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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Jurnal Kesehatan Andalas Jurnal Biodjati Indonesian Journal of Cardiology Buletin Ilmiah Nagari Membangun Majalah Kedokteran Andalas
Yose Ramda Ilhami
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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The Role of Endothelial Microparticle in Coronary Heart Disease as The Complications of Diabetes Mellitus Eka Fithra Elfi; Yose Ramda Ilhami; Eryati Darwin
Jurnal Biodjati Vol 4, No 1 (2019): May
Publisher : UIN Sunan Gunung Djati Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15575/biodjati.v4i1.4164

Abstract

  Coronary heart disease (CHD) is caused by obstruction of coronary blood flow due to endothelial dysfunction triggered by various genetic and non-genetic risk factors such as hyperlipidemia, hypertension, hyperglycemia and obesity. Endothelial cell activation due to hyperglycaemia in diabetes mellitus induces production of pro-inflammatory factors that damage the cell membrane triggering the formation of membrane particles called microparticles. Endothe-lial microparticles contain proteins including endothelial nitric oxide synthase (eNOS) which plays a role in the production of nitric oxide (NO). To determine the role of microparticles in the occurrence of coro-nary heart disease in diabetes mellitus due to endothelial dysfunction, a study was conducted by comparing the levels of eNOS and NO in DM patients who had CHD with DM patients who had no CHD. Blood samples from 20 DM patients who had CHD and 20 DM patients who had no CHD of the outpatients in Cardiology Department and Inter-nal Medicine department of regional public hospital were included in this study. All patients were fulfilled inclusion and exclusion criteria and diagnosed by the appropriate specialist. The eNOS and NO lev-els were measured using the ELISA method. The results of this study show that eNOS levels in the group of DM patients who had CHD (21,292±12,415 ng/ml) were significantly lower (p <0.05) than those in the group of DM patients who had no CHD (29,721±11,952 ng/ml). Nitric oxide levels in DM patients who had CHD (0,053±0,021 nmol/ μl) were not statistically different to the levels in DM patients who had no CHD (0,047±0,032 nmol/μl). From the results of this study we concluded that endothelial microparticle protein eNOS plays a role in the occurrence of CHD due to the complications of diabetes mellitus 
Hubungan Aktivitas Fisik dengan Kadar Glukosa Darah Puasa pada Pasien Diabetes Melitus yang Datang ke Poli Klinik Penyakit Dalam Rumah Sakit M. Djamil Padang Mala Azitha; Dinda Aprilia; Yose Ramda Ilhami
Jurnal Kesehatan Andalas Vol 7, No 3 (2018)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v7i3.893

Abstract

Aktivitas fisik merupakan satu dari empat pilar program penatalaksanaan diabetes mellitus. Aktivitas fisik yang kurang juga merupakan salah satu penyebab meningkatnya angka kejadian diabetes melitus. Tujuan penelitian ini adalah menentukan hubungan aktivitas fisik dengan kadar glukosa darah puasa pada pasien diabetes melitus. Jenis penelitian ini adalah analitik dengan pendekatan potong lintang terhadap 120 pasien diabetes melitus yang datang ke poliklinik penyakit dalam rumah sakit Dr. M. Jamil Padang yang memenuhi kritia inklusi dan ekslusi. Pada penelitian ini didapatkan dari 36 pasien dengan kadar glukosa darah puasa normal ada 24 pasien dengan aktivitas fisik ringan dan 12 pasien dengan aktivitas fisik sedang-berat. Dari 84 pasien yang memiliki kadar glukosa darah puasa meningkat, terdapat 60 pasien dengan aktivitas fisik ringan dan 24 pasien dengan aktivitas fisik sedang-berat. Hasil penelitian diolah dengan rumus Chi-square sehingga nilai p=0.602 (p>0.05). Simpulan studi ini ialah tidak terdapat hubungan yang bermakna antara aktivitas fisik dengan kadar glukosa darah puasa pada pasien diabetes melititus yang datang ke poliklinik rumah sakit M. Jamil Padang.
Disfungsi Mitokondria pada Gagal Jantung Akut Yose Ramda Ilhami
JURNAL KEDOKTERAN DAN KESEHATAN Vol 7, No 1 (2020)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V7I1.8945

Abstract

Mitokondria merupakan organel penting yang bermanfaat dalam homeostasis tubuh tidak hanya pada pembentukan ATP saja tetapi juga memiliki fungsi lain seperti mengatur pensinyalan sel dengan memodulasi keadaan redoks, memberikan cofactor untuk reaksi biokimia dan menghasilkan ligand untuk transduksi sinyal. Pada keadaan gagal jantung terjadi gangguan mitokondria yang diakibatkan oleh berbagai mekanisme meliputi hiperasetilasi protein, gangguan homeostasis kalsium, pembentukan spesies oksigen reaktif dan peningkatan respons inflamasi
Perdarahan saluran cerna setelah dilakukan intervensi koroner perkutan: suatu keputusan terapi yang sulit Meidianaser Putra; Muhammad Fadil; Yose Ramda Ilhami
Majalah Kedokteran Andalas Vol 41, No 3 (2018): Published in September 2018
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v41.i3.p120-133.2018

