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All Journal Jurnal Pendidikan dan Pembelajaran PROSIDING SEMINAR KIMIA Jurnal Kimia Mulawarman JURNAL ATOMIK Jurnal Abdimas Mahakam Jurnal Riset Kefarmasian Indonesia
Eva Marliana, Eva
Jurusan Kimia Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Mulawarman
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences

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UJI Brine Shrimp Lethality Test (BSLT) UMBI BAWANG TIWAI (Eleutherine bulbosa (Mill.) Urb) DAN UJI TOKSISITAS AKUT FRAKSI AKTIF Lestari, Dwi; Kartika, Rudi; Marliana, Eva
Jurnal Riset Kefarmasian Indonesia Vol 1 No 1 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (310.051 KB) | DOI: 10.33759/jrki.v1i1.43

Abstract

Eleutherine bulbosa (Mill.) Urb come from the Iridaceae family, this species contains secondary metabolites in the form of flavonoids and quinones. This research method includes Brine Shrimp Lethality Test (BSLT) toxicity using Artemia salina Leach larvae to determine the LC50 value. This study used experimental methods pharmacologically using a completely randomized design in the same direction pattern in the selection of test animals, 25 animals used were white mice divided into 5 groups with 5 mice per group, with 4 hours observed to find out toxic symptoms and continued observation every 24 hours to see death. Testing of BSLT results showed that ethanol extract had LC50 toxicity = 66.68 ppm (very toxic category), n-hexane fraction had LC50 toxicity = 47.64 ppm (very toxic category), chloroform fraction had LC50 toxicity = 295.1 ppm ( toxic category), and the water fraction has a toxicity of LC50 = 194.54 ppm (very toxic category). The chloroform fraction is an active fraction. Acute toxicity test LD50 value according to the calculation method of Miller Tainter Probit (187,499 mg/KgBB), the method of calculation of Thompson Weil (182,810 mg/KgBB), how to calculate Indonesian Pharmacopoeia (187,068 mg/KgBB). Based on the three calculations, the LD50 value is in the medium category (50-500 mg/kgBB).
PENINGKATAN HASIL BELAJAR SISWA MENGGUNAKAN COOPERATIVE LEARNING TEKNIK INDEX CARD MATCH DI KELAS IV Marliana, Eva; Margiati, K Y; Halidjah, Siti
Jurnal Pendidikan dan Pembelajaran Khatulistiwa Vol 7, No 9 (2018): September 2018
Publisher : Jurnal Pendidikan dan Pembelajaran Khatulistiwa

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Abstract

AbstractThe general problem of research "Whether by using cooperative learning index card match techniques can improve student learning outcomes in learning the use of units of time in class IV Elementary School 11 Pontianak East?".Using descriptive method. The Class Action Research Form is collaborative. The subjects of the research are teachers as researchers and students of class IV which amounted to 24 people. Using direct observation techniques and documentation techniques, data collection tools of observation sheets and test instruments. Score data of teachers' ability to design and implement learning using cooperative learning index card match technique can improve learning outcomes of learners in learning class IV Mathematics. The study was conducted 3 cycles. Every cycle I meeting. The results achieved in this study the ability of teachers to design the learning cycle with an average score of 2.70, cycle II 3.36, cycle III 3.93. The ability of teachers to implement learning cycle I average 3.05, cycle II 3.53, cycle 3 3.81. Student learning outcomes in learning cycle I average 70.42, cycle II 82.29, cycle III 90.21. Implementation of cooperative learning index card match techniques in learning Mathematics can improve student learning outcomes fourth grade Elementary School 11 Pontianak East. Keywords:Learning Outcomes, Cooperative Learning Index Card Match Techniques, Mathematics.
POTENSI AKTIVITAS ANTIOKSIDAN EKSTRAK METANOL DAUN KELEDANG (Artocarpus lanceifolius Roxb) Novia Rahmawati Isyahro; Nanang Tri Widodo; Eva Marliana
PROSIDING SEMINAR KIMIA 2021: SEMINAR NASIONAL KIMIA 2021
Publisher : PROSIDING SEMINAR KIMIA

