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All Journal Media Ilmu Keolahragaan Indonesia Medical Journal of Indonesia Majalah Kedokteran Nusantara The Journal Of Medical School Sumatera Medical Journal
Aznan Lelo
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Health Professions Immunology & microbiology Medicine & Pharmacology

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The chronopharmacological effect of curcumin on human gall-bladder Rasyid, Abdul; Rahman, Abdul R.; Jaalam, Kamaruddin; Lelo, Aznan
Medical Journal of Indonesia Vol 10, No 4 (2001): October-December
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (540.244 KB) | DOI: 10.13181/mji.v10i4.40

Abstract

Human gallbladder physiologically contracts and relaxes periodically. It has been demonstrated that curcumin (C) an active compound of Curcuma xanthorrhiza and Curcuma domestica produces a positive cholekinetic effect. The objective of this study is to define the influence of physiologic contraction and refilling of human gallbladder on the cholekinetic effect of Curcumin, and to determine the rime to achieve the maximum gall-bladder contraction after administration of 40 mg curcumin. Twelve healthy volunteers ingested 40 mg C and placebo (P) in a randomized double blind cross over study design. The volumes of gallbladder before and after taking C and P were half hourly determined by utrasonography and calculated using the ellipsoid methad for 6.0 hours. After P administration there is no gallbladder contraction. While afier C administration there was a contraction phase for 2 hours followed by a refilling phase for another 2.5 hours and then followed by second gall-bladder contraction started for 4.5 up to 6.0 hours. The maximal volume of gallblndder after 6.A hours was less than the basal volume, The cholekinetic effect of C is not chronopharmacologically influenced by the gall-bladder physiologic periodic contraction and refilling. The maximum contraction effect of C was achieved at 2 hours after oral administraion. (Med J Indones 2001; 10: 219-23)Keywords: curcumin, gall bladder, contraction
Hubungan Koloni Pseudomonas Aeruginosa dengan Persentase Split Take Thickness Skin Graft (STSG) Pada Pasien Luka Bakar Di RSUP H. Adam Malik Medan Nst, Roni Marzuki; Buchari, Frank Bietra; Tarigan, Utama; Lelo, Aznan
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 50, No 3 (2017): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Abstract

Pendahuluan Luka bakar masih merupakan masalah global. Insiden luka bakar di seluruh dunia pada tahun 2004 diperkirakan 1,1 per 100.000 penduduk. Dan hampir separuh terjadi di wilayah Asia Tenggara. Skin graft digunakan dalam berbagai situasi klinis termasuk rekonstruksi luka bakar. ). Patogen yang paling umum yang menyebabkan kegagalan graft adalah coagulase positive staphylococcus, Pseudomonas dan beta-haemolytic Streptococcus. Oleh karena itu, peneliti perlu meneliti hubungan koloni Pseudomonas aeruginosa dengan tingkat keberhasilan skin graft pada pasien luka bakar di RSUP H. Adam Malik Medan.Metode Penelitian ini merupakan penelitian descriptive analitik dengan desain penelitian crossectional, dilakukan di Departemen Ilmu Bedah Plastik RSUP H. Adam Malik Medan selama periode Februari sampai Juni 2014. Populasi dalam penelitian ini adalah seluruh penderita luka bakaryang dirawat di RSUP H. Adam Malik Medan pada kurun waktu Februari sampai Juni 2014 yang dilakukan skin graft.Hasil Dari 22 kasus luka bakar dijumpai persentase take skin graft > 80% pada 16 pasien (72.7%), persentase take skin graft antara 50-80% pada 5 pasien (22.7%), dan persentase take skin graft < 50% dijumpai pada 1 pasien. take skin graft >80% pada luka bakar dengan Pseudomonas aeroginosa dijumpai pada 3/7 kasus (42,86%) yang lebih sedikit pada luka bakar non Pseudomonas aeroginosa yaitu pada 13/15 kasus (86,67%). Take <80% pada penderita luka bakar dengan Pseudomonas aeroginosa ( 4/7 = 57.14% ) lebih banyak dari pada luka bakar dengan non Pseudomonas aeroginosa ( 2/15 = 13,33% ). Namun perbedaan ini secara statistik hampir bermakna (p=0,073).Kesimpulan Tingkat keberhasilan skin graft sebesar >80% pada luka bakar dengan Pseudomonas aeroginosa dijumpai pada 3/7 kasus (42,86%) yang lebih sedikit pada luka bakar non Pseudomonas aeroginosa yaitu pada 13/15 kasus (86,67%). Berdasarkan uji chi square tidak dijumpai adanya hubungan koloni Pseudomonas aeruginosa dengan tingkat keberhasilan skin graft pada penderita luka bakar (p=0,073)Kata Kunci Pseudomonas Aeruginosa, Split Take Thickness Skin Graft (STSG), Luka Bakar
The Effect of Torbangun Leaves Tea on Msg-induced Fetal Develop-ment Disorder in Mice M.Kes, Sufitni; Feriyawati, Lita; Pane, Yunita Sari; Lelo, Aznan
Sumatera Medical Journal Vol. 2 No. 1 (2019): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (472.383 KB) | DOI: 10.32734/sumej.v2i1.717