Abstract

Intervensi koroner perkutan merupakan prosedur invasif jantung yang sering dilakukan untuk mengobati pasien dengan penyakit arteri koroner. Komplikasi yang menakutkan seperti diseksi koroner atau penyumbatan koroner akut pada era balon angioplasti telah banyak berkurang dengan ditemukannya stent arteri koroner dan penggunaan rutin terapi antiplatelet dan antitrombotik. Peningkatan penggunaan DAPT tersebut meningkatkan risiko pasien untuk terjadinya cedera saluran cerna dan perdarahan. Mengobati pasien yang mengalami perdarahan setelah IKP merupakan suatu hal yang rumit, karena kita harus  mempertimbangkan intervensi yang tepat untuk mengelola perdarahan aktif, untuk menimbang manfaat potensial untuk meneruskan atau menghentikan terapi antiplatelet dan untuk mengevaluasi apakah diperlukan transfusi sel darah merah yang bisa menimbulkan efek samping yang merugikan. Pemberian PPI direkomendasikan oleh panduan Amerika dan Eropa untuk terapi yang bisa diberikan pada perdarahan saluran cerna akibat pemberian antiplatelet dan hemostasis endoskopi merupakan pilihan yang direkomendasikan untuk mengurangi angka morbiditas dan mortalitas.
PERANAN DURASI QRS DAN SKOR QRS SELVESTER DALAM KEBERHASILAN REPERFUSI MIOKARD Yose Ramda Ilhami
Majalah Kedokteran Andalas Vol 38, No 3 (2015): Published in December 2015
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (343.73 KB) | DOI: 10.22338/mka.v38.i3.p218-227.2015

Abstract

AbstrakPerubahan gambaran elektrokardiogram (EKG) terjadi pada fase akut IMA EST baik berupa perubahan repolarisasi ataupun perubahan depolarisasi. Skor QRS Selvester dan pemanjangan kompleks QRS merupakan parameter yang digunakan untuk memperkirakan luas infark dan penilaian iskemia. Tujuan penulisan ini adalah untuk mengetahui mekanisme perubahan durasi QRS dan skor QRS Selvester setelah reperfusi yang optimal. Penulisan artikel ini berdasarkan studi kepustakaan yang terkait dengan peranan durasi QRS dan skor QRS Selvester serta keberhasilan reperfusi miokard. Iskemia mengakibatkan perubahan gambaran listrik sel miokard normal, sehingga terjadi perubahan gambaran EKG yaitu meliputi perubahan gelombang T, elevasi segmen ST dan distorsi dengan pemanjangan kompleks QRS. Penilaian luas infark dapat dilakukan dengan menilai skor QRS Selvester. Iskemia juga mengakibatkan pemanjangan kompleks QRS melalui pemanjangan konduksi purkinye dan blok peri-infark. Reperfusi optimal dapat mengakibatkan regresi gelombang Q dan penurunan durasi kompleks QRS. Perubahan skor QRS selama reperfusi masih kontroversial. Perubahan pada durasi QRS dan skor QRS Selvester sebelum dan setelah reperfusi menandakan bahwa parameter ini merupakan parameter dinamis yang akan berubah ketika terjadinya reperfusi yang optimal pada tingkat seluler.AbstractChanges in Electro Cardiogram (ECG) occur in acute phase of STEMI either as repolarization or depolarization change. Selvester QRS score and lengthening of QRS complex duration are parameters that is used to predict infarct size and to analyze ischemia. The purpose of this literature review is to understand the mechanism of change in QRS duration and Selvester QRS score after optimal reperfusion. Ischemia causes changes in the electrical feature of normal myocardial cells including changes in the T wave, ST segment elevation and distortion with prolongation QRS complex. Assessment of infarct size can be done by assessing Selvester QRS score. Ischemia also resulted in prolongation of the QRS complex with elongation of Purkinje conduction and peri-infarction block. Optimal reperfusion may lead to regression of the Q wave and a decrease in the duration of the QRS complex. QRS score changes during reperfusion remains controversial. Changes in QRS duration and Selvester QRS score before and after reperfusion indicates that these parameters are dynamic parameters that will change when the optimal reperfusion occurs at the cellular level.
MITIGASI DAN EVAKUASI BENCANA PADA MASA PANDEMI COVID-19 BAGI MASYARAKAT PASIE NAN TIGO KOTO TANGAH KOTA PADANG Aisyah Elliyanti; Julizar Julizar; Lili Irawati; Miftah Irrahmah; Afriwardi Afriwardi; Yose Ramda Ilhami; Fika Anggraini; Rahmad Syawqi
BULETIN ILMIAH NAGARI MEMBANGUN Vol 5 No 4 (2022)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v5i4.333

