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All Journal Jurnal Pendidikan dan Pembelajaran PROSIDING SEMINAR KIMIA Jurnal Kimia Mulawarman JURNAL ATOMIK Jurnal Abdimas Mahakam Jurnal Riset Kefarmasian Indonesia
Eva Marliana, Eva
Jurusan Kimia Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Mulawarman
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences

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Journal : Jurnal Riset Kefarmasian Indonesia

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UJI Brine Shrimp Lethality Test (BSLT) UMBI BAWANG TIWAI (Eleutherine bulbosa (Mill.) Urb) DAN UJI TOKSISITAS AKUT FRAKSI AKTIF Lestari, Dwi; Kartika, Rudi; Marliana, Eva
Jurnal Riset Kefarmasian Indonesia Vol 1 No 1 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (310.051 KB) | DOI: 10.33759/jrki.v1i1.43

Abstract

Eleutherine bulbosa (Mill.) Urb come from the Iridaceae family, this species contains secondary metabolites in the form of flavonoids and quinones. This research method includes Brine Shrimp Lethality Test (BSLT) toxicity using Artemia salina Leach larvae to determine the LC50 value. This study used experimental methods pharmacologically using a completely randomized design in the same direction pattern in the selection of test animals, 25 animals used were white mice divided into 5 groups with 5 mice per group, with 4 hours observed to find out toxic symptoms and continued observation every 24 hours to see death. Testing of BSLT results showed that ethanol extract had LC50 toxicity = 66.68 ppm (very toxic category), n-hexane fraction had LC50 toxicity = 47.64 ppm (very toxic category), chloroform fraction had LC50 toxicity = 295.1 ppm ( toxic category), and the water fraction has a toxicity of LC50 = 194.54 ppm (very toxic category). The chloroform fraction is an active fraction. Acute toxicity test LD50 value according to the calculation method of Miller Tainter Probit (187,499 mg/KgBB), the method of calculation of Thompson Weil (182,810 mg/KgBB), how to calculate Indonesian Pharmacopoeia (187,068 mg/KgBB). Based on the three calculations, the LD50 value is in the medium category (50-500 mg/kgBB).
Co-Authors Agustina R. M. Alma Yulvita Pebriana Aryoga Oktabriangga Saputra Chairul salaeh Chairul Saleh Daniel Daniel Daniel Daniel Daniel Daniel Dea Rakasiwi Djihan Ryn Pratiwi Djihan Ryn Pratiwi Doni Prio Atmoko Dwi Lestari Dynda Rosiana Dewi Elfiza Amalia Ersa Marina Rahmawati Erwin Erwin Erwin Erwin Husnul Chatimah Ika Yekti Liana Sari irfa Ashari Hyahara Irvan Afandi Jumaidil Awal K Y Margiati, K Y Madaniah Fathirah Medi Hendra, Medi Mirna Hidaya Tullah Muh. Naufal Hisyam Mulyadi Tanjung Nanang Tri Widodo Noor Hindryawati Novia Rahmawati Isyahro Nur Hidayah Nur Khasanah Nur Khsanah Nurfadzillah - Rahmat Gunawan Riski Vebryanti Ramadhani Ritbey Ruga Rudi Kartika, Rudi Sahira Fara Nabila Siti Halidjah Soerja Koesnarpadi Tjitjik Sri Tjahjandarie Tjitjik Srie Tjahjandarie Wihda Nisa Alhayyu Winni Astuti Winni Astuti