Abstract

The safety of MSG on the fetus has not been confirmed yet. The objective of this research is to determine the effect of tea of torbangun leaves on fetal development disorder of mice. The present study is experimental with a Completely Randomized Design (CRD). Data obtained were then analyzed by ANOVA, with p<0,05 as the level of significant. The comparison of mean values ± SEM increase number of live fetuses group C1-T1 (4,60 ± 0,93; 11,40 ± 0,87), p=0,018. The comparison of mean values ± SEM decrease number of embryo re-sorption percentage group C0-C1 (00,00 ± 00,00; 36,74 ± 15,13), group C1-C2 (36,74 ± 15,13; 00,00 ± 0,00), group C1-T1 (36,74 ± 15,13; 00,00 ± 0,00), and group C1-T2 (36,74 ± 15,13; 15,00 ± 22,36), p=0,020. This study concluded that T1 group is giving the best effect on increasing life fetuses and decreasing embryo re-sorption percentage.
Salat Dhuha Improves Blood Pressure: A Randomized Controlled Trial Boy, Elman; Lelo, Aznan; Tarigan, Amira Permatasari; Machrina, Yetty; Yusni, Yusni; Harahap, Juliandi; Sembiring, Rosita Juwita; Syafril, Santi; Sumartiningsih, Sri
Media Ilmu Keolahragaan Indonesia Vol 11, No 2 (2021): December 2021
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/miki.v11i2.34225

Abstract

The prevalence of hypertension increases with age, more than 1 in every two elderly has hypertension, dominated by women. The primary prevention of hypertension is a worldwide public health concern. Salat dhuha is a moderate-intensity physical activity. Salat 2 movement cycles demonstrated improved systolic and diastolic blood pressure in adults. Our study purpose was to assess the effect of 2 and 8 movement cycles (rakaat) of salat dhuha to improve systolic and diastolic blood pressure in healthy Muslim elderly women. Muslim elderly women in a government senior residence (aged 60-74 years) participated in a 6 weeks controlled trial. We completed formal physical, clinical, and blood assessments before admission. Participants with hypertension history were excluded. The participants were randomized into 2 groups. The intervention group performed 8 rakaat of salat dhuha (n=13) and the control group performed 2 rakaat of salat dhuha (n=13). Two participants were dropped out of this study. At baseline and at the end of 6 weeks, a blood pressure examination is recorded. Parametric and nonparametric methods were used to analyze the data. The baseline characteristics of the two groups of participants were homogeneous. Compared to the control, the 8 rakaat of salat dhuha achieved a significant reduction in systolic and diastolic blood pressure (P0.05) at the end of the 6-weeks period. The findings show that salat dhuha has significant potential to improve blood pressure.
Co-Authors Abdul R. Rahman Abdul Rasyid Buchari, Frank Bietra ELMAN BOY Feriyawati, Lita Harahap, Juliandi Kamaruddin Jaalam Nst, Roni Marzuki Santi Syafril, Santi Sembiring, Rosita Juwita Sri Sumartiningsih Sufitni Tarigan, Amira Permatasari Tarigan, Utama Yetty Machrina Yunita Sari Pane Yusni Yusni