Abstract

Disaster events both natural and non-natural factors such as epidemics can occur anytime and anywhere, which can affect communities and individuals. This natural or human-caused event or series of events can result in human casualties and suffering. Losses caused by disasters can be minimized or prevented if people's understanding of the disaster itself is sufficient, especially during the Covid-19 pandemic. Purpose: This activity is to conduct disaster mitigation training in the conditions of the Covid-19 pandemic for teachers at the Kanzul Ulum Islamic Boarding School, Kelurahan, in Pasie Nan Tigo, Koto Tangah District, Padang City. Activity target: the people of Pasie Nan Tigi Koto are able to carry out disaster mitigation and evacuation in the event of an earthquake followed by a tsunami, rising sea levels and waves. Method: activities in the form of lectures and exercises that begin with the distribution of masks to all participants involved in the activity, and filling out questionnaires on Covid-19 prevention and disaster management. After delivering the material, it was followed by a discussion on Covid-19 prevention, as well as drills on disaster mitigation and victim evacuation. The results of the activity were an increase in disaster mitigation and evacuation capabilities as well as an increase in participants' awareness in implementing health protocols for the prevention of Covid-19. Most of the participants' understanding of Covid-19 prevention and disaster management had increased, as evidenced by the increase in the number of correct questionnaire answers during the post-test compared to the pre-test from 50% to 80%. In addition, participants' skills have also increased regarding disaster mitigation, the implementation of evacuation techniques when a disaster occurs and how to evacuate victims when the disaster has subsided. Conclusion: Every individual left behind in a disaster-prone area needs to receive knowledge and training skills in disaster mitigation and evacuation techniques during the Covid-19 pandemic.
Management of Acute Coronary Syndrome Indonesia : Insight from One ACS Multicenter Registry Dafsah Arifa Juzar; Akhtar Fajar Muzakkir; Yose Ramda Ilhami; Nahar Taufiq; Tri Astiawati; I Made Junior R A; Miftah Pramudyo; Andria Priyana; Afdhalun Hakim; Setyasih Anjarwani; Jusup Endang; Bambang Widyantoro
Jurnal Kardiologi Indonesia Vol 43 No 2 (2022): Indonesian Journal of Cardiology: April - June 2022
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1406

Abstract

Background Acute coronary syndrome (ACS) is a life-threatening disorder which contributes to high morbidity and mortality in the world. Registry of ACS offers a great guidance for improvement and research. We collated a multicentre registry to gain information about demographic, management, and outcomes of ACS in Indonesia. Methods IndONEsia Acute Coronary Syndrome Registry (One ACS Registry) was a prospective nationwide multicenter registry with 14 hospitals participating in submitting data of ACS via standardized electronic case report form (eCRF). Between July 2018 and June 2019, 7634 patients with ACS were registered. This registry recorded baseline characteristics; onset, awareness, and transfer time; physical examination and additional test; diagnosis; in-hospital medications and intervention; complications; and in-hospital outcomes. Results Nearly half of patients (48.8%) were diagnosed with STE-ACS. Most prevalent risk factors were male gender, smoking, hypertension. Patients with NSTE-ACS tended to have more concomitant diseases including diabetes mellitus, dyslipidemia, prior AMI, HF, PCI, and CABG. Majority of ACS patients in our registry (89.4%) were funded by national health coverage. Antiplatelet, anticoagulant, antihypertensive, and statins were prescribed as 24-hours therapy and discharge therapy; however presription of potent P2Y12 inhibitor was low. More STE-ACS patients underwent reperfusion therapy than non-reperfusion (65.2% vs. 34.8%), and primary PCI was the most common method (45.7%). Only 21.8% STE-ACS patients underwent reperfusion strategy within 0-3 hours of onset. Invasive strategy performed in 17.6% of NSTE-ACS patients, and only 6.7% performed early (within <24 hours). Patients underwent early invasive strategy had a shorter median LoS than late invasive strategy (P<0.001). A shorter median LoS also found in intermediate and low risk patients. Mortality rate in our ACS patients was 8.9%; STE-ACS patients showed higher mortality than NSTE-ACS (11.7 vs. 6.2%). Conclusion Our registry showed a comparable proportion between STE- and NSTE-ACS patients, with male gender predominant in middle age. Both STE- and NSTE-ACS sharing the same risk factors. We need an improvement in referral time, especially in patients with STE-ACS. Evidence from our registry showed that there are two issues that need to be addressed in order to improve ACS outcomes: optimal and adequate medical treatment and invasive strategy.
Co-Authors Afdhalun Hakim Afriwardi Afriwardi Aisyah Elliyanti Akhtar Fajar Muzakkir Andria Priyana Bambang Widyantoro Dafsah Arifa Juzar Dinda Aprilia Eka Fithra Elfi Eryati Darwin Fika Anggraini I Made Junior R A Julizar Julizar Jusup Endang Lili Irawati Mala Azitha Meidianaser Putra Miftah Irrahmah Miftah Pramudyo Muhammad Fadil Nahar Taufiq Rahmad Syawqi Setyasih Anjarwani Tri Astiawati