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All Journal Damianus Journal of Medicine Jurnal Farmasi Galenika (Galenika Journal of Pharmacy)
I Made Agus Suarsana
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Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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3-YEAR OLD BOY FROM KOROWAY TRIBE WITH NOMA AND MALNUTRITION Tasya Gitaputri Pranoto; Imanuel Yulius Malino; Theo Adolf Rompas; I Made Agus Suarsana
Bahasa Indonesia Vol 21 No 1 (2022): Damianus Journal of Medicine
Publisher : Atma Jaya Catholic University of Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25170/djm.v21i1.2982

Abstract

Background: Noma is a rare infectious disease that rapidly destroys the soft tissues, perforating the hard tissues and the skin of the face. It was first named in the eighteenth century. Children aged between 2 and 6 years with poor oral hygiene, malnutrition, malaria, HIV infection, measles, living in a poor condition, and resource-constrained areas are at risk of the disease. This case emphasized the needs of greater understanding not only of the disease but also the multifactorial approach to attain health. Case Presentation Summary: A 3 year-old boy from Koroway was admitted with a month history of a lesion on the left cheek. The lesion had started as a vesicle on the left gum, progressing rapidly into an ulcer. At present, there was a hole on the left cheek. An ulcer with diameter of 5 cm, a greyish black area and edema appears on the external surface of the cheek, mandibular bone and teeth exposed. Associated with the lesion was pain, pus, malnutrition, no immunization records, and has a past history of recently malaria. The patient was living with his parents, a brother, and a sister in the tree house at Koroway. Physical examination revealed pale conjunctiva and ronkhi at the basal of the lungs. His height was 89 cm, weighed 10 kg which showed thinness. Laboratory findings were microcytic hypochromic anemia, elevated erythrocyte sedimentation rate, normal leukocytes, and hypoalbuminemia, Mantoux test was negative and no HIV infection was found. The patient was managed by blood transfusion, administration of antibiotics, debridement of the affected area, and putting on a high carbohydrate and protein diet, which was local foods such as bananas, eggs, and sago. After the lesion was smaller and no other complication revealed, the patient was discharged. Learning Points/Discussion: NOMA is an abandoned disease and known as the “face of poverty”. Early intervention can be made to minimize tissue destruction. Nevertheless, adequate steps regarding the availability, accessibility, and utilization of the resources with cultural approach might help to improve the health condition of individuals living in susceptible areas.
The Effectiveness of Ethanol Extract of Robusta Coffee Seeds on Blood Glucose, Urea, and Creatinine Levels of Male White Rats Induced by Streptozotocin: Efektivitas Ekstrak Etanol Biji Kopi Robusta terhadap Kadar Glukosa Darah, Urea, dan Kreatinin Tikus Putih Jantan yang Diinduksi Streptozotocin Joni Tandi; Mimi Marsella; I Made Agus Suarsana; Niluh Puspita Dewi; Magfirah Magfirah; Tien Wahyu Handayani; Maria Kanan
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 9 No. 2 (2023): (October 2023)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2023.v9.i2.16352

Abstract

Background: Traditional medicine plays a role in alternative treatment systems for diabetes mellitus. Objectives: This study aimed to screen the secondary metabolite of the ethanol extract from robusta coffee (Coffea canephora Pierre) seeds. We aimed to clarify the effects of these extracts on blood glucose, urea, and creatinine levels in Streptozotocin-Induced Diabetic Rats. Material and Methods: Phytochemical screening of extracts was carried out qualitatively according to standard methods. The rats were administered ethanol extracts of C. canephora Pierre seeds at doses of 100, 200, and 300 mg/kg body weight for 28 days. Blood glucose, urea, and creatinine levels were then compared between the control and diabetes groups. Results: The ethanol extract of C. canephora Pierre seeds contains alkaloids, flavonoids, saponins, and tannins. Group doses of 100-300 mg/kg body weight can significantly reduce blood glucose, urea, and creatinine levels. It can be concluded that the ethanol extract C. canephora Pierre seeds is a potential source of antidiabetic. Conclusions: The ethanol extract of C. canephora Pierre seeds shows potential as an antidiabetic agent.
Co-Authors Handi Wirawan Imanuel Yulius Malino Joan Tanumihardja Joni Tandi, Joni Magfirah Magfirah Maria Kanan Mimi Marsella Ni Putu Indra Dewi Niluh Puspita Dewi Santoso Anindita Tasya Gitaputri Pranoto Theo Adolf Rompas Tien Wahyu Handayani