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Abstract

Uji aktivitas antioksidan ekstrak metanol dari daun Artocarpus lanceifolius Roxb. telah dilakukan. Penelitian ini bertujuan untuk mengetahui sifat antioksidan ekstrak metanol dari daun Artocarpus lanceifolius Roxb. Aktivitas antioksidan ekstrak metanol daun keledang ditentukan menggunakan metode peredaman radikal DPPH. Berdasarkan hasil uji fitokimia diketahui bahwa ekstrak metanol mengandung flavonoid, fenolik, steroid dan triterpenoid. Ekstrak metanol menunjukkan aktivitas antioksidan dengan kategori sedang yang memiliki nilai IC50 sebesar 129,963 mg/L. Ekstrak metanol dari daun Artocarpus lanceifolius Roxb. memiliki potensi sebagai antioksidan. Kata kunci: Artocarpus lanceifolius Roxb, Antioksidan, IC50.
AKTIVITAS EKSTRAK METANOL DAUN KELEDANG (Artocarpus lanceifolius Roxb) SEBAGAI ANTIINFLAMASI Nur Hidayah; Daniel Daniel; Eva Marliana
PROSIDING SEMINAR KIMIA 2021: SEMINAR NASIONAL KIMIA 2021
Publisher : PROSIDING SEMINAR KIMIA

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Abstract

Uji aktivitas antiinflamasi daun keledang (Artocarpus lanceifolius Roxb) terhadap penghambatan denaturasi protein secara in vitro telah dilakukan. Penelitian ini bertujuan untuk mengetahui persen penghambatan denaturasi protein dan kekuatan aktivitas antiinflamasi dari ekstrak metanol daun keledang (Artocarpus lanceifolius Roxb). Metode yang digunakan ialah metode in vitro menggunakan Bovine serum albumine (BSA) sebagai protein yang diinduksi oleh panas. Kontrol positif yang digunakan adalah natrium diklofenak. Hasil skrining fitokimia pada ekstrak metanol daun Artocarpus lanceifolius Roxb diketahui mengandung senyawa metabolit sekunder flavonoid, fenolik, triterpenoid dan steroid. Aktivitas antiinflamasi ekstrak metanol daun keledang (Artocarpus lanceifolius Roxb) dalam IC50 adalah 195,0704 mg/L Ekstrak metanol daun keledang (Artocarpus lanceifolius Roxb) memiliki potensi sebagai antiinflamasi. Kata Kunci: Artocarpus lanceifolius Roxb, Antiinflamasi, In Vitro.
ANALISIS KUALITAS DAN KOMPOSISI ASAM LEMAK DARI MINYAK BIJI WIJEN (Sesamum Indicum L) Aryoga Oktabriangga Saputra; Daniel Daniel; Eva Marliana
PROSIDING SEMINAR KIMIA 2021: SEMINAR NASIONAL KIMIA 2021
Publisher : PROSIDING SEMINAR KIMIA

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Abstract

Biji wijen (Sesamum Indicum L) merupakan salah satu sumber minyak nabati. Tanaman wijen banyak dimanfaatkan sebagai bahan pangan. Biji wijen merupakan salh satu sumber minyak nabati yang belum diketahui sifat fisiko-kimianya, sehingga pemanfaatan biji wijen belum maksimal. Pada penelitian ini, minyak biji wijen diperoleh melalui proses ektraksi dengan metode maserasi menggunakan pelarut n-heksana. Hasil ekstraksi berupa minyak berwarna kuningyang diproses kembali untuk menghasilkan minyak lebih murni dengan penetralan dan pemucatan. Minyak hasil ekstraksi yang telah dimurnikan tersebut dianalisis sifat fisiko-kimianya. Komposisi asam lemak dari minyak biji wijen adalah eicosanioc acid (5,12%), 9,12-octadecadienoic acid (2,71%), n-hexadecanoic acid (14,52%), octadecanoic acid (5,91%), 9-octadecanoic acid (43,57%) dan 10(E), 12(Z)-conjugated linoleic acid (21,64%). Sifat fisika dan kimia dari minyak biji wijen adalah bobot jenis dan indeks biasnya sebesar 1,037 gram/mL dan 1,465. Bilangan asamnya sebesar 9,117 mg KOH/g sampel. Bilangan penyabunan sebesar 172,8 mg KOH/g sampel. Bilangan iod sebesar 91,3184 g iod/100 g sampel. Bilangan peroksida sebesar 6,546 meq O2/kg sampel. Kadar materi tidak tersabunkan sebesar 0,001% dan kadar asam lemak bebas sebesar 4,309%. Kata Kunci: Sesamum Indicum L, minyak nabati, ekstraksi, asam lemak.
AKTIVITAS ANTIINFLAMASI EKSTRAK METANOL DAUN PARE HUTAN (Momordica balsamina Linn.) DALAM MENGHAMBAT DENATURASI PROTEIN Minarti Minarti; Ritbey Ruga; Eva Marliana
PROSIDING SEMINAR KIMIA 2021: SEMINAR NASIONAL KIMIA 2021
Publisher : PROSIDING SEMINAR KIMIA

