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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya Medical Journal of Indonesia Research Journal of Life Science Program Kreativitas Mahasiswa - Penelitian INDONESIAN JOURNAL OF PHARMACY MNJ (Malang Neurology Journal) Majalah Kesehatan FKUB
Diana Lyrawati
Laboratorium Farmasi Fakultas Kedokteran Universitas Brawijaya Malang
Agriculture, Biological Sciences & Forestry Education Environmental Science Medicine & Pharmacology Neuroscience Public Health

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Journal : INDONESIAN JOURNAL OF PHARMACY

 1 
MONOSODIUM GLUTAMATE EXPOSURE AT EARLY DEVELOPMENTAL STAGE INCREASES APOPTOSIS AND STEREOTYPIC BEHAVIOR RISKS ON ZEBRAFISH (DANIO RERIO) LARVAE Nia Kurnianingsih; Juliyatin Putri Utami; Nurdiana Nurdiana; Diana Lyrawati
Indonesian Journal of Pharmacy Vol 27 No 3, 2016
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1107.374 KB) | DOI: 10.14499/indonesianjpharm27iss3pp128

Abstract

Excessive glutamate may give neurotoxic effects and contribute to Autism spectrum disorder(ASD). In this study, we investigated prolonged exposure effects of 10 µg/mL Monosodium Glutamate (MSG) on intracellular calcium level, bax, bcl-2, ratio of bax/bcl-2 genes expression, caspase-3, apoptosis of brain cells and stereotypic behavior of Zebrafish (Danio rerio) larvae at early developmental stages. Genes expression were determined by real time PCR, caspase-3 using ELISA, intracellular Ca2+ and apoptotic cells of brain using confocal microscopy, locomotor activity by using crossing lines assay whereas stereotypic behavior by circle swimming. The results indicated that MSG exposure increased brain bax and bcl-2; and caspase-3; intracellular Ca2+; and apoptosis; stereotypic behavior; and decreased locomotor activity. Termination of MSG treatments resulted in recovery of bax, bcl-2, caspase-3 basal levels and stereotypic behavior. In conclusion, MSG exposure at early embryonic stage increased brain cell damage and risk of behavior changes.
Co-Authors Alifia Putri Febriyanti Aswaty Nur Beta Herilla Sekti Debby Shintiya D Desie Suci Permata Sari Devi Anggraeni Pramulawati Djala, Fany Lairin Edi Widjajanto Elhemeidy, Rehab Mohammed Mustofa Ellen Natalia Faridha Khaira H Firman Mulyo Wicaksono Fitria Nurindro Rahmahani Habiba Aurora Herawati Sudoyo Herin Mawarti Herlina Y Handoko Hidayat Sujuti Imam Sarwono Indah Dina Maritha Juniartha, Putu Kenichi Yano Krisna Bayu Tambunan M Aris Widodo M. Rasjad Indra Mahfud, Rania Arif Martina Kurnia Rohmah Masruroh Rahayu, Masruroh Mohamad Rasjad Indra Mudjiwijono Handaru Muhammad Rasjad Indra Neshya Ruriana Putri, Neshya Ruriana Nia Kurnianingsih Noorma Lukitasari Novita Fahrianti Putri Nur Lailatul Fitria Nur Samsu Nurdiana Nurdiana Oktavia Rahayu Adianingsih Retty Ratnawati Retty Ratnawati Rudy Salam, Rudy Sangkot Marzuki Setyawati Soeharto, Setyawati Supranowo Supranowo Tatit Nurseta Tri Yudani Mardining Raras Utami, Juliyatin Putri Widjadjanto, Edi Yitania Sari