kering teh oolong (Camelliasinensis) yang diambil dari cafe teh “Omah Lor” Kemuning, yangberada di Desa Kemuning, Kecamatan Ngargoyoso, KabupatenKaranganyar. Sampel diuji secara kualitatif menggunakan reaksimurexid. Kemudian dianalisis secara kuantitatif menggunakan metodeTitrasi Bebas Air. Hasil penelitian ini menunjukkan bahwa secarakualitatif sampel positif mengandung kafein yang ditandai denganperubahan warna menjadi merah. Secara kuantitatif, rata-rata kadarkafein pada teh oolong sebesar 1,864%. Kesimpulan dari penelitian iniadalah teh oolong secara kualitatif mengandung kafein, dan kadarkafein dalam teh oolong adalah 1,864%. Berdasarkan pemeriksaankuantitatif yang dilakukan diperoleh kadar kafein dalam teh oolongsebesar 1,864%. Dari hasil tersebut dapat diketahui bahwa kadarkafein dalam sampel rendah, yaitu sesuai literatur kadar kafein dalamteh sebesar 1,00 – 4,80%.
Perbandingan Kadar Kafein pada Teh Hitam (Camellia Sinensis) yang Diseduh dan Direbus dengan Metode Titrasi Bebas Air Anita Agustina Styawan; Muchson Arrosyid; S Sutaryono
Prosiding University Research Colloquium Proceeding of The 10th University Research Colloquium 2019: Bidang MIPA dan Kesehatan
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

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Abstract

Tanaman teh merupakan minuman paling banyak dikonsumsi masyarakat setelah air. Teh mengandung banyak senyawa yang berkhasiat untuk tubuh seperti kafein. Proses penyeduhan teh dengan waktu dan suhu yang tidak optimum dapat mempengaruhi kandungan kafein didalamnya. Semakin tinggi suhu dan lama waktu penyeduhan, kadar kafein dalam teh semakin meningkat. Dan proses penyeduhan dengan pemanasan dapat memperlebar jarak antar molekul dalam teh. Lebarnya jarak antar molekul dalam teh dapat mempermudah molekul air untuk menembus padatan teh sehingga kafein akan mudah terekstrak dalam pelarut air. Penelitian ini bertujuan untuk menganalisis kadar kafein pada teh hitam yang diseduh dan direbus, kemudian membandingkan kadar kafein pada teh hitam dengan proses penyeduhan diseduh (tanpa pemanasan) dan direbus (dengan pemanasan). Metode penelitian yang digunakan adalah eksperimental. Penelitian ini menggunakan sampel simplisia kering daun teh hitam (Camellia sinensis). Sampel diuji secara kualitatif menggunakan reaksi Murexid. Dianalisis kuantitatif menggunakan Titrasi Bebas Air. Hasil penelitian menunjukkan bahwa secara kualitatif sampel positif mengandung kafein yang ditandai dengan perubahan warna menjadi merah. Secara kuantitatif, kadar kafein pada teh hitam yang diseduh sebesar 10,718% b/v dan kadar kafein pada teh hitam yang direbus sebesar 10,986% b/v. Kesimpulan dari penelitian ini adalah terdapat perbedaan yang signifikan kadar kafein pada teh hitam yang diseduh dan direbus dengan nilai signifikasi 0,034<0,05.
Co-Authors Anggit Khusnul Khotimah Anisa Dita Rahmawati Aristhasari Putri Choiril Hana Mustofa Choril Hana Mustofa Dayah Ainus Dian Irawati Dwi Joko Yulianto Gandis Rohmanti Hendra Budiman Ida Naim Muslimah Lenny Apriyaningsih Muchson Arrosyid Nofia Putri Lestari Nurul Hidayati Putri Susanti Rahmi Nurhaini, Rahmi Refida Ramadhani Nur Cholifa S Sutaryono Sutaryono Sutaryono Yenni Kusuma Wardhani