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Abstract

Aktivitas antiinflamasi ekstrak matanol daun pare hutan (Momordica balsamina Linn.) dalam menghambat denaturasi protein telah dilakukan. Penelitian ini bertujuan untuk mengetahui aktivitas antiinflamasi dari ekstrak metanol daun pare hutan (Momordica balsamina Linn.) dengan metode penghambatan denaturasi protein. Protein yang digunakan adalah bovine serum albumin (BSA) 0,2% (w/v) dalam tris buffer saline (TBS). Kontrol positif yang digunakan adalah natrium diklofenak. Hasil uji fitokimia ekstrak metanol daun pare hutan (Momordica balsamina Linn.) mengandung senyawa golongan alkaloid, steroid, fenolik dan flavonoid. Hasil uji aktivitas antiinflamasi ekstrak metanol daun pare hutan (Momordica balsamina Linn.) diperoleh nilai inhibition concentration 50% (IC50) sebesar 127,95 µg/mL. Ekstrak metanol daun pare hutan (Momordica balsamina Linn.) memiliki aktivitas sebagai antiinflamasi sedang. Kata Kunci: Momordica balsamina Linn., Antiinflamasi, Bovine Serum Albumin, Inhibition Concentration 50%.
THREE PRENYLATED FLAVONOIDS FROM MACARANGA PEARSONII MERR. Eva Marliana; Tjitjik Sri Tjahjandarie; Mulyadi Tanjung
PROSIDING SEMINAR KIMIA PROCEEDING OF INTERNATIONAL CONFERENCE 2015
Publisher : PROSIDING SEMINAR KIMIA

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Abstract

Three prenylated flavonoids, 4’-O-methyl-8-isoprenyleriodictiol (1), 4’-O-methyl-8-isoprenylnaringenin (2) and lonchocarpol A (3) have been isolated from the leaves of Macaranga pearsonii Merr.. The structure of compounds have been elucidated based on its spectroscopic data, including UV, 1D and 2D NMR, and HREISMS spectra.
AKTIVITAS ANTIOKSIDAN SENYAWA FLAVONOID DARI Macaranga pearsonii Merr. Eva Marliana; Tjitjik Srie Tjahjandarie; Mulyadi Tanjung
JURNAL KIMIA MULAWARMAN Vol 13 No 2 (2016)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Abstract

Tiga senyawa flavanon , 4’-O-metil-8-isoprenileriodiktiol (1), 4’-O-metil-8-isoprenilnaringenin (2) and Lonkokarpol A (3) , telah diisolasi dari ekstrak metanol daun Macaranga pearsonii Merr. Elusidasi struktur senyawa berdasarkan data spektroskopi UV, 1D and 2D NMR, and HREISMS. Senyawa 1 – 3 ditentukan aktivitas antioksidannya terhadap peredaman radikal bebas 2,2-diphenyl-1-picrylhydrazyl (DPPH), dengan nilai IC50 adalah 536,89 μM, 1226,11 μM dan 426,43 μM.
STUDI KOMPUTASI BERBASIS DFT TERHADAP FENOMENA QUANTUM TUNNELING DALAM ISOMERISASI METILHIDROKSIKARBENA Jumaidil Awal; Rahmat Gunawan; Eva Marliana
JURNAL KIMIA MULAWARMAN Vol 9 No 2 (2012)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Abstract

