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All Journal Biogenesis: Jurnal Ilmiah Biologi Biotropika The Journal of Pure and Applied Chemistry Research Jurnal Biodjati Biota Abdi: Jurnal Pengabdian dan Pemberdayaan Masyarakat JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Wira Eka Putra
Universitas Negeri Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Journal : Biotropika

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Expression of Erythroid Progenitor Cells and Erythrocytes on Dexamethasone Induced-Mice Putra, Wira Eka; Soewondo, Aris
Biotropika: Journal of Tropical Biology Vol 3, No 1 (2015)
Publisher : Biotropika: Journal of Tropical Biology

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Abstract

Dexamethasone (Dex) is synthetic corticosteroid, known as anti-inflamation drug to ameliorate autoimmune diseases. It worked by inhibiting production of proinflamatory citokines. The aim of this experiment was to confirm the effect of administration of Dex on erythroid progenitor cells, TER-119+VLA-4+ and erythrocytes, TER-119+VLA-4- expression from bone marrow compartments. Two weeks old BALB/c mice were used and grouped into 3 injection treatments of Dex with six replications i.e. no injection (control), 0.5 mg/kg BW (dose 1), 10 mg/kg BW (dose 2). To investigate the therapeutic effect of dexamethasone, the mice were sacrified on day-7. The bone marrow cells were isolated and analyzed by flow cytometry. Data analysis was confirmed with the Kruskal-Wallis test followed by Mann-Whitney test with significance level (α) of 0.05. The result showed that administration of Dex on BALB/c mice increase the expression of erythroid progenitor cells, TER-119+ VLA-4+ and erythrocytes, TER-119+VLA-4- from bone marrow.Key words: Dex, erythrocytes, erythroid progenitor cells
Expression of Erythroid Progenitor Cells and Erythrocytes on Dexamethasone Induced-Mice Wira Eka Putra; Muhaimin Rifa'i; Aris Soewondo
Biotropika: Journal of Tropical Biology Vol 3, No 1 (2015)
Publisher : University of Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Dexamethasone (Dex) is synthetic corticosteroid, known as anti-inflamation drug to ameliorate autoimmune diseases. It worked by inhibiting production of proinflamatory citokines. The aim of this experiment was to confirm the effect of administration of Dex on erythroid progenitor cells, TER-119+VLA-4+ and erythrocytes, TER-119+VLA-4- expression from bone marrow compartments. Two weeks old BALB/c mice were used and grouped into 3 injection treatments of Dex with six replications i.e. no injection (control), 0.5 mg/kg BW (dose 1), 10 mg/kg BW (dose 2). To investigate the therapeutic effect of dexamethasone, the mice were sacrified on day-7. The bone marrow cells were isolated and analyzed by flow cytometry. Data analysis was confirmed with the Kruskal-Wallis test followed by Mann-Whitney test with significance level (α) of 0.05. The result showed that administration of Dex on BALB/c mice increase the expression of erythroid progenitor cells, TER-119+ VLA-4+ and erythrocytes, TER-119+VLA-4- from bone marrow.Key words: Dex, erythrocytes, erythroid progenitor cells
Co-Authors Ahmad Hapiz Ahmad Taufiq Ana Mar'a Konita Firdaus Aris Soewondo Bagus Priambodo Bayyinatul Muchtaromah Eko Budi Minarno Evi Susanti Facthur Rohman Faturrahman Galuh Wening Permatasari Hendra Susanto Intan Chairun Nisa Maharani Retna Duhita Mardiana Lelitawati Mei Rhomawati Mochammad Fitri Atho'illah Muhaimin Rifa'i Muhaimin Rifa'i Nik Ahmad Nizam Nik Malek Prilya Dewi Fitriasari Salsabila Kasta Hygiea Iswara Sukiman Sukiman Syafira Maharani