Density functional theory-based methods have been applied to predict the most possible one among the isomerizations of methylhydroxycarbene considering the probability of hydrogen tunneling occurrence. B3LYP/6-31+G(d,p) and M08-SO/6-31+G(d,p) methods were applied in all computations using GAMESS-US software. There were three steps of computation in this research. First, electronic structure computations of both equilibrium and transition compounds involved in all isomerization alternatives in order to obtain the optimum structures of the compounds. Second, vibrational computations of optimum transition structures to ensure that each of the respective structures is well on its potential energy surface. Third, tunneling analysis accomplished by intrinsic reaction coordinate (IRC) computatuins for all isomerization alternatives followed by tunneling probabilitycalculation using the Wentzel-Kramers-Brillouin (WKB) formula for methylhydroxycarbene isomerizations. The result of this research showed that the DFT methods successfully produced the optimum structure of each compound. Both DFT methods also successfully mapped all the intrinsic reaction coordinates. B3LYP/6-31+G(d,p) method gave tunneling probabilities of 3.55 x 10-19 for the isomerization into acetaldehyde and 3.30 x 10-20 for that into vinyl alcohol. While M08-SO/6-31+G(d,p) method gave tunneling probabilities of 2.38 x 10-23 for the isomerization into acetaldehyde and 4.79 x 10-23 for that into vinyl alcohol.Keywords: DFT, methylhydroxycarbene, hydrogen tunneling, isomerization
Aktivitas Antioksidan dan Antimalaria Senyawa Fenolik dari Daun Macaranga beccariana Merr. Eva Marliana; Chairul Saleh; Medi Hendra
JURNAL KIMIA MULAWARMAN Vol 15 No 2 (2018)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v15i2.611

Abstract

Macaranga beccariana Merr. is an endemic plant of Kalimantan which is no report yet about its biological activity and isolated compounds. Therefore, in order to know the potency of M. beccariana, determination of antioxidant and antimalarial activities along with isolation of bioactive compounds from this plant must be carried out. In this research, the leaves of M. beccariana was extracted using methanol to obtain methanol extract. Furthermore, the extract was separated and purified to obtain compound 1 and compound 2. Based on structure elucidation using spectrometer analysis including UV, 1H and 13C NMR, compounds 1 and 2 which belong to phenolics were identified as 4-hidroxybenzoic acid and 3,4-dihidroxybenzoic acid, respectively. Moreover, antioxidant activity using DPPH (2,2-diphenyl-1-picrylhydrazyl) and antimalarial activity towards Plasmodium falciparum strain 3D7 using Giemsa staining were performed. Rutine and chloroquine difosfat were used as positive controls for antioxidant and antimalarial, respectively. The results showed that the methanol extract of M. beccariana and its isolated compounds (1 and 2) are active for those activities. It can be concluded that the leaves of M. beccariana has good potency as antioxidant and antimalarial agents.
Co-Authors Agustina R. M. Alma Yulvita Pebriana Aryoga Oktabriangga Saputra Chairul salaeh Chairul Saleh Daniel Daniel Daniel Daniel Daniel Daniel Dea Rakasiwi Djihan Ryn Pratiwi Djihan Ryn Pratiwi Doni Prio Atmoko Dwi Lestari Dynda Rosiana Dewi Elfiza Amalia Ersa Marina Rahmawati Erwin Erwin Erwin Erwin Husnul Chatimah Ika Yekti Liana Sari irfa Ashari Hyahara Irvan Afandi Jumaidil Awal K Y Margiati, K Y Madaniah Fathirah Medi Hendra, Medi Mirna Hidaya Tullah Muh. Naufal Hisyam Mulyadi Tanjung Nanang Tri Widodo Noor Hindryawati Novia Rahmawati Isyahro Nur Hidayah Nur Khasanah Nur Khsanah Nurfadzillah - Rahmat Gunawan Riski Vebryanti Ramadhani Ritbey Ruga Rudi Kartika, Rudi Sahira Fara Nabila Siti Halidjah Soerja Koesnarpadi Tjitjik Sri Tjahjandarie Tjitjik Srie Tjahjandarie Wihda Nisa Alhayyu Winni Astuti Winni Astuti